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Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: Where are the insulin resistance genes?

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Florez, J. C.·2008·Diabetologia

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  1. Reaven GM, Bernstein R, Davis B, Olefsky JM (1976) Nonketotic diabetes mellitus: insulin deficiency or insulin resistance? Am J Med 60:80–88 · DOI · Paper page
  2. Haffner SM, Miettinen H, Gaskill SP, Stern MP (1995) Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican-Americans. Diabetes 44:1386–1391 · DOI · Paper page
  3. Gerich JE (2000) Insulin resistance is not necessarily an essential component of type 2 diabetes. J Clin Endocrinol Metab 85:2113–2115
  4. Polonsky KS, Sturis J, Bell GI (1996) Non-insulin-dependent diabetes mellitus—a genetically programmed failure of the beta cell to compensate for insulin resistance. N Engl J Med 334:777–783 · DOI · Paper page
  5. Vaxillaire M, Froguel P (2006) Genetic basis of maturity-onset diabetes of the young. Endocrinol Metab Clin N Am 35:371–384 · DOI
  6. Love-Gregory LD, Wasson J, Ma J et al (2004) A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4α gene on chromosome 20 q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an Ashkenazi Jewish population. Diabetes 53:1134–1140 · DOI · Paper page
  7. Silander K, Mohlke KL, Scott LJ et al (2004) Genetic variation near the hepatocyte nuclear factor-4α gene predicts susceptibility to type 2 diabetes. Diabetes 53:1141–1149 · DOI · Paper page
  8. Weedon MN, Owen KR, Shields B et al (2004) Common variants of the hepatocyte nuclear factor-4α P2 promoter are associated with type 2 diabetes in the U.K. population. Diabetes 53:3002–3006 · DOI
  9. Hansen SK, Rose CS, Glumer C et al (2005) Variation near the hepatocyte nuclear factor (HNF)-4α gene associates with type 2 diabetes in the Danish population. Diabetologia 48:452–458 · DOI
  10. Winckler W, Graham RR, de Bakker PIW et al (2005) Association testing of variants in the hepatocyte nuclear factor 4α gene with risk of type 2 diabetes in 7,883 people. Diabetes 54:886–892 · DOI
  11. Winckler W, Burtt NP, Holmkvist J et al (2005) Association of common variation in the HNF1α gene region with risk of type 2 diabetes. Diabetes 54:2336–2342 · DOI
  12. Weedon MN, Owen KR, Shields B et al (2005) A large-scale association analysis of common variation of the HNF1α gene with type 2 diabetes in the U.K. Caucasian population. Diabetes 54:2487–2491 · DOI
  13. Bonnycastle LL, Willer CJ, Conneely KN et al (2006) Common variants in Maturity-Onset Diabetes of the Young genes contribute to risk of type 2 diabetes in Finns. Diabetes 55:2534–2540 · DOI
  14. Holmkvist J, Cervin C, Lyssenko V et al (2006) Common variants in HNF-1α and risk of type 2 diabetes. Diabetologia 49:2882–2891 · DOI
  15. Willer CJ, Bonnycastle LL, Conneely KN et al (2007) Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes. Diabetes 56:256–264 · DOI
  16. Holmkvist J, Almgren P, Lyssenko V et al (2008) Common variants in MODY genes and future risk of type 2 diabetes. Diabetes (in press). DOI 10.2337/db06–1464 · DOI
  17. Winckler W, Weedon MN, Graham RR et al (2007) Evaluation of common variants in the six known Maturity-Onset Diabetes of the Young (MODY) genes for association with type 2 diabetes. Diabetes 56:685–693 · DOI · Paper page
  18. Weedon MN, Clark VJ, Qian Y et al (2006) A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses. Am J Hum Genet 79:991–1001 · DOI
  19. Kavvoura FK, Ioannidis JP (2005) Ala45Thr polymorphism of the NEUROD1 gene and diabetes susceptibility: a meta-analysis. Hum Genet 116:192–199 · DOI
  20. Inoue H, Tanizawa Y, Wasson J et al (1998) A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome). Nat Genet 20:143–148 · DOI · Paper page
