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High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease
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AIMS/HYPOTHESIS: To assess thiamine status by analysis of plasma, erythrocytes and urine in type 1 and type 2 diabetic patients and links to markers of vascular dysfunction. METHODS: Diabetic patients (26 type 1 and 48 type 2) with and without microalbuminuria and 20 normal healthy control volunteers were recruited. Erythrocyte activity of transketolase, the concentrations of thiamine and related phosphorylated metabolites in plasma, erythrocytes and urine, and markers of metabolic control and vascular dysfunction were determined. RESULTS: Plasma thiamine concentration was decreased 76% in type 1 diabetic patients and 75% in type 2 diabetic patients: normal volunteers 64.1 (95% CI 58.5-69.7) nmol/l, type 1 diabetes 15.3 (95% CI 11.5-19.1) nmol/l, p < 0.001, and type 2 diabetes 16.3 (95% CI 13.0-9.6) nmol/l, p < 0.001. Renal clearance of thiamine was increased 24-fold in type 1 diabetic patients and 16-fold in type 2 diabetic patients. Plasma thiamine concentration correlated negatively with renal clearance of thiamine (r = -0.531, p < 0.001) and fractional excretion of thiamine (r = -0.616, p < 0.001). Erythrocyte transketolase activity correlated negatively with urinary albumin excretion (r = -0.232, p < 0.05). Thiamine transporter protein contents of erythrocyte membranes of type 1 and type 2 diabetic patients were increased. Plasma thiamine concentration and urinary excretion of thiamine correlated negatively with soluble vascular adhesion molecule-1 (r = -0.246, p < 0.05, and -0.311, p < 0.01, respectively). CONCLUSIONS/INTERPRETATION: Low plasma thiamine concentration is prevalent in patients with type 1 and type 2 diabetes, associated with increased thiamine clearance. The conventional assessment of thiamine status was masked by increased thiamine transporter content of erythrocytes.
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“Several training interventions have not produced changes in basal IL-6 or CRP concentrations (213 -218) , while significant reductions in inflammatory markers have been observed following training without changes in BMI or body fat in elderly participants (219,220) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [213]
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Thiamine Deficiency in Diabetes: Implications for Diabetic Ketoacidosis
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Metadata
- Authors
- Thornalley, P. J., Babaei-Jadidi, R., Al Ali, H., Rabbani, N., Antonysunil, A., Larkin, J., Ahmed, A., Rayman, G., & Bodmer, C. W.
- Affiliations
- University of Essex (GB)
- Colchester Hospital (GB)
- National Health Service (GB)
- Corresponding author
- Thornalley, P. J.
- Venue
- Diabetologia
- Published
- 2007-08-04
- Volume
- 50
- Issue
- 10
- Pages
- 2164-2170
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- PMC
- PMC1998885
- OpenAlex
- W2039005156
- Cited by
- 260
- References
- 46
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 9 · 2023: 20 · 2022: 24 · 2021: 22 · 2020: 18 · 2019: 15 · 2018: 18 · 2017: 14 · 2016: 15 · 2015: 15 · 2014: 7 · 2013: 10 · 2012: 18
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Diabetologia (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Nottingham Trent University's Institutional Repository (Nottingham Trent Repository) (acceptedVersion)
- Funders
- Diabetes UK
- Topics
- Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
- Keywords
- thiamine deficiency, type 1 diabetes, type 2 diabetes, microalbuminuria, erythrocyte transketolase, thiamine transporter, vascular dysfunction
- MeSH terms
- Albuminuria, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Glomerular Filtration Rate, Humans, Reference Values, Thiamine, Thiamine Deficiency, Thiamine Monophosphate, Thiamine Pyrophosphate, Vascular Diseases, Biomarkers
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