Cited by 388Nicotinic Acetylcholine Receptors StudyAnesthesia and Sedative AgentsNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 345 of the 346 references it cites were found in a registry or an index.

General anaesthetic actions on ligand-gated ion channels

Open access

Krasowski, M. D., Harrison, N. L.·1999·Cellular and Molecular Life Sciences (CMLS)

DOI 10.1007/s000180050371PMC PMC2854026

Open this paper in CoChat — free account

Abstract

The molecular mechanisms of general anaesthetics have remained largely obscure since their introduction into clinical practice just over 150 years ago. This review describes the actions of general anaesthetics on mammalian neurotransmitter-gated ion channels. As a result of research during the last several decades, ligand-gated ion channels have emerged as promising molecular targets for the central nervous system effects of general anaesthetics. The last 10 years have witnessed an explosion of studies of anaesthetic modulation of recombinant ligand-gated ion channels, including recent studies which utilize chimeric and mutated receptors to identify regions of ligand-gated ion channels important for the actions of general anaesthetics. Exciting future directions include structural biology and gene-targeting approaches to further the understanding of general anaesthetic molecular mechanisms.

Integrity signals

Registry

Crossref · 10.1007/s000180050371

Cites

345 of 345 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
The Structure of the Potassium Channel: Molecular Basis of K + Conduction and Selectivity
Doyle, D., Morais-Cabral, J. H., Pfuetzner, R. A., Kuo, A., Gulbis, J. M., Cohen, S. L., Chait, B. T., & MacKinnon, R. (1998) · Science · doi:10.1126/science.280.5360.69 · Cited by 6,851
Magnesium gates glutamate-activated channels in mouse central neurones
Nowak, L. M., Bregestovski, P. D., Ascher, P., Herbet, A., & Prochiantz, A. (1984) · Nature · doi:10.1038/307462a0 · Cited by 4,116
Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5
Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640
Glycine potentiates the NMDA response in cultured mouse brain neurons
Johnson, J. W., & Ascher, P. (1987) · Nature · doi:10.1038/325529a0 · Cited by 3,182
Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones
Mayer, M. L., Westbrook, G. L., & Guthrie, P. B. (1984) · Nature · doi:10.1038/309261a0 · Cited by 2,941
Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders
Epstein, F. H., Lipton, S. A., & Rosenberg, P. A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199403033300907 · Cited by 2,676
Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus
Collingridge, G. L., Kehl, S. J., & McLennan, H. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014478 · Cited by 2,413
The Membrane Actions of Anesthetics and Tranquilizers
Seeman, P. M. (1972) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06931-5 · Cited by 2,241
GABAA Receptor Channels
Macdonald, R. L., & Olsen, R. W. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.003033 · Cited by 1,975
NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones
MacDermott, A. B., Mayer, M. L., Westbrook, G. L., Smith, S. J., & Barker, J. L. (1986) · Nature · doi:10.1038/321519a0 · Cited by 1,835
Molecular and cellular mechanisms of general anaesthesia
Franks, N. P., & Lieb, W. R. (1994) · Nature · doi:10.1038/367607a0 · Cited by 1,786
The physiology of excitatory amino acids in the vertebrate central nervous system
Mayer, M. L., & Westbrook, G. L. (1987) · Progress in Neurobiology · doi:10.1016/0301-0082(87)90011-6 · Cited by 1,711
RNA editing in brain controls a determinant of ion flow in glutamate-gated channels
Sommer, B., Köhler, M., Sprengel, R., & Seeburg, P. H. (1991) · Cell · doi:10.1016/0092-8674(91)90568-j · Cited by 1,517
Ethanol Inhibits NMDA-Activated Ion Current in Hippocampal Neurons
Lovinger, D. M., White, G., & Weight, F. F. (1989) · Science · doi:10.1126/science.2467382 · Cited by 1,448
Requirement for Glycine in Activation of NMDA-Receptors Expressed in Xenopus Oocytes
Kleckner, N. W., & Dingledine, R. J. (1988) · Science · doi:10.1126/science.2841759 · Cited by 1,427
The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate
Anis, N. A., Berry, S. C., Burton, N. R., & Lodge, D. (1983) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1983.tb11031.x · Cited by 1,399
Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine
Picciotto, M. R., Zoli, M., Rimondini, R., Léna, C., Marubio, L. M., Pich, E. M., Fuxe, K., & Changeux, J.-P. (1998) · Nature · doi:10.1038/34413 · Cited by 1,320
Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology
Pritchett, D. B., Sontheimer, H. W., Shivers, B. D., Ymer, S., Kettenmann, H., Schofield, P. R., & Seeburg, P. H. (1989) · Nature · doi:10.1038/338582a0 · Cited by 1,273
GABA A ‐receptor heterogeneity in the adult rat brain: Differential regional and cellular distribution of seven major subunits
Fritschy, J., & Mohler, H. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903590111 · Cited by 1,244
Which GABAA-receptor subtypes really occur in the brain?
McKernan, R. M., & Whiting, P. J. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)80023-3 · Cited by 1,222
Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors
Mihic, S. J., Ye, Q., Wick, M. J., Koltchine, V. V., Krasowski, M. D., Finn, S. E., Mascia, M. P., Valenzuela, C. F., Hanson, K. K., Greenblatt, E. P., et al. (1997) · Nature · doi:10.1038/38738 · Cited by 1,219
Self-citation
International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function.
Barnard, E. A., Skolnick, P., Olsen, R. W., Möhler, H., Sieghart, W., Biggio, G., Bræstrup, C., Bateson, A. N., & Langer, S. Z. (1998) · PubMed · Cited by 1,204
Glutamate receptors in the mammalian central nervous system
Ozawa, S., Kamiya, H., & Tsuzuki, K. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00085-3 · Cited by 1,133
The Time Course of Glutamate in the Synaptic Cleft
Clements, J. D., Lester, R. A. J., Tong, G., Jahr, C. E., & Westbrook, G. L. (1992) · Science · doi:10.1126/science.1359647 · Cited by 1,089
Physiological Diversity of Nicotinic Acetylcholine Receptors Expressed by Vertebrate Neurons
McGehee, D. S., & Role, L. W. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.002513 · Cited by 1,022
Determination of the subunit stoichiometry of a voltage-activated potassium channel
