Cited by 103Genetic Associations and EpidemiologyForensic and Genetic ResearchEvolution and Genetic Dynamics

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

Open access

Southam, L., Soranzo, N., Montgomery, S. B., Frayling, T. M., McCarthy, M. I., Barroso, I., Zeggini, E.·2009·Diabetologia

DOI 10.1007/s00125-009-1419-3PMC PMC2723682

Open this paper in CoChat — free account Open PDF

Abstract

AIMS/HYPOTHESIS: According to the thrifty genotype hypothesis, the high prevalence of type 2 diabetes and obesity is a consequence of genetic variants that have undergone positive selection during historical periods of erratic food supply. The recent expansion in the number of validated type 2 diabetes- and obesity-susceptibility loci, coupled with access to empirical data, enables us to look for evidence in support (or otherwise) of the thrifty genotype hypothesis using proven loci. METHODS: We employed a range of tests to obtain complementary views of the evidence for selection: we determined whether the risk allele at associated 'index' single-nucleotide polymorphisms is derived or ancestral, calculated the integrated haplotype score (iHS) and assessed the population differentiation statistic fixation index (F (ST)) for 17 type 2 diabetes and 13 obesity loci. RESULTS: We found no evidence for significant differences for the derived/ancestral allele test. None of the studied loci showed strong evidence for selection based on the iHS score. We find a high F (ST) for rs7901695 at TCF7L2, the largest type 2 diabetes effect size found to date. CONCLUSIONS/INTERPRETATION: Our results provide some evidence for selection at specific loci, but there are no consistent patterns of selection that provide conclusive confirmation of the thrifty genotype hypothesis. Discovery of more signals and more causal variants for type 2 diabetes and obesity is likely to allow more detailed examination of these issues.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s00125-009-1419-3

Cites

15 of 15 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Genetics of Food Intake Self-Regulation in Childhood: Literature Review and Research Opportunities
Faith, M. S., Carnell, S., & Kral, T. V. E. (2013) · Human Heredity · doi:10.1159/000353879 · Cited by 7,633
Impact of Informing Overweight Individuals about the Role of Genetics in Obesity: An Online Experimental Study
Lippa, N. C., & Sanderson, S. C. (2013) · Human Heredity · doi:10.1159/000353712 · Cited by 6,095
A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity
Frayling, T. M., Timpson, N. J., Weedon, M. N., Zeggini, E., Freathy, R. M., Lindgren, C. M., Perry, J. R. B., Elliott, K. S., Lango, H., Rayner, N. W., et al. (2007) · Science · doi:10.1126/science.1141634 · Cited by 4,531
A second generation human haplotype map of over 3.1 million SNPs
The International HapMap Consortium (2007) · Nature · doi:10.1038/nature06258 · Cited by 4,438
Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?
Neel, J. V. (1962) · Europe PMC (PubMed Central) · Cited by 3,172
A Map of Recent Positive Selection in the Human Genome
Voight, B. F., Kudaravalli, S., Wen, X., & Pritchard, J. K. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040072 · Cited by 2,925
Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?
(1962) · PubMed Central · Cited by 2,182
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
the GIANT Consortium (2009) · Nature Genetics · doi:10.1038/ng.287 · Cited by 1,720
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
Thorleifsson, G., Walters, G. B., Gudbjartsson, D. F., Steinthorsdottir, V., Sulem, P., Helgadottir, A., Styrkarsdottir, U., Gretarsdottir, S., Thorlacius, S., Jonsdottir, I., et al. (2009) · Nature Genetics · doi:10.1038/ng.274 · Cited by 1,375
Common variants near MC4R are associated with fat mass, weight and risk of obesity
The Prostate, L., Loos, R. J. F., KORA, Study, N. H., Initiative, D. G., Study, T. S., The Wellcome Trust Case Control Consortium, FUSION, Lindgren, C. M., Li, S., et al. (2008) · Nature Genetics · doi:10.1038/ng.140 · Cited by 1,325

