Age-associated B cells in autoimmune diseases

Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis

Edwards, J. C. W., Szczepański, L., Szechiński, J., Filipowicz-Sosnowska, A., Emery, P., Close, D. R., Stevens, R. M., & Shaw, T. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032534 · Cited by 2,623 · see citing works

Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis

Bjornevik, K., Cortese, M., Healy, B. C., Kuhle, J., Mina, M. J., Leng, Y., Elledge, S. J., Niebuhr, D. W., Scher, A. I., Munger, K. L., et al. (2022) · Science · doi:10.1126/science.abj8222 · Cited by 2,049 · see citing works

Epidemiology and estimated population burden of selected autoimmune diseases in the United States

Jacobson, D. L., Gange, S. J., Rose, N. R., & Graham, N. M. H. (1997) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1997.4412 · Cited by 1,667 · see citing works

B cells regulate autoimmunity by provision of IL-10

Fillatreau, S., Sweenie, C. H., McGeachy, M. J., Gray, D., & Anderton, S. M. (2002) · Nature Immunology · doi:10.1038/ni833 · Cited by 1,647 · see citing works

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

Jenks, S. A., Cashman, K. S., Zumaquero, E., Marigorta, U. M., Patel, A. V., Wang, X., Tomar, D., Woodruff, M. C., Simon, Z., Bugrovsky, R., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.08.015 · Cited by 1,078 · see citing works

IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

Shen, P., Roch, T., Lampropoulou, V., O’Connor, R. A., Stervbo, U., Hilgenberg, E., Ries, S., Dang, V. D., Jaimes, Y., Daridon, C., et al. (2014) · Nature · doi:10.1038/nature12979 · Cited by 1,048 · see citing works

Rituximab (monoclonal anti-CD20 antibody): mechanisms of action and resistance

Smith, M. R. (2003) · Oncogene · doi:10.1038/sj.onc.1206939 · Cited by 835 · see citing works

Toll-like receptor 7 (TLR7)–driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity

Rubtsov, A. V., Rubtsova, K., Fischer, A., Meehan, R. T., Gillis, J. Z., Kappler, J. W., & Marrack, P. (2011) · Blood · doi:10.1182/blood-2011-01-331462 · Cited by 808 · see citing works

Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19

Woodruff, M. C., Ramonell, R. P., Nguyen, D. C., Cashman, K. S., Saini, A. S., Haddad, N. S., Ley, A. M., Kyu, S., Howell, J. C., Ozturk, T., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-00814-z · Cited by 791 · see citing works

B cell depletion as a novel treatment for systemic lupus erythematosus: A phase I/II dose‐escalation trial of rituximab

Looney, R. J., Anolik, J. H., Campbell, D., Felgar, R. E., Young, F. M., Arend, L. J., Sloand, J. A., Rosenblatt, J. D., & Sanz, I. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20430 · Cited by 779 · see citing works

B cell depletion therapies in autoimmune disease: advances and mechanistic insights

Lee, D. S. W., Rojas, O. L., & Gommerman, J. L. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-00092-2 · Cited by 666 · see citing works

TLR7 escapes X chromosome inactivation in immune cells

Souyris, M., Cénac, C., Azar, P., Daviaud, D., Canivet, A., Grunenwald, S., Pienkowski, C., Chaumeil, J., Mejía, J. E., & Guéry, J. (2018) · Science Immunology · doi:10.1126/sciimmunol.aap8855 · Cited by 650 · see citing works

A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice

Hao, Y., O'Neill, P., Naradikian, M. S., Scholz, J. L., & Cancro, M. P. (2011) · Blood · doi:10.1182/blood-2011-01-330530 · Cited by 622 · see citing works

TLR7 gain-of-function genetic variation causes human lupus

Brown, G. J., Cañete, P. F., Wang, H., Medhavy, A., Bones, J., Roco, J. A., He, Y., Qin, Y., Cappello, J., Ellyard, J. I., et al. (2022) · Nature · doi:10.1038/s41586-022-04642-z · Cited by 596 · see citing works

IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE

Wang, S., Wang, J., Kumar, V., Karnell, J. L., Naiman, B., Gross, P. S., Rahman, S., Zerrouki, K., Hanna, R., Morehouse, C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03750-7 · Cited by 578 · see citing works

Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritis

Leandro, M. J., Cambridge, G., Ehrenstein, M. R., & Edwards, J. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21617 · Cited by 561 · see citing works

Evolution of Autoantibody Responses via Somatic Hypermutation Outside of Germinal Centers

William, J., Euler, C. W., Christensen, S. R., & Shlomchik, M. J. (2002) · Science · doi:10.1126/science.1073924 · Cited by 558 · see citing works

Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation.

Matsumoto, M., Baba, A., Yokota, T., Nishikawa, H., Ohkawa, Y., Kayama, H., Kallies, A., Nutt, S., Sakaguchi, S., Takeda, K., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.016 · Cited by 543 · see citing works

Class-Switch Recombination Occurs Infrequently in Germinal Centers

Roco, J. A., Mesin, L., Binder, S. C., Nefzger, C. M., González-Figueroa, P., Cañete, P. F., Ellyard, J. I., Shen, Q., Robert, P. A., Cappello, J. Y., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.07.001 · Cited by 518 · see citing works

Infectious mononucleosis and risk for multiple sclerosis: A meta‐analysis

Thacker, E. L., Mirzaei, F., & Ascherio, A. (2006) · Annals of Neurology · doi:10.1002/ana.20820 · Cited by 517 · see citing works

T-bet regulates IgG class switching and pathogenic autoantibody production

Peng, S. L., Szabo, S. J., & Glimcher, L. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082114899 · Cited by 498 · see citing works

Age-Associated B Cells

Cancro, M. P. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-092419-031130 · Cited by 464 · see citing works

Reassessing B cell contributions in multiple sclerosis

Li, R., Patterson, K. R., & Bar‐Or, A. (2018) · Nature Immunology · doi:10.1038/s41590-018-0135-x · Cited by 397 · see citing works

The Role of CXCR4 in Maintaining Peripheral B Cell Compartments and Humoral Immunity

Nie, Y., Waite, J. C., Brewer, F., Sunshine, M. J., Littman, D. R., & Zou, Y.-R. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041185 · Cited by 397 · see citing works

Circulating CD21 low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells

Rakhmanov, M., Keller, B., Gutenberger, S., Foerster, C., Hoenig, M., Driessen, G. J. A., van der Burg, M., van Dongen, J. J. M., Wiech, E., Visentini, M., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901984106 · Cited by 334 · see citing works

A review of the current use of rituximab in autoimmune diseases

Gürcan, H. M., Keskin, D. B., Stern, J. N. H., Nitzberg, M. A., Shekhani, H. N., & Ahmed, A. R. (2008) · International Immunopharmacology · doi:10.1016/j.intimp.2008.10.004 · Cited by 314 · see citing works

A new CD21low B cell population in the peripheral blood of patients with SLE

Wehr, C., Eibel, H., Masilamani, M., Illges, H., Schlesier, M., Peter, H., & Warnatz, K. (2004) · Clinical Immunology · doi:10.1016/j.clim.2004.05.010 · Cited by 308 · see citing works

T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance

Rubtsova, K., Rubtsov, A. V., van Dyk, L. F., Kappler, J. W., & Marrack, P. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312348110 · Cited by 300 · see citing works

Targeting B cells and plasma cells in autoimmune diseases

Hofmann, K., Clauder, A.-K., & Manz, R. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00835 · Cited by 294 · see citing works