  21. Hardy C, Khanim F, Torres R et al (1999) Clinical and molecular genetic analysis of 19 Wolfram syndrome kindreds demonstrating a wide spectrum of mutations in WFS1. Am J Hum Genet 65:1279–1290 · DOI · Paper page
  22. Sandhu MS, Weedon MN, Fawcett KA et al (2007) Common variants in WFS1 confer risk of type 2 diabetes. Nat Genet 39:951–953 · DOI · Paper page
  23. Franks PW, Rolandsson O, Debenham SL et al (2008) Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations. Diabetologia 51:458–463 · DOI
  24. Florez JC, Jablonski KA, McAteer J et al (2008) Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program. Diabetologia 51:451–457 · DOI
  25. Aguilar-Bryan L, Bryan J (1999) Molecular biology of adenosine triphosphate-sensitive potassium channels. Endocr Rev 20:101–135
  26. Ashcroft FM, Gribble FM (1999) ATP-sensitive K+ channels and insulin secretion: their role in health and disease. Diabetologia 42:903–919 · DOI · Paper page
  27. Altshuler D, Hirschhorn JN, Klannemark M et al (2000) The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 26:76–80 · DOI · Paper page
  28. Inoue H, Ferrer J, Warren-Perry M et al (1997) Sequence variants in the pancreatic islet beta-cell inwardly rectifying K+ channel Kir6.2 (Bir) gene: identification and lack of role in Caucasian patients with NIDDM. Diabetes 46:502–507 · DOI
  29. Hansen L, Echwald SM, Hansen T, Urhammer SA, Clausen JO, Pedersen O (1997) Amino acid polymorphisms in the ATP-regulatable inward rectifier Kir6.2 and their relationships to glucose- and tolbutamide-induced insulin secretion, the insulin sensitivity index, and NIDDM. Diabetes 46:508–512 · DOI
  30. Hani EH, Boutin P, Durand E et al (1998) Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR): a meta-analysis suggests a role in the polygenic basis of type II diabetes mellitus in Caucasians. Diabetologia 41:1511–1515 · DOI · Paper page
  31. Gloyn AL, Hashim Y, Ashcroft SJ, Ashfield R, Wiltshire S, Turner RC (2001) Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with type 2 diabetes mellitus (UKPDS 53). Diabet Med 18:206–212 · DOI · Paper page
  32. Nielsen E-MD, Hansen L, Carstensen B et al (2003) The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes. Diabetes 52:573–577 · DOI · Paper page
  33. Love-Gregory L, Wasson J, Lin J, Skolnick G, Suarez B, Permutt MA (2003) E23K single nucleotide polymorphism in the islet ATP-sensitive potassium channel gene (Kir6.2) contributes as much to the risk of type II diabetes in Caucasians as the PPARγ Pro12Ala variant. Diabetologia 46:136–137 · DOI
  34. Florez JC, Burtt N, de Bakker PIW et al (2004) Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region. Diabetes 53:1360–1368 · DOI · Paper page
  35. van Dam RM, Hoebee B, Seidell JC, Schaap MM, de Bruin TWA, Feskens EJM (2005) Common variants in the ATP-sensitive K+ channel genes KCNJ11 (Kir6.2) and ABCC8 (SUR1) in relation to glucose intolerance: population-based studies and meta-analyses. Diabet Med 22:590–598 · DOI
  36. Schwanstecher C, Meyer U, Schwanstecher M (2002) KIR6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic β-cell ATP-sensitive K+ channels. Diabetes 51:875–879 · DOI · Paper page
  37. Riedel MJ, Boora P, Steckley D, de Vries G, Light PE (2003) Kir6.2 polymorphisms sensitize β-cell ATP-sensitive potassium channels to activation by acyl CoAs: A possible cellular mechanism for increased susceptibility to type 2 diabetes? Diabetes 52:2630–2635 · DOI
  38. Riedel MJ, Light PE (2005) Saturated and cis/trans unsaturated acyl CoA esters differentially regulate wild-type and polymorphic β-cell ATP-sensitive K+ channels. Diabetes 54:2070–2079 · DOI
