Interaction of metabolic and haemodynamic factors in mediating experimental diabetic nephropathy
Open accessAbstract
Diabetic nephropathy seems to occur as a result of an interaction of metabolic and haemodynamic factors. Glucose dependent pathways are activated within the diabetic kidney. These include increased oxidative stress, renal polyol formation and accumulation of advanced glycated end-products. Haemodynamic factors are also implicated in the pathogenesis of diabetic nephropathy and include increased systemic and intraglomerular pressure and activation of various vasoactive hormone pathways including the renin-angiotensin system and endothelin. These haemodynamic pathways, independently and with metabolic pathways, activate intracellular second messengers such as protein kinase C and MAP kinase, nuclear transcription factors such as NF-kappaB and various growth factors such as the prosclerotic cytokine, TGF-beta and the angiogenic, permeability enhancing growth factor, VEGF. These pathways ultimately lead to increased renal albumin permeability and extracellular matrix accumulation which results in increasing proteinuria, glomerulosclerosis and tubulointerstitial fibrosis. Therapeutic strategies involved in the management and prevention of diabetic nephropathy include currently available treatments such as intensified glycaemic control and antihypertensive agents, particularly those which interrupt the renin-angiotensin system. More novel strategies to influence vasoactive hormone action or to inhibit various metabolic pathways such as inhibitors of advanced glycation, specific protein kinase C isoforms and aldose reductase are at present under experimental and clinical investigation. It is predicted that multiple therapies will be required to reduce the progression of diabetic nephropathy.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
DKD is considered to occur as a result of an interplay between metabolic and hemodynamic factors.
“DKD is considered to occur as a result of an interplay between metabolic and hemodynamic factors (58), with many of the putative pathways leading to injury having already been delineated (59).”
From GLP-1 agonists in the treatment of chronic kidney disease in type 2 diabetes and obesity (2025) · cites this paper as [58]
Cites
Stratton, I. M. (2000) · BMJ · doi:10.1136/bmj.321.7258.405 · Cited by 9,059 · see citing works
Zatz, R., Dunn, B. R., Meyer, T. W., Anderson, S., Rennke, H. G., & Brenner, B. M. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112521 · Cited by 1,204 · see citing works
Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene
Mullins, J. J., Peters, J., & Ganten, D. (1990) · Nature · doi:10.1038/344541a0 · Cited by 919 · see citing works
Hostetter, T. H., Rennke, H. G., & Brenner, B. M. (1982) · The American Journal of Medicine · doi:10.1016/0002-9343(82)90490-9 · Cited by 800 · see citing works
Zatz, R., Meyer, T. W., Rennke, H. G., & Brenner, B. M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.17.5963 · Cited by 524 · see citing works
Role of angiotensin II in diabetic nephropathy
Leehey, D. J., Singh, A. K., Alavi, N., & Singh, R. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.07715.x · Cited by 273 · see citing works
Kelly, D. J., Wilkinson‐Berka, J. L., Allen, T. J., Cooper, M. E., & Skinner, S. L. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.00019.x · Cited by 166 · see citing works
Self-citationAnimal models of spontaneous diabetic kidney disease
Velasquez, M. T., Kimmel, P. L., & Michaelis, O. E. (1990) · The FASEB Journal · doi:10.1096/fasebj.4.11.2199283 · Cited by 118 · see citing works