MacKinnon, R. (1991) · Nature · doi:10.1038/350232a0 · Cited by 928
Minimum Alveolar Anesthetic Concentration
Eger, E. I., Saidman, L. J., & Brandstater, B. (1965) · Anesthesiology · doi:10.1097/00000542-196511000-00010 · Cited by 868
Contrasting properties of two forms of long-term potentiation in the hippocampus
Nicoll, R. A., & Malenka, R. C. (1995) · Nature · doi:10.1038/377115a0 · Cited by 861
Mutations in the K+ channel signature sequence
Heginbotham, L., Lü, Z., Abramson, T., & MacKinnon, R. (1994) · Biophysical Journal · doi:10.1016/s0006-3495(94)80887-2 · Cited by 853
Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons
Westbrook, G. L., & Mayer, M. L. (1987) · Nature · doi:10.1038/328640a0 · Cited by 852
The Tetrameric Structure of a Glutamate Receptor Channel
Rosenmund, C., Stern-Bach, Y., & Stevens, C. F. (1998) · Science · doi:10.1126/science.280.5369.1596 · Cited by 794
Cooperative Modulation of [3H]MK‐801 Binding to the N‐Methyl‐d‐Aspartate Receptor‐Ion Channel Complex by l‐Glutamate, Glycine, and Polyamines
Ransom, R. W., & Stec, N. L. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb01818.x · Cited by 753
Control of Kinetic Properties of AMPA Receptor Channels by Nuclear RNA Editing
Lomeli, H., Mosbacher, J., Melcher, T., Höger, T., Geiger, J. R. P., Kuner, T., Monyer, H., Higuchi, M., Bach, A., & Seeburg, P. H. (1994) · Science · doi:10.1126/science.7992055 · Cited by 746
Pharmacological studies on presynaptic inhibition
Eccles, J. C., Schmidt, R. F., & Willis, W. D. (1963) · The Journal of Physiology · doi:10.1113/jphysiol.1963.sp007205 · Cited by 744
Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin
Jevtović‐Todorović, V., Todorovć, S. M., Mennerick, S. J., Powell, S., Dikranian, K. T., Benshoff, N. D., Zorumski, C. F., & Olney, J. W. (1998) · Nature Medicine · doi:10.1038/nm0498-460 · Cited by 675
Structure of a glutamate-receptor ligand-binding core in complex with kainate
Armstrong, N., Sun, Y., Chen, G.-Q., & Gouaux, E. (1998) · Nature · doi:10.1038/27692 · Cited by 672
Zinc Selectively Blocks the Action of N -Methyl-D-Aspartate on Cortical Neurons
Peters, S., Koh, J., & Choi, D. W. (1987) · Science · doi:10.1126/science.2883728 · Cited by 668
Structure and function of the NMDA receptor channel
Mori, H., & Mishina, M. (1995) · Neuropharmacology · doi:10.1016/0028-3908(95)00109-j · Cited by 658
Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A
Das, S., Sasaki, Y., Rothe, T., Premkumar, L. S., Takasu, M. A., Crandall, J. E., Dikkes, P., Conner, D. A., Posina, V. R., Cheung, W., et al. (1998) · Nature · doi:10.1038/30748 · Cited by 618
Structure-activity relationships for steroid interaction with the gamma-aminobutyric acidA receptor complex.
Harrison, N. L., Majewska, M., Harrington, J. W., & Barker, J. L. (1987) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-5347(25)00332-5 · Cited by 611
Self-citation
A Molecular Determinant for Submillisecond Desensitization in Glutamate Receptors
Mosbacher, J., Schoepfer, R., Monyer, H., Burnashev, N., SEEBURG, P. H., & Ruppersberg, J. P. (1994) · Science · doi:10.1126/science.7973663 · Cited by 610
The effect of subunit composition of rat brain GABAA receptors on channel function
Sigel, E., Baur, R., Trube, G., Möhler, H., & Malherbe, P. (1990) · Neuron · doi:10.1016/0896-6273(90)90224-4 · Cited by 595
Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging
Michaelis, E. K. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00055-5 · Cited by 578
Determination and Applications of MAC
Quasha, A. L., Eger, E. I., & Tinker, J. H. (1980) · Anesthesiology · doi:10.1097/00000542-198010000-00008 · Cited by 573
Do general anaesthetics act by competitive binding to specific receptors?
Franks, N. P., & Lieb, W. R. (1984) · Nature · doi:10.1038/310599a0 · Cited by 572
Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons
Traynelis, S. F., & Cull-Candy, S. G. (1990) · Nature · doi:10.1038/345347a0 · Cited by 566
GABA as an inhibitory neurotransmitter in human cerebral cortex
McCormick, D. A. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.62.5.1018 · Cited by 557
Anesthetic Potency (MAC) Is Independent of Forebrain Structures in the Rat
Rampil, I. J., Mason, P., & Singh, H. (1993) · Anesthesiology · doi:10.1097/00000542-199304000-00014 · Cited by 548
Evolutionary history of the ligand-gated ion-channel superfamily of receptors
Ortells, M. O., & Lunt, G. G. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93887-4 · Cited by 524
How does xenon produce anaesthesia?
Franks, N. P., Dickinson, R., de Sousa, S. L. M., Hall, A. C., & Lieb, W. R. (1998) · Nature · doi:10.1038/24525 · Cited by 514
Excitotoxicity and the NMDA receptor -- still lethal after eight years
Rothman, S. M. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93869-y · Cited by 508
Modulation of the GABA receptor complex by a steroid anaesthetic
Harrison, N. L., & Simmonds, M. A. (1984) · Brain Research · doi:10.1016/0006-8993(84)90299-3 · Cited by 501
Self-citation
Enhanced LTP in Mice Deficient in the AMPA Receptor GluR2
Jia, Z., Agopyan, N., Miu, P., Xiong, Z., Henderson, J., Gerlai, R. T., Taverna, F. A., Velumian, A. A., MacDonald, J. F., Carlen, P. L., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80225-1 · Cited by 497
Exaggerated Anesthetic Requirements in the Preferentially Anesthetized Brain
Antognini, J. F., & Schwartz, K. R. (1993) · Anesthesiology · doi:10.1097/00000542-199312000-00015 · Cited by 495
Mice Deficient in the α7 Neuronal Nicotinic Acetylcholine Receptor Lack α-Bungarotoxin Binding Sites and Hippocampal Fast Nicotinic Currents
Orr‐Urtreger, A., Göldner, F. M., Saeki, M., Lorenzo, I., Goldberg, L. B., Biasi, M. D., Dani, J. A., Patrick, J. W., & Beaudet, A. L. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-23-09165.1997 · Cited by 494
Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death
Forrest, D., Yuzaki, M., Soares, H. D., Ng, L., Luk, D. C., Sheng, M., Stewart, C. L., Morgan, J. I., Connor, J. A., & Curran, T. (1994) · Neuron · doi:10.1016/0896-6273(94)90350-6 · Cited by 491
Functional domains of GABAA receptors
Smith, G. B., & Olsen, R. W. (1995) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)89009-4 · Cited by 491
Stoichiometry and Assembly of a Recombinant GABAAReceptor Subtype
Tretter, V. E., Ehya, N., Fuchs, K., & Sieghart, W. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02728.1997 · Cited by 484