Show all 15 references

Sorted by citations

Globalization of Diabetes
Hu, F. B. (2011) · Diabetes Care · doi:10.2337/dc11-0442 · Cited by 1,954
β Cell Dysfunction Versus Insulin Resistance in the Pathogenesis of Type 2 Diabetes in East Asians
Yabe, D., Seino, Y., Fukushima, M., & Seino, S. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0602-9 · Cited by 328
On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations
Qasim, A., Turcotte, M., de Souza, R. J., Samaan, M. C., Champredon, D., Dushoff, J., Speakman, J. R., & Meyre, D. (2018) · Obesity Reviews · doi:10.1111/obr.12625 · Cited by 241
Genetics of Obesity: What have we Learned?
Choquet, H., & Meyre, D. (2011) · Current Genomics · doi:10.2174/138920211795677895 · Cited by 253
Evolutionary perspectives on the obesity epidemic: adaptive, maladaptive, and neutral viewpoints
Speakman, J. R. (2013) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071811-150711 · Cited by 163
Gene-Environment and Gene-Treatment Interactions in Type 2 Diabetes
Franks, P. W., Pearson, E. R., & Florez, J. C. (2013) · Diabetes Care · doi:10.2337/dc12-2211 · Cited by 154
Ethnic and population differences in the genetic predisposition to human obesity
Stryjecki, C., Alyass, A., & Meyre, D. (2017) · Obesity Reviews · doi:10.1111/obr.12604 · Cited by 147
The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression
Samaan, Z., Anand, S., Zhang, X., Desai, D., Rivera, M., Pare, G., Thabane, L., Xie, C., Gerstein, H., Engert, J. C., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.160 · Cited by 129
Type 2 Diabetes Risk Alleles Demonstrate Extreme Directional Differentiation among Human Populations, Compared to Other Diseases
Chen, R., Corona, E., Sikora, M., Dudley, J. T., Morgan, A. A., Moreno‐Estrada, A., Nilsen, G. B., Ruau, D., Lincoln, S. E., Bustamante, C. D., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002621 · Cited by 129
The evolution of body fatness: trading off disease and predation risk
Speakman, J. R. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.167254 · Cited by 123
The Role of RNA Editing in Cancer Development and Metabolic Disorders
Kung, C.-P., Maggi, L. B., & Weber, J. D. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00762 · Cited by 101
Revisiting the Thrifty Gene Hypothesis via 65 Loci Associated with Susceptibility to Type 2 Diabetes
Ayub, Q., Moutsianas, L., Chen, Y., Panoutsopoulou, K., Colonna, V., Pagani, L., Prokopenko, I., Ritchie, G. R. S., Tyler‐Smith, C., McCarthy, M. I., et al. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.12.010 · Cited by 88
Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study
Reddon, H., Gerstein, H. C., Engert, J. C., Mohan, V., Bosch, J., Desai, D., Bailey, S. D., Díaz, R., Yusuf, S., Anand, S. S., et al. (2016) · Scientific Reports · doi:10.1038/srep18672 · Cited by 87
Thinking evolutionarily about obesity.
Genné-Bacon, E. A. (2014) · Europe PMC (PubMed Central) · Cited by 80
Natural selection at genomic regions associated with obesity and type-2 diabetes: East Asians and sub-Saharan Africans exhibit high levels of differentiation at type-2 diabetes regions
Klimentidis, Y. C., Abrams, M., Wang, J., Fernández, J. R., & Allison, D. B. (2010) · Human Genetics · doi:10.1007/s00439-010-0935-z · Cited by 75
The genetics of childhood obesity and interaction with dietary macronutrients
Garver, W. S., Newman, S. B., Gonzales‐Pacheco, D., Castillo, J., Jelínek, D., Heidenreich, R. A., & Orlando, R. A. (2013) · Genes & Nutrition · doi:10.1007/s12263-013-0339-5 · Cited by 81
Metabolic Diseases and Down Syndrome: How Are They Linked Together?
Moreau, M., Benhaddou, S., Dard, R., Tolu, S., Hamzé, R., Vialard, F., Movassat, J., & Janel, N. (2021) · Biomedicines · doi:10.3390/biomedicines9020221 · Cited by 76
Transferability and Fine Mapping of Type 2 Diabetes Loci in African Americans
Ng, M. C. Y., Saxena, R., Li, J., Palmer, N. D., Dimitrov, L., Xu, J., Rasmussen-Torvik, L. J., Zmuda, J. M., Siscovick, D. S., Patel, S. R., et al. (2013) · Diabetes · doi:10.2337/db12-0266 · Cited by 62
Analysis of Positive Selection at Single Nucleotide Polymorphisms Associated with Body Mass Index Does Not Support the “Thrifty Gene” Hypothesis
