The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection
Open accessAbstract
To observe the diagnostic values of circular RNAs (circRNAs), their expression profiles between gastric cancer patients' plasma and healthy controls were first assessed by circRNA microarray. Then, circRNA levels were measured by reverse transcription quantitative polymerase chain reaction (RT-qPCR) and RT-droplet digital PCR (RT-ddPCR), respectively. A total of 343 differentially expressed circRNAs were found. The top 10 elevated circRNAs in patients were hsa_circ_0088300, hsa_circ_0075825, hsa_circ_0019172, hsa_circ_0000220, hsa_circ_0035277, hsa_circ_0000301, hsa_circ_0000189, hsa_circ_0090080, hsa_circ_0001888, and hsa_circ_0001874. The top 10 reduced circRNAs were hsa_circ_0004771, hsa_circ_0001190, hsa_circ_0061276, hsa_circ_0092337, hsa_circ_0058495, hsa_circ_0061274, hsa_circ_0075829, hsa_circ_0080845, hsa_circ_0001006, and hsa_circ_0003764. In cancer and dysplasia tissues, hsa_circ_0001017 and hsa_circ_0061276 were downregulated. Their levels were significantly associated with distal metastasis. The area under receiver operating characteristic curve in combinative use was 0.966 with 95.5% sensitivity and 95.7% specificity. Patients with low plasma hsa_circ_0001017 or hsa_circ_0061276 had a much shorter overall survival than those with high levels. Patients whose plasma hsa_circ_0001017 or hsa_circ_0061276 levels recovered to normal after operation had a longer disease-free survival. Finally, the in vitro model indicated gastric cancer cells secreting circRNAs into plasma. In conclusion, RT-ddPCR is a potent non-invasive and absolute quantification method for simultaneous detection of multiple circRNAs. Hsa_circ_0001017 and hsa_circ_0061276 are new potential biomarkers for gastric cancer. KEY MESSAGE: A total of 343 circRNAs are differentially expressed between gastric cancer patients' plasma and healthy controls. Hsa_circ_0001017 and hsa_circ_0061276 are downregulated in gastric cancer tissues. The RT-ddPCR is a potent method for simultaneous detection of multiple circRNAs in plasma. Hsa_circ_0001017 and hsa_circ_0061276 are potential biomarkers for gastric cancer.
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1 retracted
RETRACTED ARTICLE: Circular RNA 0000096 affects cell growth and migration in gastric cancer
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Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis
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Using circular RNA as a novel type of biomarker in the screening of gastric cancer
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Self-citationCircular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/β-catenin pathway
Li, F., Zhang, L., Li, W., Deng, J., Zheng, J., An, M., Lu, J., & Zhou, Y. (2015) · Oncotarget · doi:10.18632/oncotarget.3469 · Cited by 637
Quantitation of targets for PCR by use of limiting dilution.
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Self-citationConsiderations for Digital PCR as an Accurate Molecular Diagnostic Tool
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Circular RNA participates in the carcinogenesis and the malignant behavior of cancer
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Plasma long noncoding RNA protected by exosomes as a potential stable biomarker for gastric cancer
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Cited by
The biogenesis, biology and characterization of circular RNAs
Kristensen, L. S., Andersen, M. S., Stagsted, L. V. W., Ebbesen, K. K., Hansen, T. B., & Kjems, J. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0158-7 · Cited by 4,823
Specific expression and functions of circular RNAs
Misir, S., Wu, N., & Yang, B. B. (2022) · Cell Death & Differentiation · doi:10.1038/s41418-022-00948-7 · Cited by 469
Recent advances in gastric cancer early diagnosis
Necula, L., Matei, L., Dragu, D., Neagu, A. I., Mambet, C., Nedeianu, S., Bleotu, C., Diaconu, C. C., & Chivu-Economescu, M. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i17.2029 · Cited by 435
Shen, Y., Yu, X., Zhu, L., Li, T., Yan, Z., & Guo, J. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1693-y · Cited by 256
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Metadata
- Authors
- Li, T., Shao, Y., Fu, L., Xie, Y., Zhu, L., Sun, W., Yu, R., Xiao, B., & Guo, J.
- Venue
- Journal of Molecular Medicine
- Published
- 2017-11-02
- Volume
- 96
- Issue
- 1
- Pages
- 85-96
- ISSN
- 0946-2716 (ISSN-L)
- 1432-1440
- OpenAlex
- W2766204235
- Cited by
- 266
- References
- 32
- FWCI
- 11.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
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