Impaired glucose tolerance, Type II diabetes mellitus and carotid atherosclerosis: prospective results from the Bruneck Study
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Aims/hypothesis Cardiovascular disease is a well-known severe complication of impaired glucose tolerance and Type II (non-insulin-dependent) diabetes mellitus. The independent contribution of glucose intolerance to cardiovascular disease and the underlying pathogenic mechanisms are still, however, not clear.Methods In this prospective population-based study, 826 subjects aged 40-79 years underwent high resolution duplex ultrasound examinations of carotid arteries and extensive clinical and laboratory screenings for potential vascular risk factors at baseline and 5 years later. The ultrasound protocol involved measurements of maximum axial diameter of atherosclerotic plaques, if any, in common and internal carotid arteries on both sides and enable differentiation of two main stages in carotid artery disease, termed early non-stenotic and advanced stenotic atherosclerosis. Intima-media thickness was assessed at the follow-up examination.Results Type II diabetes and, to a lesser extent, impaired glucose tolerance were found to be statistically significant risk predictors of 5-year changes in carotid atherosclerosis. These associations were in part independent of other vascular risk factors typically clustering with glucose intolerance. Both impaired glucose tolerance and Type II diabetes mellitus were not independently related to early non-stenotic atherosclerosis. In contrast, Type II diabetes mellitus was the strongest single risk predictor of advanced stenotic atherosclerosis [odds ratio 5.0 (95% confidence intervals 2.3-11.1)] and impaired glucose tolerance was of relevance as well [odds ratio 2.8 (1.2-6.4)] (p < 0.001).Conclusion/interpretation Impaired glucose tolerance and, to a greater extent, Type II diabetes were strong independent predictors of advanced carotid atherosclerosis in our prospective population-based study.
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Bonora et al found an association between the MS and progression of carotid atherosclerosis in the Bruneck cohort.
“Bonora et al 27 found an association between the MS and progression of carotid atherosclerosis, a CHD surrogate, in the Bruneck cohort.”
From Diabetes, the Metabolic Syndrome, and Angiographic Progression of Coronary Arterial Disease in Postmenopausal Women (2006) · cites this paper as [27]
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Self-citation
- Authors
- Bonora, E., Kiechl, S., Oberhollenzer, F., Egger, G., Bonadonna, R. C., Muggeo, M., & Willeit, J.
- Affiliations
- University of Verona (IT)
- Innsbruck Medical University (AT)
- Krankenhaus Bruneck (IT)
- Venue
- Diabetologia
- Published
- 2000-02-08
- Volume
- 43
- Issue
- 2
- Pages
- 156-164
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2035191964
- Cited by
- 140
- References
- 71
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 3 · 2015: 8 · 2014: 8 · 2013: 2 · 2012: 6
- FWCI
- 8.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Regione del Veneto
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
- Keywords
- impaired glucose tolerance, type 2 diabetes, carotid atherosclerosis, carotid artery stenosis, carotid plaque, intima-media thickness, cardiovascular risk factors, Bruneck Study
- MeSH terms
- Adult, Age Factors, Aged, Arteriosclerosis, Body Constitution, Carotid Arteries, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Female, Humans, Italy, Lipids, Male, Middle Aged, Predictive Value of Tests, Risk Factors, Sex Factors, Ultrasonography, Cohort Studies, Carotid Stenosis, Glucose Intolerance
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