B cells expressing the transcription factor T-bet drive lupus-like autoimmunity

Rubtsova, K., Rubtsov, A. V., Thurman, J. M., Mennona, J. M., Kappler, J. W., & Marrack, P. (2017) · Journal of Clinical Investigation · doi:10.1172/jci91250 · Cited by 280 · see citing works

Changes in B- and T-Lymphocyte and Chemokine Levels With Rituximab Treatment in Multiple Sclerosis

Piccio, L. M., Naismith, R. T., Trinkaus, K. M., Klein, R. S., Parks, B. J., Lyons, J., & Cross, A. H. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.99 · Cited by 274 · see citing works

Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system

Sørensen, T. L., Trebst, C., Kivisäkk, P., Klaege, K. L., Majmudar, A., Ravid, R., Lassmann, H., Olsen, D. B., Strieter, R. M., Ransohoff, R. M., et al. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00097-8 · Cited by 262 · see citing works

Epstein–Barr Virus in Multiple Sclerosis: Theory and Emerging Immunotherapies

Bar‐Or, A., Pender, M. P., Khanna, R., Steinman, L., Hartung, H., Maniar, T., Croze, E., Aftab, B. T., Giovannoni, G., & Joshi, M. A. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.11.003 · Cited by 262 · see citing works

Age-Associated B Cells: A T-bet–Dependent Effector with Roles in Protective and Pathogenic Immunity

Rubtsova, K., Rubtsov, A. V., Cancro, M. P., & Marrack, P. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1501209 · Cited by 246 · see citing works

Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells

Naradikian, M. S., Myles, A., Beiting, D. P., Roberts, K. J., Dawson, L. A., Herati, R. S., Bengsch, B., Linderman, S. L., Stelekati, E., Spolski, R. J., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600522 · Cited by 239 · see citing works

CD11c-Expressing B Cells Are Located at the T Cell/B Cell Border in Spleen and Are Potent APCs

Rubtsov, A. V., Rubtsova, K., Kappler, J. W., Jacobelli, J., Friedman, R. S., & Marrack, P. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500055 · Cited by 235 · see citing works

Expansion of Autoreactive Unresponsive CD21−/low B Cells in Sjögren's Syndrome–Associated Lymphoproliferation

Saadoun, D., Terrier, B., Bannock, J. M., Vazquez, T., Massad, C., Kang, I., Joly, F., Rosenzwajg, M., Sène, D., Benech, P. D., et al. (2012) · Arthritis & Rheumatism · doi:10.1002/art.37828 · Cited by 230 · see citing works

Dual Role of Fas/FasL-Mediated Signal in Peripheral Immune Tolerance

Yamada, A., Arakaki, R., Saitō, M., Kudo, Y., & Ishimaru, N. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00403 · Cited by 220 · see citing works

Expansion of CD19CD21 B Cells in Common Variable Immunodeficiency (CVID) Patients with Autoimmune Cytopenia

Warnatz, K. (2002) · Immunobiology · doi:10.1078/0171-2985-00198 · Cited by 218 · see citing works

The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans

Johnson, J. L., Rosenthal, R. L., Knox, J. J., Myles, A., Naradikian, M. S., Madej, J., Kostiv, M., Rosenfeld, A. M., Meng, W., Christensen, S. R., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.03.020 · Cited by 212 · see citing works

Rituximab for the treatment of multiple sclerosis: a review

Chisari, C. G., Sgarlata, E., Arena, S., Toscano, S., Luca, M., & Patti, F. (2021) · Journal of Neurology · doi:10.1007/s00415-020-10362-z · Cited by 209 · see citing works

Age-Associated B Cells with Proinflammatory Characteristics Are Expanded in a Proportion of Multiple Sclerosis Patients

Claes, N., Fraussen, J., Vanheusden, M., Hellings, N., Stinissen, P., Wijmeersch, B. V., Hupperts, R., & Somers, V. A. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502448 · Cited by 206 · see citing works

Epstein‐Barr virus load in the peripheral blood of patients with rheumatoid arthritis: Accurate quantification using real‐time polymerase chain reaction

Balandraud, N., Meynard, J. B., Auger, I., Sovran, H., Mugnier, B., Reviron, D., Roudier, J., & Roudier, C. (2003) · Arthritis & Rheumatism · doi:10.1002/art.10933 · Cited by 196 · see citing works

IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation

Zumaquero, E., Stone, S. L., Scharer, C. D., Jenks, S. A., Nellore, A., Mousseau, B., Rosal-Vela, A., Botta, D., Bradley, J. E., Wojciechowski, W., et al. (2019) · eLife · doi:10.7554/elife.41641 · Cited by 189 · see citing works

The chemokine receptor CXCR3 is expressed in a subset of B-cell lymphomas and is a marker of B-cell chronic lymphocytic leukemia

Jones, D., Benjamin, R. J., Shahsafaei, A., & Dorfman, D. M. (2000) · Blood · doi:10.1182/blood.v95.2.627 · Cited by 188 · see citing works

Low-level Hypermutation in T Cell–independent Germinal Centers Compared with High Mutation Rates Associated with T Cell–dependent Germinal Centers

Toellner, K., Jenkinson, W. E., Taylor, D. R., Khan, M., Sze, D., Sansom, D. M., Vinuesa, C. G., & MacLennan, I. C. M. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011112 · Cited by 187 · see citing works

Patients with systemic lupus erythematosus have abnormally elevated Epstein–Barr virus load in blood

Moon, U. Y., Park, S. J., Oh, S. T., Kim, W., Park, S., Lee, S., Cho, C., Kim, H., Lee, W.-K., & Lee, S. K. (2004) · Arthritis Research & Therapy · doi:10.1186/ar1181 · Cited by 184 · see citing works

In senescence, age‐associated B cells secrete TNF α and inhibit survival of B‐cell precursors*

Ratliff, M., Alter, S., Frasca, D., Blomberg, B. B., & Riley, R. L. (2013) · Aging Cell · doi:10.1111/acel.12055 · Cited by 183 · see citing works

SLE Peripheral Blood B Cell, T Cell and Myeloid Cell Transcriptomes Display Unique Profiles and Each Subset Contributes to the Interferon Signature

Becker, A. M., Dao, K. H., Han, B. K., Kornu, R., Lakhanpal, S., Mobley, A. B., Li, Q., Lian, Y., Wu, T., Reimold, A. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067003 · Cited by 183 · see citing works

Elevated Levels of Antibodies to Epstein-Barr Virus Antigens in Sera and Synovial Fluids of Patients with Rheumatoid Arthritis

Alspaugh, M. A., Henle, G., Lennette, E. T., & Henle, W. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110127 · Cited by 182 · see citing works

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models

Dai, X., James, R. G., Habib, T., Singh, S., Jackson, S. W., Khim, S., Moon, R. T., Liggitt, D., Wolf‐Yadlin, A., Buckner, J. H., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66963 · Cited by 178 · see citing works

T-bet+ B cells are induced by human viral infections and dominate the HIV gp140 response

Knox, J. J., Buggert, M., Kardava, L., Seaton, K. E., Eller, M. A., Canaday, D. H., Robb, M. L., Ostrowski, M., Deeks, S. G., Slifka, M. K., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.92943 · Cited by 172 · see citing works

Shared transcriptional profiles of atypical B cells suggest common drivers of expansion and function in malaria, HIV, and autoimmunity

Holla, P., Dizon, B. L. P., Ambegaonkar, A. A., Rogel, N., Goldschmidt, E., Boddapati, A. K., Sohn, H., Sturdevant, D. E., Austin, J. W., Kardava, L., et al. (2021) · Science Advances · doi:10.1126/sciadv.abg8384 · Cited by 155 · see citing works