Evidence for a Tetrameric Structure of Recombinant NMDA Receptors
Laube, B., Kuhse, J., & Betz, H. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-08-02954.1998 · Cited by 482
Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice
Mulle, C., Sailer, A. W., Pérez‐Otaño, I., Dickinson-Anson, H., Castillo, P. E., Bureau, I., Maron, C., Gage, F. H., Mann, J. R., Bettler, B., et al. (1998) · Nature · doi:10.1038/33408 · Cited by 480
From ion currents to genomic analysis: Recent advances in GABAA receptor research
Rabow, L. E., Russek, S. J., & Farb, D. H. (1995) · Synapse · doi:10.1002/syn.890210302 · Cited by 478
Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor
Cooper, E., Couturier, S., & Ballivet, M. (1991) · Nature · doi:10.1038/350235a0 · Cited by 470
Mice devoid of γ-aminobutyrate type A receptor β3 subunit have epilepsy, cleft palate, and hypersensitive behavior
Homanics, G. E., DeLorey, T. M., Firestone, L. L., Quinlan, J. J., Handforth, A., Harrison, N. L., Krasowski, M. D., Rick, C., Korpi, E. R., Mäkelä, R., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.4143 · Cited by 469
Self-citation
The Anesthetic Properties of Xenon in Animals and Human Beings, with Additional Observations on Krypton
Cullen, S. C., & Gross, E. G. (1951) · Science · doi:10.1126/science.113.2942.580 · Cited by 466
Mice Lacking the β3Subunit of the GABAAReceptor Have the Epilepsy Phenotype and Many of the Behavioral Characteristics of Angelman Syndrome
DeLorey, T. M., Handforth, A., Anagnostaras, S., Homanics, G. E., Minassian, B. A., Asatourian, A., Fanselow, M. S., Delgado‐Escueta, A. V., Ellison, G., & Olsen, R. W. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-20-08505.1998 · Cited by 460
Selective modulation of NMDA responses by reduction and oxidation
Aizenman, E., Lipton, S. A., & Loring, R. H. (1989) · Neuron · doi:10.1016/0896-6273(89)90310-3 · Cited by 453
Stoichiometry of a Recombinant GABAAReceptor
Chang, Y., Wang, R., Barot, S., & Weiss, D. S. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-17-05415.1996 · Cited by 440
Action of brief pulses of glutamate on AMPA/kainate receptors in patches from different neurones of rat hippocampal slices.
Colquhoun, D., Jónás, P., & Sakmann, B. J. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019417 · Cited by 438
Molecular mechanisms of general anaesthesia
Franks, N. P., & Lieb, W. R. (1982) · Nature · doi:10.1038/300487a0 · Cited by 431
Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina.
Cutting, G. R., Lu, L., O’Hara, B. F., Kasch, L. M., Montrose‐Rafizadeh, C., Donovan, D. M., Shimada, S., Antonarakis, S. E., Guggino, W. B., & Uhl, G. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.7.2673 · Cited by 427
GABAA receptor needs two homologous domains of the & beta;-subunit for activation by GABA but not by pentobarbital
Αmin, J., & Weiss, D. S. (1993) · Nature · doi:10.1038/366565a0 · Cited by 426
Potentiation of NMDA receptor currents by arachidonic acid
Miller, B., Sarantis, M., Traynelis, S. F., & Attwell, D. (1992) · Nature · doi:10.1038/355722a0 · Cited by 425
Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors.
Günther, U., Benson, J. A., Benke, D., Fritschy, J., Reyes, G., Knoflach, F., Crestani, F., Aguzzi, A., Arigoni, M., Lang, Y., et al. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7749 · Cited by 423
N-glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluR1
Hollmann, M., Maron, C., & Heinemann, S. (1994) · Neuron · doi:10.1016/0896-6273(94)90419-7 · Cited by 421
Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the α subunit
Akabas, M. H., Kaufmann, C. M., Archdeacon, P., & Karlin, A. (1994) · Neuron · doi:10.1016/0896-6273(94)90257-7 · Cited by 421
Human neuronal nicotinic receptors
Gotti, C., Fornasari, D., & Clementi, F. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00034-8 · Cited by 417
COMPARATIVE PHARMACOLOGY OF THE KETAMINE ISOMERS
White, P. F., Schüttler, J., Shafer, A., Stanski, D. R., Horai, Y., & Trevor, A. J. (1985) · British Journal of Anaesthesia · doi:10.1093/bja/57.2.197 · Cited by 416
Chimaeric nicotinic–serotonergic receptor combines distinct ligand binding and channel specificities
Eiselé, J.-L., Bertrand, S., Galzi, J., Devillers‐Thiéry, A., Changeux, J., & Bertrand, D. (1993) · Nature · doi:10.1038/366479a0 · Cited by 405
Insensitivity to anaesthetic agents conferred by a class of GABAA receptor subunit
Davies, P. A., Hanna, M. C., Hales, T. G., & Kirkness, E. F. (1997) · Nature · doi:10.1038/385820a0 · Cited by 404
Studien über die Narkose : zugleich ein Beitrag zur allgemeinen Pharmakologie
Overton, E. (1901) · G. Fischer eBooks · Cited by 400
The interaction of the general anesthetic etomidate with the γ-aminobutyric acid type A receptor is influenced by a single amino acid
Belelli, D., Lambert, J. J., Peters, J. A., Wafford, K. A., & Whiting, P. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.11031 · Cited by 392
Conserved quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamer.
Langosch, D., Thomas, L., & Betz, H. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.19.7394 · Cited by 390
Chapter 6 Glutamate receptors and the induction of excitotoxic neuronal death
Choi, D. W. (1994) · Progress in Brain Research · doi:10.1016/s0079-6123(08)60767-0 · Cited by 385
Differential synaptic localization of two major gamma-aminobutyric acid type A receptor alpha subunits on hippocampal pyramidal cells.
Nusser, Z., Sieghart, W., Benke, D., Fritschy, J., & Somogyi, P. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11939 · Cited by 384
Neuronal Nicotinic Acetylcholine Receptors
Lindstrom, J. (1996) · Springer eBooks · doi:10.1007/978-1-4899-1775-1_10 · Cited by 382
Prolongation of hippocampal inhibitory postsynaptic potentials by barbiturates
Nicoll, R. A., Eccles, J. C., OSHIMA, T., & Rubia, F. J. (1975) · Nature · doi:10.1038/258625a0 · Cited by 373
Nervous system distribution of the serotonin 5-HT3 receptor mRNA.
Tecott, L. H., Maricq, A. V., & Julius, D. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.4.1430 · Cited by 368
Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons
Paternain, A. V., Morales, M., & Lerma, J. (1995) · Neuron · doi:10.1016/0896-6273(95)90253-8 · Cited by 367
Substitution of a mutant α 2a -adrenergic receptor via “hit and run” gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo
Lakhlani, P. P., MacMillan, L. B., Guo, T., McCool, B. A., Lovinger, D. M., Maze, M., & Limbird, L. E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9950 · Cited by 361
The Role of the GABAA Receptor/Chloride Channel Complex in Anesthesia
Tanelian, D. L., Kosek, P. S., Módy, I., & MacIver, M. B. (1993) · Anesthesiology · doi:10.1097/00000542-199304000-00020 · Cited by 349
Pharmacology of GABA receptor CI− channels in rat retinal bipolar cells
Feigenspan, A., Wässle, H., & Bormann, J. (1993) · Nature · doi:10.1038/361159a0 · Cited by 347
Multiple Mechanisms of Ketamine Blockade of N-methyl-D-aspartate Receptors
Orser, B. A., Pennefather, P., & MacDonald, J. F. (1997) · Anesthesiology · doi:10.1097/00000542-199704000-00021 · Cited by 346
The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones
Hales, T. G., & Lambert, J. J. (1991) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1991.tb12479.x · Cited by 345
Some Physical Mechanisms in Narcosis.
Mullins, L. J. (1954) · Chemical Reviews · doi:10.1021/cr60168a003 · Cited by 344
Functional Architecture Of The Nicotinic Acetylcholine Receptor: From Electric Organ To Brain
Galzi, J., Revah, F., Bessis, A., & Changeux, J. (1991) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.31.040191.000345 · Cited by 332
Synaptic Potentials Mediated via α-Bungarotoxin-Sensitive Nicotinic Acetylcholine Receptors in Rat Hippocampal Interneurons
Frazier, C. J., Buhler, A. V., Weiner, J. L., & Dunwiddie, T. V. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-20-08228.1998 · Cited by 329
GABAA receptor pharmacology
Johnston, G. A. R. (1996) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(95)02043-8 · Cited by 327
NMDA receptors: from genes to channels
Sucher, N. J., Awobuluyi, M., Choi, Y., & Lipton, S. A. (1996) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(96)80008-3 · Cited by 312
Localizing 3H-GABA in Nerve Terminals of Rat Cerebral Cortex by Electron Microscopic Autoradiography
Bloom, F. E., & Iversen, L. L. (1971) · Nature · doi:10.1038/229628a0 · Cited by 307
KETAMINE INFUSIONS: PHARMACOKINETICS AND CLINICAL EFFECTS
Idvall, J., Ahlgren, I., Aronsen, K. F., & Stenberg, P. B. (1979) · British Journal of Anaesthesia · doi:10.1093/bja/51.12.1167 · Cited by 306
Modulation of the GABAA receptor by depressant barbiturates and pregnane steroids
Peters, J. A., Kirkness, E. F., Callachan, H., Lambert, J. J., & Turner, A. J. (1988) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1988.tb11646.x · Cited by 294
Topology profile for a glutamate receptor: Three transmembrane domains and a channel-lining reentrant membrane loop
Bennett, J. A., & Dingledine, R. J. (1995) · Neuron · doi:10.1016/0896-6273(95)90293-7 · Cited by 288
Pentobarbitone pharmacology of mammalian central neurones grown in tissue culture.
Barker, J. L., & Ransom, B. R. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012388 · Cited by 277
The Effect of the Interaction of Propofol and Alfentanil on Recall, Loss of Consciousness, and the Bispectral Index
Iselin-Chaves, I. A., Flaishon, R., Sebel, P. S., Howell, S. T., Gan, T. J., Sigl, J. C., Ginsberg, B., & Glass, P. S. A. (1998) · Anesthesia & Analgesia · doi:10.1097/00000539-199810000-00038 · Cited by 267
Modulation of the GABAA receptor by progesterone metabolites
Callachan, H., Cottrell, G. A., Hather, N. Y., Lambert, J. J., Nooney, J. M., & Peters, J. A. (1987) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1987.0049 · Cited by 256
Propofol and Other Intravenous Anesthetics Have Sites of Action on the γ-Aminobutyric Acid Type A Receptor Distinct from That for Isoflurane
Krasowski, M. D., Koltchine, V. V., Rick, C., Ye, Q., Finn, S. E., & Harrison, N. L. (1998) · Molecular Pharmacology · doi:10.1124/mol.53.3.530 · Cited by 250
Self-citation
Inhibition by propofol (2,6 di‐isopropylphenol) of the N‐methyl‐D‐aspartate subtype of glutamate receptor in cultured hippocampal neurones
Orser, B. A., Bertlik, M., Wang, L., & MacDonald, J. F. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb16660.x · Cited by 249
SOLUBILITY COEFFICIENTS FOR INHALED ANAESTHETICS FOR WATER, OIL AND BIOLOGICAL MEDIA
Steward, A. N., ALLOTT, P. R., Cowles, A. L., & MAPLESON, W. W. (1973) · British Journal of Anaesthesia · doi:10.1093/bja/45.3.282 · Cited by 242
The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit.
Wingrove, P. B., Wafford, K. A., Bain, C., & Whiting, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.10.4569 · Cited by 242
Subunit‐dependent interaction of the general anaesthetic etomidate with the γ‐aminobutyric acid type A receptor
Hill‐Venning, C., Belelli, D., Peters, J. A., & Lambert, J. J. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0700927 · Cited by 239
A Novel Class of GABAA Receptor Subunit in Tissues of the Reproductive System
Hedblom, E., & Kirkness, E. F. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.24.15346 · Cited by 237
Propofol modulates activation and desensitization of GABAA receptors in cultured murine hippocampal neurons
Orser, B. A., Wang, L., Pennefather, P., & MacDonald, J. F. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-12-07747.1994 · Cited by 237
Glycine receptors: heterogeneous and widespread in the mammalian brain
Betz, H. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90045-v · Cited by 236
The TIPS/TINS Lecture: The molecular biology of mammalian glutamate receptor channels
SEEBURG, P. H. (1993) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(93)90047-n · Cited by 236
MAC of sevoflurane in humans and the New Zealand white rabbit
Scheller, M. S., Saidman, L. J., & Partridge, B. L. (1988) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03010656 · Cited by 234
Molecular Interactions Between Inhaled Anesthetics and Proteins
Eckenhoff, R. G., & Johansson, J. S. (1997) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01337-1 · Cited by 233
Effect of Nitrous Oxide on Excitatory and Inhibitory Synaptic Transmission in Hippocampal Cultures
Mennerick, S. J., Jevtović‐Todorović, V., Todorovic, S. M., Shen, W., Olney, J. W., & Zorumski, C. F. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09716.1998 · Cited by 227
Alpha4beta2 Neuronal Nicotinic Acetylcholine Receptors in the Central Nervous System Are Inhibited by Isoflurane and Propofol, but alpha7-type Nicotinic Acetylcholine Receptors Are Unaffected
