A search for tyrosine kinase receptors expressed in the rat embryonic pancreas
Open accessAbstract
It is known that during embryonic life, interactions between the pancreatic epithelium and its surrounding mesenchyme are important for proper development of the pancreas. These interactions are thought to be mediated by soluble factors, which could be, as in other tissues, the ligands of tyrosine kinase receptors. In this study, we screened for tyrosine kinase receptors expressed in pancreata of 13-day-old embryonic rats. Using a polymerase chain reaction-based approach that exploits sequence similarities within the catalytic kinase domains of these receptors, we identified 30 different tyrosine kinase receptors. The same approach was then used on cDNA prepared from fractions enriched in epithelium or in mesenchyme. Receptors for factors such as platelet derived growth factors were found to be expressed both in the epithelial and the mesenchymal fractions. Receptors for stem cell factor, for epidermal growth factor family members were mainly found in the epithelial fraction. The profile of expression of receptor tyrosine kinases in the embryonic pancreas was finally compared to the one found in other tissues and cell types, such as kidney, brain or INS-1 cells. Platelet derived growth factor receptors and ErbB2 were found to be enriched in the embryonic pancreas when compared with other tissues. It will now be possible to test the effects of the ligands of the different receptors we have cloned, on the differentiation and growth of the pancreas.
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The molecular basis for proliferative responses to PDGF decline and the roles of Pdgf signalling in islet β-cell growth and development were not established.
“However, the molecular basis for these observations and the roles of Pdgf signalling in islet β-cell growth and development were not established17,18,32.”
From PDGF signalling controls age-dependent proliferation in pancreatic β-cells (2011) · cites this paper as [32]
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Beta Cell Dysfunction and Insulin Resistance
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PDGF signalling controls age-dependent proliferation in pancreatic β-cells
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- Authors
- LeBras, S., Czernichow, P., & Scharfmann, R.
- Affiliations
- Inserm (FR)
- ORCID
- Scharfmann, R.
- Venue
- Diabetologia
- Published
- 1998-11-23
- Volume
- 41
- Issue
- 12
- Pages
- 1474-1481
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2068985207
- Cited by
- 35
- References
- 39
- Citations by year
- 2015: 1 · 2014: 1 · 2013: 1 · 2012: 6
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission
- Centre National de la Recherche Scientifique
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Keywords
- receptor tyrosine kinase, embryonic pancreas, pancreatic development, pancreatic epithelium, platelet-derived growth factor receptor, ERBB2, CD117, epidermal growth factor receptor, INS-1 cells
- MeSH terms
- Animals, Epithelium, Female, Gestational Age, Mesoderm, Pancreas, Pregnancy, Receptor, Insulin, RNA, Messenger, Polymerase Chain Reaction, Rats, Wistar, Receptors, Platelet-Derived Growth Factor, Receptor, IGF Type 1, DNA, Complementary, Erb-b2 Receptor Tyrosine Kinases, Receptor Protein-Tyrosine Kinases, Rats
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