The expansion of human T-bet high CD21 low B cells is T cell dependent

Keller, B., Strohmeier, V., Harder, I., Unger, S., Payne, K. J., Andrieux, G., Boerries, M., Felixberger, P. T., Landry, J. J. M., Nieters, A., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abh0891 · Cited by 149 · see citing works

Development of Tbet- and CD11c-expressing B cells in a viral infection requires T follicular helper cells outside of germinal centers

Song, W., Antao, O. Q., Condiff, E., Sanchez, G. M., Chernova, I., Zembrzuski, K., Steach, H. R., Rubtsova, K., Angeletti, D., Lemenze, A. D., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.01.002 · Cited by 144 · see citing works

T-bet regulates T-independent IgG2a class switching

Gerth, A. (2003) · International Immunology · doi:10.1093/intimm/dxg093 · Cited by 129 · see citing works

Epstein–Barr virus persistence and infection of autoreactive plasma cells in synovial lymphoid structures in rheumatoid arthritis

Croia, C., Serafini, B., Bombardieri, M., Kelly, S., Humby, F., Severa, M., Rizzo, F., Coccia, E. M., Migliorini, P., Aloisi, F., et al. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202352 · Cited by 123 · see citing works

Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice

Ricker, E., Manni, M., Flores-Castro, D., Jenkins, D., Gupta, S. K., Rivera‐Correa, J., Meng, W., Rosenfeld, A. M., Pannellini, T., Bachu, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25102-8 · Cited by 110 · see citing works

Induction of brain‐infiltrating T‐bet–expressing B cells in multiple sclerosis

van Langelaar, J., Rijvers, L., Janssen, M., Wierenga‐Wolf, A. F., Melief, M., Siepman, T. A. M., de Vries, H. E., Unger, P. A., van Ham, S. M., Hintzen, R. Q., et al. (2019) · Annals of Neurology · doi:10.1002/ana.25508 · Cited by 109 · see citing works

Outcomes of rituximab therapy in refractory lupus: A meta-analysis

Alshaiki, F., Obaid, E. F., Almuallim, A. A., Taha, R., El-Haddad, H., & Almoallim, H. M. (2018) · European Journal of Rheumatology · doi:10.5152/eurjrheum.2018.17096 · Cited by 107 · see citing works

Overexpression of T-bet in HIV infection is associated with accumulation of B cells outside germinal centers and poor affinity maturation

Austin, J. W., Buckner, C. M., Kardava, L., Wang, W., Zhang, X., Melson, V. A., Swanson, R. G., Martins, A. J., Zhou, J. Q., Hoehn, K. B., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aax0904 · Cited by 103 · see citing works

Germinal center–dependent and –independent memory B cells produced throughout the immune response

Viant, C., Wirthmiller, T., ElTanbouly, M. A., Chen, S. T., Kara, E. E., Cipolla, M., Ramos, V., Oliveira, T. Y., Stamatatos, L., & Nussenzweig, M. C. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20202489 · Cited by 99 · see citing works

A Molecular Mechanism for TNF-α–Mediated Downregulation of B Cell Responses

Frasca, D., Romero, M., Diaz, A., Alter-Wolf, S., Ratliff, M., Landin, A. M., Riley, R. L., & Blomberg, B. B. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003964 · Cited by 98 · see citing works

TLR7 drives accumulation of ABCs and autoantibody production in autoimmune-prone mice

Rubtsov, A. V., Rubtsova, K., Kappler, J. W., & Marrack, P. (2012) · Immunologic Research · doi:10.1007/s12026-012-8365-8 · Cited by 98 · see citing works

T-bet+CD11c+ B cells are critical for antichromatin immunoglobulin G production in the development of lupus

Liu, Y., Zhou, S., Qian, J., Wang, Y., Yu, X., Dai, D., Dai, M., Wu, L., Liao, Z., Xue, Z., et al. (2017) · Arthritis Research & Therapy · doi:10.1186/s13075-017-1438-2 · Cited by 86 · see citing works

Plasmodium DNA-mediated TLR9 activation of T-bet+ B cells contributes to autoimmune anaemia during malaria

Rivera‐Correa, J., Guthmiller, J. J., Vijay, R., Fernández-Arias, C., Pardo-Ruge, M., González, S. M., Butler, N. S., & Rodrı́guez, A. (2017) · Nature Communications · doi:10.1038/s41467-017-01476-6 · Cited by 85 · see citing works

B cells expressing CD11b effectively inhibit CD4+ T‐cell responses and ameliorate experimental autoimmune hepatitis in mice

Liu, X., Jiang, X., Liu, R.-H., Wang, L., Qian, T., Zheng, Y.-J., Deng, Y.-T., Huang, E., Xu, F.-K., Wang, J.-Y., et al. (2015) · Hepatology · doi:10.1002/hep.28001 · Cited by 78 · see citing works

Gammaherpesvirus Latency Accentuates EAE Pathogenesis: Relevance to Epstein-Barr Virus and Multiple Sclerosis

Casiraghi, C., Shanina, I., Cho, S., Freeman, M. L., Blackman, M. A., & Horwitz, M. S. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002715 · Cited by 72 · see citing works

Generation of functional murine CD11c + age‐associated B cells in the absence of B cell T‐bet expression

Du, S. W., Arkatkar, T., Jacobs, H. M., Rawlings, D. J., & Jackson, S. W. (2018) · European Journal of Immunology · doi:10.1002/eji.201847641 · Cited by 72 · see citing works

Aryl Hydrocarbon Receptor-Mediated Induction of EBV Reactivation as a Risk Factor for Sjögren’s Syndrome

Inoue, H., Mishima, K., Yamamoto-Yoshida, S., Ushikoshi‐Nakayama, R., Nakagawa, Y., Yamamoto, K., Ryo, K., Ide, F., & Saito, I. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101575 · Cited by 70 · see citing works

CD11c+ T-bet+ B Cells Require IL-21 and IFN-γ from Type 1 T Follicular Helper Cells and Intrinsic Bcl-6 Expression but Develop Normally in the Absence of T-bet

Levack, R. C., Newell, K. L., Popescu, M., Cabrera-Martinez, B., & Winslow, G. M. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000206 · Cited by 61 · see citing works

Reduced response to Epstein–Barr virus antigens by T-cells in systemic lupus erythematosus patients

Draborg, A. H., Jacobsen, S., Westergaard, M. C. W., Mortensen, S., Larsen, J. L., Houen, G., & Duus, K. (2014) · Lupus Science & Medicine · doi:10.1136/lupus-2014-000015 · Cited by 60 · see citing works

Transcription Factor T-bet in B Cells Modulates Germinal Center Polarization and Antibody Affinity Maturation in Response to Malaria

Ly, A., Liao, Y., Pietrzak, H. M., Ioannidis, L. J., Sidwell, T., Gloury, R., Doerflinger, M., Triglia, T., Qin, R. Z., Groom, J. R., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.087 · Cited by 58 · see citing works

T-bet-Expressing B Cells Are Positively Associated with Crohn's Disease Activity and Support Th1 Inflammation

Wang, Z., Wang, Z., Wang, J., Diao, Y., Qian, X., & Zhu, N. (2016) · DNA and Cell Biology · doi:10.1089/dna.2016.3304 · Cited by 57 · see citing works

Expression of inhibitory receptors by B cells in chronic human infectious diseases restricts responses to membrane-associated antigens

Ambegaonkar, A. A., Kwak, K., Sohn, H., Manzella‐Lapeira, J., Brzostowski, J. A., & Pierce, S. K. (2020) · Science Advances · doi:10.1126/sciadv.aba6493 · Cited by 52 · see citing works

