Insulin Sensitivity, Insulin Secretion, and Glucose Tolerance Versus Intima-Media Thickness in Nondiabetic Postmenopausal Women
Abstract
To study the association between insulin sensitivity and secretion vs. early manifestations of atherosclerosis, we performed a 5-yr prospective study in 84 nondiabetic, postmenopausal women, aged 58.7 +/- 0.4 yr (mean +/- SD). Insulin sensitivity was measured with the euglycemic, hyperinsulinemic clamp, and insulin secretion was measured as the acute response to iv arginine (5 g). Early atherosclerosis was studied by ultrasonography of the right carotid artery. Mean intima-media thickness (IMT), determined 1 cm proximal to the bifurcation, was 0.81 +/- 0.14 mm at baseline and increased by 0.012 +/- 0.014 mm/yr over the 5 yr (P < 0.001). The maximal IMT, determined in the carotid bifurcation, was 1.42 +/- 0.42 mm at baseline and increased by 0.035 +/- 0.049 mm/yr (P < 0.001). Neither basal IMT nor the increase in mean or maximal IMT correlated to insulin sensitivity or secretion. In contrast, both baseline IMT and the progression in IMT over the 5-yr follow-up (both mean common carotid artery IMT and maximal bifurcation IMT) correlated with systolic blood pressure and low-density lipoprotein cholesterol. We conclude that carotid intima-media thickness is not related to insulin sensitivity or secretion in nondiabetic, postmenopausal women. Instead, the strongest association is seen with systolic blood pressure and low-density lipoprotein cholesterol levels.
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The MS and insulin resistance have been associated with atherosclerosis in cross-sectional studies.
“although the MS and insulin resistance have been associated with atherosclerosis in crosssectional studies, [23][24][25][26]”
From Diabetes, the Metabolic Syndrome, and Angiographic Progression of Coronary Arterial Disease in Postmenopausal Women (2006) · cites this paper as [25]
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POUR LE DIPLÔME D'ÉTAT DE DOCTEUR EN MÉDECINE
Sabatier, P., Médecine, F. D., Clinique, M. S., & Bally, É. (2013)
- Authors
- Larsson, H., Berglund, G., & Ahrén, B.
- Affiliations
- Lund University (SE)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2003-10
- Volume
- 88
- Issue
- 10
- Pages
- 4791-4797
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1968099917
- Cited by
- 19
- References
- 37
- Citations by year
- 2024: 1 · 2021: 3 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 2
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- insulin sensitivity, insulin secretion, intima-media thickness, early atherosclerosis, postmenopausal women, carotid artery, glucose tolerance, systolic blood pressure, LDL cholesterol, arginine-stimulated insulin secretion, hyperinsulinemic-euglycemic clamp
- MeSH terms
- Insulin Secretion, Aged, Carotid Artery Diseases, Female, Follow-Up Studies, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Middle Aged, Predictive Value of Tests, Prospective Studies, Ultrasonography, Glucose Clamp Technique, Tunica Intima, Tunica Media, Postmenopause, Glucose Intolerance
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