The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Human placenta and trophoblast development: key molecular mechanisms and model systems
Open accessAbstract
Abnormal placentation is considered as an underlying cause of various pregnancy complications such as miscarriage, preeclampsia and intrauterine growth restriction, the latter increasing the risk for the development of severe disorders in later life such as cardiovascular disease and type 2 diabetes. Despite their importance, the molecular mechanisms governing human placental formation and trophoblast cell lineage specification and differentiation have been poorly unravelled, mostly due to the lack of appropriate cellular model systems. However, over the past few years major progress has been made by establishing self-renewing human trophoblast stem cells and 3-dimensional organoids from human blastocysts and early placental tissues opening the path for detailed molecular investigations. Herein, we summarize the present knowledge about human placental development, its stem cells, progenitors and differentiated cell types in the trophoblast epithelium and the villous core. Anatomy of the early placenta, current model systems, and critical key regulatory factors and signalling cascades governing placentation will be elucidated. In this context, we will discuss the role of the developmental pathways Wingless and Notch, controlling trophoblast stemness/differentiation and formation of invasive trophoblast progenitors, respectively.
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Cites
Single-cell reconstruction of the early maternal–fetal interface in humans
Vento-Tormo, R., Efremova, M., Botting, R. A., Turco, M. Y., Vento-Tormo, M., Meyer, K. B., Park, J.-E., Stephenson, E., Polański, K., Goncalves, A., et al. (2018) · Nature · doi:10.1038/s41586-018-0698-6 · Cited by 2,358
The “Great Obstetrical Syndromes” are associated with disorders of deep placentation
Brosens, I., Pijnenborg, R., Vercruysse, L., & Romero, R. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.08.009 · Cited by 1,568
The developmental origins of chronic adult disease
Barker, D. (2004) · Acta Paediatrica · doi:10.1111/j.1651-2227.2004.tb00236.x · Cited by 790
Maternal and Fetal Hypothalamic‐Pituitary‐Adrenal Axes During Pregnancy and Postpartum
MASTORAKOS, G., & ILIAS, I. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1290.016 · Cited by 621
The Role of Placental Hormones in Mediating Maternal Adaptations to Support Pregnancy and Lactation
Napso, T., Yong, H. E. J., Lopez-Tello, J., & Sferruzzi-Perri, A. N. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01091 · Cited by 470
The influence of the intrauterine environment on human placental development
Burton, G. J., Jauniaux, E., & Charnock-Jones, D. S. (2010) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082764gb · Cited by 307
Du, W. J., Chi, Y., Yang, Z. X., Li, Z. J., Cui, J. J., Song, B. Q., Li, X., Yang, S. G., Han, Z. B., & Han, Z. C. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0418-9 · Cited by 200
Hemberger, M., Udayashankar, R., Tesar, P., Moore, H., & Burton, G. J. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq128 · Cited by 181
Genome amplification and cellular senescence are hallmarks of human placenta development
Velicky, P., Meinhardt, G., Plessl, K., Vondra, S., Weiss, T., Haslinger, P., Lendl, T., Aumayr, K., Mairhofer, M., Zhu, X., et al. (2018) · PLOS Genetics · doi:10.1371/journal.pgen.1007698 · Cited by 102
Self-citationClark, A. R., James, J. L., Stevenson, G. N., & Collins, S. L. (2018) · Placenta · doi:10.1016/j.placenta.2018.05.001 · Cited by 86
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Cited by
The placenta in fetal growth restriction: What is going wrong?
Sun, C., Groom, K. M., Oyston, C., Chamley, L. W., Clark, A. R., & James, J. L. (2020) · Placenta · doi:10.1016/j.placenta.2020.05.003 · Cited by 253
Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy
Swingle, K. L., Safford, H. C., Geisler, H. C., Hamilton, A. G., Thatte, A. S., Billingsley, M. M., Joseph, R. A., Mrksich, K., Padilla, M. S., Ghalsasi, A. A., et al. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.2c12893 · Cited by 145
Yang, F., Huang, L., Tso, A., Wang, H., Cui, L., Lin, L., Wang, X., Ren, M., Fang, X., Liu, J., et al. (2020) · PLOS Genetics · doi:10.1371/journal.pgen.1008739 · Cited by 31
Fernandez-Jimenez, N., Fore, R., Cilleros-Portet, A., Lepeule, J., Perron, P., Kvist, T., Tian, F.-Y., Lesseur, C., Binder, A. M., Lozano, M., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-04267-y · Cited by 20
Metadata
- Authors
- Knöfler, M., Haider, S., Saleh, L., Pollheimer, J., Gamage, T. K. J. B., & James, J.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2019-05-03
- Volume
- 76
- Issue
- 18
- Pages
- 3479-3496
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- OpenAlex
- W2942777904
- Cited by
- 769
- References
- 10
- FWCI
- 67.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Knöfler, M., Haider, S., Saleh, L., Pollheimer, J., Gamage, T. K. J. B., & James, J. (2019). Human placenta and trophoblast development: key molecular mechanisms and model systems. Cellular and Molecular Life Sciences. https://doi.org/10.1007/s00018-019-03104-6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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