Anti-TLR7 Antibody Protects Against Lupus Nephritis in NZBWF1 Mice by Targeting B Cells and Patrolling Monocytes

Murakami, Y., Fukui, R., Tanaka, R., Motoi, Y., Kanno, A., Sato, R., Yamaguchi, K., Amano, H., Furukawa, Y., Suzuki, H., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.777197 · Cited by 52 · see citing works

Age-associated B cells in viral infection

Mouat, I. C., & Horwitz, M. S. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010297 · Cited by 46 · see citing works

Tailoring B cell depletion therapy in MS according to memory B cell monitoring

Novi, G., Bovis, F., Fabbri, S., Tazza, F., Gazzola, P., Maietta, I., Currò, D., Bruschi, N., Roccatagliata, L., Boffa, G., et al. (2020) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000845 · Cited by 44 · see citing works

The Differentiation in vitro of Human Tonsil B Cells With the Phenotypic and Functional Characteristics of T-bet+ Atypical Memory B Cells in Malaria

Ambegaonkar, A. A., Nagata, S., Pierce, S. K., & Sohn, H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00852 · Cited by 44 · see citing works

Mass Cytometry Identifies Expansion of T-bet+ B Cells and CD206+ Monocytes in Early Multiple Sclerosis

Couloume, L., Ferrant, J., Gallou, S. L., Mandon, M., Jean, R., Bescher, N., Zéphir, H., Edan, G., Thouvenot, É., Ruet, A., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.653577 · Cited by 41 · see citing works

Hyper‐metabolic B cells in the spleens of old mice make antibodies with autoimmune specificities

Frasca, D., Romero, M., Garcia, D., Diaz, A., & Blomberg, B. B. (2021) · Immunity & Ageing · doi:10.1186/s12979-021-00222-3 · Cited by 37 · see citing works

TLR9 signalling in HCV-associated atypical memory B cells triggers Th1 and rheumatoid factor autoantibody responses

Comarmond, C., Lorin, V., Marques, C., Maciejewski‐Duval, A., Joher, N., Planchais, C., Touzot, M., Biard, L., Hieu, T., Quiniou, V., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.06.029 · Cited by 36 · see citing works

T-bet+CD27+CD21– B cells poised for plasma cell differentiation during antibody-mediated rejection of kidney transplants

Louis, K., Bailly, É., Macedo, C., Lau, L., Ramaswami, B., Chang, A., Chandran, U. R., Landsittel, D. P., Gu, X., Chalasani, G., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.148881 · Cited by 36 · see citing works

Latent gammaherpesvirus exacerbates arthritis through modification of age-associated B cells

Mouat, I. C., Morse, Z. J., Shanina, I., Brown, K. L., & Horwitz, M. S. (2021) · eLife · doi:10.7554/elife.67024 · Cited by 33 · see citing works

A novel humanized cutaneous lupus erythematosus mouse model mediated by IL-21-induced age-associated B cells

Zhou, S., Li, Q., Zhou, S., Zhao, M., Lu, L., Wu, H., & Lu, Q. (2021) · Journal of Autoimmunity · doi:10.1016/j.jaut.2021.102686 · Cited by 33 · see citing works

CD27-CD38lowCD21low B-Cells Are Increased in Axial Spondyloarthritis

Wilbrink, R., Spoorenberg, A. J. P. L., Arends, S., van der Geest, K. S. M., Brouwer, E., Bootsma, H., Kroese, F. G. M., & Verstappen, G. M. P. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.686273 · Cited by 31 · see citing works

Low percentages of regulatory T cells in common variable immunodeficiency (CVID) patients with autoimmune diseases and its association with increased numbers of CD4+CD45RO+ T and CD21low B cells

López‐Herrera, G., Segura-Méndez, N. H., O’Farrill-Romanillos, P. M., Nuñez-Nuñez, M. E., Zarate-Hernández, M. C., Mogica‐Martínez, D., Yamazaki‐Nakashimada, M. A., Staines‐Boone, A. T., Santos‐Argumedo, L., & Berrón‐Ruiz, L. (2019) · Allergologia et Immunopathologia · doi:10.1016/j.aller.2019.01.003 · Cited by 27 · see citing works

Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint

Masle‐Farquhar, E., Peters, T. J., Miosge, L. A., Parish, I. A., Weigel, C., Oakes, C. C., Reed, J. H., & Goodnow, C. C. (2022) · Cell Reports · doi:10.1016/j.celrep.2021.110259 · Cited by 27 · see citing works

T-bet+ Memory B Cells Link to Local Cross-Reactive IgG upon Human Rhinovirus Infection

Eccles, J. D., Turner, R. B., Kirk, N. A., Muehling, L. M., Borish, L., Steinke, J. W., Payne, S. C., Wright, P. W., Thacker, D. F., Lahtinen, S. J., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.027 · Cited by 25 · see citing works

MZ B cells migrate in a T‐bet dependent manner and might contribute to the remission of collagen‐induced arthritis by the secretion of IL‐10

Huber, K., Sármay, G., & Kövesdi, D. (2016) · European Journal of Immunology · doi:10.1002/eji.201546248 · Cited by 24 · see citing works

Age-associated B cells: are they the key to understanding why autoimmune diseases are more prevalent in women?

Rubtsova, K., Marrack, P., & Rubtsov, A. V. (2011) · Expert Review of Clinical Immunology · doi:10.1586/eci.11.83 · Cited by 22 · see citing works

In RA, becoming seronegative over the first year of treatment does not translate to better chances of drug-free remission

de Moel, E. C., Derksen, V. F. A. M., Trouw, L. A., Bang, H., Goekoop-Ruiterman, Y. P. M., Steup‐Beekman, G. M., Huizinga, T. W. J., Allaart, C. F., Toes, R. E. M., & van der Woude, D. (2018) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2018-213823 · Cited by 21 · see citing works

Age-associated B cells are long-lasting effectors that impede latent γHV68 reactivation

Mouat, I. C., Shanina, I., & Horwitz, M. S. (2022) · Scientific Reports · doi:10.1038/s41598-022-25543-1 · Cited by 12 · see citing works

Gammaherpesvirus infection licenses age-associated B cells for pathogenicity in MS and EAEPreprint

Mouat, I. C., Allanach, J. R., Fan, V., Girard, A. M., Shanina, I., Vorobeychik, G., & Horwitz, M. S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.22.453263 · Cited by 5 · see citing works

Age-associated B cells are long-lasting effectors that restrain reactivation of latent γHV68Preprint

Mouat, I. C., Shanina, I., & Horwitz, M. S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.29.474434 · Cited by 1 · see citing works

Pathogenesis of autoimmune disease

Pisetsky, D. S. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00720-1 · Cited by 656 · see citing works

The Role of Viral Infections in the Onset of Autoimmune Diseases

Sundaresan, B., Shirafkan, F., Ripperger, K., & Rattay, K. (2023) · Viruses · doi:10.3390/v15030782 · Cited by 194 · see citing works

Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice

Nickerson, K. M., Smita, S., Hoehn, K. B., Marinov, A. D., Thomas, K., Kos, J. T., Yang, Y., Bastacky, S., Watson, C. T., Kleinstein, S. H., et al. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20221346 · Cited by 133 · see citing works

Sex/gender-related differences in inflammaging

Olivieri, F., Marchegiani, F., Matacchione, G., Giuliani, A., Ramini, D., Fazioli, F., Sabbatinelli, J., & Bonafè, M. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111792 · Cited by 86 · see citing works

Immune dysregulation

Long, A. M., Kleiner, A., & Looney, R. J. (2023) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.11.001 · Cited by 72 · see citing works