Wang, G., & Speakman, J. R. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.014 · Cited by 61
Genetics of Type 2 Diabetes in East Asian Populations
Cho, Y. S., Lee, J., Park, K. S., & Nho, C. W. (2012) · Current Diabetes Reports · doi:10.1007/s11892-012-0326-z · Cited by 57
MicroRNA Regulators of Anxiety and Metabolic Disorders
Meydan, C., Shenhar‐Tsarfaty, S., & Soreq, H. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.07.001 · Cited by 52
Genetics: A Starting Point for the Prevention and the Treatment of Obesity
Novelli, G., Cassadonte, C., Sbraccia, P., & Biancolella, M. (2023) · Nutrients · doi:10.3390/nu15122782 · Cited by 54
Pacific Populations, Metabolic Disease and ‘Just‐So Stories’: A Critique of the ‘Thrifty Genotype’ Hypothesis in Oceania
Gosling, A. L., Buckley, H. R., Matisoo-Smith, E. A., & Merriman, T. R. (2015) · Annals of Human Genetics · doi:10.1111/ahg.12132 · Cited by 51
Geographic differences in allele frequencies of susceptibility SNPs for cardiovascular disease
Ding, K., & Kullo, I. J. (2011) · BMC Medical Genetics · doi:10.1186/1471-2350-12-55 · Cited by 77
Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Glycaemic Traits
Marullo, L., Moustafa, J. S. E.-S., & Prokopenko, I. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0551-8 · Cited by 48
Obesity: an evolutionary context
Speakman, J. R., & Elmquist, J. K. (2022) · Life Metabolism · doi:10.1093/lifemeta/loac002 · Cited by 52
Positive selection of protective variants for type 2 diabetes from the Neolithic onward: a case study in Central Asia
Ségurel, L., Austerlitz, F., Toupance, B., Gautier, M., Kelley, J. L., Pasquet, P., Lonjou, C., Georges, M., Voisin, S. A. C., Cruaud, C., et al. (2013) · European Journal of Human Genetics · doi:10.1038/ejhg.2012.295 · Cited by 41
The melatonin receptor 1B gene links circadian rhythms and type 2 diabetes mellitus: an evolutionary story
Zhu, H., Zhao, Z., Liu, H., Cai, J., Lu, Q., Ji, L., & Xu, J. (2023) · Annals of Medicine · doi:10.1080/07853890.2023.2191218 · Cited by 43
A mathematical model of weight loss under total starvation: evidence against the thrifty-gene hypothesis
Speakman, J. R., & Westerterp, K. R. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.010009 · Cited by 41
Type 2 diabetes mellitus, its impact on quality of life and how the disease can be managed-a review
Garg, P., & Duggal, N. (2022) · Obesity Medicine · doi:10.1016/j.obmed.2022.100459 · Cited by 55
Intrauterine Programming of Diabetes and Adiposity
Tomar, A. S., Tallapragada, D. S. P., Nongmaithem, S. S., Shrestha, S., Yajnik, C. S., & Chandak, G. R. (2015) · Current Obesity Reports · doi:10.1007/s13679-015-0175-6 · Cited by 39
Revisiting the evolutionary origins of obesity: lazy versus peppy‐thrifty genotype hypothesis
Reddon, H., Patel, Y. S., Turcotte, M., Pigeyre, M., & Meyre, D. (2018) · Obesity Reviews · doi:10.1111/obr.12742 · Cited by 38
Translational potential of mouse models of human metabolic disease
Farooqi, I. S., & Xu, Y. (2024) · Cell · doi:10.1016/j.cell.2024.07.011 · Cited by 37
The Microbiota and Evolution of Obesity
Saad, M. J. A., & Santos, A. (2024) · Endocrine Reviews · doi:10.1210/endrev/bnae033 · Cited by 37
Transferred maternal fatty acids stimulate fetal adipogenesis and lead to neonatal and adult obesity
Szabo, A. J. (2018) · Medical Hypotheses · doi:10.1016/j.mehy.2018.10.022 · Cited by 31
Is there an impatience genotype leading to non-adherence to long-term therapies?
Reach, G. (2010) · Diabetologia · doi:10.1007/s00125-010-1755-3 · Cited by 26
Examining the growing challenge: Prevalence of diabetes in young adults (Review)
Murtaza, G., Riaz, S., Zafar, M., Raza, M. A., Kaleem, I., Imran, H., Al‑Harbi, A., Sabouri, A., Niaz, T. A., & Bashir, S. (2024) · Medicine International · doi:10.3892/mi.2024.201 · Cited by 25
Signatures of natural selection on genetic variants affecting complex human traits
Zhang, G., Muglia, L. J., Chakraborty, R., Akey, J. M., & Williams, S. M. (2013) · Applied & Translational Genomics · doi:10.1016/j.atg.2013.10.002 · Cited by 25
The Ethnoepidemiology of Obesity
Valéra, B., Sohani, Z. N., Rana, A., Poirier, P., & Anand, S. S. (2014) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2014.10.005 · Cited by 24
Commentary: The Invention of Aboriginal Diabetes: The Role of the Thrifty Gene Hypothesis in Canadian Health Care Provision
Hay, T. (2018) · Ethnicity & Disease · doi:10.18865/ed.28.s1.247 · Cited by 21
Race, regionality and pre-diabetes in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study
Lee, L. T., Alexandrov, A. W., Howard, V. J., Kabagambe, E. K., Hess, M. A., McLain, R. M., Safford, M. M., & Howard, G. (2014) · Preventive Medicine · doi:10.1016/j.ypmed.2014.02.013 · Cited by 18
Evolutionary triangulation: informing genetic association studies with evolutionary evidence
Huang, M., Graham, B. E., Zhang, G., Harder, R., Kodaman, N., Moore, J. H., Muglia, L. J., & Williams, S. M. (2016) · BioData Mining · doi:10.1186/s13040-016-0091-7 · Cited by 19
The Importance of Global Studies of the Genetics of Type 2 Diabetes
McCarthy, M. I. (2011) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2011.35.2.91 · Cited by 17
Evolution of Obesity
Speakman, J. R. (2015) · Springer eBooks · doi:10.1007/978-3-319-12125-3_9-1 · Cited by 18
Epidemiology of Type 2 Diabetes in Indigenous Communities in the United States
WEDEKIND, L. E., Mitchell, C. M., Andersen, C. C., Knowler, W. C., & Hanson, R. L. (2021) · Current Diabetes Reports · doi:10.1007/s11892-021-01406-3 · Cited by 18
Colorectal cancer risk and patients’ survival: influence of polymorphisms in genes somatically mutated in colorectal tumors
Huhn, S., Bevier, M., Pardini, B., Naccarati, A., Vodičková, L., Novotný, J. P., Vodička, P., Hemminki, K., & Försti, A. (2014) · Cancer Causes & Control · doi:10.1007/s10552-014-0379-1 · Cited by 16
Genetic Determinants of Type 2 Diabetes in Asians
Qi, Q., Wang, X., Strizich, G., & Wang, T. (2015) · International Journal of Diabetology & Vascular Disease Research · doi:10.19070/2328-353x-si01001 · Cited by 19
Metabolic Syndrome
Lanktree, M. B., & Hegele, R. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-800685-6.00015-1 · Cited by 15
Can Evidence from Genome-Wide Association Studies and Positive Natural Selection Surveys Be Used to Evaluate the Thrifty Gene Hypothesis in East Asians?
Koh, X.-H., Liu, X., & Teo, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110974 · Cited by 14
Adaptive genetic variation and heart disease risk
Parnell, L. D., Lee, Y., & Lai, C. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283378e42 · Cited by 14
Understanding the contemporary high obesity rate from an evolutionary genetic perspective
Wu, T., & Xu, S. (2023) · Hereditas · doi:10.1186/s41065-023-00268-x · Cited by 18
Evidence of Polygenic Adaptation in the Systems Genetics of Anthropometric Traits
Polimanti, R. A., Yang, B. Z., Zhao, H., & Gelernter, J. E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160654 · Cited by 13
Signatures of Natural Selection at the FTO (Fat Mass and Obesity Associated) Locus in Human Populations
Liu, X., Weidle, K., Schröck, K., Tönjes, A., Schleinitz, D., Breitfeld, J., Stümvoll, M., Böttcher, Y., Schöneberg, T., & Kovacs, P. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117093 · Cited by 13
Irrational use of antibiotics and the risk of diabetes in Ghana
Mensah, K. B., & Ansah, C. (2016) · Ghana Medical Journal · doi:10.4314/gmj.v50i2.9 · Cited by 11
Behaviors and Characteristics of African American and European American Females That Impact Weight Management
Capers, C. F., Baughman, K. R., & Logue, E. E. (2011) · Journal of Nursing Scholarship · doi:10.1111/j.1547-5069.2011.01393.x · Cited by 10
Deciphering Biochemical and Molecular Signatures Associated with Obesity in Context of Metabolic Health
Masih, D., Tripathi, J. K., Rakhra, G., Vats, A., Verma, S. K., Jha, P. K., Sharma, M., Ashraf, M. Z., & Singh, S. N. (2021) · Genes · doi:10.3390/genes12020290 · Cited by 9
Evidence of selection at insulin receptor substrate-1 gene loci
Yoshiuchi, I. (2012) · Acta Diabetologica · doi:10.1007/s00592-012-0414-1 · Cited by 9
Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases
Huhn, S., Bevier, M., Rudolph, A., Pardini, B., Naccarati, A., Hein, R., Hoffmeister, M., Vodičková, L., Novotný, J. P., Brenner, H., et al. (2012) · BMC Medical Genetics · doi:10.1186/1471-2350-13-94 · Cited by 8
A global evolutionary and metabolic analysis of human obesity gene risk variants
Castillo, J., Hazlett, Z. S., Orlando, R. A., & Garver, W. S. (2017) · Gene · doi:10.1016/j.gene.2017.07.002 · Cited by 8
Genome-Wide Association Studies of Type 2 Diabetes
SLADEK, R. M., & Prokopenko, I. (2016) · Springer eBooks · doi:10.1007/978-3-319-01574-3_2 · Cited by 7
Evidence for natural selection at the melanocortin-3 receptor gene in European and African populations
Yoshiuchi, I. (2016) · Acta Diabetologica · doi:10.1007/s00592-016-0846-0 · Cited by 8
Two SNPs Associated with Type 2 Diabetes and Obesity at Melanocortin-4 Receptor Gene Loci Exhibited High Fst Values and Natural Selection
Yoshiuchi, I. (2012) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.s11-005 · Cited by 7
Integrating the Thrifty Genotype and Evolutionary Mismatch Hypotheses to understand variation in cardiometabolic disease risk
Brassington, L., Arner, A. M., Watowich, M. M., Damstedt, J., Ng, K. S., Lim, Y. A. L., Venkataraman, V. V., Wallace, I. J., Kraft, T. S., & Lea, A. J. (2024) · Evolution Medicine and Public Health · doi:10.1093/emph/eoae014 · Cited by 11
Native Hawaiian and Pacific Islander populations in genomic research
Ha, E. K., Shriner, D., Callier, S., Riley, L., Adeyemo, A., Rotimi, C. N., & Bentley, A. R. (2024) · npj Genomic Medicine · doi:10.1038/s41525-024-00428-6 · Cited by 6
SH2B1 Tunes Hippocampal ERK Signaling to Influence Fluid Intelligence in Humans and Mice
Du, X., Yan, Y., Yu, J., Zhu, T., Huang, C., Zhang, L., Shan, X., Li, R., Dai, Y., Lv, H., et al. (2023) · Research · doi:10.34133/research.0269 · Cited by 6
Polymorphisms in CTNNBL1 in relation to colorectal cancer with evolutionary implications.
Huhn, S., Ingelfinger, D., Bermejo, J. L., Bevier, M., Pardini, B., Naccarati, A., Steinke, V., Rahner, N., Holinski‐Feder, E., Morak, M., et al. (2011) · PubMed · Cited by 6
The role of diet, lifestyle, and genes
Hu, F. B. (2011) · Cited by 6
Assessment of the potential role of natural selection in type 2 diabetes and related traits across human continental ancestry groups: comparison of phenotypic with genotypic divergence
Hanson, R. L., Hout, C. V. V., Hsueh, W., Shuldiner, A. R., Kobes, S., Sinha, M., Baier, L. J., & Knowler, W. C. (2020) · Diabetologia · doi:10.1007/s00125-020-05272-8 · Cited by 7
Health Disparities Among Indigenous Peoples: Exploring the Roles of Evolutionary and Developmental Mismatch on Cardiometabolic Health
Gurven, M., Sarrieddine, A., & Lea, A. J. (2024) · Annual Review of Anthropology · doi:10.1146/annurev-anthro-041222-101445 · Cited by 5
Future management of human obesity: understanding the meaning of genetic susceptibility
Jenkins, A. B., & Campbell, L. V. (2014) · Advances in Genomics and Genetics · doi:10.2147/agg.s53594 · Cited by 7
Analysis of Evolution and Ethnic Diversity at Glucose-Associated SNPs of Circadian Clock-Related Loci with Cryptochrome 1, Cryptochrome 2, and Melatonin receptor 1B
Yoshiuchi, I. (2021) · Biochemical Genetics · doi:10.1007/s10528-021-10045-y · Cited by 5
Climate Change and Type 2 Diabetes
Shubair, M. M., Haider, M., & Bassa, M. (2013) · Journal of Endocrinology and Diabetes Mellitus · Cited by 5
Examining How Our Shared Evolutionary History Shapes Future Disease Outcomes
Ayele, F. T., & Peprah, E. K. (2017) · Global Heart · doi:10.1016/j.gheart.2017.01.008 · Cited by 4
Metabolic Syndrome
Lanktree, M. B., & Hegele, R. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801812-5.00015-9 · Cited by 9
Genetics of Diabetes: Are They Thrifty Genotype?
Inoue, I., & Nakaoka, H. (2017) · Evolutionary studies · doi:10.1007/978-4-431-56603-8_13 · Cited by 4
The Metabolic Syndrome
Lanktree, M. B., JOY, T. R., & Hegele, R. A. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382227-7.00083-5 · Cited by 5
Ancestral susceptibility to colorectal cancer
Huhn, S., Pardini, B., Naccarati, A., Vodička, P., Hemminki, K., & Försti, A. (2012) · Mutagenesis · doi:10.1093/mutage/ger061 · Cited by 3
Effects of subtotal pancreatectomy and long‐term glucose and lipid overload on insulin secretion and glucose homeostasis in minipigs
Goutchtat, R., Quenon, A., Clarisse, M., Delalleau, N., Coddeville, A., Gobert, M., Gmyr, V., Kerr-Conte, J. A., Pattou, F. N., & Hübert, T. (2023) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.425 · Cited by 3
Ancestral diets and modern diseases
Sudano, M., & Gregorio, F. (2011) · Mediterranean Journal of Nutrition and Metabolism · doi:10.1007/s12349-011-0067-6 · Cited by 4
Variation at Diabetes- and Obesity-Associated Loci May Mirror Neutral Patterns of Human Population Diversity and Diabetes Prevalence in India
Raj, S. M., Halebeedu, P. P., Kadandale, J. S., Lahr, M. M., Romero, I. G., Yadhav, J. R., Iliescu, M., Rai, N., Crivellaro, F., Chaubey, G., et al. (2013) · Annals of Human Genetics · doi:10.1111/ahg.12028 · Cited by 3
The concept of adaptive types in modern human ecology research
Козлов, А. И. (2024) · Moscow University Anthropology Bulletin (Vestnik Moskovskogo Universiteta Seria XXIII Antropologia) · doi:10.55959/msu2074-8132-24-4-5 · Cited by 2
Unlocking Ethiopia’s genomic landscape and its global significance: a call for inclusive genomics research
Degechisa, S. T., & Baye, T. M. (2026) · Human Genomics · doi:10.1186/s40246-025-00878-8 · Cited by 2
The complex web of obesity: from genetics to precision medicine
Nair, J. M., & Bharadwaj, D. (2024) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2024.2365785 · Cited by 3
Progress, pitfalls, and prospects
Franks, P. W., Pearson, E. R., & Florez, J. C. (2013) · Cited by 2
Evolution of Obesity
Speakman, J. R. (2016) · Springer eBooks · doi:10.1007/978-3-319-11251-0_9 · Cited by 2
Modern interpretations of evolutionary, anthropological and ecological aspects of the “thrifty genotype” hypothesis
Козлов, А. И., Gasanov, E. V., & Parfenteva, O. I. (2023) · Moscow University Anthropology Bulletin (Vestnik Moskovskogo Universiteta Seria XXIII Antropologia) · doi:10.32521/2074-8132.2023.4.047-057 · Cited by 2
Diabetes and Health Care: An Overview
Abhilash, M., & Augustine, R. (2014) · Apple Academic Press eBooks · doi:10.1201/b16415-6 · Cited by 2
Diabetes and Health Care
Abhilash, M., & Augustine, R. (2014) · Apple Academic Press eBooks · doi:10.1201/b16415-2 · Cited by 1
Analysis of genetic selection at insulin receptor substrate-2 gene loci
Yoshiuchi, I. (2021) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-021-00745-y · Cited by 1
Evolution of Obesity
Speakman, J. R. (2023) · Springer eBooks · doi:10.1007/978-3-031-40116-9_9 · Cited by 1
Traditional Ethnic Diets, Genetic Pre-Susceptibility and Gene-Diet Interaction Associations with Type 2 Diabetes and Risk Factors
Mercado, C. I. (2012) · ResearchWorks at the University of Washington (University of Washington) · Cited by 1
Progresión del Síndrome Metabólico desde el feto a la adolescencia. Cuando la inflamación toca la puerta
Aguirre, M., Rojas, J., & Souki, A. J. (2011)
Insulin Resistance, Metabolic Syndrome, and Therapy
Levine, T. B., & Levine, A. B. (2012) · Wiley eBooks · doi:10.1002/9781118480045.ch15
Nouvelle remise en cause de la thèse du génotype économe
Cauchi, S. (2014) · Médecine des Maladies Métaboliques · doi:10.1016/s1957-2557(14)70765-5
Will we ever cure diabetes?
Maddaloni, E., & Pozzilli, P. (2014) · Diabetes Management · doi:10.2217/dmt.14.6
Diabetes in Native Chicago
POLLAK, M. (2021) · University of Nebraska Press eBooks · doi:10.5250/9781496212061
Evidence for Natural Selection and Ethnic Diversity at the Adenylate cyclase 3 Gene Associated with Obesity and Type 2 DiabetesPreprint
Yoshiuchi, I. (2020) · Research Square · doi:10.21203/rs.3.rs-18469/v1
Current literature in diabetes
(2010) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1015
How Human Became Fat? An Anthropological Approach to the Development of Fatnessin Humans
Devi, N. K., Murry, B., Bindhani, B. K., & Saraswathy, K. N. (2023) · The Oriental Anthropologist A Bi-annual International Journal of the Science of Man · doi:10.1177/0972558x231158793
Análise do componente genético do Diabetes Mellitus tipo 2
Mota, D. M. D. (2024) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.76.2024.tde-20032024-084845

Authors: Southam, L., Soranzo, N., Montgomery, S. B., Frayling, T. M., McCarthy, M. I., Barroso, I., & Zeggini, E.
Affiliations: Centre for Human Genetics (GB)
St Thomas' Hospital (GB)
Wellcome Sanger Institute (GB)
University of Exeter (GB)
Corresponding author: Zeggini, E.
ORCID: Southam, L.
Soranzo, N.
Montgomery, S. B.
Frayling, T. M.
McCarthy, M. I.
Barroso, I.
Zeggini, E.
Venue: Diabetologia
Publisher: Springer Science and Business Media LLC
Published: 2009-06-13
Volume: 52
Issue: 9
Pages: 1846-1851
ISSN: 0012-186X (ISSN-L)
1432-0428
DOI: 10.1007/s00125-009-1419-3
PMC: PMC2723682
OpenAlex: W2071881237
Cited by: 103
References: 15
Citations by year: 2026: 1 · 2025: 2 · 2024: 9 · 2023: 8 · 2022: 2 · 2021: 6 · 2020: 2 · 2018: 5 · 2017: 7 · 2016: 9 · 2015: 6 · 2014: 12 · 2013: 8 · 2012: 13
FWCI: 5.04
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: Diabetologia (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust (WT077016/Z/05/Z, 088885, 077016, WT088885/Z/09/Z, 079557)
National Institute for Health and Care Research
Medical Research Council (G0601261)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords: thrifty genotype hypothesis, type 2 diabetes, obesity, genetic susceptibility loci, positive selection, integrated haplotype score, fixation index, TCF7L2
MeSH terms: Diabetes Mellitus, Type 2, Food Supply, Gene Frequency, Genotype, Humans, Models, Genetic, Obesity, Risk Factors, Selection, Genetic, Prevalence, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks