The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Circular RNA participates in the carcinogenesis and the malignant behavior of cancer
Open accessAbstract
Circular RNAs (circRNAs) are long, non-coding RNAs that result from the non-canonical splicing of linear pre-mRNAs. However, the characteristics and the critical role of circRNA in co-/post-transcriptional regulation were not well recognized until the "microRNA sponge" function of circRNA is discovered. Recent studies have mainly been devoted to the function of the circular RNA sponge for miR-7 (ciRS-7) and sex-determining region Y (SRY) by targeting microRNA-7 (miR-7) and microRNA-138 (miR-138), respectively. In this review, we illustrate the specific role of circRNAs in a wide variety of cancers and in regulating the biological behavior of cancers via miR-7 or miR-138 regulation. Furthermore, circRNA, together with its gene silencing ability, also shows its potential in RNA interference (RNAi) therapy by binding to target RNAs, which provides a novel perspective in cancer treatment. Thus, this review concerns the biogenesis, biological function, oncogenesis, progression and possible therapies for cancer involving circRNAs.
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Circular RNAs are a large class of animal RNAs with regulatory potency
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990
Natural RNA circles function as efficient microRNA sponges
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Non-coding RNAs in human disease
Esteller, M. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3074 · Cited by 4,825
circRNA biogenesis competes with pre-mRNA splicing
Ashwal-Fluss, R., Meyer, M., Pamudurti, N. R., Ivanov, A., Bartok, O., Hanan, M., Evantal, N., Memczak, S., Rajewsky, N., & Kadener, S. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.019 · Cited by 3,083
Long non-coding RNAs: new players in cell differentiation and development
Fatica, A., & Bozzoni, I. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3606 · Cited by 2,980
Detecting and characterizing circular RNAs
Jeck, W. R., & Sharpless, N. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2890 · Cited by 2,702
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Circular intronic long noncoding RNAs
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The RNA Binding Protein Quaking Regulates Formation of circRNAs
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Cited by
CircRNA: a novel type of biomarker for cancer
Zhang, H.-D., Jiang, L.-H., Sun, D.-W., Hou, J.-C., & Ji, Z.-L. (2018) · Breast Cancer · doi:10.1007/s12282-017-0793-9 · Cited by 760
Chen, J., Li, Y., Zheng, Q., Bao, C., He, J., Chen, B., Lyu, D., Zheng, B., Xu, Y., Long, Z., et al. (2017) · Cancer Letters · doi:10.1016/j.canlet.2016.12.006 · Cited by 686
A comprehensive overview and evaluation of circular RNA detection tools
Zeng, X., Lin, W., Guo, M., & Zou, Q. (2017) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1005420 · Cited by 346
Circular RNAs: a new frontier in the study of human diseases
Chen, Y., Li, C., Tan, C., & Liu, X. (2016) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2016-103758 · Cited by 293
Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression
Xue, C., Li, G., Lu, J., & Li, L. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00788-w · Cited by 268
Metadata
- Authors
- Zhao, Z.-J., & Shen, J.
- Venue
- RNA Biology
- Publisher
- Informa UK Limited
- Published
- 2016-06-03
- Volume
- 14
- Issue
- 5
- Pages
- 514-521
- ISSN
- 1547-6286 (ISSN-L)
- 1555-8584
- OpenAlex
- W2190251428
- Cited by
- 425
- References
- 76
- FWCI
- 12.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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