Impact of aging on treatment considerations for multiple sclerosis patients

Macaron, G., Larochelle, C., Arbour, N., Galmard, M., Girard, M., Prat, A., & Duquette, P. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1197212 · Cited by 67 · see citing works

Age-Associated B Cells in Autoimmune Diseases: Pathogenesis and Clinical Implications

Xie, G., Chen, X., Gao, Y., Yang, M., Zhou, S., Lu, L., Wu, H., & Lu, Q. (2025) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-025-09021-w · Cited by 54 · see citing works

The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis

Weinand, K., Sakaue, S., Nathan, A., Jonsson, A. H., Zhang, F., Watts, G. F. M., Suqri, M. A., Zhu, Z., Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network, Albrecht, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48620-7 · Cited by 50 · see citing works

Inflammaging: triggers, molecular mechanisms, immunological consequences, sex differences, and cutaneous manifestations

Karpuzoglu, E., Holladay, S. D., & Gogal, R. M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1704203 · Cited by 43 · see citing works

Senescence, NK cells, and cancer: navigating the crossroads of aging and disease

Gergues, M., Bari, R., Koppisetti, S., Gosiewska, A., Kang, L., & HARIRI, R. J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1565278 · Cited by 42 · see citing works

Aberrant B Cell Signaling in Autoimmune Diseases

Corneth, O. B. J., Neys, S. F. H., & Hendriks, R. W. (2022) · Cells · doi:10.3390/cells11213391 · Cited by 37 · see citing works

Gammaherpesvirus infection drives age-associated B cells toward pathogenicity in EAE and MS

Mouat, I. C., Allanach, J. R., Fettig, N. M., Fan, V., Girard, A. M., Shanina, I., Osborne, L. C., Vorobeychik, G., & Horwitz, M. S. (2022) · Science Advances · doi:10.1126/sciadv.ade6844 · Cited by 36 · see citing works

PANoptosis in autoimmune diseases interplay between apoptosis, necrosis, and pyroptosis

Liu, K., Wang, M., Li, D., Duong, N. T. D., Liu, Y., Ma, J., Xin, K., & Zhou, Z. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1502855 · Cited by 35 · see citing works

Modern concept of autoimmunity in rheumatology

Nasonov, E. L. (2023) · Rheumatology Science and Practice · doi:10.47360/1995-4484-2023-397-420 · Cited by 37 · see citing works

Low-density granulocytes and neutrophil extracellular trap formation are increased in incomplete systemic lupus erythematosus

Henning, S., Reimers, T., Abdulahad, W. H., Fierro, J. J., der Meer, B. D., Bootsma, H., Horváth, B., de Leeuw, K., & Westra, J. (2024) · Rheumatology · doi:10.1093/rheumatology/keae300 · Cited by 33 · see citing works

Epigenetic Dysregulation in the Pathogenesis of Systemic Lupus Erythematosus

Araki, Y., & Mimura, T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021019 · Cited by 31 · see citing works

Age/autoimmunity-associated B cells in inflammatory arthritis: An emerging therapeutic target

Li, Z., Cai, M.-L., Qin, Y., & Chen, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1103307 · Cited by 31 · see citing works

Peripheral immune landscape for hypercytokinemia in myasthenic crisis utilizing single-cell transcriptomics

Zhong, H., Huan, X., Zhao, R., Su, M., Yan, C., Song, J., Xi, J., Zhao, C., Luo, F., & Luo, S. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04421-y · Cited by 30 · see citing works

Human and Murine Toll-like Receptor-Driven Disease in Systemic Lupus Erythematosus

von Hofsten, S., Fenton, K. A., & Pedersen, H. L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105351 · Cited by 30 · see citing works

Correlation of Professional Antigen‐Presenting Tbet + CD11c + B Cells With Bone Destruction in Untreated Rheumatoid Arthritis

McGrath, S., Grimstad, K., Thorarinsdottir, K., Forslind, K., Glinatsi, D., Agelii, M. L., Aranburu, A., Sundell, T., Jonsson, C. A., Camponeschi, A., et al. (2024) · Arthritis & Rheumatology · doi:10.1002/art.42857 · Cited by 28 · see citing works

Counteracting Immunosenescence—Which Therapeutic Strategies Are Promising?

Hieber, C., Grabbe, S., & Bros, M. (2023) · Biomolecules · doi:10.3390/biom13071085 · Cited by 28 · see citing works

The role of autoantibodies in bridging obesity, aging, and immunosenescence

Valentino, T. R., Chen, N., Makhijani, P., Khan, S. M., Winer, S., Revelo, X. S., & Winer, D. A. (2024) · Immunity & Ageing · doi:10.1186/s12979-024-00489-2 · Cited by 26 · see citing works

Upregulated Fcrl5 disrupts B cell anergy and causes autoimmune disease

Ono, C., Tanaka, S., Myouzen, K., Iwasaki, T., Ueda, M. T., Oda, Y., Yamamoto, K., Kochi, Y., & Baba, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1276014 · Cited by 25 · see citing works

Non-apoptotic FAS signaling controls mTOR activation and extrafollicular maturation in human B cells

Staniek, J., Kalina, T., Andrieux, G., Boerries, M., Janowska, I., Fuentes, M., Díez, P., Bakardjieva, M., Stančíková, J., Raabe, J., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adj5948 · Cited by 23 · see citing works

Age-associated B cell infiltration in salivary glands represents a hallmark of Sjögren’s-like disease in aging mice

Bagavant, H., Durślewicz, J., Pyclik, M. J., Makuch, M., Papinska, J. A., & Deshmukh, U. S. (2024) · GeroScience · doi:10.1007/s11357-024-01159-3 · Cited by 23 · see citing works

Autoantibodies to Interferons in Infectious Diseases

Quirós-Roldán, E., Sottini, A., Signorini, S. G., Serana, F., Tiecco, G., & Imberti, L. (2023) · Viruses · doi:10.3390/v15051215 · Cited by 23 · see citing works

Lymphocytes Change Their Phenotype and Function in Systemic Lupus Erythematosus and Lupus Nephritis

Moysidou, E., Christodoulou, M., Λιούλιος, Γ., Stai, S., Karamitsos, T. D., Dimitroulas, T., Fylaktou, A., & Stangou, M. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252010905 · Cited by 23 · see citing works

B cell development: transcriptional regulation and immunological mechanisms in homeostasis

Gómez-Manríquez, J., Hernández‐Bello, J., Muñóz-Valle, J. F., Sifuentes-Franco, S., Graciano‐Machuca, O., & Morales‐Núñez, J. J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1593338 · Cited by 22 · see citing works

Roads and detours for CAR T cell therapy in autoimmune diseases

Avouac, J., Barzel, A., Caiati, D., Davis, R. S., Gottschalk, S. M., Grieshaber‐Bouyer, R., Mao, X., Prak, E. T. L., Radic, M. Z., Scherlinger, M., et al. (2026) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01349-4 · Cited by 23 · see citing works

T-bet+ B cells are activated by and control endogenous retroviruses through TLR-dependent mechanisms

Rauch, E., Amendt, T., Krol, A. L., Lang, F. B., Linse, V., Hohmann, M., Keim, A.-C., Kreutzer, S., Kawengian, K. J., Buchholz, M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45201-6 · Cited by 21 · see citing works

The influence of sex-specific factors on biological transformations and health outcomes in aging processes

Huang, Y., Li, H., Liang, R., Chen, J., & Tang, Q. (2024) · Biogerontology · doi:10.1007/s10522-024-10121-x · Cited by 22 · see citing works

Immunosenescence and age-related immune cells: causes of age-related diseases

Kim, N., Sim, S.-J., Han, H.-G., Yoon, J.-H., & Han, Y. (2024) · Archives of Pharmacal Research · doi:10.1007/s12272-024-01529-7 · Cited by 21 · see citing works

