The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Retinal cryptochrome in a migratory passerine bird: a possible transducer for the avian magnetic compass
Abstract
The currently discussed model of magnetoreception in birds proposes that the direction of the magnetic field is perceived by radical-pair processes in specialized photoreceptors, with cryptochromes suggested as potential candidate molecules mediating magnetic compass information. Behavioral studies have shown that magnetic compass orientation takes place in the eye and requires light from the blue-green part of the spectrum. Cryptochromes are known to absorb in the same spectral range. Because of this we searched for cryptochrome (CRY) in the retina of European robins, Erithacus rubecula, passerine birds that migrate at night. Here, we report three individually expressed cryptochromes, eCRY1a, eCRY1b, and eCRY2. While eCRY1a and eCRY2 are similar to the cryptochromes found in the retina of the domestic chicken, eCRY1b has a unique carboxy (C)-terminal. In light of the 'radical-pair' model, our findings support a potential role of cryptochromes as transducers for the perception of magnetic compass information in birds.
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“It seems a logical next step to more complex living creatures, especially since four different types of cryptochrome have been confirmed in the eyes of migratory birds [103] and cryptochromes from the migratory garden warbler form radicals with millisecond lifetimes under the influence of the blue spectral range [104].”
From The future of quantum biology (2018) · cites this paper as [103]
Citations
Cites
Structure and Function of DNA Photolyase and Cryptochrome Blue-Light Photoreceptors
Sancar, A. (2003) · Chemical Reviews · doi:10.1021/cr0204348 · Cited by 1,317
A Model for Photoreceptor-Based Magnetoreception in Birds
Ritz, T., Adem, S., & Schulten, K. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76629-x · Cited by 1,176 · cited 6×
“…activated by light (Griffin et al. 1999; Van Gelder et al. 2003), and not all ‘radical-pair’ processes in flavoproteins have immediate physiological functions, the fact that cryptochromes are found in the robin’s retina is very intriguing in view of the ‘radical-pair’ model (Ritz et al. 2000).”
BackgroundInfluentialCryptochromes: Blue Light Receptors for Plants and Animals
Cashmore, A. R., Jarillo, J. A., Wu, Y., & Liu, D. (1999) · Science · doi:10.1126/science.284.5415.760 · Cited by 1,027
Magnetic Orientation in Animals
Wiltschko, R., & Wiltschko, W. (1995) · Zoophysiology · doi:10.1007/978-3-642-79749-1 · Cited by 741
Self-citationLight-Independent Role of CRY1 and CRY2 in the Mammalian Circadian Clock
Griffin, E. A., Staknis, D., & Weitz, C. J. (1999) · Science · doi:10.1126/science.286.5440.768 · Cited by 646
Resonance effects indicate a radical-pair mechanism for avian magnetic compass
Ritz, T., Thalau, P., Phillips, J. B., Wiltschko, R., & Wiltschko, W. (2004) · Nature · doi:10.1038/nature02534 · Cited by 617 · cited 2×
“…site of magnetoreception (W. Wiltschko et al. 2002, 2003), and an involvement of a ‘radical-pair’ mechanism is now supported by experimental evidence (Ritz et al. 2004), the wavelength dependency observed in orientation experiments argues against a role for the four color receptors present in…”
BackgroundSelf-citationMiyamoto, Y., & Sancar, A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6097 · Cited by 406
Mouritsen, H., Janssen‐Bienhold, U., Liedvogel, M., Feenders, G., Stalleicken, J., Dirks, P., & Weiler, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405968101 · Cited by 304
Light-induced electron transfer in a cryptochrome blue-light photoreceptor
Giovani, B., Byrdin, M., Ahmad, M., & Brettel, K. (2003) · Nature Structural & Molecular Biology · doi:10.1038/nsb933 · Cited by 274
Lateralization of magnetic compass orientation in a migratory bird
Wiltschko, W., Traudt, J., Güntürkün, O., Prior, H., & Wiltschko, R. (2002) · Nature · doi:10.1038/nature00958 · Cited by 217
Self-citation
Research works printed but not linked: 1
- Nalbach HO, Wolf-Oberhollenzer F, Remy M (1993) Exploring the image. In: Zeigler HP, Bischof HP (eds) Vision, brain, and behavior in birds. MIT Press, Cambridge, Mass., pp 25–46
Cited by
Sorted by citations
The Radical-Pair Mechanism of Magnetoreception
Hore, P. J., & Mouritsen, H. (2016) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-032116-094545 · Cited by 813
Magnetic orientation and magnetoreception in birds and other animals
Wiltschko, W., & Wiltschko, R. (2005) · Journal of Comparative Physiology A · doi:10.1007/s00359-005-0627-7 · Cited by 587
Self-citationChemical magnetoreception in birds: The radical pair mechanism
Rodgers, C. T., & Hore, P. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711968106 · Cited by 542
Chemical compass model of avian magnetoreception
Maeda, K., Henbest, K. B., Cintolesi, F., Kuprov, I., Rodgers, C. T., Liddell, P. A., Gust, D., Timmel, C. R., & Hore, P. J. (2008) · Nature · doi:10.1038/nature06834 · Cited by 496
The physics and neurobiology of magnetoreception
Johnsen, S., & Lohmann, K. J. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1745 · Cited by 420
Metadata
- Authors
- Möller, A., Sagasser, S., Wiltschko, W., & Schierwater, B.
- Affiliations
- Goethe University Frankfurt (DE)
- Leibniz University Hannover (DE)
- Corresponding author
- Wiltschko, Wolfgang
- Venue
- Naturwissenschaften
- Published
- 2004-11-17
- Volume
- 91
- Issue
- 12
- Pages
- 585-588
- ISSN
- 0028-1042 (ISSN-L)
- 1432-1904
- OpenAlex
- W2043842271
- Cited by
- 173
- References
- 25
- Citations by year
- 2026: 5 · 2025: 7 · 2023: 4 · 2022: 11 · 2021: 13 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 10 · 2016: 14 · 2015: 6 · 2014: 12 · 2013: 6 · 2012: 9
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Die Naturwissenschaften (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Yale University
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electromagnetic Fields and Biological Effects
- Physical Sciences › Earth and Planetary Sciences › Geophysics › Geomagnetism and Paleomagnetism Studies
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- avian magnetoreception, magnetic compass, European robin, Erithacus rubecula, radical pair mechanism, nocturnal migration, photoreceptors, blue-green light
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Biological Clocks, Chickens, Flavoproteins, Molecular Sequence Data, Retina, Sequence Alignment, Conserved Sequence, Sequence Homology, Amino Acid, DNA Primers, Songbirds, Cryptochromes
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