Kelly, D. J., Skinner, S. L., Gilbert, R. E., Cox, A. J., Cooper, M. E., & Wilkinson‐Berka, J. L. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00038.x · Cited by 103 · see citing works
Self-citationCooper, M. E., Allen, T. J., O??Brien, R. C., Macmillan, P. A., Clarke, B. E., Jerums, G., & Doyle, A. E. (1988) · Journal of Hypertension · doi:10.1097/00004872-198812000-00009 · Cited by 95 · see citing works
Self-citationPathophysiology of diabetic nephropathy
Cooper, M. E., Gilbert, R. E., & Epstein, M. (1998) · Metabolism · doi:10.1016/s0026-0495(98)90362-6 · Cited by 67 · see citing works
Self-citationCooper, M. E., Allen, T. J., O’Brien, R. C., Papazoglou, D., Clarke, B. E., Jerums, G., & Doyle, A. E. (1990) · Diabetes · doi:10.2337/diab.39.12.1575 · Cited by 58 · see citing works
Self-citationExperimental diabetic nephropathy: Is it relevant to the human disease
Kelly, D. J., Allen, T. J., & Cooper, M. E. (2000) · Nephrology · doi:10.1046/j.1440-1797.2000.00003.x · Cited by 4 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Mechanisms of Diabetic Complications
Forbes, J. M., & Cooper, M. E. (2013) · Physiological Reviews · doi:10.1152/physrev.00045.2011 · Cited by 2,890 · see citing works
Self-citationAdvanced Glycation End Products and Diabetic Complications
Singh, V. P., Bali, A., Singh, N., & Jaggi, A. S. (2014) · The Korean Journal of Physiology & Pharmacology · doi:10.4196/kjpp.2014.18.1.1 · Cited by 1,518 · see citing works
Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy
Navarro‐González, J. F., Fernández, C. M., de Fuentes, M. M., & García-Pérez, J. (2011) · Nature Reviews Nephrology · doi:10.1038/nrneph.2011.51 · Cited by 1,073 · see citing works
Extracellular Matrix Metabolism in Diabetic Nephropathy
Mason, R. M., & Wahab, N. A. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000065640.77499.d7 · Cited by 653 · see citing works
Renal Autoregulation in Health and Disease
Carlström, M., Wilcox, C. S., & Arendshorst, W. J. (2015) · Physiological Reviews · doi:10.1152/physrev.00042.2012 · Cited by 485 · see citing works
Candido, R., Forbes, J. M., Thomas, M. C., Thallas, V., Dean, R. G., Burns, W. C., Tikellis, C., Ritchie, R. H., Twigg, S. M., Cooper, M. E., et al. (2003) · Circulation Research · doi:10.1161/01.res.0000065620.39919.20 · Cited by 449 · see citing works
Self-citationMarkers of and Risk Factors for the Development and Progression of Diabetic Kidney Disease
MacIsaac, R. J., Ekinci, E. I., & Jerums, G. (2014) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2013.10.048 · Cited by 385 · see citing works
Fibrosis in Chronic Kidney Disease: Pathogenesis and Consequences
Panizo, S., Martínez‐Arias, L., Alonso‐Montes, C., Cannata, P., Martín-Carro, B., Martín, J. L. F., Naves‐Díaz, M., Carrillo‐López, N., & Cannata-Andía, J. B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22010408 · Cited by 375 · see citing works
Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials
Calcutt, N. A., Cooper, M. E., Kern, T. S., & Schmidt, A. M. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2476 · Cited by 353 · see citing works
Self-citationRole of Advanced Glycation End Products in Diabetic Nephropathy
Forbes, J. M., Cooper, M. E., Oldfield, M. D., & Thomas, M. C. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000077413.41276.17 · Cited by 351 · see citing works
Self-citationNephrin Expression Is Reduced in Human Diabetic Nephropathy
Doublier, S., Salvidio, G., Lupia, E., Ruotsalainen, V., Verzola, D., Deferrari, G., & Camussi, G. (2003) · Diabetes · doi:10.2337/diabetes.52.4.1023 · Cited by 341 · see citing works
CURCUMIN, THE ACTIVE PRINCIPLE OF TURMERIC (CURCUMA LONGA), AMELIORATES DIABETIC NEPHROPATHY IN RATS
Sharma, S., Kulkarni, S. K., & Chopra, K. (2006) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2006.04468.x · Cited by 309 · see citing works
Kowluru, R. A., Koppolu, P., Chakrabarti, S., & Chen, S. (2003) · Free Radical Research · doi:10.1080/10715760310001604189 · Cited by 289 · see citing works
QUERCETIN, AN ANTI‐OXIDANT BIOFLAVONOID, ATTENUATES DIABETIC NEPHROPATHY IN RATS
Anjaneyulu, M., & Chopra, K. (2004) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2004.03982.x · Cited by 248 · see citing works
Microalbuminuria and hypertension with focus on type 1 and type 2 diabetes*
Mogensen, C. E. (2003) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01157.x · Cited by 226 · see citing works
The role of advanced glycation in the pathogenesis of diabetic retinopathy
Stitt, A. W. (2003) · Experimental and Molecular Pathology · doi:10.1016/s0014-4800(03)00035-2 · Cited by 226 · see citing works
Pathogenesis of diabetic nephropathy
Cao, Z., & Cooper, M. E. (2011) · Journal of Diabetes Investigation · doi:10.1111/j.2040-1124.2011.00131.x · Cited by 219 · see citing works
Self-citationLi, J., Wang, W., Huang, X. R., Oldfield, M. D., Schmidt, A. M., Cooper, M. E., & Lan, H. Y. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63225-7 · Cited by 217 · see citing works
Self-citationCooper, M. E., & El‐Osta, A. (2010) · Circulation Research · doi:10.1161/circresaha.110.223552 · Cited by 211 · see citing works
Self-citationThe role of protein kinase C activation in diabetic nephropathy
Noh, H., & King, G. L. (2007) · Kidney International · doi:10.1038/sj.ki.5002386 · Cited by 212 · see citing works
Diabetic Nephropathy: a Tangled Web to Unweave
Magee, C., Grieve, D., Watson, C. J., & Brazil, D. P. (2017) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-017-6755-9 · Cited by 192 · see citing works
Kidney disease in diabetes: From mechanisms to clinical presentation and treatment strategies
Ricciardi, C. A., & Gnudi, L. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154890 · Cited by 197 · see citing works
Ohshiro, Y., Ronald, C. W., Yasuda, Y., Hiraoka‐Yamamoto, J., Clermont, A. C., Isshiki, K., Yagi, K., Arikawa, E., Kern, T. S., & King, G. L. (2006) · Diabetes · doi:10.2337/db06-0895 · Cited by 189 · see citing works
Diabetic Nephropathy: Where Hemodynamics Meets Metabolism
Forbes, J. M., Fukami, K., & Cooper, M. E. (2007) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2007-949721 · Cited by 183 · see citing works
Self-citationThe gut–renal axis: do incretin-based agents confer renoprotection in diabetes?
Muskiet, M. H. A., Smits, M. M., Morsink, L. M., & Diamant, M. (2013) · Nature Reviews Nephrology · doi:10.1038/nrneph.2013.272 · Cited by 182 · see citing works
Resveratrol, a Polyphenolic Phytoalexin, Attenuates Diabetic Nephropathy in Rats
Sharma, S., Anjaneyulu, M., Kulkarni, S., & Chopra, K. (2005) · Pharmacology · doi:10.1159/000089720 · Cited by 177 · see citing works
Zhang, C., Xiao, C., Wang, P., Xu, W., Zhang, A., Li, Q., & Xu, X. (2014) · Human Immunology · doi:10.1016/j.humimm.2014.02.007 · Cited by 166 · see citing works
Increased plasma urotensin II levels in patients with diabetes mellitus
Totsune, K., Takahashi, K., Arihara, Z., Sone, M., Ito, S., & Murakami, O. (2003) · Clinical Science · doi:10.1042/cs20020271 · Cited by 160 · see citing works
Metabolic memory and diabetic nephropathy: potential role for epigenetic mechanisms
Tonna, S. J., El‐Osta, A., Cooper, M. E., & Tikellis, C. (2010) · Nature Reviews Nephrology · doi:10.1038/nrneph.2010.55 · Cited by 152 · see citing works
