Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
Open accessAbstract
Obesity results from the interaction of genetic and environmental factors. To search for sequence variants that affect variation in two common measures of obesity, weight and body mass index (BMI), both of which are highly heritable, we performed a genome-wide association (GWA) study with 305,846 SNPs typed in 25,344 Icelandic, 2,998 Dutch, 1,890 European Americans and 1,160 African American subjects and combined the results with previously published results from the Diabetes Genetics Initiative (DGI) on 3,024 Scandinavians. We selected 43 variants in 19 regions for follow-up in 5,586 Danish individuals and compared the results to a genome-wide study on obesity-related traits from the GIANT consortium. In total, 29 variants, some correlated, in 11 chromosomal regions reached a genome-wide significance threshold of P < 1.6 x 10(-7). This includes previously identified variants close to or in the FTO, MC4R, BDNF and SH2B1 genes, in addition to variants at seven loci not previously connected with obesity.
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- Authors
- Thorleifsson, G., Walters, G. B., Gudbjartsson, D. F., Steinthorsdottir, V., Sulem, P., Helgadottir, A., Styrkarsdottir, U., Gretarsdottir, S., Thorlacius, S., Jonsdottir, I., Jonsdottir, T., Olafsdottir, E. J., Olafsdottir, G. H., Jonsson, T., Jonsson, F., Borch-Johnsen, K., Hansen, T., Andersen, G., Jorgensen, T., Lauritzen, T., Aben, K. K., Verbeek, A. L., Roeleveld, N., Kampman, E., Yanek, L. R., Becker, L. C., Tryggvadottir, L., Rafnar, T., Becker, D. M., Gulcher, J., Kiemeney, L. A., Pedersen, O., Kong, A., Thorsteinsdottir, U., & Stefansson, K.
- Affiliations
- deCODE Genetics (Iceland) (IS)
- Steno Diabetes Center Copenhagen (DK)
- Aarhus University (DK)
- Radboud University Nijmegen (NL)
- Johns Hopkins University (US)
- University of Copenhagen (DK)
- ORCID
- Venue
- Nature Genetics
- Published
- 2008-12-14
- Volume
- 41
- Issue
- 1
- Pages
- 18-24
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2163144326
- Cited by
- 1,375
- References
- 36
- Citations by year
- 2026: 11 · 2025: 20 · 2024: 49 · 2023: 50 · 2022: 45 · 2021: 57 · 2020: 68 · 2019: 57 · 2018: 60 · 2017: 75 · 2016: 67 · 2015: 96 · 2014: 83 · 2013: 146 · 2012: 107
- FWCI
- 72.56
- Type
- journal article
- Language
- en
- Open access
- green
- research.wur.nl
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL087698, U01HL072518, HL072518, HL087698)
- National Center for Research Resources (M01RR000052)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Keywords
- obesity, body mass index, weight, genetic loci, single nucleotide polymorphisms, FTO, MC4R gene, BDNF gene, central nervous system gene expression, dietary intake, genetic susceptibility, replication study
- MeSH terms
- Base Sequence, Body Weight, Diabetes Mellitus, Type 2, Gene Expression Regulation, Humans, Obesity, Genome, Human, Body Mass Index, Quantitative Trait, Heritable, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Genome-Wide Association Study
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