Flood, P. D., Ramírez-Latorre, J. A., & Role, L. W. (1997) · Anesthesiology · doi:10.1097/00000542-199704000-00016 · Cited by 223
SELECTIVE ACTIONS OF VOLATILE GENERAL ANAESTHETICS AT MOLECULAR AND CELLULAR LEVELS
Franks, N. P., & Lieb, W. R. (1993) · British Journal of Anaesthesia · doi:10.1093/bja/71.1.65 · Cited by 218
Propofol Activates GABAA Receptor-Chloride Ionophore Complex in Dissociated Hippocampal Pyramidal Neurons of the Rat
Hara, M., Kai, Y., & Ikemoto, Y. (1993) · Anesthesiology · doi:10.1097/00000542-199310000-00021 · Cited by 215
Developmental Changes of Inhibitory Synaptic Currents in Cerebellar Granule Neurons: Role of GABAAReceptor α6 Subunit
Tia, S., Wang, J. F., Kotchabhakdi, N., & Vicini, S. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-11-03630.1996 · Cited by 214
Ethanol potentiation of 5-hydroxytryptamine3 receptor-mediated ion current in neuroblastoma cells and isolated adult mammalian neurons.
Lovinger, D. M., & White, G. (1991) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)12934-9 · Cited by 214
Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors.
Hadingham, K. L., Wingrove, P. B., Bourdellès, B. L., Palmer, K. J., RAGAN, C. I., & Whiting, P. J. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13682-1 · Cited by 214
Structural Basis for the Inhibition of Firefly Luciferase by a General Anesthetic
Franks, N. P., Jenkins, A., Conti, E., Lieb, W. R., & Brick, P. (1998) · Biophysical Journal · doi:10.1016/s0006-3495(98)77664-7 · Cited by 213
Comparison of MAC and the Rate of Rise of Alveolar Concentration of Sevoflurane with Halothane and Isoflurane in the Dog
Kazama, T., & Ikeda, K. (1988) · Anesthesiology · doi:10.1097/00000542-198803000-00020 · Cited by 212
Neuronally Restricted RNA Splicing Regulates the Expression of a Novel GABA A Receptor Subunit Conferring Atypical Functional Properties
Whiting, P. J., McAllister, G., Vassilatis, D. K., Bonnert, T. P., HEAVENS, R. P., Smith, D. W., Hewson, L., O’Donnell, R., Rigby, M. R., SIRINATHSINGHJI, D. J. S., et al. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05027.1997 · Cited by 211
Mutations of γ-aminobutyric acid and glycine receptors change alcohol cutoff: Evidence for an alcohol receptor?
Wick, M. J., Mihic, S. J., Ueno, S., Mascia, M. P., Trudell, J. R., Brozowski, S. J., Ye, Q., Harrison, N. L., & Harris, R. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6504 · Cited by 211
Self-citation
A relationship between alcohol intoxication and the disordering of brain membranes by a series of short-chain alcohols.
Lyon, R. C., McComb, J. A., Schreurs, J., & Goldstein, D. B. (1981) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32727-8 · Cited by 209
Differential Sensitivities of Mammalian Neuronal and Muscle Nicotinic Acetylcholine Receptors to General Anesthetics
Violet, J. M., Downie, D. L., Nakisa, R. C., Lieb, W. R., & Franks, N. P. (1997) · Anesthesiology · doi:10.1097/00000542-199704000-00017 · Cited by 208
gamma-Aminobutyric acid A or C receptor? gamma-Aminobutyric acid rho 1 receptor RNA induces bicuculline-, barbiturate-, and benzodiazepine-insensitive gamma-aminobutyric acid responses in Xenopus oocytes.
Shimada, S., Cutting, G. R., & Uhl, G. R. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09011-x · Cited by 206
Polyhalogenated and Perfluorinated Compounds that Disobey the Meyer-Overton Hypothesis
Koblin, D. D., Chortkoff, B. S., Laster, M. J., Eger, E. I., Halsey, M. J., & Ionescu, P. (1994) · Anesthesia & Analgesia · doi:10.1213/00000539-199412000-00004 · Cited by 205
Activation and deactivation rates of recombinant GABA(A) receptor channels are dependent on alpha-subunit isoform
Lavoie, A. M., Tingey, J., Harrison, N. L., Pritchett, D. B., & Twyman, R. E. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78280-8 · Cited by 205
Self-citation
Neurosteroids and GABA, receptor function
Jeremy, J., Belelli, D., Hill‐Venning, C., & Peters, J. A. (1995) · Cited by 205
The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex
Kuhse, J., Betz, H., & Kirsch, J. (1995) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(95)80044-1 · Cited by 205
Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors.
Hadingham, K. L., Wingrove, P. B., Wafford, K. A., Bain, C., Kemp, J. A., Palmer, K. J., Wilson, A. W., Wilcox, A. S., Sikela, J. M., & RAGAN, C. I. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13351-8 · Cited by 202
Comparative pharmacology of the optical isomers of ketamine in mice
Ryder, S., Way, W. L., & Trevor, A. J. (1978) · European Journal of Pharmacology · doi:10.1016/0014-2999(78)90217-0 · Cited by 199
Actions of anesthetics on ligand‐gated ion channels: role of receptor subunit composition
Harris, R. A., Mihic, S. J., Dildy‐Mayfield, J. E., & Machu, T. K. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.14.7589987 · Cited by 198
Enhancement of homomeric glycine receptor function by longchain alcohols and anaesthetics
Mascia, M. P., Machu, T. K., & Harris, R. A. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb16042.x · Cited by 198
Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit.
Xu, M., & Akabas, M. H. (1996) · The Journal of General Physiology · doi:10.1085/jgp.107.2.195 · Cited by 197
Transmembrane topology of two kainate receptor subunits revealed by N-glycosylation.
Wo, Z. G., & Oswald, R. E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.7154 · Cited by 195
Motor Discoordination Results from Combined Gene Disruption of the NMDA Receptor NR2A and NR2C Subunits, But Not from Single Disruption of the NR2A or NR2C Subunit
Kadotani, H., Hirano, T., Masugi, M., Nakamura, K., Nakao, K., Katsuki, M., & Nakanishi, S. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-24-07859.1996 · Cited by 195
Temperature Dependence of the Potency of Volatile General Anesthetics
Franks, N. P., & Lieb, W. R. (1996) · Anesthesiology · doi:10.1097/00000542-199603000-00027 · Cited by 193
Can the Lipid Theories of Anesthesia Account for the Cutoff in Anesthetic Potency in Homologous Series of Alcohols?
Pringle, M. J., Brown, K. B., & Miller, K. W. (1981) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)12536-4 · Cited by 193
Enhancement of gamma‐aminobutyric acid‐activated Cl‐ currents in cultured rat hippocampal neurones by three volatile anaesthetics.
Jones, M. V., Brooks, P. A., & Harrison, N. L. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019086 · Cited by 192