Self-citationLee, F., Cao, Z., Long, D. M., Panagiotopoulos, S., Jerums, G., Cooper, M. E., & Forbes, J. M. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000135055.61833.a8 · Cited by 150 · see citing works
Self-citationAdvanced glycation end products and diabetic complications
Stitt, A. W., Jenkins, A. J., & Cooper, M. E. (2002) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.11.9.1205 · Cited by 150 · see citing works
Self-citationProtective Role of Cannabinoid Receptor Type 2 in a Mouse Model of Diabetic Nephropathy
Barutta, F., Piscitelli, F., Pinach, S., Bruno, G., Gambino, R., Rastaldi, M. P., Salvidio, G., Marzo, V. D., Perin, P. C., & Gruden, G. (2011) · Diabetes · doi:10.2337/db10-1809 · Cited by 145 · see citing works
Inflammatory Mechanisms as New Biomarkers and Therapeutic Targets for Diabetic Kidney Disease
Alicic, R. Z., Johnson, E. J., & Tuttle, K. R. (2018) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2017.12.002 · Cited by 145 · see citing works
Twigg, S. M., Cao, Z., McLennan, S., Burns, W. C., Brammar, G. C., Forbes, J. M., & Cooper, M. E. (2002) · Endocrinology · doi:10.1210/en.2002-220619 · Cited by 143 · see citing works
Self-citationBrouwers, O., Niessen, P. M. G., Miyata, T., Østergaard, J. A., Flyvbjerg, A., Peutz‐Kootstra, C. J., Sieber, J., Mundel, P. H., Brownlee, M., Janssen, B. J., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-3088-5 · Cited by 139 · see citing works
Interactions between Renin Angiotensin System and Advanced Glycation in the Kidney
Thomas, M. C., Tikellis, C., Burns, W. M., Bialkowski, K., Cao, Z., Coughlan, M. T., Jandeleit-Dahm, K. A. M., Cooper, M. E., & Forbes, J. M. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005010013 · Cited by 135 · see citing works
Self-citationAdelusi, T. I., Du, L., Meng, H., Zhou, X., Qian, X., Chowdhury, A., Sun, Y., Lü, Q., & Yin, X. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109732 · Cited by 133 · see citing works
Early oxidative stress in the diabetic kidney: effect of DL-α-lipoic acid
Obrosova, I. G., Fathallah, L., Liu, E., & Nourooz‐Zadeh, J. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01195-4 · Cited by 129 · see citing works
Pat, B., Yang, T., Kong, C., Watters, D. J., Johnson, D. W., & Gobe, G. C. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00157.x · Cited by 128 · see citing works
Koch, A., Kuhlmann, A., M�nter, K., Ritz, E., Amann, K., Gross, M.-L., Elshakmak, A., & Sz�b�, A. (2003) · Diabetologia · doi:10.1007/s00125-003-1106-8 · Cited by 126 · see citing works
Coughlan, M. T., Thallas-Bonke, V., Pete, J., Long, D. M., Gasser, A., Tong, D. C. K., Arnstein, M., Thorpe, S. R., Cooper, M. E., & Forbes, J. M. (2007) · Endocrinology · doi:10.1210/en.2006-1300 · Cited by 124 · see citing works
Self-citationDiabetic nephropathy: Important pathophysiologic mechanisms
Soldatos, G., & Cooper, M. E. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.09.042 · Cited by 123 · see citing works
Self-citationNew insights: A role forO-GlcNAcylation in diabetic complications
Peterson, S. B., & Hart, G. W. (2016) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2015.1135102 · Cited by 123 · see citing works
Tarabra, E., Giunti, S., Barutta, F., Salvidio, G., Burt, D. J., Deferrari, G., Gambino, R., Vergola, D., Pinach, S., Perin, P. C., et al. (2009) · Diabetes · doi:10.2337/db08-0895 · Cited by 121 · see citing works
Imatinib Attenuates Diabetic Nephropathy in Apolipoprotein E-Knockout Mice
Lassila, M., Jandeleit-Dahm, K. A. M., Seah, K. K., Smith, C. M., Calkin, A. C., Allen, T. J., & Cooper, M. E. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004050392 · Cited by 117 · see citing works
Self-citationDiabetic nephropathy: where are we on the journey from pathophysiology to treatment?
