Cited by 414Bone Metabolism and DiseasesRheumatoid Arthritis Research and TherapiesImmune Response and Inflammation

The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.

Mechanistic insight into osteoclast differentiation in osteoimmunology

Takayanagi, Hiroshi·2005·Journal of Molecular Medicine

Open this paper in CoChat — free account

Abstract

Recently a close relationship between the immune and skeletal systems or the interdisciplinary field called osteoimmunology has attracted much attention due to the observations that bone destruction is caused by an abnormal activation of the immune system in rheumatoid arthritis, and that mice lacking immunomodulatory molecules often exhibit an unexpected bone phenotype. Osteoclasts are cells of monocyte/macrophage origin that degrade the bone matrix. They are among the key players in the control of bone metabolism in health and disease. Receptor activator of NF-kappaB ligand (RANKL), a tumor necrosis factor (TNF) family cytokine, induces the differentiation of osteoclasts in the presence of macrophage-colony stimulating factor. RANKL activates TRAF6, c-Fos, and calcium signaling pathways, all of which are indispensable for the induction and activation of nuclear factor of activated T cells (NFAT) c1, the master transcription factor for osteoclastogenesis. The autoamplification of NFATc1 gene results in the efficient induction of osteoclast-specific genes. An AP-1 transcription factor complex containing c-Fos plays a crucial role in these processes, although results in conditional knockout mice show that Jun family members have a redundant role. The immunoreceptor tyrosine-based activation motif (ITAM) is an important signaling component for a number of receptors in the immune system including T-cell, B-cell, NK-cell, and Fc receptors, but its contribution to the skeletal sys…

Integrity signals

Registry

Crossref · 10.1007/s00109-004-0612-6

Cites

76 of 76 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Down-Regulation of Na+/K+ATPase Activity by Human Parvovirus B19 Capsid Protein VP1
Almilaji, A., Szteyn, K., Fein, E., Pakladok, T., Muñoz, C., Elvira, B., Towhid, S. T., Alesutan, I., Shumilina, E. V., Bock, C. –., et al. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350083 · Cited by 8,700
Osteoclast differentiation and activation
Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670 · cited 1×
“Based on the fact that the addition of RANKL and M-CSF can induce osteoclast differentiation in culture, it has been generally believed that RANKL and M-CSF are not only essential but also sufficient for osteoclastogenesis [24].”
Background
The versatility and universality of calcium signalling
Berridge, M. J., Lipp, P., & Bootman, M. D. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036035 · Cited by 5,701
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
Lacey, D. L., Timms, E., Tan, H.-L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81569-x · Cited by 5,439
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S.-I., Tomoyasu, A., Yano, K., Goto, M., Murakami, A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3597 · Cited by 4,224
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.
Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351
Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts
Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J.-I., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00369-6 · Cited by 2,701
Self-citation
TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function
Rao, A., Luo, C. H., & Hogan, P. G. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.707 · Cited by 2,592
Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.
Bucay, N., Sarosi, I., Dunstan, C. R., Morony, S., Tarpley, J., Capparelli, C., Scully, S., Tan, H. L., Xu, W., Lacey, D. L., et al. (1998) · Genes & Development · doi:10.1101/gad.12.9.1260 · Cited by 2,483
Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families
Suda, T., Takahashi, N., Udagawa, N., Jimi, E., Gillespie, M. T., & Martin, T. J. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0367 · Cited by 2,345

Flagged first, then by citations

Show all 76 references

Sorted by citations

Items 101–200 of 414

Transcriptional Regulation of Heart Valve Progenitor Cells
Chakraborty, S., Combs, M. D., & Yutzey, K. E. (2009) · Pediatric Cardiology · doi:10.1007/s00246-009-9616-x · Cited by 59
Protein Inhibitor of Activated STAT 3 Modulates Osteoclastogenesis by Down-Regulation of NFATc1 and Osteoclast-Associated Receptor
Kim, K., Lee, J., Kim, J. H., Jin, H. M., Zhou, B., Lee, S. Y., & Kim, N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.9.5588 · Cited by 57
IKKβ activation is sufficient for RANK-independent osteoclast differentiation and osteolysis
Otero, J. E., Dai, S., Alhawagri, M., Darwech, I., & Abu‐Amer, Y. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4 · Cited by 56
Tumor–host cell interactions in the bone disease of myeloma
Fowler, J. A., Edwards, C. M., & Croucher, P. I. (2010) · Bone · doi:10.1016/j.bone.2010.06.029 · Cited by 55
Mechanisms of bone loss in rheumatoid arthritis
Findlay, D. M., & Haynes, D. R. (2005) · Modern Rheumatology · doi:10.1007/s10165-005-0412-z · Cited by 56
RANKL/RANK as Key Factors for Osteoclast Development and Bone Loss in Arthropathies
Leibbrandt, A., & Penninger, J. M. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-0298-6_7 · Cited by 54
VEGF‐A expression in osteoclasts is regulated by NF‐κB induction of HIF‐1α
Trebec‐Reynolds, D. P., Voronov, I., Heersche, J. N. M., & Manolson, M. F. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22542 · Cited by 56
The roles of interferons in osteoclasts and osteoclastogenesis
Xiong, Q., Zhang, L., Ge, W., & Tang, P. (2016) · Joint Bone Spine · doi:10.1016/j.jbspin.2015.07.010 · Cited by 54
Iguratimod (T-614) suppresses RANKL-induced osteoclast differentiation and migration in RAW264.7 cells via NF-κB and MAPK pathways
Gan, K., Yang, L., Xu, L., Feng, X., Zhang, Q., Wang, F., Tan, W., & Zhang, M. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.03.038 · Cited by 56
Alisol-B, a novel phyto-steroid, suppresses the RANKL-induced osteoclast formation and prevents bone loss in mice
Lee, J., Kobayashi, Y., Nakamichi, Y., Udagawa, N., Takahashi, N., Im, N.-K., Seo, H.-J., Jeon, W. B., Yonezawa, T., Cha, B., et al. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.04.014 · Cited by 52
Evidence that calcineurin is required for the genesis of bone-resorbing osteoclasts
Sun, L., Peng, Y., Zaidi, N., Zhu, L.-L., Iqbal, J. Z., Yamoah, K., Wang, X., Liu, P., Abe, E., Moonga, B. S., et al. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00415.2005 · Cited by 51
Tacrolimus and cyclosporine A inhibit human osteoclast formation via targeting the calcineurin-dependent NFAT pathway and an activation pathway for c-Jun or MITF in rheumatoid arthritis
Miyazaki, M., Fujikawa, Y., Takita, C., & Tsumura, H. (2006) · Clinical Rheumatology · doi:10.1007/s10067-006-0287-1 · Cited by 53
Osteoclasts and Microgravity
Smith, J. K. (2020) · Life · doi:10.3390/life10090207 · Cited by 52
“This activates cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) and the calcineurin pathway [21,24,25,27], a key costimulatory pathway of NFATc1 [21,23] and an important signaling component of a number of immune cell receptors [28] (Figures 4 and 5).”
Background
Protective effects of curcumin against osteoporosis and its molecular mechanisms: a recent review in preclinical trials
Yang, S., Sun, Y., Капилевич, Л. В., Zhang, X., & Huang, Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1249418 · Cited by 52
The Enigmatic Function of TREM-2 in Osteoclastogenesis
Colonna, M., Turnbull, I. R., & Klesney‐Tait, J. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-72009-8_13 · Cited by 52
Molecular mechanisms involved in the mitogenic effect of lactoferrin in osteoblasts
Naot, D., Chhana, A., Matthews, B. G., Callon, K. E., Tong, P. C., Lin, J., Costa, J. L., Watson, M., Grey, A. B., & Cornish, J. (2011) · Bone · doi:10.1016/j.bone.2011.04.002 · Cited by 52
Formononetin Attenuates Osteoclastogenesis via Suppressing the RANKL-Induced Activation of NF-κB, c-Fos, and Nuclear Factor of Activated T-Cells Cytoplasmic 1 Signaling Pathway
Huh, J.-E., Lee, W. I., Kang, J. W., Nam, D., Choi, D.-Y., Park, D., Lee, S. H., & Lee, J.-D. (2014) · Journal of Natural Products · doi:10.1021/np500417d · Cited by 53
Bisphosphonate therapy in rheumatoid arthritis
Breuil, V., & Euller‐Ziegler, L. (2006) · Joint Bone Spine · doi:10.1016/j.jbspin.2005.10.019 · Cited by 52
Effects of CoCr metal wear debris generated from metal-on-metal hip implants and Co ions on human monocyte-like U937 cells
Posada, O. M., Tate, R. J., & Grant, M. H. (2014) · Toxicology in Vitro · doi:10.1016/j.tiv.2014.11.006 · Cited by 51
TRAF-6 Dependent Signaling Pathway Is Essential for TNF-Related Apoptosis-Inducing Ligand (TRAIL) Induces Osteoclast Differentiation
Yen, M., Hsu, P., Liao, H., Lee, B.-H., & Tsai, H.-F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038048 · Cited by 54
Molecular effects of gallium on osteoclastic differentiation of mouse and human monocytes
Verron, É., Loubat, A., Carle, G. F., Vignes‐Colombeix, C., Stražić, I., Guicheux, J., Rochet, N., Bouler, J., & Scimeca, J. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.12.015 · Cited by 51
Molecular dysfunctions in acute rejection after renal transplantation revealed by integrated analysis of transcription factor, microRNA and long noncoding RNA
Sui, W., Lin, H., Peng, W., Huang, Y., Chen, J., Zhang, Y., & Dai, Y. (2013) · Genomics · doi:10.1016/j.ygeno.2013.05.002 · Cited by 49
Inhibition of Osteoclastogenesis and Bone Resorption in vitro and in vivo by a prenylflavonoid xanthohumol from hops
Li, J., Zeng, L., Xie, J., Yue, Z., Deng, H., Ma, X., Zheng, C., Wu, X., Luo, J., & Liu, M. (2015) · Scientific Reports · doi:10.1038/srep17605 · Cited by 50
Endotoxins affect bioactivity of chitosan derivatives in cultures of bone marrow-derived human mesenchymal stem cells
Lieder, R., Gaware, V. S., Thormodsson, F. R., Einarsson, J. M., Ng, C., Gíslason, J., Másson, M., Petersen, P. H., & Sigurjónsson, Ó. E. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.08.043 · Cited by 48
Identification of a novel mutation ofSH3BP2in cherubism and demonstration thatSH3BP2mutations lead to increased NFAT activation
Lietman, S. A., Kalinchinko, N., Deng, X., Kohanski, R. A., & Levine, M. A. (2006) · Human Mutation · doi:10.1002/humu.9433 · Cited by 49
IL-1R/TLR2 through MyD88 Divergently Modulates Osteoclastogenesis through Regulation of Nuclear Factor of Activated T Cells c1 (NFATc1) and B Lymphocyte-induced Maturation Protein-1 (Blimp1)
Chen, Z., Su, L., Xu, Q., Katz, J., Michalek, S. M., Fan, M., Feng, X., & Zhang, P. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.663518 · Cited by 48
Role of the NF-κB axis in immune modulation of osteoclasts and bone loss
Abu‐Amer, Y., Darwech, I., & Otero, J. E. (2008) · Autoimmunity · doi:10.1080/08916930701694543 · Cited by 45
Identification of LRRc17 as a Negative Regulator of Receptor Activator of NF-κB Ligand (RANKL)-induced Osteoclast Differentiation
Kim, T. S., Kim, K., Lee, S. H., So, H., Lee, J., Kim, N., & Choi, Y. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807722200 · Cited by 45
Osteoclast Biology and Bone Resorption
Ross, F. P. (2013) · Wiley eBooks · doi:10.1002/9781118453926.ch3 · Cited by 47
TNF-related apoptosis-inducing ligand (TRAIL) induces osteoclast differentiation from monocyte/macrophage lineage precursor cells
Yen, M., Tsai, H.-F., Wu, Y., Hwa, H., Lee, B.-H., & Hsu, P. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2007.12.003 · Cited by 44
Scientific basis for the efficacy of combined use of antirheumatic drugs against bone destruction in rheumatoid arthritis
Suematsu, A., Tajiri, Y., Nakashima, T., Taka, J., Ochi, S., Oda, H., Nakamura, K., Tanaka, S., & Takayanagi, H. (2007) · Modern Rheumatology · doi:10.1007/s10165-006-0531-1 · Cited by 44
Self-citation
Activated Invariant NKT Cells Regulate Osteoclast Development and Function
Hu, M., Bassett, J. H. D., Danks, L., Howell, P., Xu, K., Spanoudakis, E., Kotsianidis, Ι., BOYDE, A., Williams, G. R., Horwood, N., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002353 · Cited by 43
Runx1-Mediated Regulation of Osteoclast Differentiation and Function
Soung, D. Y., Kalinowski, J., Baniwal, S. K., Jacome-Galarza, C. E., Frenkel, B., Lorenzo, J., & Drissi, H. (2014) · Molecular Endocrinology · doi:10.1210/me.2013-1305 · Cited by 40
Harpagoside Inhibits RANKL-Induced Osteoclastogenesis via Syk-Btk-PLCγ2-Ca2+ Signaling Pathway and Prevents Inflammation-Mediated Bone Loss
Kim, J., Park, S., Baek, J. M., Erkhembaatar, M., Kim, M. S., Yoon, K., Oh, J., & Lee, M. S. (2015) · Journal of Natural Products · doi:10.1021/acs.jnatprod.5b00233 · Cited by 41
Water-soluble fullerene (C60) inhibits the osteoclast differentiation and bone destruction in arthritis
Yudoh, K. (2009) · International Journal of Nanomedicine · doi:10.2147/ijn.s7505 · Cited by 41
Nothing but skin and bone
Ross, F. P. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28605 · Cited by 43
SH3BP2 is an activator of NFAT activity and osteoclastogenesis
Lietman, S. A., Yin, L., & Levine, M. A. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.04.080 · Cited by 41
Regulation and enzymatic basis of bone resorption by human osteoclasts
Fuller, K., Kirstein, B., & Chambers, T. J. (2007) · Clinical Science · doi:10.1042/cs20060274 · Cited by 40
TRAIL inhibits RANK signaling and suppresses osteoclast activation via inhibiting lipid raft assembly and TRAF6 recruitment
Liao, H., Tsai, H.-F., Wu, C., Chyuan, I., & Hsu, P. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1353-3 · Cited by 42
Caveolin-1 Regulates Osteoclastogenesis and Bone Metabolism in a Sex-dependent Manner
Lee, Y. D., Yoon, S., Park, C., Lee, J. Y., Lee, Z. H., & Kim, H. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.598581 · Cited by 36
RANK(L) as a Key Target for Controlling Bone Loss
Leibbrandt, A., & Penninger, J. M. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-89520-8_9 · Cited by 37
Tanshinone IIA suppresses inflammatory bone loss by inhibiting the synthesis of prostaglandin E2 in osteoblasts
Kwak, H. B., Sun, H.-M., Ha, H., Kim, H., Lee, J.-H., Kim, H., Shin, H., & Lee, Z. H. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.10.034 · Cited by 37
New Roles for Osteoclasts in Bone
Boyce, B. F., Yao, Z., Zhang, Q., GUO, R., Lu, Y., Schwarz, E. M., & Xing, L. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1402.084 · Cited by 40
Genipin Inhibits RANKL-Induced Osteoclast Differentiation Through Proteasome-Mediated Degradation of c-Fos Protein and Suppression of NF-κB Activation
Lee, C. H., Kwak, S. C., Kim, J., Oh, H. M., Rho, M., Yoon, K., Yoo, W., Lee, M. S., & Oh, J. (2014) · Journal of Pharmacological Sciences · doi:10.1254/jphs.13174fp · Cited by 39
The Osteoclast-Associated Receptor (OSCAR) Is a Novel Receptor Regulated by Oxidized Low-Density Lipoprotein in Human Endothelial Cells
Goettsch, C., Rauner, M., Sinningen, K., Helas, S., Al‐Fakhri, N., Nemeth, K., Hamann, C., Kopprasch, S., Aikawa, E. R., Bornstein, S. R., et al. (2011) · Endocrinology · doi:10.1210/en.2011-1282 · Cited by 37
Adenylate cyclase and calmodulin-dependent kinase have opposite effects on osteoclastogenesis by regulating the PKA-NFATc1 pathway
Yoon, S.-H., Ryu, J., Lee, Y., Lee, Z. H., & Kim, H. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.310 · Cited by 38
Activated T lymphocytes suppress osteoclastogenesis by diverting early monocyte/macrophage progenitor lineage commitment towards dendritic cell differentiation through down-regulation of receptor activator of nuclear factor-kappaB and c-Fos
Grčević, D., Lukic, I., Kovačić, N., Ivčević, S., Katavić, V., & Marušić, A. (2006) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03181.x · Cited by 36
What Is Breast in the Bone?
Shemanko, C. S., Cong, Y., & Forsyth, A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101764 · Cited by 40
Decrease of Markers Related to Bone Erosion in Serum of Patients with Musculoskeletal Disorders after Serial Low-Dose Radon Spa Therapy
Cucu, A., Shreder, K., Kraft, D., Rühle, P. F., Klein, G., Thiel, G., Frey, B., Gaipl, U. S., & Fournier, C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00882 · Cited by 39
Evodiamine inhibits RANKL ‐induced osteoclastogenesis and prevents ovariectomy‐induced bone loss in mice
Jin, H., Yao, L., Chen, K., Liu, Y., Wang, Q., Wang, Z., Liu, Q., Cao, Z., Kenny, J., Tickner, J. C., et al. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13955 · Cited by 36
Vaspin Attenuates RANKL-Induced Osteoclast Formation in RAW264.7 Cells
Kamio, N., Kawato, T., Tanabe, N., Kitami, S., Morita, T., Ochiai, K., & Maeno, M. (2013) · Connective Tissue Research · doi:10.3109/03008207.2012.761978 · Cited by 36
Anti-Arthritic and Anti-Cancer Activities of Polyphenols: A Review of the Most Recent In Vitro Assays
Ali, M. U., Benfante, V., Stefano, A., Yezzi, A. J., Raimondo, D. D., Tuttolomondo, A., & Comelli, A. (2023) · Life · doi:10.3390/life13020361 · Cited by 38
Possible key role of immune system in Schmorl’s nodes
Zhang, N., Li, F., Huang, Y., Teng, C., & Chen, W.-S. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2009.09.044 · Cited by 35
The affinity of human RANK binding to its ligand RANKL
Zhang, S., Liu, C., Huang, P., Zhou, S., Ren, J., Kitamura, Y., Tang, P., Bi, Z., & Gao, B. (2009) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2009.04.008 · Cited by 34
OSCAR‐collagen signaling in monocytes plays a proinflammatory role and may contribute to the pathogenesis of rheumatoid arthritis
Schultz, H. S., Guo, L., Keller, P., Fleetwood, A. J., Sun, M., Guo, W., Ma, C., Hamilton, J. A., Björkdahl, O., Berchtold, M. W., et al. (2016) · European Journal of Immunology · doi:10.1002/eji.201545986 · Cited by 35
The Adapter 3BP2: How It Plugs into Leukocyte Signaling
Deckert, M., & Rottapel, R. K. (2007) · Springer eBooks · doi:10.1007/0-387-34132-3_8 · Cited by 33
Elevated Response to Type I IFN Enhances RANKL-Mediated Osteoclastogenesis in Usp18-Knockout Mice
Yim, H. Y., Park, C., Lee, Y. D., Arimoto, K., Jeon, R., Baek, S. H., Zhang, D., Kim, H., & Kim, K. I. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501496 · Cited by 32
Circulating RANKL is inversely related to RANKL mRNA levels in bone in osteoarthritic males
Findlay, D. M., Chehade, M. J., Tsangari, H., Neale, S. D., Hay, S. J., Hopwood, B., Pannach, S., O’Loughlin, P. D., & Fazzalari, N. L. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2348 · Cited by 33
Stem cell-mediated osteogenesis: therapeutic potential for bone tissue engineering
Neman, J., Hambrecht, A. C., Jandial, R., & Cadry (2012) · Biologics · doi:10.2147/btt.s22407 · Cited by 34
Effect of interferon-γ on the fusion of mononuclear osteoclasts into bone-resorbing osteoclasts
Kim, J.-W., Lee, M.-S., Lee, C.-H., Kim, H.-Y., Chae, S.-U., Kwak, H.-B., & Oh, J. (2012) · BMB Reports · doi:10.5483/bmbrep.2012.45.5.281 · Cited by 32
Oral Malodorous Compound Induces Osteoclast Differentiation Without Receptor Activator of Nuclear Factor κB Ligand
Ii, H., Imai, T., Yaegaki, K., Irie, K., Ekuni, D., & Morita, M. (2010) · Journal of Periodontology · doi:10.1902/jop.2010.100116 · Cited by 30
Effects on osteoclast and osteoblast activities in cultured mouse calvarial bones by synovial fluids from patients with a loose joint prosthesis and from osteoarthritis patients
Andersson, M. K., Lundberg, P., Ohlin, A., Perry, M. J., Lie, A., Stark, A., & Lerner, U. H. (2007) · Arthritis Research & Therapy · doi:10.1186/ar2127 · Cited by 31
Locally administered T cells from mice immunized with lipopolysaccharide (LPS) accelerate LPS-induced bone resorption
Ozaki, Y., Ukai, T., Yamaguchi, M., Yokoyama, M., Haro, E. R. A., Yoshimoto, M., Kaneko, T., Yoshinaga, M., Nakamura, H., Shiraishi, C., et al. (2009) · Bone · doi:10.1016/j.bone.2009.01.375 · Cited by 31
RANKL Up-regulates Brain-type Creatine Kinase via Poly(ADP-ribose) Polymerase-1 during Osteoclastogenesis
Chen, J., Sun, Y. J., Mao, X., Liu, Q., Wu, H., & Chen, Y. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.157743 · Cited by 30
Effects of pulsed electromagnetic fields on the expression of NFATc1 and CAII in mouse osteoclast-like cells
He, J., Zhang, Y., Chen, J., Zheng, S., Huang, H., & Dong, X. (2014) · Aging Clinical and Experimental Research · doi:10.1007/s40520-014-0239-6 · Cited by 29
Kinins and Neuro-osteogenic Factors
Lerner, U. H., Persson, E., & Lundberg, P. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-373884-4.00063-x · Cited by 30
Osteoimmunology: Crosstalk Between T Cells and Osteoclasts in Osteoporosis
Lu, Z., Xiao, P., Liu, S., Huang, C., Li, W., Mao, Y., Xu, Y., & Tian, Y. (2025) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-025-09046-1 · Cited by 34
Inhibition of RANKL-mediated osteoclast differentiation by selective TRAF6 decoy peptides
Poblenz, A. T., Jacoby, J. J., Singh, S., & Darnay, B. G. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.05.151 · Cited by 29
Betulin Suppresses Osteoclast Formation via Down-Regulating NFATc1
Kim, K., Lee, Y., Hwang, H.-G., Sung, S. H., Lee, M., & Son, Y. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7060154 · Cited by 29
Effects of mechanical stress on cytokine production in mandible‐derived osteoblasts
Yamamoto, K., Yamamoto, T., Ichioka, H., Akamatsu, Y., Oseko, F., Mazda, O., Imanishi, J., Kanamura, N., & Kita, M. (2011) · Oral Diseases · doi:10.1111/j.1601-0825.2011.01832.x · Cited by 29
Retinoic acid inhibits NFATc1 expression and osteoclast differentiation
Balkan, W., Rodríguez‐Gonzalez, M., Pang, M., Fernández, I. C., & Troen, B. R. (2011) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-011-0261-0 · Cited by 29
The P2X7 Receptor: A Key Player in Immune-Mediated Bone Loss?
Kvist, T., Schwarz, P., & Jørgensen, N. R. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/954530 · Cited by 29
Bone-Resorbing Cells in Multiple Myeloma: Osteoclasts, Myeloma Cell Polykaryons, or Both?
Silvestris, F., Ciavarella, S., Matteo, M. D., Tucci, M., & Dammacco, F. (2009) · The Oncologist · doi:10.1634/theoncologist.2008-0087 · Cited by 29
Effects of interleukin‐7/interleukin‐7 receptor on RANKL‐mediated osteoclast differentiation and ovariectomy‐induced bone loss by regulating c‐Fos/c‐Jun pathway
Zhao, J., Wu, Z., Yu, Y., Wang, L., & Li, C. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26548 · Cited by 28
NF-κB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating factor
Kubota, T., Hoshino, M., Aoki, K., Ohya, K., Komano, Y., Nanki, T., Miyasaka, N., & Umezawa, K. (2007) · Arthritis Research & Therapy · doi:10.1186/ar2298 · Cited by 28
Bisphosphonate Therapy Ameliorates Hearing Loss in Mice Lacking Osteoprotegerin
Kanzaki, S., Takada, Y., Ogawa, K., & Matsuo, K. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080812 · Cited by 27
Prostate cancer promotes CD11b positive cells to differentiate into osteoclasts
Mizutani, K., Sud, S., & Pienta, K. J. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22021 · Cited by 28
Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitro
Algate, K., Haynes, D. R., Fitzsimmons, T. R., Romeo, O., Wagner, F. F., Holson, E. B., Reid, R., Fairlie, D. P., Bartold, P. M., & Cantley, M. D. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29137 · Cited by 30
NFAT2 Is an essential mediator of orthopedic particle‐induced osteoclastogenesis
Yamanaka, Y., Abu‐Amer, W., Foglia, D., Otero, J. E., Clohisy, J. C. F., & Abu‐Amer, Y. (2008) · Journal of Orthopaedic Research® · doi:10.1002/jor.20714 · Cited by 28
Effect of low‐level laser therapy as an adjuvant in the treatment of periodontitis induced in rats subjected to 5‐fluorouracil chemotherapy
Theodoro, L. H., Longo, M., Ervolino, E., Duque, C., Alves, M. L. F., Assem, N. Z., Louzada, L. M., & Garcia, V. G. (2016) · Journal of Periodontal Research · doi:10.1111/jre.12347 · Cited by 31
Dietary dried plum increases bone mass, suppresses proinflammatory cytokines and promotes attainment of peak bone mass in male mice
Shahnazari, M., Turner, R. T., Iwaniec, U. T., Wronski, T. J., Li, M., Ferruzzi, M. G., Nissenson, R. A., & Halloran, B. P. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.04.007 · Cited by 27
Sulforaphane inhibits osteoclast differentiation by suppressing the cell-cell fusion molecules DC-STAMP and OC-STAMP
Takagi, T., Inoue, H., Takahashi, N., Katsumata-Tsuboi, R., & Uehara, M. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.12.075 · Cited by 27
Dynamics of Early Signalling Events during Fracture Healing and Potential Serum Biomarkers of Fracture Non-Union in Humans
Burska, A., Giannoudis, P., Tan, B., Ilas, D., Jones, E., & Ponchel, F. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020492 · Cited by 27
Osthole‐loaded N‐octyl‐O‐sulfonyl chitosan micelles (NSC‐OST) inhibits RANKL‐induced osteoclastogenesis and prevents ovariectomy‐induced bone loss in rats
Wang, L., Zheng, S., Huang, G., Sun, J., Pan, Y., Si, Y., Tu, P., Xu, G., Ma, Y., & Guo, Y. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15064 · Cited by 27
Comparison of osteoclast precursors in peripheral blood mononuclear cells from rheumatoid arthritis and osteoporosis patients
Nose, M., Yamazaki, H., Hagino, H., Morio, Y., Hayashi, S., & Teshima, R. (2008) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-008-0011-0 · Cited by 26
Osteoblasts-Derived Exosomal lncRNA-MALAT1 Promotes Osteoclastogenesis by Targeting the miR-124/NFATc1 Signaling Axis in Bone Marrow-Derived Macrophages
Zhang, C., Pan, L., Zhang, H., Ke, T., Yang, Y., Zhang, L., Chen, L., & Tan, J. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s395607 · Cited by 28
Activated platelets positively regulate RANKL‐mediated osteoclast differentiation
Weicht, B., Maitz, P., Kandler, B., Fischer, M., Watzek, G., & Gruber, R. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21360 · Cited by 27
Mechanical stress enhances production of cytokines in human periodontal ligament cells induced by Porphyromonas gingivalis
Yamamoto, T., Kita, M., Yamamoto, K., Akamatsu, Y., Oseko, F., & Kanamura, N. (2010) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2010.09.017 · Cited by 26
Effect of combined Low-Dose Radon- and Hyperthermia Treatment (LDRnHT) of patients with ankylosing spondylitis on serum levels of cytokines and bone metabolism markers: a pilot study
Moder, A., Hufnagl, C., Albrecht, G. L., Hitzl, W., Hartl, A. J., Jakab, M., & Ritter, M. (2010) · International Journal of Low Radiation · doi:10.1504/ijlr.2010.037663 · Cited by 25
Effect of cyclic mechanical loading on osteoclast recruitment in periodontal tissue
Nozaki, K., Kaku, M., Yamashita, Y., Yamauchi, M., & Miura, H. (2009) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2008.01193.x · Cited by 25
Signaling pathways in osteogenesis and osteoclastogenesis: Lessons from cranial sutures and applications to regenerative medicine
Maxhimer, J. B., Bradley, J. P., & Lee, J. C. (2015) · Genes & Diseases · doi:10.1016/j.gendis.2014.12.004 · Cited by 26
Vindoline Inhibits RANKL-Induced Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss in Mice
Zhan, Y., Liang, J., Tian, K., Che, Z., Wang, Z., Yang, X., Su, Y., Lin, X., Song, F., Zhao, J., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01587 · Cited by 25
Modulation of osteoclast function in bone by the immune system
Quinn, J. M. W., & Saleh, H. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.11.002 · Cited by 28
Osteoclasts, no longer osteoblast slaves
Boyce, B. F., & Xing, L. (2006) · Nature Medicine · doi:10.1038/nm1206-1356 · Cited by 25
Immunology of Osteoporosis: Relevance of Inflammatory Targets for the Development of Novel Interventions
Ahmad, S. S., Ahmed, F., Ali, R., Ghoneim, M. M., Alshehri, S., Najmi, A. K., Ahmad, S., Ahmad, M. Z., Ahmad, J., & Khan, M. A. (2022) · Immunotherapy · doi:10.2217/imt-2021-0282 · Cited by 25
The IL6 gene polymorphism −634C>G and IL17F gene polymorphism 7488T>C influence bone mineral density in young and elderly Japanese women
Oishi, Y., WATANABE, Y., Shinoda, S., Naka, M., Ozawa, Y., Matsuyama, T., Morozumi, K., & Fuke, Y. (2012) · Gene · doi:10.1016/j.gene.2012.04.054 · Cited by 24
Upstream Stimulatory Factors Regulate OSCAR Gene Expression in RANKL-Mediated Osteoclast Differentiation
Kim, J. H., Kim, K., Jin, H. M., Youn, B. U., Song, I., Choi, H.-S., & Kim, N. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.08.036 · Cited by 24
Bone Development and Remodeling
Maes, C., & Kronenberg, H. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00060-3 · Cited by 26
Protein Kinase C Inhibitor, GF109203X Attenuates Osteoclastogenesis, Bone Resorption and RANKL‐Induced NF‐κB and NFAT Activity
Yao, J., Li, J., Zhou, L., Cheng, J., Chim, S. M., Zhang, G., Quinn, J. M. W., Tickner, J. C., Zhao, J., & Xu, J. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24858 · Cited by 25
Arctigenin suppresses receptor activator of nuclear factor κB ligand (RANKL)-mediated osteoclast differentiation in bone marrow-derived macrophages.
Kim, A., Kim, H., Lee, J., Choi, J.-H., Kim, S. N., Kim, D. K., Kim, J. H., Mun, S., Kim, J.-W., Jeon, H., et al. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.02.026 · Cited by 21

Authors: Takayanagi, H.
Affiliations: Tokyo Medical and Dental University (JP)
Corresponding author: Takayanagi, Hiroshi
Venue: Journal of Molecular Medicine
Publisher: Springer Science and Business Media LLC
Published: 2005-01-26
Volume: 83
Issue: 3
Pages: 170-179
ISSN: 0946-2716 (ISSN-L)
1432-1440
DOI: 10.1007/s00109-004-0612-6
OpenAlex: W2124273389
Cited by: 413
References: 76
Citations by year: 2026: 3 · 2025: 11 · 2024: 4 · 2023: 8 · 2022: 5 · 2021: 11 · 2020: 14 · 2019: 10 · 2018: 13 · 2017: 17 · 2016: 16 · 2015: 24 · 2014: 24 · 2013: 18 · 2012: 26
FWCI: 3.42
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Molecular Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Takeda Science Foundation
Mitsubishi Foundation
Japan Society for the Promotion of Science
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: osteoclastogenesis, osteoimmunology, RANKL, TRAF6, c-fos, NFATc1, AP-1, ITAM signaling, FcRγ, DAP12, osteoclast-associated receptor, traps, TLR2, TLR4, phospholipase C-gamma, calcium signaling
MeSH terms: Animals, Carrier Proteins, Cell Differentiation, Humans, Membrane Glycoproteins, Osteoclasts, Receptors, Immunologic, Transcription Factors, Signal Transduction, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mechanistic insight into osteoclast differentiation in osteoimmunology

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks