Cancer and diabetes: are we ready for prime time?
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The underlying mechanisms of tumorigenesis in type 2 diabetes seem related to insulin resistance, hyperinsulinemia, elevated IGF-1, and hyperglycemia driving ATP production in cancer cells through the glycolytic pathway (Warburg effect).
“The underlying mechanisms of tumorigenesis in T2DM seem to be related to insulin resistance, hyperinsulinemia, elevated levels of IGF-1 [140-142], and hyperglycemia with the latter driving ATP production in cancer cells through the glycolytic pathway, a mechanism known as the Warburg effect [142].”
From Metformin: An Old But Still the Best Treatment for Type 2 Diabetes (2013) · cites this paper as [142]
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- Authors
- Smith, U., & Gale, E. A. M.
- Affiliations
- Sahlgrenska University Hospital (SE)
- Southmead Hospital (GB)
- Corresponding author
- Gale, E. A. M.
- ORCID
- Smith, U.
- Venue
- Diabetologia
- Published
- 2010-06-13
- Volume
- 53
- Issue
- 8
- Pages
- 1541-1544
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W1968802243
- Cited by
- 73
- References
- 15
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 9 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 10 · 2014: 9 · 2013: 3 · 2012: 6
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Explore Bristol Research (submittedVersion)
- Bristol Research (University of Bristol) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Keywords
- cancer, diabetes mellitus, diabetes and cancer risk, cancer prevention
- MeSH terms
- Diabetes Mellitus, Type 2, Humans, Neoplasms
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