Self-citation
Identification of a putative γ-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14–q21 and mouse chromosome 4
Cutting, G. R., Curristin, S. M., Zoghbi, H. Y., O’Hara, B. F., Seldin, M. F., & Uhl, G. R. (1992) · Genomics · doi:10.1016/0888-7543(92)90312-g · Cited by 191
Effects of Ethanol on Recombinant Human Neuronal Nicotinic Acetylcholine Receptors Expressed in Xenopus Oocytes
Cardoso, R. A., Brozowski, S. J., Chavez-Noriega, L. E., Harpold, M. M., Valenzuela, C. F., & Harris, R. A. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38200-x · Cited by 190
Direct activation of GABAA receptors by barbiturates in cultured rat hippocampal neurons.
Rho, J. M., Donevan, S. D., & Rogawski, M. A. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021784 · Cited by 189
Barbiturate interactions at the human GABAA receptor: dependence on receptor subunit combination
Thompson, S. A., Whiting, P. J., & Wafford, K. A. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15221.x · Cited by 188
The GABAA receptors
Stephenson, F. A. (1995) · Biochemical Journal · doi:10.1042/bj3100001 · Cited by 185
Chloride-dependent enhancement by barbiturates of gamma-aminobutyric acid receptor binding
Olsen, R., & Snowman, A. M. (1982) · Journal of Neuroscience · doi:10.1523/jneurosci.02-12-01812.1982 · Cited by 184
Alcohols and neurotransmitter gated ion channels: past, present and future
Lovinger, D. M. (1997) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/pl00005051 · Cited by 182
Gene Knockout of the α6 Subunit of the γ-Aminobutyric Acid Type A Receptor: Lack of Effect on Responses to Ethanol, Pentobarbital, and General Anesthetics
Homanics, G. E., Ferguson, C., Quinlan, J. J., Daggett, J., Snyder, K., Lagenaur, C. F., Mi, Z., Wang, X., Grayson, D. R., & Firestone, L. L. (1997) · Molecular Pharmacology · doi:10.1124/mol.51.4.588 · Cited by 180
Chapter 10 Structure and function of neuronal nicotinic acetylcholine receptors
Lindstrom, J. M., Anand, R., Gerzanich, V., Peng, X.-D., Wang, F., & Wells, G. B. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)62094-4 · Cited by 179
Effects of volatile anesthetics on the kinetics of inhibitory postsynaptic currents in cultured rat hippocampal neurons
Jones, M. V., & Harrison, N. L. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.70.4.1339 · Cited by 179
Self-citation
Distribution in the Brain and Metabolism of Ketamine in the Rat after Intravenous Administration
Cohen, M. L., Chan, S.-L., Way, W. L., & Trevor, A. J. (1973) · Anesthesiology · doi:10.1097/00000542-197310000-00003 · Cited by 174
The effect of external pH changes on responses to excitatory amino acids in mouse hippocampal neurones.
Vyklický, L., Vlachová, V., & Krůšek, J. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018304 · Cited by 170
Stereoselective Effects of Etomidate Optical Isomers on Gamma-aminobutyric Acid Type A Receptors and Animals
Tomlin, S. L., Jenkins, A., Lieb, W. R., & Franks, N. P. (1998) · Anesthesiology · doi:10.1097/00000542-199803000-00022 · Cited by 167
Anaesthetic potencies of primary alkanols: implications for the molecular dimensions of the anaesthetic site
Alifimoff, J. K., Firestone, L. L., & Miller, K. W. (1989) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1989.tb11777.x · Cited by 167
Positive modulation of human gamma-aminobutyric acid type A and glycine receptors by the inhalation anesthetic isoflurane.
Harrison, N. L., Kugler, J., Jones, M. V., Greenblatt, E. P., & Pritchett, D. B. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13234-3 · Cited by 167
Self-citation
Potentiation of gamma‐aminobutyric‐acid‐activated chloride conductance by a steroid anaesthetic in cultured rat spinal neurones.
Barker, J. L., Harrison, N. L., Lange, G. D., & Owen, D. G. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016547 · Cited by 166
Self-citation
Halothane, Isoflurane, and Enflurane MAC in Pregnant and Nonpregnant Female and Male Mice and Rats
Mazze, R. I., Rice, S. A., & Baden, J. M. (1985) · Anesthesiology · doi:10.1097/00000542-198503000-00021 · Cited by 165
The cataleptic state induced by ketamine: a review of the neuropharmacology of anesthesia
Winters, W. D., Ferrer-Allado, T., Guzman-Flores, C., & Alcaraz, M. (1972) · Neuropharmacology · doi:10.1016/0028-3908(72)90016-0 · Cited by 164
Structure and function of inhibitory glycine receptors
Betz, H. (1992) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583500004340 · Cited by 163
Physico-chemical correlates of alcohol intoxication
McCreery, M. J., & Hunt, W. A. (1978) · Neuropharmacology · doi:10.1016/0028-3908(78)90050-3 · Cited by 159
Anesthesia Sensitivity in Mice that Lack the β3 Subunit of the γ-Aminobutyric Acid Type A Receptor
Quinlan, J. J., Homanics, G. E., & Firestone, L. L. (1998) · Anesthesiology · doi:10.1097/00000542-199803000-00030 · Cited by 158
Presynaptic ionotropic receptors
McGehee, D. S., & Role, L. W. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80118-8 · Cited by 157
Ethanol modulation of the gamma-aminobutyric acidA- and glycine-activated Cl- current in cultured mouse neurons.
Aguayo, L. G., & Pancetti, F. C. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22381-3 · Cited by 157
Dual Actions of Volatile Anesthetics on GABAAIPSCs
Banks, M. I., & Pearce, R. A. (1999) · Anesthesiology · doi:10.1097/00000542-199901000-00018 · Cited by 156
Partitioning of long-chain alcohols into lipid bilayers: implications for mechanisms of general anesthesia.
Franks, N. P., & Lieb, W. R. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.14.5116 · Cited by 156
Differences in affinity and efficacy of benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes.
Wafford, K. A., Whiting, P. J., & Kemp, J. A. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13605-5 · Cited by 155
Glutamate receptors of the kainate type and synaptic transmission
Lerma, J. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)20055-4 · Cited by 153
Facilitatory effect of docosahexaenoic acid on N‐methyl‐D‐aspartate response in pyramidal neurones of rat cerebral cortex.
Nishikawa, M., Kimura, S., & Akaike, N. (1994) · Journal of Physiology · doi:10.1113/jphysiol.1994.sp020051 · Cited by 153
Potentiation of inhibition by general anaesthetics in neurones of the olfactory cortex in vitro
