Cited by 388Nicotinic Acetylcholine Receptors StudyAnesthesia and Sedative AgentsNeuroscience and Neuropharmacology Research

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General anaesthetic actions on ligand-gated ion channels

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Krasowski, M. D., Harrison, N. L.·1999·Cellular and Molecular Life Sciences (CMLS)

DOI 10.1007/s000180050371PMC PMC2854026

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Abstract

The molecular mechanisms of general anaesthetics have remained largely obscure since their introduction into clinical practice just over 150 years ago. This review describes the actions of general anaesthetics on mammalian neurotransmitter-gated ion channels. As a result of research during the last several decades, ligand-gated ion channels have emerged as promising molecular targets for the central nervous system effects of general anaesthetics. The last 10 years have witnessed an explosion of studies of anaesthetic modulation of recombinant ligand-gated ion channels, including recent studies which utilize chimeric and mutated receptors to identify regions of ligand-gated ion channels important for the actions of general anaesthetics. Exciting future directions include structural biology and gene-targeting approaches to further the understanding of general anaesthetic molecular mechanisms.

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Authors: Krasowski, M. D., & Harrison, N. L.
Affiliations: University of Chicago (US)
ORCID: Krasowski, M. D.
Harrison, N. L.
Venue: Cellular and Molecular Life Sciences (CMLS)
Publisher: Springer Science and Business Media LLC
Published: 1999-08-01
Volume: 55
Issue: 10
Pages: 1278-1303
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s000180050371
PMC: PMC2854026
OpenAlex: W2088909919
Cited by: 384
References: 346
Citations by year: 2026: 2 · 2025: 8 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 9 · 2020: 12 · 2019: 8 · 2018: 7 · 2017: 13 · 2016: 10 · 2015: 12 · 2014: 14 · 2013: 12 · 2012: 14
FWCI: 5.40
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (7r01gm056850-03, 5k04gm000623-04)
National Institute of Mental Health (F30MH011504)
National Institute of General Medical Sciences (GM-45129, R01GM045129, GM56850, GM00623)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: general anesthetics, ligand-gated ion channels, anesthetic mechanisms, chimeric receptors, receptor mutations
MeSH terms: Animals, Cell Membrane, Humans, Ion Channels, Ligands, Mammals, Protein Conformation, Receptors, Cell Surface, Ion Channel Gating, Anesthetics, General

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General anaesthetic actions on ligand-gated ion channels

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