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Cited by 50Adipokines, Inflammation, and Metabolic DiseasesChronic Kidney Disease and DiabetesDiabetes, Cardiovascular Risks, and Lipoproteins

Retinol-binding protein 4 is associated with impaired glucose regulation and microalbuminuria in a Chinese population

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Xu, M., Li, X. Y., Wang, J. G., Wang, X. J., Huang, Y., Cheng, Q., Huang, H. E., Li, R. +4 more·2009·Diabetologia
DOI 10.1007/s00125-009-1386-8
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Abstract

Aims/hypothesis Increased retinol-binding protein 4 (RBP4) has been reported in association with insulin resistance and type 2 diabetes. We aimed to investigate the association of serum RBP4 with impaired glucose regulation and microalbuminuria in Chinese adults aged 40 years or older.Methods Serum RBP4 was measured in 763 individuals with normal glucose regulation, 508 with impaired glucose regulation and 524 newly diagnosed diabetic patients. Serum RBP4 was measured using ELISA and urine albumin/creatinine ratio was used to determine the urinary albumin excretion.Results Serum RBP4 concentrations were significantly higher in participants with isolated impaired fasting glucose, isolated impaired glucose tolerance, combined impaired fasting glucose/impaired glucose tolerance and diabetes than in those with normal glucose regulation, whereas serum RBP4 levels were not different in the four groups with dysregulation of glucose metabolism. RBP4 was associated with a higher risk for impaired glucose regulation (OR 1.011 for each 1 microg/ml increase in RBP4, 95% CI 1.000-1.022, p = 0.04) after adjustment for sex, age, BMI, current smoking and alcohol intake, family history of diabetes, insulin resistance, triacylglycerol, total cholesterol, and HDL- and LDL-cholesterol; the corresponding OR of combined impaired glucose regulation and type 2 diabetes was 1.022 (95% CI 1.009-1.035, p = 0.0009). RBP4 was associated with the risk of microalbuminuria (OR 1.023, 95% CI 1.004-1.042, p = 0.01) after adjustment for sex, age, smoking habit and alcohol intake, BMI, waist/hip ratio, homeostasis model assessment of insulin resistance, GFR, triacylglycerol, total cholesterol, and HDL- and LDL-cholesterol.Conclusions/interpretation Serum RBP4 level is closely associated with impaired glucose regulation and is an independent risk factor for microalbuminuria.

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  • Evidence of a cross-sectional association between prediabetes and eGFR is mixed, including both positive and null findings.

    “In contrast, evidence of a cross-sectional association between prediabetes and eGFR, a late marker of CKD, is mixed, including both studies with positive54 and null findings.55,57”

    From Prediabetes: a high-risk state for diabetes development (2012) · cites this paper as [55]

  • There is evidence linking prediabetes to increased risk of early forms of nephropathy and chronic kidney disease.

    “There is evidence to link prediabetes to increased risk of early forms of nephropathy and chronic kidney disease (CKD), defined based on methods such as urinary albumin excretion rate (AER) and estimated glomerular filtration rate (eGFR).51–55”

    From Prediabetes: a high-risk state for diabetes development (2012) · cites this paper as [55]

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Authors
Xu, M., Li, X. Y., Wang, J. G., Wang, X. J., Huang, Y., Cheng, Q., Huang, H. E., Li, R., Xiang, J., Tan, J. R., Dai, M., & Ning, G.
Affiliations
  • Shanghai Jiao Tong University (CN)
  • Shanghai Municipal Center For Disease Control Prevention (CN)
Corresponding author
Ning, G.
ORCID
Venue
Diabetologia
Publisher
Springer Science and Business Media LLC
Published
2009-06-09
Volume
52
Issue
8
Pages
1511-1519
ISSN
  • 0012-186X (ISSN-L)
  • 1432-0428
DOI
10.1007/s00125-009-1386-8
OpenAlex
W2016600480
Cited by
50
References
31
Citations by year
2025: 1 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 4
FWCI
4.70
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Diabetologia (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
retinol-binding protein 4, prediabetes, microalbuminuria, type 2 diabetes, impaired fasting glucose, impaired glucose tolerance, insulin resistance, urinary albumin excretion, Chinese adults
MeSH terms
Adult, Aged, Albuminuria, Blood Pressure, China, Diabetes Mellitus, Type 2, Female, Glucose Tolerance Test, Humans, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Triglycerides, Glucose Intolerance, Waist-Hip Ratio, Retinol-Binding Proteins, Plasma

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