Scholfield, C. N. (1980) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00587527 · Cited by 152
A single amino acid determines differences in ethanol actions on strychnine-sensitive glycine receptors.
Mascia, M. P., Mihic, S. J., Valenzuela, C. F., Schofield, P. R., & Harris, R. A. (1996) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09257-0 · Cited by 151
The Nicotinic Acetylcholine Receptor: Structure and Autoimmune Pathology
Conti-Tronconi, B. M., McLane, K. E., Raftery, M. A., Grando, S. A., & Protti, M. P. (1994) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409239409086798 · Cited by 148
Anesthetic actions within the spinal cord: contributions to the state of general anesthesia
Collins, J. G., Kendig, J. J., & Mason, P. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)98377-b · Cited by 147
General anesthetics potentiate gamma-aminobutyric acid actions on gamma-aminobutyric acidA receptors expressed by Xenopus oocytes: lack of involvement of intracellular calcium.
LIN, L. H., Chen, L. L., Zirrolli, J. A., & Harris, R. A. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10387-x · Cited by 140
Point mutations in the M2 region of the alpha, beta, or gamma subunit of the GABAA channel that abolish block by picrotoxin.
Gurley, D. A., Αmin, J., Ross, P. C., Weiss, D. S., & White, G. (1995) · PubMed · Cited by 140
Actions of the general anesthetic propofol on recombinant human GABAA receptors: influence of receptor subunits.
Sanna, E., Mascia, M. P., Klein, R. L., Whiting, P. J., Biggio, G., & HARRIS, R. A. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10610-1 · Cited by 139
General anesthetics modulate GABA receptor channel complex in rat dorsal root ganglion neurons
Nakahiro, M., Yeh, J. Z., Brunner, E. E., & Narahashi, T. (1989) · The FASEB Journal · doi:10.1096/fasebj.3.7.2541038 · Cited by 138
A steroid anesthetic prolongs inhibitory postsynaptic currents in cultured rat hippocampal neurons
Harrison, N. L., Vicini, S., & Barker, J. L. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-02-00604.1987 · Cited by 138
Self-citation
Differential effects of ketamine enantiomers on NMDA receptor currents in cultured neurons
Zeilhofer, H. U., Swandulla, D., Geißlinger, G., & Brune, K. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90248-3 · Cited by 137
Modification of NMDA Receptor Channels and Synaptic Transmission by Targeted Disruption of the NR2C Gene
Ebralidze, A. K., Rossi, D. J., Tonegawa, S., & Slater, N. T. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-16-05014.1996 · Cited by 136
The interaction of general anaesthetics with recombinant GABAA and glycine receptors expressed in Xenopus laevis oocytes: a comparative study
Pistis, M., Belelli, D., Peters, J. A., & Lambert, J. J. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701563 · Cited by 134
Enhancement of Glycine Receptor Function by Ethanol Is Inversely Correlated with Molecular Volume at Position α267
Ye, Q., Koltchine, V. V., Mihic, S. J., Mascia, M. P., Wick, M. J., Finn, S. E., Harrison, N. L., & Harris, R. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.6.3314 · Cited by 134
Self-citation
Thermodynamic analysis of the relative effectiveness of narcotics
Brink, F., & Posternak, J. M. (1948) · Journal of Cellular and Comparative Physiology · doi:10.1002/jcp.1030320208 · Cited by 132
Effects of two volatile anesthetics and a volatile convulsant on the excitatory and inhibitory amino acid responses in dissociated CNS neurons of the rat
Wakamori, M., Ikemoto, Y., & Akaike, N. (1991) · Journal of Neurophysiology · doi:10.1152/jn.1991.66.6.2014 · Cited by 131
Biophysical and pharmacological properties of cloned GABAA receptor subunits expressed in xenopus oocytes
Levitan, E. S., Blair, L. A. C., Dionne, V. E., & Barnard, E. A. (1988) · Neuron · doi:10.1016/0896-6273(88)90125-0 · Cited by 131
Effects of inhalational general anaesthetics on native glycine receptors in rat medullary neurones and recombinant glycine receptors in Xenopus oocytes
Downie, D. L., Hall, A. C., Lieb, W. R., & Franks, N. P. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15430.x · Cited by 131
Effects of optical isomers of ketamine on excitation of cat and rat spinal neurones by amino acids and acetylcholine
Lodge, D., Anis, N. A., & Burton, N. R. (1982) · Neuroscience Letters · doi:10.1016/0304-3940(82)90330-5 · Cited by 130
Potentiation of gamma-aminobutyric acid type A receptor-mediated chloride currents by novel halogenated compounds correlates with their abilities to induce general anesthesia.
Mihic, S. J., McQuilkin, S. J., Eger, E. I., Ionescu, P., & HARRIS, R. A. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09824-4 · Cited by 127
Clinical Pharmacokinetics of Hypnotics
Breimer, D. D. (1977) · Clinical Pharmacokinetics · doi:10.2165/00003088-197702020-00002 · Cited by 125
Identification of Amino Acid Residues that Control Functional Behavior in GluR5 and GluR6 Kainate Receptors
Swanson, G. T., Gereau, R. W., Green, T., & Heinemann, S. F. (1997) · Neuron · doi:10.1016/s0896-6273(00)80972-1 · Cited by 124
Alcohols and anesthetics enhance the function of 5-hydroxytryptamine3 receptors expressed in Xenopus laevis oocytes.
Machu, T. K., & Harris, R. A. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23856-3 · Cited by 124
Distribution of GABA receptor ρ subunit transcripts in the rat brain
Wegelius, K., Pasternack, M., Hiltunen, J. O., Rivera, C., Kaila, K., Saarma, M., & Reeben, M. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00023.x · Cited by 123
Novel properties of homomeric beta 1 gamma-aminobutyric acid type A receptors: actions of the anesthetics propofol and pentobarbital.
Sanna, E., Garau, F., & HARRIS, R. A. (1995) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08530-x · Cited by 121
Amino acids lining the channel of the gamma-aminobutyric acid type A receptor identified by cysteine substitution.
Xu, M., & Akabas, M. H. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80569-9 · Cited by 114
The role of 5-HT3 receptors in drug dependence
Grant, K. A. (1995) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(95)01120-n · Cited by 114
Effects of Ethanol and Anesthetics on Type 1 and 5 Metabotropic Glutamate Receptors Expressed in Xenopus laevis Oocytes
Minami, K., Gereau, R. W., Minami, M., Heinemann, S. F., & Harris, R. A. (1998) · Molecular Pharmacology · doi:10.1124/mol.53.1.148 · Cited by 114

