Cited by 261Alcoholism and Thiamine DeficiencyBiochemical Acid Research StudiesFolate and B Vitamins Research

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High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease

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Thornalley, P. J., Babaei-Jadidi, R., Al Ali, H., Rabbani, N., Antonysunil, A., Larkin, J., Ahmed, A., Rayman, G., Bodmer, C. W.·2007·Diabetologia

DOI 10.1007/s00125-007-0771-4PMC PMC1998885

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AIMS/HYPOTHESIS: To assess thiamine status by analysis of plasma, erythrocytes and urine in type 1 and type 2 diabetic patients and links to markers of vascular dysfunction. METHODS: Diabetic patients (26 type 1 and 48 type 2) with and without microalbuminuria and 20 normal healthy control volunteers were recruited. Erythrocyte activity of transketolase, the concentrations of thiamine and related phosphorylated metabolites in plasma, erythrocytes and urine, and markers of metabolic control and vascular dysfunction were determined. RESULTS: Plasma thiamine concentration was decreased 76% in type 1 diabetic patients and 75% in type 2 diabetic patients: normal volunteers 64.1 (95% CI 58.5-69.7) nmol/l, type 1 diabetes 15.3 (95% CI 11.5-19.1) nmol/l, p < 0.001, and type 2 diabetes 16.3 (95% CI 13.0-9.6) nmol/l, p < 0.001. Renal clearance of thiamine was increased 24-fold in type 1 diabetic patients and 16-fold in type 2 diabetic patients. Plasma thiamine concentration correlated negatively with renal clearance of thiamine (r = -0.531, p < 0.001) and fractional excretion of thiamine (r = -0.616, p < 0.001). Erythrocyte transketolase activity correlated negatively with urinary albumin excretion (r = -0.232, p < 0.05). Thiamine transporter protein contents of erythrocyte membranes of type 1 and type 2 diabetic patients were increased. Plasma thiamine concentration and urinary excretion of thiamine correlated negatively with soluble vascular adhesion molecule-1 (r = -0.246, p < 0.05, and -0.311, p < 0.01, respectively). CONCLUSIONS/INTERPRETATION: Low plasma thiamine concentration is prevalent in patients with type 1 and type 2 diabetes, associated with increased thiamine clearance. The conventional assessment of thiamine status was masked by increased thiamine transporter content of erythrocytes.

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Self-citation

Authors: Thornalley, P. J., Babaei-Jadidi, R., Al Ali, H., Rabbani, N., Antonysunil, A., Larkin, J., Ahmed, A., Rayman, G., & Bodmer, C. W.
Affiliations: University of Essex (GB)
Colchester Hospital (GB)
National Health Service (GB)
Corresponding author: Thornalley, P. J.
ORCID: Thornalley, P. J.
Rabbani, N.
Larkin, J.
Ahmed, A.
Rayman, G.
Venue: Diabetologia
Publisher: Springer Science and Business Media LLC
Published: 2007-08-04
Volume: 50
Issue: 10
Pages: 2164-2170
ISSN: 0012-186X (ISSN-L)
1432-0428
DOI: 10.1007/s00125-007-0771-4
PMC: PMC1998885
OpenAlex: W2039005156
Cited by: 260
References: 46
Citations by year: 2026: 6 · 2025: 7 · 2024: 9 · 2023: 20 · 2022: 24 · 2021: 22 · 2020: 18 · 2019: 15 · 2018: 18 · 2017: 14 · 2016: 15 · 2015: 15 · 2014: 7 · 2013: 10 · 2012: 18
FWCI: 6.95
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/4.0/ (tdm)
creativecommons.org/licenses/by-nc/4.0/ (vor)
Locations: Diabetologia (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Nottingham Trent University's Institutional Repository (Nottingham Trent Repository) (acceptedVersion)
Funders: Diabetes UK
Topics: Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
Keywords: thiamine deficiency, type 1 diabetes, type 2 diabetes, microalbuminuria, erythrocyte transketolase, thiamine transporter, vascular dysfunction
MeSH terms: Albuminuria, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Glomerular Filtration Rate, Humans, Reference Values, Thiamine, Thiamine Deficiency, Thiamine Monophosphate, Thiamine Pyrophosphate, Vascular Diseases, Biomarkers

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High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease

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