Adipocyte-specific deficiency of Janus kinase (JAK) 2 in mice impairs lipolysis and increases body weight, and leads to insulin resistance with ageing
Abstract
Aims/hypothesis The growing obesity epidemic necessitates a better understanding of adipocyte biology and its role in metabolism. The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway mediates signalling by numerous cytokines and hormones that regulate adipocyte function, illustrating the physiological importance of adipose JAK-STAT. The aim of this study was to investigate potential roles of adipocyte JAK2, an essential player in the JAK-STAT pathway, in adipocyte biology and metabolism. Methods We generated adipocyte-specific Jak2 knockout (A-Jak2 KO) mice using the Cre-loxP system with Cre expression driven by the Ap2 (also known as Fabp4) promoter. Results Starting at 2-3 months of age, male and female A-Jak2 KO mice gradually gained more body weight than control littermates primarily due to increased adiposity. This was associated with reduced energy expenditure in A-Jak2 KO mice. In perigonadal adipose tissue, the expression of numerous genes involved in lipid metabolism was differentially regulated. In addition, adipose tissue from A-Jak2 KO mice displayed impaired lipolysis in response to isoprenaline, growth hormone and leptin stimulation, suggesting that adipose JAK2 directly modulates the lipolytic program. Impaired lipid homeostasis was also associated with disrupted adipokine secretion. Accordingly, while glucose metabolism was normal at 2 months of age, by 5-6 months of age, A-Jak2 KO mice had whole-body insulin resistance. Concl…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Adipocyte-specific JAK2-KO mice have impaired lipolysis and increased body weight through decreased STAT3 activation, which results in insulin resistance with ageing.
“adipocyte-specific JAK2-KO mice have impaired lipolysis and increased body weight through decreased STAT3 activation, which results in insulin resistance with ageing (Shi et al., 2014).”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Shi et al., 2014
Cites
Insulin signalling and the regulation of glucose and lipid metabolism
Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326 · see citing works
The global obesity pandemic: shaped by global drivers and local environments
Swinburn, B. A., Sacks, G., Hall, K. D., McPherson, K., Finegood, D. T., Moodie, M. L., & Gortmaker, S. L. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60813-1 · Cited by 4,888 · see citing works
Obesity and insulin resistance
Kahn, B. B., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10842 · Cited by 3,283 · see citing works
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.
Guilherme, A., Virbasius, J. V., Puri, V., & Czech, M. P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2391 · Cited by 2,292 · see citing works
Adipose tissue remodeling and obesity
Sun, K., Kusminski, C. M., & Scherer, P. E. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45887 · Cited by 1,941 · see citing works
Teglund, S., McKay, C., Schuetz, E. G., van Deursen, J. M., Stravopodis, D. J., Wang, D., Brown, M. P., Bodner, S. M., Grosveld, G. C., & Ihle, J. N. (1998) · Cell · doi:10.1016/s0092-8674(00)81444-0 · Cited by 1,266 · see citing works
He, W., Barak, Y., Hevener, A. L., Olson, P., Liao, D., Le, J., Nelson, M. C., Ong, E. S., Olefsky, J. M., & Evans, R. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536828100 · Cited by 978 · see citing works
Blüher, M., Michael, M. D., Peroni, O. D., Ueki, K., Carter, N., Kahn, B. B., & Kahn, C. R. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00199-5 · Cited by 806 · see citing works
Interleukin-6 stimulates lipolysis and fat oxidation in humans
van Hall, G., Steensberg, A., Sacchetti, M., Fischer, C., Keller, C., Schjerling, P., Hiscock, N., Møller, K., Saltin, B., Febbraio, M. A., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021687 · Cited by 767 · see citing works
Direct effects of leptin on brown and white adipose tissue.