Sexual dimorphism in atherosclerotic plaques of aged Ldlr−/− mice

Smit, V., de Mol, J., Kleijn, M. N. A. B., Depuydt, M. A. C., de Winther, M. P. J., Bot, I., Kuiper, J., & Foks, A. C. (2024) · Immunity & Ageing · doi:10.1186/s12979-024-00434-3 · Cited by 19 · see citing works

Splenic marginal zone B cells restrict Mycobacterium tuberculosis infection by shaping the cytokine pattern and cell-mediated immunity

Tsai, C.-Y., Oo, M., Peh, J.-H., Yeo, B. C. M., Aptekmann, A. A., Lee, B. T. K., Liu, J. J. J., Tsao, W.-S., Dick, T., Fink, K., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114426 · Cited by 18 · see citing works

B cell–intrinsic Myd88 regulates disease progression in murine lupus

Tilstra, J. S., Kim, M.-J., Gordon, R. A., Leibler, C., Cosgrove, H. A., Bastacky, S., Nickerson, K. M., & Shlomchik, M. J. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20230263 · Cited by 18 · see citing works

CD11c + B cells in relapsing–remitting multiple sclerosis and effects of anti‐CD20 therapy

Mahdaoui, S. E., Hansen, M. M., von Essen, M. R., Hvalkof, V. H., Hansen, R. H., Mahler, M. R., Jennum, P., Sellebjerg, F. T., & Christensen, J. R. (2024) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.52009 · Cited by 18 · see citing works

Atypical B Cells Promote Cancer Progression and Poor Response to Bacillus Calmette-Guérin in Non–Muscle Invasive Bladder Cancer

Yolmo, P., Rahimi, S., Chenard, S. W., Conseil, G., Jenkins, D., Sachdeva, K., Emon, I. M., Hamilton, J., Xu, M., Rangachari, M., et al. (2024) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-23-1114 · Cited by 18 · see citing works

NADPH oxidase in B cells and macrophages protects against murine lupus by regulation of TLR7

Gordon, R. A., Cosgrove, H. A., Marinov, A. D., Gingras, S., Tilstra, J. S., Campbell, A. M., Bastacky, S., Kashgarian, M. J., Perl, A., Nickerson, K. M., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.178563 · Cited by 16 · see citing works

Phenotypic and functional characteristics of murine CD11c+ B cells which is suppressed by metformin

Oleo, I. R. D., Kim, V., Atisha‐Fregoso, Y., Shih, A., Lee, K., Diamond, B., & Kim, S. J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1241531 · Cited by 16 · see citing works

Emerging insights into atypical B cells in pediatric chronic infectious diseases and immune system disorders: T(o)-bet on control of B-cell immune activation

Olivieri, G., Cotugno, N., & Palma, P. (2023) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2023.10.009 · Cited by 16 · see citing works

Fat‐associated lymphoid clusters: Supporting visceral adipose tissue B cell function in immunity and metabolism

Daley, A. D., & Bénézech, C. (2024) · Immunological Reviews · doi:10.1111/imr.13339 · Cited by 16 · see citing works

Human Atypical B Cells. An Overview

Sanz, I. (2025) · Immunological Reviews · doi:10.1111/imr.70058 · Cited by 15 · see citing works

BCMA/CD19 CAR T cell therapy for refractory myasthenia gravis: Proteomic signatures and single-cell transcriptomics of disease flares

Huang, X., Zhang, Z., Liu, D., Luo, T., An, X., Yang, M., Li, S., Wang, G., Li, H., Cao, J., et al. (2026) · Science Advances · doi:10.1126/sciadv.aeb6424 · Cited by 15 · see citing works

CD11c high B Cell Expansion Is Associated With Severity and Brain Atrophy in Neuromyelitis Optica

Amano, E., Sato, W., Kimura, Y., Kimura, A., Lin, Y., Okamoto, T., Sato, N., Yokota, T., & Yamamura, T. (2024) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000200206 · Cited by 15 · see citing works

Immune Aging and Its Implication for Age-Related Disease Progression

Sato, Y. (2025) · Physiology · doi:10.1152/physiol.00051.2024 · Cited by 17 · see citing works

Xist Deletion in B Cells Results in Systemic Lupus Erythematosus PhenotypesPreprint

Lovell, C. D., Jiwrajka, N., Amerman, H. K., Cancro, M. P., & Anguera, M. C. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.15.594175 · Cited by 15 · see citing works

T Cell Development and Responses in Human Immune System Mice

Maharlooei, M. K., Li, H. W., & Sykes, M. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-082223-041615 · Cited by 14 · see citing works

Tracking clonal dynamics of CD8 T cells and immune dysregulation in progression of systemic lupus erythematosus with nephritis

Paek, S.-J., Lee, H., Lee, Y. J., Bang, S., Kim, D., Kang, B.-K., Park, D. J., Joo, Y. B., Kim, M., Kim, H., et al. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01504-2 · Cited by 14 · see citing works

Epstein–Barr virus and genetic risk variants as determinants of T-bet+ B cell-driven autoimmune diseases

Bogers, L., Kuiper, K. L., Smolders, J., Rip, J., & van Luijn, M. M. (2023) · Immunology Letters · doi:10.1016/j.imlet.2023.07.006 · Cited by 14 · see citing works

Pharmacotherapy of autoimmune rheumatic diseases – from monoclonal antibodies to CAR T cells: 20 years later

Nasonov, E. L., Rumyantsev, A. G., & MIu, S. (2024) · Rheumatology Science and Practice · doi:10.47360/1995-4484-2024-262-279 · Cited by 14 · see citing works

Comparative single-cell multiplex immunophenotyping of therapy-naive patients with rheumatoid arthritis, systemic sclerosis, and systemic lupus erythematosus shed light on disease-specific composition of the peripheral immune system

Balog, J. Á., Zvara, Á., Bukovinszki, V., Puskás, L. G., Balog, A., & Szebeni, G. J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1376933 · Cited by 13 · see citing works

Non-Genomic Hallmarks of Aging—The Review

Holmannová, D., Borský, P., Kovaříková, H., Štveráková, T., Vošmik, M., Hruška, L., Fiala, Z., & Borská, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015468 · Cited by 12 · see citing works

Regulation of B‐cell function and expression of CD11c, T‐bet, and FcRL5 in response to different activation signals

Kleberg, L., Courey‐Ghaouzi, A., Lautenbach, M. J., Färnert, A., & Sundling, C. (2024) · European Journal of Immunology · doi:10.1002/eji.202350736 · Cited by 12 · see citing works

Persistent transcriptional changes in cardiac adaptive immune cells following myocardial infarction: New evidence from the re-analysis of publicly available single cell and nuclei RNA-sequencing data sets

de Winter, N., Ji, J., Sintou, A., Forte, E., Lee, M., Noseda, M., Li, A., Koenig, A. L., Lavine, K. J., Hayat, S., et al. (2024) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2024.04.016 · Cited by 12 · see citing works

Activated polyreactive B cells are clonally expanded in autoantibody positive and patients with recent-onset type 1 diabetes

Nicholas, C. A., Tensun, F., Evans, S. A., Toole, K. P., Prendergast, J. E., BRONCUCIA, H. C., Hesselberth, J. R., Gottlieb, P. A., Wells, K. L., & Smith, M. J. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115425 · Cited by 12 · see citing works

The Chromatin Landscape of Pathogenic Transcriptional Cell States in Rheumatoid ArthritisPreprint

