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Cardiac contractile dysfunction in Lep/Lep obesity is accompanied by NADPH oxidase activation, oxidative modification of sarco(endo)plasmic reticulum Ca2+-ATPase and myosin heavy chain isozyme switch
Open accessAbstract
Aims/hypothesis Obesity is an independent risk factor for heart diseases but the underlying mechanism is not clear. This study examined cardiac contraction, oxidative stress, oxidative modification of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) and the myosin heavy chain (MHC) isoform switch in obese mice.Methods Mechanical properties were evaluated in ventricular myocytes from C57BL/6J lean and Lep/Lep obese mice (formerly known as ob/ob mice), including peak shortening (PS), time to 50 or 90% PS, time to 50 or 90% relengthening (TR50, TR90), maximal velocity of shortening/relengthening (+/-dL/dt), intracellular Ca2+ and its decay (tau). Oxidative stress, lipid peroxidation, protein damage and SERCA activity were assessed by glutathione/glutathione disulfide, malondialdehyde, protein carbonyl and 45Ca2+ uptake, respectively. NADPH oxidase was determined by immunoblotting.Results Myocytes from Lep/Lep mice displayed depressed PS and +/- dL/dt, prolonged TR50, TR90, elevated resting [Ca2+]i, prolonged tau, reduced contractile capacity at high stimulus frequencies and diminished responsiveness to extracellular Ca2+ compared with lean controls. Cardiac glutathione/glutathione disulfide was decreased whereas malondialdehyde, protein carbonyl, membrane p47(phox) and membrane gp91(phox) were increased in the Lep/Lep group. SERCA isoenzyme 2a was markedly modified by oxidation in Lep/Lep hearts and associated with decreased 45Ca2+ uptake. The MHC isozyme displayed a shift from the alpha to the beta isoform in Lep/Lep hearts. Short-term incubation of angiotensin II with myocytes mimicked the mechanical defects, SERCA oxidation and 45Ca2+ uptake seen in Lep/Lep myocytes. Incubation of the NADPH oxidase inhibitor apocynin with Lep/Lep myocytes alleviated contractile defects without reversing SERCA oxidation or activity.Conclusions/interpretation These data indicate that obesity-related cardiac defects may be related to NADPH oxidase activation, oxidative damage to SERCA and the MHC isozyme switch.
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“In ob/ob mice, cardiomyocyte contractile function is reduced and is associated with reduced calcium sensitivity and altered calcium transients (88, 207).”
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Metadata
- Authors
- Li, S.-Y., Yang, X., Ceylan-Isik, A. F., Du, M., Sreejayan, N., & Ren, J.
- Affiliations
- University of Wyoming (US)
- Corresponding author
- Ren, J.
- Venue
- Diabetologia
- Published
- 2006-04-13
- Volume
- 49
- Issue
- 6
- Pages
- 1434-1446
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2149180473
- Cited by
- 187
- References
- 51
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 8 · 2021: 6 · 2020: 10 · 2019: 8 · 2018: 11 · 2017: 10 · 2016: 7 · 2015: 12 · 2014: 10 · 2013: 10 · 2012: 16
- FWCI
- 10.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association (7-00-RA-21)
- American Heart Association (0355521Z)
- Ohio State University
- Montana State University
- National Institutes of Health
- National Institute on Aging (R03AG021324, AG-21324, R03 AG21324, 1R03 AG21324-01, R03 AG21324-01, 1 R03 AG21324)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Keywords
- cardiac contractile dysfunction, obesity, ob/ob mice, NADPH oxidase, oxidative stress, angiotensin II, apocynin, oxidative modification, ventricular myocytes, lipid peroxidation, protein carbonylation, glutathione, p47phox
- MeSH terms
- Calcium-Transporting ATPases, Animals, Endoplasmic Reticulum, Enzyme Activation, Glutathione, Homozygote, Male, Mice, Inbred C57BL, Mice, Obese, Myocardial Contraction, Sarcoplasmic Reticulum, Cell Culture Techniques, NADPH Oxidases, Glutathione Disulfide, Calcium Signaling, Leptin, Muscle Cells, Mice
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