Cited by 141Metabolism, Diabetes, and CancerCancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Challenges and Perspectives in the Treatment of Diabetes Associated Breast Cancer

Open access
Samuel, Samson Mathews, Varghese, Elizabeth, Varghese, Sharon, Büsselberg, Dietrich·2018·Cancer Treatment Reviews

Abstract

Type 2 diabetes mellitus is one of the most common chronic disease worldwide and affects all cross-sections of the society including children, women, youth and adults. Scientific evidence has linked diabetes to higher incidence, accelerated progression and increased aggressiveness of different cancers. Among the different forms of cancer, research has reinforced a link between diabetes and the risk of breast cancer. Some studies have specifically linked diabetes to the highly aggressive, triple negative breast cancers (TNBCs) which do not respond to conventional hormonal/HER2 targeted interventions, have chances of early recurrence, metastasize, tend to be more invasive in nature and develop drug resistance. Commonly used anti-diabetic drugs, such as metformin, have recently gained importance in the treatment of breast cancer due to their proposed anti-cancer properties. Here we discuss the link between diabetes and breast cancer, the metabolic disturbances in diabetes that support the development of breast cancer, the challenges involved and future perspective and directions. We link the three main metabolic disturbances (dyslipidemia, hyperinsulinemia and hyperglycemia) that occur in diabetes to potential aberrant molecular pathways that may lead to the development of an oncogenic phenotype of the breast tissue, thereby leading to acceleration of cell growth, proliferation, migration, inflammation, angiogenesis, EMT and metastasis and inhibition of apoptosis in breast cancer cells. Furthermore, managing diabetes and treating cancer using a combination of anti-diabetic and classical anti-cancer drugs should prove to be more efficient in the treatment diabetes associated cancers.

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Crossref · 10.1016/j.ctrv.2018.08.004

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213 of 213 references verified0 citation errors · 0 not checkable

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  • The metabolic changes that occur as a result of diabetes (hyperinsulinemia, hyperglycemia, and dyslipidemia) potentiate signaling pathways and may increase the oncogenic nature of breast tissue through accelerating cell growth and migration, angiogenesis, increasing metastasis, and decreasing the response to chemotherapy.

    “The metabolic changes that occur as a result of diabetes (hyperinsulinemia, hyperglycemia, and dyslipidemia) potentiate signaling pathways and may increase the oncogenic nature of breast tissue through accelerating cell growth and migration, angiogenesis, increasing metastasis, and decreasing the response to chemotherapy (158, 244–247).”

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Authors
Samuel, S. M., Varghese, E., Varghese, S., & Büsselberg, D.
Affiliations
Weill Cornell Medical College in Qatar (QA)
Corresponding author
Büsselberg, Dietrich
Venue
Cancer Treatment Reviews
Publisher
Elsevier BV
Published
2018-11
Volume
70
Pages
98-111
ISSN
0305-7372 (ISSN-L)
OpenAlex
W2887292818
Cited by
141
References
215
Citations by year
2026: 10 · 2025: 20 · 2024: 27 · 2023: 22 · 2022: 18 · 2021: 21 · 2020: 9 · 2019: 10 · 2018: 3
FWCI
1.05
Type
journal article
Language
en
Open access
Locations
  • Cancer Treatment Reviews (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
Qatar Foundation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords
type 2 diabetes, breast cancer, triple-negative breast cancer, metformin, dyslipidemia, hyperinsulinemia, hyperglycemia, metabolic disorders, tumor progression, metastasis, epithelial-mesenchymal transition, angiogenesis, inflammation, apoptosis, combination therapy
MeSH terms
Antineoplastic Agents, Breast Neoplasms, Diabetes Mellitus, Type 2, Female, Humans, Hypoglycemic Agents, Prognosis, Comorbidity

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