Weinand, K., Sakaue, S., Nathan, A., Jonsson, A., Zhang, F., Watts, G., Zhu, Z., Rao, D. A., Anolik, J., Brenner, M., et al. (2023) · bioRxiv · doi:10.1101/2023.04.07.536026 · Cited by 23 · see citing works

RNase T2 restricts TLR13-mediated autoinflammation in vivo

Gomez-Diaz, C., Greulich, W., Wefers, B., Wang, M., Bolsega, S., Effern, M., Varga, D. P., Han, Z., Chen, M., Bérouti, M., et al. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20241424 · Cited by 11 · see citing works

Rheumatoid Arthritis Related B‐Cell Changes Are Found Already in the Risk‐RA Phase

de Vries, C., Huang, W., Sharma, R. K., Wangriatisak, K., Turcinov, S., Cîrciumaru, A., Rönnblom, L., Grönwall, C., Hensvold, A. H., Lundberg, K., et al. (2025) · European Journal of Immunology · doi:10.1002/eji.202451391 · Cited by 11 · see citing works

Inflammasome activation and accelerated immune aging in autoimmune disorders

Mittal, R., Saavedra, D., Mittal, M., Lemos, J. R. N., & Hirani, K. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1688060 · Cited by 12 · see citing works

In silico screening of a series of 1,6-disubstituted 1 H -pyrazolo[3,4- d ]pyrimidines as potential selective inhibitors of the Janus kinase 3

Faris, A., Hadni, H., Saleh, B. A., Khelfaoui, H., Harkati, D., Ahsaine, H. A., Elhallaoui, M., & El-Hiti, G. A.-R. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2220829 · Cited by 11 · see citing works

As time goes by: Treatment challenges in elderly people with multiple sclerosis

Gelibter, S., Saraceno, L., Pirro, F., Susani, E. L., & Protti, A. (2024) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2024.578368 · Cited by 11 · see citing works

Nanoparticle–Host Interactions: The Impact of Physiological and Pathological Factors on Biodistribution, Immune Processes, and Translational Challenges

Qoura, L. A., Kostyushev, D. S., Parodi, A., Boyarintsev, D. I., Chulanov, V., & Pokrovsky, V. S. (2026) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-026-00888-z · Cited by 10 · see citing works

B cell abnormalities and autoantibody production in patients with partial RAG deficiency

Min, Q., Csomós, K., Li, Y., Dong, L., Hu, Z., Meng, X., Yu, M., Walter, J. E., & Wang, J. O. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1155380 · Cited by 10 · see citing works

The role of age-associated B cells in systemic lupus erythematosus

Su, Q. Y., Zheng, X., Han, X.-T., Li, Q., Gao, Y.-R., Zhang, S., & Li, X.-F. (2025) · Journal of Autoimmunity · doi:10.1016/j.jaut.2025.103433 · Cited by 10 · see citing works

The role of B lymphocyte subsets in nephrotic syndrome: functions, mechanisms, clinical significance and future perspectives

Liao, Y., Hu, H., Wan, Q., & Song, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1598197 · Cited by 9 · see citing works

Aging modulates homeostatic leukocyte trafficking to the peritoneal cavity in a sex-specific manner

Hopkin, S. J., Pezhman, L., Begum, J., Kavanagh, D. P. J., McGettrick, H. M., Iqbal, A. J., & Chimen, M. (2023) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiad053 · Cited by 9 · see citing works

Radiation therapy induces immunosenescence mediated by p90RSK

Imanishi, M., Cheng, H., Kotla, S., Deswal, A. M., Le, N.-T., Chini, E. N., Ko, K. A., Samanthapudi, V. S. K., Lee, L.-L., Herrmann, J., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.988713 · Cited by 10 · see citing works

Unravelling B cell heterogeneity: insights into flow cytometry-gated B cells from single-cell multi-omics data

Pernes, J. I., Alsayah, A., Tucci, F. A., & Bashford-Rogers, R. J. M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1380386 · Cited by 8 · see citing works

Latent, Lytic, and Linked to Multiple Sclerosis—How EBV Drives Autoimmunity

Läderach, F., Bremer, E., & Münz, C. (2026) · European Journal of Immunology · doi:10.1002/eji.70153 · Cited by 8 · see citing works

Interaction of aging and Immunosenescence: New therapeutic targets of aging

Liao, S., Ning, Q., Chen, Y., Zhao, X., & Tang, S. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109397 · Cited by 8 · see citing works

Effects of anti-CD20 therapy on circulating and intrathecal follicular helper T cell subsets in multiple sclerosis

Mahdaoui, S. E., Hansen, M. M., Hansen, M. B., Hvalkof, V. H., Søndergaard, H. B., Mahler, M. R., Christensen, J. R., Sellebjerg, F. T., & von Essen, M. R. (2024) · Clinical Immunology · doi:10.1016/j.clim.2024.110262 · Cited by 8 · see citing works

B cell-intrinsic IFN-γ promotes excessive CD11c+ age-associated B cell differentiation and compromised germinal center selection in lupus mice

Liu, S., Zhang, W., Tian, S., Zhang, Y., Yin, Z., Huang, G., Zhang, H., & Li, F. (2024) · Cellular Immunology · doi:10.1016/j.cellimm.2024.104883 · Cited by 7 · see citing works

Compromised B-cell homeostasis: Unraveling the link between major depression, infection and autoimmune disorders

Yin, Y., Liu, Y., Du, L., & Wu, S. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.01.095 · Cited by 7 · see citing works

The role of double-negative B cells in the pathogenesis of systemic lupus erythematosus

Qiu, X., Wen, R., Wu, F., Mao, J., Azad, T., Wang, Y., Zhu, J., Zhou, X., Xie, H., Hong, K., et al. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103821 · Cited by 7 · see citing works

Adipose immune microenvironment: catalyst of age-related adipose tissue dysfunction

Song, Y., Xing, H., Luo, Y., Li, B., Li, Y., & Dong, Z. (2025) · Immunity & Ageing · doi:10.1186/s12979-025-00545-5 · Cited by 8 · see citing works

T‐bet‐expressing B cells contribute to the autoreactive plasma cell pool in Lyn ‐/‐ mice

Ottens, K., Schneider, J., & Satterthwaite, A. B. (2023) · European Journal of Immunology · doi:10.1002/eji.202250300 · Cited by 7 · see citing works

LILRB4 as a novel immunotherapeutic target for multiple diseases

Wang, X., Li, L., Liu, D., Jin, Y., Zhao, X., Li, S., Hou, R., Guan, Z., Ma, W., Zheng, J., et al. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116762 · Cited by 6 · see citing works

The multilayered identity of B cell memory

Glaros, V., Francis, N., & Kreslavsky, T. (2026) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01377-5 · Cited by 8 · see citing works

Autoimmunity-Associated SNP rs3024505 Disrupts STAT3 Binding in B Cells, Leading to IL10 Dysregulation

Uvarova, A. N., Zheremyan, E. A., Ustiugova, A. S., Murashko, M. M., Bogomolova, E. A., Демин, Д. Э., Stasevich, E. M., Kuprash, D. V., & Korneev, K. V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251810196 · Cited by 6 · see citing works

Single cell decomposition of multicellular aging programs associated with impaired lung regenerationPreprint

Gote-Schniering, J., Melo-Narváez, M. C., Boosarpu, G., Lauer, D., Prakki, S. R. S., Wang, H., Brunner, M., Khan, S., Ansari, M., Ammeter, M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.24.666371 · Cited by 6 · see citing works

Pronounced impairment of B cell differentiation during bone regeneration in adult immune experienced mice

Tchouto, M. N., Bucher, C. H., Meß, A.-K., Haas, S. F., Schmidt‐Bleek, K., Duda, G. N., Beule, D., & Milek, M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1511902 · Cited by 5 · see citing works

Estrogen Modulation of B Cell Immunity: Implications for HIV Control and Therapeutic Strategies

Kasibante, J., Brown, T. T., Lake, J. E., & Abdel‐Mohsen, M. (2025) · Comprehensive physiology · doi:10.1002/cph4.70050 · Cited by 7 · see citing works

The Impact of HIV on B Cell Compartment and Its Implications for COVID-19 Vaccinations in People with HIV

Wang, L., Vulesevic, B., Vigano, M., As’sadiq, A., Kang, K., Fernández, C., Samarani, S., Anis, A. H., Ahmad, A., & Costiniuk, C. T. (2024) · Vaccines · doi:10.3390/vaccines12121372 · Cited by 5 · see citing works

Cellular and molecular determinants mediating the dysregulated germinal center immune dynamics in systemic lupus erythematosus

Georgakis, S., Ioannidou, K., Mora, B. B., Orfanakis, M., Brenna, C., Müller, Y. D., Estrada, P. M. D. R., Sharma, A., Pantaleo, G., de Leval, L., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1530327 · Cited by 5 · see citing works

Understanding rheumatic disease through continuous cell state analysis

Marshall, L. M., Raychaudhuri, S., & Viatte, S. (2025) · Nature Reviews Rheumatology · doi:10.1038/s41584-025-01253-6 · Cited by 5 · see citing works

Pathogenic Role of Age‐Associated B Cells in Autoimmune Disorders and Myasthenia Gravis

Akamine, H., & Uzawa, A. (2025) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.70011 · Cited by 5 · see citing works

Evolving Approach to Clinical Cytometry for Immunodeficiencies and Other Immune Disorders

Akha, A. A. S., Csomós, K., Ujházi, B., Walter, J. E., & Kumánovics, A. (2023) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2023.05.002 · Cited by 5 · see citing works

Age-associated defect in ADCC response to COVID-19 vaccine

Sievers, B. L., Altaf, M., Cheng, M. T. K., Kamelian, K., Cormie, C., Bradley, J. R., Baker, S., Graves, B., Stark, H., Hein, S., et al. (2025) · npj Vaccines · doi:10.1038/s41541-025-01196-9 · Cited by 4 · see citing works

Spinal Cord Injury and Ageing: The Role of Chronic Neuroinflammation

Wang, T., Zhang, Z., Liu, J., Zhang, L., Ni, Q., Sun, B., & Sun, J. (2025) · Aging and Disease · doi:10.14336/ad.2025.10630 · Cited by 4 · see citing works

Single‐Cell Level Characterization of B Cell Depletion and Repopulation Following Rituximab in Systemic Lupus Erythematosus

Jang, H., Buang, N. B., Sutherland, C., Lee, W., Overend, L., Rupall, T. S., Burnham, K. L., Pickering, M. C., Botto, M., & Davenport, E. E. (2026) · Arthritis & Rheumatology · doi:10.1002/art.70116 · Cited by 4 · see citing works

Hem1 inborn errors of immunity: waving goodbye to coordinated immunity in mice and humans

Christodoulou, A., Tsai, J. Y., Suwankitwat, N., Anderson, A., & Iritani, B. M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1402139 · Cited by 4 · see citing works

Senolytic Vaccines from the Central and Peripheral Tolerance Perspective

Vasilieva, M., Shatalova, R. O., Matveeva, K. S., Shindyapin, V. V., Minskaia, E., Ivanov, R. A., & Shevyrev, D. (2024) · Vaccines · doi:10.3390/vaccines12121389 · Cited by 5 · see citing works

Integrated analyses uncover new features of atypical memory B cells and novel targets for intervention

Fan, F., Liu, S., Wang, B., Song, X., & Wang, W. (2025) · Immunobiology · doi:10.1016/j.imbio.2025.152877 · Cited by 4 · see citing works

Higher frequencies of age-associated B-cells in early arthritis are linked to atherosclerosis and immune circuits—a potential role as a biomarker for risk stratification

Miranda-Prieto, D., Alpéri, M., Pérez-Álvarez, Á. I., Alonso-Castro, S., Suárez, A., & Rodríguez‐Carrio, J. (2025) · Lara D. Veeken · doi:10.1093/rheumatology/keaf318 · Cited by 4 · see citing works

Immunogenicity of tick-borne-encephalitis-virus-(TBEV)-vaccination and impact of age on humoral and cellular TBEV-specific immune responses in patients with rheumatoid arthritis

Rack, C., Almanzar, G., Schäfer, A., Völkl, S., Dobler, G., Mutterer, A., Schmalzing, M., Hick, S., Steimer, M., Jahn, L., et al. (2024) · Vaccine · doi:10.1016/j.vaccine.2024.01.022 · Cited by 4 · see citing works

Enhancing vaccine effectiveness in the elderly to counter antibiotic resistance: The potential of adjuvants via pattern recognition receptors

Jung, M., Kim, H., Choi, E., Shin, M., & Shin, S. J. (2024) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2024.2317439 · Cited by 5 · see citing works

Lupus and other autoimmune diseases: Epidemiology in the population of African ancestry and diagnostic and management challenges in Africa

Essouma, M., & Noubiap, J. J. (2024) · Journal of Allergy and Clinical Immunology Global · doi:10.1016/j.jacig.2024.100288 · Cited by 4 · see citing works

Meeting report: Hidden links in autoimmunity

Guerau‐de‐Arellano, M., Morris, M. A., Sherman, M. A., & Esch, T. R. (2024) · Science Immunology · doi:10.1126/sciimmunol.ads5884 · Cited by 4 · see citing works

Pathogenic Roles of Age‐Associated B Cells in Neuromyelitis Optica Spectrum Disorder

Amano, E., Sato, W., & Yamamura, T. (2025) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.70012 · Cited by 4 · see citing works

Atypical B cells mediate poor response to Bacillus Calmette Guérin immunotherapy in non-muscle invasive bladder cancerPreprint

Yolmo, P., Rahimi, S., Chenard, S. W., Conseil, G., Jenkins, D., Sachdeva, K., Emon, I. M., Hamilton, J., Xu, M., Rangachari, M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.30.522127 · Cited by 4 · see citing works

Age-associated B cells, key players in autoimmune pathogenesis

Hassani, S.-S., Ekrani, S. T., Rajabinejad, M., Faraj, T. A., Rezaiemanesh, A., & Esmaeili, S. (2026) · Immunity & Ageing · doi:10.1186/s12979-026-00564-w · Cited by 2 · see citing works

Age‐Associated B Cells: Origins, Regulation, and Tissue‐Specific Pathogenic Contributions in Autoimmune, Metabolic, and Neurological Diseases

Rubtsova, K. (2026) · Immunological Reviews · doi:10.1111/imr.70144

Age-Associated B Cells in Autoimmune Diseases: Pathogenesis and Clinical Implications

Xie, G., Chen, X., Gao, Y., Yang, M., Zhou, S., Lu, L., Wu, H., & Lu, Q. (2025) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-025-09021-w · Cited by 54 · see citing works

The role of age-associated B cells in systemic lupus erythematosus

Su, Q. Y., Zheng, X., Han, X.-T., Li, Q., Gao, Y.-R., Zhang, S., & Li, X.-F. (2025) · Journal of Autoimmunity · doi:10.1016/j.jaut.2025.103433 · Cited by 10 · see citing works

Highlights of 2024: The rising role of age‐associated B cells in autoimmune diseases

Lee, A. Y. S., & Reed, J. H. (2025) · Immunology and Cell Biology · doi:10.1111/imcb.70023 · Cited by 3 · see citing works