Siegrist-Kaiser, C. A., Pauli, V., Juge-Aubry, C. E., Boss, O., Pernin, A., Chin, W. W., Cusin, I., Rohner‐Jeanrenaud, F., Burger, A. G., Zapf, J., et al. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119834 · Cited by 366 · see citing works
Leptin controls adipose tissue lipogenesis via central, STAT3–independent mechanisms
Buettner, C., Muse, E. D., Cheng, A. M., Chen, L., Scherer, T., Pocai, A., Su, K., Cheng, B., Li, X., Harvey-White, J. D., et al. (2008) · Nature Medicine · doi:10.1038/nm1775 · Cited by 342 · see citing works
Hunt, C. R., Ro, J., Dobson, D. E., Min, H. Y., & Spiegelman, B. M. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.3786 · Cited by 329 · see citing works
Lemonnier, D. (1972) · Journal of Clinical Investigation · doi:10.1172/jci107115 · Cited by 315 · see citing works
Regulation of lipogenic enzyme gene expression by nutrients and hormones
Girard, J. R., Perdereau, D., Foufelle, F., Prip‐Buus, C., & Ferré, P. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.1.7905448 · Cited by 265 · see citing works
Interleukin-6 Regulates Human Adipose Tissue Lipid Metabolism and Leptin Productionin Vitro
Trujillo, M. E., Sullivan, S., Harten, I. A., Schneider, S. H., Greenberg, A. S., & Fried, S. K. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0603 · Cited by 249 · see citing works
Wagner, K., Krempler, A., Triplett, A. A., Qi, Y., George, N. M., Zhu, J., & Rui, H. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.12.5510-5520.2004 · Cited by 249 · see citing works
Gene expression profile of omental adipose tissue in human obesity
Gómez‐Ambrosi, J., Catalán, V., Diez-Caballero, A., Martínez‐Cruz, L. A., Gil, M. J., García‐Foncillas, J., Cienfuegos, J. A., Salvador, J., Mato, J. M., & Frühbeck, G. (2003) · The FASEB Journal · doi:10.1096/fj.03-0591fje · Cited by 173 · see citing works
The Role of GH in Adipose Tissue: Lessons from Adipose-Specific GH Receptor Gene-Disrupted Mice
List, E. O., Berryman, D. E., Funk, K. R., Sustarsic, E. G., Jara, A., Kelder, B., Wang, X., Kutz, L. C., Troike, K. M., Lozier, N. R., et al. (2013) · Molecular Endocrinology · doi:10.1210/me.2012-1330 · Cited by 142 · see citing works
Floyd, Z. E., & Stephens, J. M. (2003) · Diabetes · doi:10.2337/diabetes.52.2.308 · Cited by 140 · see citing works
Sos, B. C., Harris, C. A., Nordstrom, S. M., Tran, J. L., Balázs, M., Caplazi, P., Febbraio, M., Applegate, M. A. B., Wagner, K., & Weiss, E. J. (2011) · Journal of Clinical Investigation · doi:10.1172/jci42894 · Cited by 135 · see citing works
Zhang, K., Guo, W., Yang, Y., & Wu, J. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22936 · Cited by 134 · see citing works
Erythropoietin protects against diabetes through direct effects on pancreatic β cells
Choi, D., Schroer, S. A., Lu, S. Y., Wang, L., Wu, X., Liu, Y., Zhang, Y., Gaisano, H. Y., Wagner, K., Wu, H., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100665 · Cited by 128 · see citing works
Self-citationUrs, S., Harrington, A. N., Liaw, L., & Small, D. J. (2006) · Transgenic Research · doi:10.1007/s11248-006-9000-z · Cited by 112 · see citing works
Huan, J., Li, J., Han, Y., Chen, K., Wu, N. L., & Zhao, A. Z. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304165200 · Cited by 109 · see citing works
Emerging roles of JAK–STAT signaling pathways in adipocytes
Richard, A. J., & Stephens, J. M. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.03.007 · Cited by 108 · see citing works
Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice
Krempler, A., Qi, Y., Triplett, A. A., Zhu, J., Rui, H., & Wagner, K. (2004) · genesis · doi:10.1002/gene.20063 · Cited by 98 · see citing works
Stimulation of 3T3-L1 Adipogenesis by Signal Transducer and Activator of Transcription 5
Nanbu-Wakao, R., Morikawa, Y., Matsumura, I., Masuho, Y., Muramatsu, M., Senba, E., & Wakao, H. (2002) · Molecular Endocrinology · doi:10.1210/mend.16.7.0862 · Cited by 96 · see citing works
Cernkovich, E. R., Deng, J., Bond, M. C., Combs, T. P., & Harp, J. B. (2008) · Endocrinology · doi:10.1210/en.2007-1148 · Cited by 87 · see citing works
The Regulation and Activation of Ciliary Neurotrophic Factor Signaling Proteins in Adipocytes