Flagged first, then by citations

1 of the 346 references couldn’t be matched to a known paper.

Sorted by citations

Molecular Structure and Function of the Glycine Receptor Chloride Channel
Lynch, J. W. (2004) · Physiological Reviews · doi:10.1152/physrev.00042.2003 · Cited by 803
Molecular and neuronal substrates for general anaesthetics
Rudolph, U., & Antkowiak, B. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1496 · Cited by 771
The sedative component of anesthesia is mediated by GABAA receptors in an endogenous sleep pathway
Nelson, L. E., Guo, T. Z., Lu, J., Saper, C. B., Franks, N. P., & Maze, M. (2002) · Nature Neuroscience · doi:10.1038/nn913 · Cited by 568
General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA A receptor β3 subunit
Jurd, R., Arrasa, M., Lambert, S., Drexler, B., Siegwart, R., Crestani, F., Zaugg, M., Vogt, K. E., Ledermann, B., Antkowiak, B., et al. (2003) · The FASEB Journal · doi:10.1096/fj.02-0611fje · Cited by 558
Emerging molecular mechanisms of general anesthetic action
Hemmings, H. C., Akabas, M. H., Goldstein, P. A., Trudell, J. R., Orser, B. A., & Harrison, N. L. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.08.006 · Cited by 550
Self-citation

See all 388

Authors: Krasowski, M. D., & Harrison, N. L.
Affiliations: University of Chicago (US)
ORCID: Krasowski, M. D.
Harrison, N. L.
Venue: Cellular and Molecular Life Sciences (CMLS)
Publisher: Springer Science and Business Media LLC
Published: 1999-08-01
Volume: 55
Issue: 10
Pages: 1278-1303
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s000180050371
PMC: PMC2854026
OpenAlex: W2088909919
Cited by: 384
References: 346
Citations by year: 2026: 2 · 2025: 8 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 9 · 2020: 12 · 2019: 8 · 2018: 7 · 2017: 13 · 2016: 10 · 2015: 12 · 2014: 14 · 2013: 12 · 2012: 14
FWCI: 5.40
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (7r01gm056850-03, 5k04gm000623-04)
National Institute of Mental Health (F30MH011504)
National Institute of General Medical Sciences (GM-45129, R01GM045129, GM56850, GM00623)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: general anesthetics, ligand-gated ion channels, anesthetic mechanisms, chimeric receptors, receptor mutations
MeSH terms: Animals, Cell Membrane, Humans, Ion Channels, Ligands, Mammals, Protein Conformation, Receptors, Cell Surface, Ion Channel Gating, Anesthetics, General

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

General anaesthetic actions on ligand-gated ion channels

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks