The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Metabolic regulation by p53
Open accessAbstract
We are increasingly aware that cellular metabolism plays a vital role in diseases such as cancer, and that p53 is an important regulator of metabolic pathways. By transcriptional activation and other means, p53 is able to contribute to the regulation of glycolysis, oxidative phosphorylation, glutaminolysis, insulin sensitivity, nucleotide biosynthesis, mitochondrial integrity, fatty acid oxidation, antioxidant response, autophagy and mTOR signalling. The ability to positively and negatively regulate many of these pathways, combined with feedback signalling from these pathways to p53, demonstrates the reciprocal and flexible nature of the regulation, facilitating a diverse range of responses to metabolic stress. Intriguingly, metabolic stress triggers primarily an adaptive (rather than pro-apoptotic) p53 response, and p53 is emerging as an important regulator of metabolic homeostasis. A better understanding of how p53 coordinates metabolic adaptation will facilitate the identification of novel therapeutic targets and will also illuminate the wider role of p53 in human biology.
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Citations
Cites
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
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In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
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BackgroundCancer cell metabolism: warburg and beyond
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Backgroundp53 Regulates Mitochondrial Respiration
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Cited by
P53 in survival, death and metabolic health: a lifeguard with a licence to kill.
Kruiswijk, F., Labuschagne, C. F., & Vousden, K. H. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4007 · Cited by 1,080
Self-citationSerine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
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Self-citationAMP-Activated Protein Kinase (AMPK) Controls the Aging Process via an Integrated Signaling Network
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Inflammatory Response in the CNS: Friend or Foe?
Sochocka, M., Diniz, B. S., & Leszek, J. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0297-1 · Cited by 573
The Pho regulon: a huge regulatory network in bacteria
Santos-Beneit, F. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00402 · Cited by 522
Metadata
- Authors
- Maddocks, O. D. K., & Vousden, K. H.
- Venue
- Journal of Molecular Medicine
- Published
- 2011-02-23
- Volume
- 89
- Issue
- 3
- Pages
- 237-245
- ISSN
- 0946-2716 (ISSN-L)
- 1432-1440
- OpenAlex
- W2051233997
- Cited by
- 355
- References
- 21
- FWCI
- 23.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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