Zvonic, S., Cornelius, P. K., Stewart, W. C., Mynatt, R. L., & Stephens, J. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m205871200 · Cited by 76 · see citing works
Shi, S. Y., García-Martín, R., Duncan, R. E., Choi, D., Lu, S.-Y., Schroer, S. A., Cai, E. P., Luk, C. T., Hopperton, K. E., Domenichiello, A. F., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.317453 · Cited by 72 · see citing works
Self-citationList, E. O., Palmer, A. J., Berryman, D. E., Bower, B., Kelder, B., & Kopchick, J. J. (2009) · Diabetologia · doi:10.1007/s00125-009-1402-z · Cited by 71 · see citing works
Fain, J. N., Ihle, J. N., & Bahouth, S. W. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1302 · Cited by 67 · see citing works
Yarwood, S. J., Sale, E. M., Sale, G. J., Houslay, M. D., Kilgour, E., & Anderson, N. G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.8662 · Cited by 66 · see citing works
Shang, C. A., & Waters, M. J. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0139 · Cited by 65 · see citing works
Disruption of JAK2 in Adipocytes Impairs Lipolysis and Improves Fatty Liver in Mice With Elevated GH
Nordstrom, S. M., Tran, J. L., Sos, B. C., Wagner, K., & Weiss, E. J. (2013) · Molecular Endocrinology · doi:10.1210/me.2013-1110 · Cited by 58 · see citing works
Stewart, W. C., Morrison, R. F., Young, S. L., & Stephens, J. M. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(99)00129-9 · Cited by 55 · see citing works
Interaction of Adipocyte Fatty Acid-binding Protein (AFABP) and JAK2
Thompson, B. R., Mazurkiewicz-Muñoz, A. M., Suttles, J., Carter‐Su, C., & Bernlohr, D. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900075200 · Cited by 51 · see citing works
Multiple Effects of Growth Hormone on Lipolysis
GOODMAN, H. M. (1968) · Endocrinology · doi:10.1210/endo-83-2-300 · Cited by 44 · see citing works
In vivo effects of interferon-alpha and interferon-gamma on lipolysis and ketogenesis
Memon, R. A., Kr, F., Moser, A. H., Doerrler, W. T., & Grünfeld, C. (1992) · Endocrinology · doi:10.1210/endo.131.4.1396316 · Cited by 43 · see citing works
Effects of leukemia inhibitory factor on 3T3-L1 adipocytes
Hogan, J. C., & Stephens, J. M. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.05980 · Cited by 43 · see citing works
Fielder, P. J., & Talamantes, F. J. (1987) · Endocrinology · doi:10.1210/endo-121-2-493 · Cited by 43 · see citing works
Ott, V., Faßhauer, M., Dalski, A., Klein, H., & Klein, J. C. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.173r001 · Cited by 41 · see citing works
STAT5A Expression in Swiss 3T3 Cells Promotes Adipogenesis In Vivo in an Athymic Mice Model System
Stewart, W. C., Pearcy, L. A., Floyd, Z. E., & Stephens, J. M. (2011) · Obesity · doi:10.1038/oby.2011.66 · Cited by 36 · see citing works
Song, H. Y., Kim, M. R., Lee, M. J., Jeon, E. S., Bae, Y. C., Jung, J. S., & Kim, J. H. (2006) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.014 · Cited by 31 · see citing works
Growth Hormone Receptor Interaction with Jak Proteins Differs Between Tissues
Hellgren, G., Albertsson-Wikland, K. G., Billig, H., Carlsson, L. M. S., & Carlsson, B. (2001) · Journal of Interferon & Cytokine Research · doi:10.1089/107999001750069935 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes
Zatterale, F., Longo, M., Naderi, J., Raciti, G. A., Desiderio, A., Miele, C., & Beguinot, F. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01607 · Cited by 1,180 · see citing works
Lipolysis: cellular mechanisms for lipid mobilization from fat stores
Grabner, G. F., Xie, H., Schweiger, M., & Zechner, R. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00493-6 · Cited by 771 · see citing works
Signaling pathways in obesity: mechanisms and therapeutic interventions
Wen, X., Zhang, B., Wu, B., Xiao, H., Li, Z., Li, R., Xu, X., & Li, T. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01149-x · Cited by 456 · see citing works
Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018440 · Cited by 314 · see citing works
“Moreover, adipocyte-specific JAK2-KO mice have impaired lipolysis and increased body weight through decreased STAT3 activation, which results in insulin resistance with ageing (Shi et al., 2014).”
BackgroundJAK/STAT – Emerging Players in Metabolism
Dodington, D. W., Desai, H. R., & Woo, M. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.11.001 · Cited by 277 · see citing works
Self-citationThe JAK / STAT pathway in obesity and diabetes
Gurzov, E. N., Stanley, W. J., Pappas, E. G., Thomas, H. E., & Gough, D. J. (2016) · FEBS Journal · doi:10.1111/febs.13709 · Cited by 253 · see citing works
Kasembeli, M. M., Bharadwaj, U., Robinson, P., & Tweardy, D. J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082299 · Cited by 199 · see citing works
The effects of growth hormone on adipose tissue: old observations, new mechanisms
Kopchick, J. J., Berryman, D. E., Puri, V., Lee, K. Y., & Jørgensen, J. O. L. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0280-9 · Cited by 191 · see citing works
Signaling pathways and intervention for therapy of type 2 diabetes mellitus
Cao, R. Y., Tian, H., Zhang, Y., Liu, G., Xu, H., Rao, G., Tian, Y., & Fu, X. (2023) · MedComm · doi:10.1002/mco2.283 · Cited by 92 · see citing works
Shi, S. Y., Lu, S.-Y., Sivasubramaniyam, T., Revelo, X. S., Cai, E. P., Luk, C. T., Schroer, S. A., Patel, P., Kim, R. H., Bombardier, É., et al. (2015) · Nature Communications · doi:10.1038/ncomms8415 · Cited by 85 · see citing works
Self-citationEffects of Di-(2-ethylhexyl) Phthalate on Lipid Metabolism by the JAK/STAT Pathway in Rats
Jia, Y., Liu, T., Zhou, L., Zhu, J. H., Wu, J., Sun, D., Xu, J., Wang, Q., Chen, H., Xu, F., et al. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13111085 · Cited by 76 · see citing works
FAK signalling controls insulin sensitivity through regulation of adipocyte survival
Luk, C. T., Shi, S. Y., Cai, E. P., Sivasubramaniyam, T., Krishnamurthy, M., Brunt, J. J., Schroer, S. A., Winer, D. A., & Woo, M. (2017) · Nature Communications · doi:10.1038/ncomms14360 · Cited by 73 · see citing works
Self-citationSTAT3: The art of multi-tasking of metabolic and immune functions in obesity
Hu, W., Lv, J., Han, M., Yang, Z. P., Li, T. X., Jiang, S., & Yang, Y. (2018) · Progress in Lipid Research · doi:10.1016/j.plipres.2018.04.002 · Cited by 63 · see citing works
Adipose tissue aging is regulated by an altered immune system
Zhang, Y.-X., Ou, M.-Y., Yang, Z.-H., Sun, Y., Li, Q.-F., & Zhou, S.-B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1125395 · Cited by 62 · see citing works
Adipocyte STAT5 deficiency promotes adiposity and impairs lipid mobilisation in mice
Kaltenecker, D., Mueller, K. M., Benedikt, P., Feiler, U., Themanns, M., Schlederer, M., Kenner, L., Schweiger, M., Haemmerle, G., & Moriggl, R. (2016) · Diabetologia · doi:10.1007/s00125-016-4152-8 · Cited by 62 · see citing works
T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders
Rani, J., Mittal, I., Pramanik, A., Singh, N., Dube, N., Sharma, S., Puniya, B. L., Raghunandanan, M. V., Mobeen, A., & Ramachandran, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-07238-0 · Cited by 60 · see citing works
Macrophage JAK2 deficiency protects against high-fat diet-induced inflammation
Desai, H. R., Sivasubramaniyam, T., Revelo, X. S., Schroer, S. A., Luk, C. T., Rikkala, P. R., Metherel, A. H., Dodington, D. W., Park, Y. J., Kim, M. J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-07923-0 · Cited by 55 · see citing works
Self-citationLatest advances in STAT signaling and function in adipocytes
Burrell, J. A., Boudreau, A., & Stephens, J. M. (2020) · Clinical Science · doi:10.1042/cs20190522 · Cited by 49 · see citing works
Shi, S. Y., Zhang, W., Luk, C. T., Sivasubramaniyam, T., Brunt, J. J., Schroer, S. A., Desai, H. R., Majerski, A., & Woo, M. (2015) · Diabetologia · doi:10.1007/s00125-015-3786-2 · Cited by 47 · see citing works
Self-citationKvasnička, A., Friedecký, D., Brumarová, R., Pavlı́ková, M., Pavelcová, K., Mašínová, J., Hasíková, L., Závada, J., Pavelká, K., Ješina, P., et al. (2023) · Arthritis Research & Therapy · doi:10.1186/s13075-023-03204-6 · Cited by 44 · see citing works
Metabolic benefits of inhibition of p38α in white adipose tissue in obesity
Zhang, S., Cao, H., Li, Y., Jing, Y., Liu, S., Cheng, Y., Wang, H., Yu, S., Peng, C., Hui, L., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2004225 · Cited by 41 · see citing works
Adipocyte JAK2 mediates growth hormone–induced hepatic insulin resistance
Corbit, K. C., Camporez, J. P., Tran, J. L., Wilson, C. G., Lowe, D. A., Nordstrom, S. M., Ganeshan, K., Perry, R. J., Shulman, G. I., Jurczak, M. J., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.91001 · Cited by 39 · see citing works
Growth hormone controls lipolysis by regulation of FSP27 expression
Sharma, R., Luong, Q. V., Sharma, V. M., Harberson, M. T., Harper, B., Colborn, A., Berryman, D. E., Jessen, N., Jørgensen, J. O. L., Kopchick, J. J., et al. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0282 · Cited by 39 · see citing works
Recent advances in JAK inhibitors for the treatment of metabolic syndrome
Collotta, D., Franchina, M. P., Carlucci, V., & Collino, M. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1245535 · Cited by 38 · see citing works
Dual Role of Caspase 8 in Adipocyte Apoptosis and Metabolic Inflammation
Luk, C. T., Chan, C. K., Chiu, F., Shi, S. Y., Misra, P. S., Li, Y. Z., Pollock‐Tahiri, E., Schroer, S. A., Desai, H. R., Sivasubramaniyam, T., et al. (2023) · Diabetes · doi:10.2337/db22-1033 · Cited by 25 · see citing works
Self-citationHjelholt, A. J., Lee, K. Y., Arlien-Søborg, M. C., Pedersen, S. B., Kopchick, J. J., Puri, V., Jessen, N., & Jørgensen, J. O. L. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.08.013 · Cited by 23 · see citing works
Han, D. J., Aslam, R., Misra, P. S., Chiu, F., Ojha, T., Chowdhury, A., Chan, C. K., Sung, H., Yuen, D. A., & Luk, C. T. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101594 · Cited by 22 · see citing works
Self-citationEffect of Janus kinase inhibition by tofacitinib on body composition and glucose metabolism
Chikugo, M., Sebe, M., Tsutsumi, R., Iuchi, M., Kishi, J., Kuroda, M., Harada, N., Nishioka, Y., & Sakaue, H. (2018) · The Journal of Medical Investigation · doi:10.2152/jmi.65.166 · Cited by 22 · see citing works
Li, J., Yang, M.-L., Yu, Z., Tian, J., Du, S., & Ding, H. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.11.007 · Cited by 21 · see citing works
Liu, S., Jiang, W., Liu, C., Guo, S., Wang, H., & Chang, X. (2023) · Food & Function · doi:10.1039/d3fo00604b · Cited by 20 · see citing works
Jiang, Y., Xie, M., Fan, W., Xue, J., Zhou, Z., Tang, J., Chen, G., & Hou, S. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00710 · Cited by 19 · see citing works
Effects of di (2-ethylhexyl) phthalate and high-fat diet on lipid metabolism in rats by JAK2/STAT5
Zhang, Y., Zhou, L., Zhang, Z., Xu, Q., Han, X., Zhao, Y., Song, X., Zhao, T., & Ye, L. (2019) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-06599-5 · Cited by 18 · see citing works
Li, Y., Wang, J., Xu, Y., Meng, Q., Su, Y., Su, Y., Miao, Y., & Wang, Y. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116760 · Cited by 17 · see citing works
Glad, C. A. M., Svensson, P., Nyström, F. H., Jacobson, P., Carlsson, L. M. S., Johannsson, G., & Andersson‐Assarsson, J. C. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01036 · Cited by 17 · see citing works
In silico analysis of non-coding RNAs and putative target genes implicated in metabolic syndrome
Dandare, A., Rabia, G., & Khan, M. J. (2021) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2021.104229 · Cited by 17 · see citing works
Vendelbo, M. H., Christensen, B., Grønbæk, S. B., Høgild, M. L., Madsen, M. A., Pedersen, S. B., Jørgensen, J. O. L., Jessen, N., & Møller, N. (2015) · European Journal of Endocrinology · doi:10.1530/eje-14-1157 · Cited by 16 · see citing works
MicroRNA‐188 regulates aging‐associated metabolic phenotype
Huang, Y. H., Xiao, Y., Liu, Y., Guo, M. A., Guo, Q., Zhou, F., Liu, T., Su, T., Xiao, Y., & Luo, X. (2019) · Aging Cell · doi:10.1111/acel.13077 · Cited by 16 · see citing works
Group IIE secretory phospholipase A2 regulates lipolysis in adipocytes
Zhi, H., Qu, L., Wu, F., Chen, L., & Tao, J. (2015) · Obesity · doi:10.1002/oby.21015 · Cited by 15 · see citing works
Zhang, X., Wang, Q., Wang, Y., Ma, C., Zhao, Q. C., Yin, H., Li, L., Wang, D., Huang, Y., Zhao, Y., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111906 · Cited by 14 · see citing works
Ji, K., He, J., Liang, H., Ren, M., Ge, X., & Masagounder, K. (2020) · Aquaculture Nutrition · doi:10.1111/anu.13164 · Cited by 9 · see citing works
PRL/PRLR Can Promote Insulin Resistance by Activating the JAK2/STAT5 Signaling Pathway
Wang, P., Jin, C., Liu, C. X., Zhao, Z.-J., & Yang, H. (2022) · Computational and Mathematical Methods in Medicine · doi:10.1155/2022/1456187 · Cited by 6 · see citing works
RetractedHu, C., Yang, M., Xue, F., Wang, S., Ma, Y., & Ma, Y. (2024) · Genomics · doi:10.1016/j.ygeno.2024.110903 · Cited by 5 · see citing works
Pavithra, S., Kumar, D. G. K., Ramesh, G., Panigrahi, M., Sahoo, M., Singh, T. U., Madhu, C. L., Kesavan, M., Shyamkumar, T. S., Kumar, D. G. K., et al. (2022) · Cytokine · doi:10.1016/j.cyto.2022.155966 · Cited by 5 · see citing works
Investigation of Pancreatic-beta Cells Role in the Biological Process of Ageing
Chaudhary, R., Khanna, J., Rohilla, M., Gupta, S., & Bansal, S. (2023) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530323666230822095932 · Cited by 4 · see citing works
Allahyari, M., Marjani, A., Jazi, M. S., & Jahanshahi, M. (2025) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.70101 · Cited by 3 · see citing works
Relationship between Indel Variants within the JAK2 Gene and Growth Traits in Goats
Wu, X.-F., Xu, Q., Wang, A., Wang, B.-Z., Lan, X., Li, W.-Y., & Liu, Y. (2024) · Animals · doi:10.3390/ani14131994 · Cited by 3 · see citing works
Anti-adipogenesis effect of indole-3-acrylic acid on human preadipocytes and HFD-induced zebrafish
Zhang, L., Zhao, J., Peng, Z., Zhang, Z., Huang, S., Dong, X., Gao, J., & Guo, X. (2024) · Acta Diabetologica · doi:10.1007/s00592-024-02256-7 · Cited by 3 · see citing works
Hepatic Igf1-Deficiency Protects Against Atherosclerosis in Female Mice
Sivasubramaniyam, T., Yang, J., Pollock, E., Chon, J., Schroer, S. A., Li, Y. Z., Metherel, A. H., Dodington, D. W., Bazinet, R. P., & Woo, M. (2021) · Endocrinology · doi:10.1210/endocr/bqab040 · Cited by 3 · see citing works
Self-citationHaissaguerre, M., Ferrière, A., Clark, S., Guzmán‐Quevedo, O., Tabarin, A., & Cota, D. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00527 · Cited by 2 · see citing works
Platelet Jak2 deficiency accelerates atherosclerosis with increased inflammatory response
Kim, D., Li, Y. Z., Yang, J., Lin, B., Wang, M. Y., Liu, J. J. Y., Bai, J., Farber, G., Razzaq, F. A., Pollock‐Tahiri, E., et al. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110603 · Cited by 2 · see citing works
Self-citationMethods for Assessing the In Vivo Role of PTEN in Glucose Homeostasis
Luk, C. T., Schroer, S. A., & Woo, M. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-3299-3_7 · Cited by 2 · see citing works
Self-citationEnkhtur, A., Yoon, J.-S., & Lee, C. (2020) · Precision and Future Medicine · doi:10.23838/pfm.2020.00121 · Cited by 2 · see citing works
Russell, T., Rowe, H., Bridgewood, C., Cuthbert, R., Watad, ., Newton, D. J., Jones, E., & McGonagle, D. (2021) · Immuno · doi:10.3390/immuno1040038 · Cited by 2 · see citing works
Growth hormone: lessons from chickens
Scanes, C. G. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1705885 · Cited by 1 · see citing works
Janus Kinase Inhibitors and Body Weight: Current Evidence and Potential
Kraev, K. I., Basheva-Kraeva, Y. M., Uchikova, M., Uchikov, P. A., Hristov, B. K., Valova, S., Doykov, M., Stanchev, D., Boyukliev, A., & Batalov, Z. (2026) · Life · doi:10.3390/life16040667 · Cited by 1 · see citing works
Chang, G., Li, Y., Jiang, Y., Wang, C., & Liu, X. (2023) · European Journal of Clinical Nutrition · doi:10.1038/s41430-023-01316-5 · Cited by 1 · see citing works
In Vivo Role of JAK2 in the Pathogenesis of Obesity and the Metabolic Syndrome
Shi, S. Y. (2015) · TSpace (University of Toronto)
Self-citationIn Vivo Role of Hepatic JAK2 and IGF-1 in Atherosclerosis
Sivasubramaniyam, T. (2018) · TSpace (University of Toronto)
Self-citationSilke, J. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733218432.793575596
Kvasnička, A., Friedecký, D., Brumarová, R., Pavlı́ková, M., Pavelcová, K., Mašínová, J., Hasíková, L., Závada, J., Pavelka, K., Ješina, P., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24716932
Kvasnička, A., Friedecký, D., Brumarová, R., Pavlíková, M., Pavelcová, K., Mašínová, J., Hasíková, L., Závada, J., Pavelka, K., Ješina, P., et al. (2024) · Figshare · doi:10.6084/m9.figshare.24716958
Kvasnička, A., Friedecký, D., Brumarová, R., Pavlíková, M., Pavelcová, K., Mašínová, J., Hasíková, L., Závada, J., Pavelka, K., Ješina, P., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26648646
Kvasnička, A., Friedecký, D., Brumarová, R., Pavlíková, M., Pavelcová, K., Mašínová, J., Hasíková, L., Závada, J., Pavelka, K., Ješina, P., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26648643
Kvasnička, A., Friedecký, D., Brumarová, R., Pavlíková, M., Pavelcová, K., Mašínová, J., Hasíková, L., Závada, J., Pavelka, K., Ješina, P., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26648649
Kageyama, K., Kikuchi, E., Hoshino, N., Ito, M., Akiyama, S., & Shiba, Y. (2026) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2026.103806
- Authors
- Shi, S. Y., Luk, C. T., Brunt, J. J., Sivasubramaniyam, T., Lu, S.-Y., Schroer, S. A., & Woo, M.
- Affiliations
- MaRS (CA)
- University of Toronto (CA)
- University Health Network (CA)
- Corresponding author
- Woo, Minna
- Venue
- Diabetologia
- Published
- 2014-02-16
- Volume
- 57
- Issue
- 5
- Pages
- 1016-1026
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2010232575
- Cited by
- 61
- References
- 45
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 10 · 2022: 4 · 2021: 4 · 2020: 6 · 2019: 6 · 2018: 8 · 2017: 5 · 2016: 3 · 2015: 6
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (93707_1, MOP-81148)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- JAK2, adipocytes, JAK/STAT signaling, lipolysis, adiposity, obesity, insulin resistance, aging, energy expenditure, adipose tissue lipid metabolism, adipokine secretion, leptin, growth hormone, isoproterenol, type 2 diabetes
- MeSH terms
- Aging, Animals, Body Composition, Body Weight, Female, Glucose Tolerance Test, Insulin Resistance, Lipolysis, Male, Obesity, Promoter Regions, Genetic, Cytokines, Adipocytes, Mice, Knockout, Adiposity, Mice, Janus Kinase 2, Adipokines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review