  39. Zeggini E, McCarthy MI (2007) TCF7L2: the biggest story in diabetes genetics since HLA? Diabetologia 50:1–4 · DOI
  40. Cauchi S, El Achhab Y, Choquet H et al (2007) TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis. J Mol Med 85:777–782 · DOI · Paper page
  41. Florez JC (2007) The new type 2 diabetes gene TCF7L2. Curr Opin Clin Nutr Metab Care 10:391–396 · DOI
  42. Miyake K, Horikawa Y, Hara K et al (2008) Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects. J Hum Genet 53:174–180 · DOI
  43. Chang YC, Chang TJ, Jiang YD et al (2007) Association study of the genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene and type 2 diabetes in the Chinese population. Diabetes 56:2631–2637 · DOI · Paper page
  44. Korinek V, Barker N, Moerer P et al (1998) Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet 19:379–383 · DOI · Paper page
  45. Drucker DJ (2007) The role of gut hormones in glucose homeostasis. J Clin Invest 117:24–32 · DOI · Paper page
  46. Yi F, Brubaker PL, Jin T (2005) TCF-4 mediates cell type-specific regulation of proglucagon gene expression by β-catenin and glycogen synthase kinase-3β. J Biol Chem 280:1457–1464 · DOI · Paper page
  47. Florez JC, Jablonski KA, Bayley N et al (2006) TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med 355:241–250 · DOI · Paper page
  48. Saxena R, Gianniny L, Burtt NP et al (2006) Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals. Diabetes 55:2890–2895 · DOI · Paper page
  49. Damcott CM, Pollin TI, Reinhart LJ et al (2006) Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: Replication and evidence for a role in both insulin secretion and insulin resistance. Diabetes 55:2654–2659 · DOI · Paper page
  50. Munoz J, Lok KH, Gower BA et al (2006) Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic women. Diabetes 55:3630–3634 · DOI
  51. Lyssenko V, Lupi R, Marchetti P et al (2007) Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 117:2155–2163 · DOI · Paper page
  52. Palmer ND, Lehtinen AB, Langefeld CD et al (2008) Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans. J Clin Endocrinol Metab 93:304–309 · DOI
  53. Liu Z, Habener JF (2008) Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation. J Biol Chem 283:8723–8735 · DOI · Paper page
  54. Shu L, Sauter NS, Schulthess FT, Matveyenko AV, Oberholzer J, Maedler K (2008) Transcription factor 7-like 2 regulates β-cell survival and function in human pancreatic islets. Diabetes 57:645–653 · DOI · Paper page
  55. Loos RJF, Franks PW, Francis RW et al (2007) TCF7L2 polymorphisms modulate proinsulin levels and β-cell function in a British Europid population. Diabetes 56:1943–1947 · DOI · Paper page
  56. Kirchhoff K, Machicao F, Haupt A et al (2008) Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion. Diabetologia 51:597–601 · DOI · Paper page
  57. Wang J, Kuusisto J, Vanttinen M et al (2007) Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion. Diabetologia 50:1192–1200 · DOI · Paper page
  58. Frayling TM, Timpson NJ, Weedon MN et al (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316:889–894 · DOI · Paper page
  59. Salonen JT, Uimari P, Aalto JM et al (2007) Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium. Am J Hum Genet 81:338–345 · DOI · Paper page
  60. Hayes MG, Pluzhnikov A, Miyake K et al (2007) Identification of type 2 diabetes genes in Mexican Americans through genome-wide association studies. Diabetes 56:3033–3044 · DOI
  61. Hanson RL, Bogardus C, Duggan D et al (2007) A search for variants associated with young-onset type 2 diabetes in American Indians in a 100K genotyping array. Diabetes 56:3045–3052 · DOI
  62. Florez JC, Manning AK, Dupuis J et al (2007) A 100 K genome-wide association scan for diabetes and related traits in the Framingham Heart Study: replication and integration with other genome-wide datasets. Diabetes 56:3063–3074 · DOI
  63. Pascoe L, Tura A, Patel SK et al (2007) Common variants of the novel type 2 diabetes genes, CDKAL1 and HHEX/IDE, are associated with decreased pancreatic β-cell function. Diabetes 56:3101–3104 · DOI · Paper page
  64. Grarup N, Rose CS, Andersson EA et al (2007) Studies of association of variants near the HHEX, CDKN2A/B and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies. Diabetes 56:3105–3111 · DOI · Paper page
  65. Staiger H, Machicao F, Stefan N et al (2007) Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function. PLoS ONE 2:e832 · DOI · Paper page
  66. Palmer ND, Goodarzi MO, Langefeld CD et al (2008) Quantitative trait analysis of T2D susceptibility loci identified from whole genome association studies in the IRAS Family Study. Diabetes 57:1093–1100 · DOI
  67. Taylor SI (1992) Lilly Lecture: molecular mechanisms of insulin resistance. Lessons from patients with mutations in the insulin-receptor gene. Diabetes 41:1473–1490 · DOI · Paper page
  68. Panhuysen CIM, Cupples LA, Wilson PWF, Herbert AG, Myers RH, Meigs JB (2003) A genome scan for loci linked to quantitative insulin traits in persons without diabetes: the Framingham Offspring Study. Diabetologia 46:579–587 · DOI
  69. Lyssenko V, Almgren P, Anevski D et al (2005) Genetic prediction of future type 2 diabetes. PLoS Med 2:e345 · DOI
  70. Vanttinen M, Nuutila P, Pihlajamaki J et al (2005) The effect of the Ala12 allele of the peroxisome proliferator-activated receptor-γ2 gene on skeletal muscle glucose uptake depends on obesity: a positron emission tomography study. J Clin Endocrinol Metab 90:4249–4254 · DOI
  71. Tonjes A, Scholz M, Loeffler M, Stumvoll M (2006) Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor γ with pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individuals. Diabetes Care 29:2489–2497 · DOI · Paper page
  72. Florez JC, Jablonski KA, Sun MW et al (2007) Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone. J Clin Endocrinol Metab 92:1502–1509 · DOI
  73. Ludovico O, Pellegrini F, Di Paola R et al (2007) Heterogeneous effect of peroxisome proliferator-activated receptor γ2 Ala12 variant on type 2 diabetes risk. Obesity 15:1076–1081 · DOI
  74. Bochenski J, Placha G, Wanic K et al (2006) New polymorphism of ENPP1 (PC-1) is associated with increased risk of type 2 diabetes among obese individuals. Diabetes 55:2626–2630 · doi:10.2337/db06-0191
  75. Chandalia M, Grundy S, Adams-Huet B, Abate N (2007) Ethnic differences in the frequency of ENPP1/PC1 121Q genetic variant in the Dallas Heart Study cohort. J Diabetes Complicat 21:143–148 · DOI
  76. McAteer JB, Prudente S, Bacci S et al (2007) The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: Evidence from an updated meta-analysis in 42,042 subjects. Diabetes 57:1125–1130 · DOI
  77. Bacci S, De Cosmo S, Prudente S, Trischitta V (2007) ENPP1 gene, insulin resistance and related clinical outcomes. Curr Opin Clin Nutr Metab Care 10:403–409 · DOI
  78. Frayling TM (2007) Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet 8:657–662 · DOI · Paper page

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Metadata

Authors
Florez, J. C.
Venue
Diabetologia
Published
2008-05-27
Volume
51
Issue
7
Pages
1100-1110
ISSN
  • 0012-186X (ISSN-L)
  • 1432-0428
OpenAlex
W2030018707
Cited by
293
References
20
FWCI
34.59
Type
journal article
Language
en
Open access
bronze
Licence
www.springer.com/tdm (tdm)

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Florez, J. C. (2008). Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: Where are the insulin resistance genes? Diabetologia. https://doi.org/10.1007/s00125-008-1025-9

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