Gallagher, H., & Suckling, R. (2016) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12630 · Cited by 111 · see citing works
Mechanical Forces in Diabetic Kidney Disease
Gnudi, L., Thomas, S. M., & Viberti, G. C. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006121362 · Cited by 113 · see citing works
Gomes, I. B., Porto, M. L., Santos, M. C. L. F. S., Campagnaro, B. P., Pereira, T. M., Meyrelles, S. S., & Vasquez, E. C. (2014) · Lipids in Health and Disease · doi:10.1186/1476-511x-13-184 · Cited by 109 · see citing works
Kim, M. N., Moon, J. H., & Cho, Y. M. (2021) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14503 · Cited by 110 · see citing works
The impact of hyperfiltration on the diabetic kidney
Premaratne, E., Verma, S. K., Ekinci, E. I., Theverkalam, G., Jerums, G., & MacIsaac, R. J. (2014) · Diabetes & Metabolism · doi:10.1016/j.diabet.2014.10.003 · Cited by 108 · see citing works
Jandeleit-Dahm, K. A. M., & Cooper, M. E. (2002) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200203000-00014 · Cited by 106 · see citing works
Self-citationRole of T Cells in Type 2 Diabetic Nephropathy
Wu, C., Sytwu, H., Lu, K., & Lin, Y. (2011) · Experimental Diabetes Research · doi:10.1155/2011/514738 · Cited by 113 · see citing works
Wilkinson‐Berka, J. L., Kelly, D. J., Koerner, S. M., Jaworski, K., Davis, B., Thallas, V., & Cooper, M. E. (2002) · Diabetes · doi:10.2337/diabetes.51.11.3283 · Cited by 105 · see citing works
Self-citationActivation of RhoA/ROCK regulates NF-κB signaling pathway in experimental diabetic nephropathy
Xie, X., Peng, J., Chang, X., Huang, K., Huang, J., Wang, S., Shen, X., Liu, P., & Huang, H. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.01.007 · Cited by 102 · see citing works
Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice
Xiao, X., Ma, B., Dong, B., Zhao, P., Tai, N., Chen, L., Wong, F. S., & Li, W. (2009) · Journal of Autoimmunity · doi:10.1016/j.jaut.2008.12.003 · Cited by 99 · see citing works
Role of advanced glycation end products and insulin resistance in diabetic nephropathy
Parwani, K., & Mandal, P. (2020) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2020.1797106 · Cited by 97 · see citing works
Potential New Therapeutic Agents for Diabetic Kidney Disease
Turgut, F. H., & Bolton, W. K. (2010) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2009.11.021 · Cited by 96 · see citing works
Meier, M., Park, J.-K., Overheu, D., Kirsch, T., Lindschau, C., Gueler, F., Leitges, M., Menne, J., & Haller, H. G. (2007) · Diabetes · doi:10.2337/db06-0891 · Cited by 96 · see citing works
Minchenko, О. H., Stevens, M. J., White, L., Abatan, O. I., Komjáti, K., Pachter, P., Szabó, C., & Obrosova, I. G. (2003) · The FASEB Journal · doi:10.1096/fj.03-0013fje · Cited by 96 · see citing works
Chen, H., Li, J., Jiao, L., Petersen, R. B., Li, J., Peng, A., Zheng, L., & Huang, K. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.266411 · Cited by 93 · see citing works
Wu, C., Chen, J.-S., Lu, K., Chen, C., Lin, S., Chu, P., Sytwu, H., & Lin, Y. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.01.036 · Cited by 92 · see citing works
Research progress in signalling pathway in diabetic nephropathy
Ni, W., Tang, L., & Wei, W. (2014) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2568 · Cited by 90 · see citing works
Heat-processed Panax ginseng and diabetic renal damage: active components and action mechanism
Kang, K. S., Ham, J., Kim, Y., Park, J. H., Cho, E. J., & Yamabe, N. (2013) · Journal of Ginseng Research · doi:10.5142/jgr.2013.37.379 · Cited by 89 · see citing works
Schutta, M. H. (2007) · Journal of the CardioMetabolic Syndrome · doi:10.1111/j.1559-4564.2007.06368.x · Cited by 89 · see citing works
Nagata, T., Fukuzawa, T., Takeda, M., Fukazawa, M., Mori, T., Nihei, T., Honda, K., Suzuki, Y., & Kawabe, Y. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12269 · Cited by 88 · see citing works
Gnudi, L., Viberti, G., Raij, L. R., Rodriguez, V., Burt, D. J., Cortés, P., Hartley, B., Thomas, S., Maestrini, S., & Gruden, G. (2003) · Hypertension · doi:10.1161/01.hyp.0000075949.19968.ef · Cited by 86 · see citing works
Giunti, S., Tesch, G. H., Pinach, S., Burt, D. J., Cooper, M. E., Cavallo‐Perin, P., Camussi, G., & Gruden, G. (2007) · Diabetologia · doi:10.1007/s00125-007-0837-3 · Cited by 85 · see citing works
Self-citationWang, J. J., Zhang, S. X., Lu, K., Chen, Y., Mott, R., Sato, S., & Ma, J. (2005) · Diabetes · doi:10.2337/diabetes.54.1.243 · Cited by 85 · see citing works
Evolving concepts in advanced glycation, diabetic nephropathy, and diabetic vascular disease
Jerums, G., Panagiotopoulos, S., Forbes, J. M., Osicka, T. M., & Cooper, M. E. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.08.017 · Cited by 85 · see citing works
Self-citationZhang, M.-H., Feng, L., Zhu, M., Gu, J., Jiang, J., Cheng, X., Ding, S., Wu, C., & Jia, X. (2013) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2013.11.015 · Cited by 84 · see citing works
Omega-3 fatty acid rich diet prevents diabetic renal disease
Garman, J. H., Mulroney, S. E., Manigrasso, M. B., Flynn, E., & Maric, C. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90326.2008 · Cited by 84 · see citing works
Apelin/APJ system in inflammation
Wang, X., Zhang, L., Li, P., Zheng, Y., Yang, Y., & Ji, S. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108822 · Cited by 83 · see citing works
Advanced glycation end products (AGEs) promote melanogenesis through receptor for AGEs
Lee, E. J., Kim, J. Y., & Oh, S. H. (2016) · Scientific Reports · doi:10.1038/srep27848 · Cited by 82 · see citing works
Protective Effects of Astragalus Saponin I on Early Stage of Diabetic Nephropathy in Rats
Yin, X., Zhang, Y., Wu, H., Zhu, X., Zheng, X., Jiang, S., Zhuo, H., Shen, J., Li, L., & Qiu, J. (2004) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fp0030597 · Cited by 81 · see citing works
Koka, V., Wang, W., Huang, X. R., Kim‐Mitsuyama, S., Truong, L. D., & Lan, H. Y. (2006) · Circulation · doi:10.1161/circulationaha.105.575589 · Cited by 81 · see citing works
Couture, R., & Girolami, J. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.07.045 · Cited by 79 · see citing works
Abatan, O. I., Charniauskaya, T., Stevens, M., Obrosova, I. G., Pacher, P., Li, F., Szab�, C., & Southan, G. J. (2004) · Diabetologia · doi:10.1007/s00125-004-1356-0 · Cited by 79 · see citing works
Zheng, Z., Zhu, W., Lei, L., Liu, X., & Wu, Y. (2020) · Drug Design Development and Therapy · doi:10.2147/dddt.s274256 · Cited by 78 · see citing works
Çam, M., Yavuz, Ö., Güven, A., Ercan, F., Bukan, N. C., & Üstündag, N. (2003) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.00082.x · Cited by 77 · see citing works
Impact of kinins in the treatment of cardiovascular diseases
Regoli, D. C., Plante, G. E., & Gobeil, F. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.04.002 · Cited by 77 · see citing works
TNF-αand Microalbuminuria in Patients with Type 2 Diabetes Mellitus
Lampropoulou, I.-T., Stangou, M. J., Papagianni, A. A., Didangelos, T., Iliadis, F. S., & Efstratiadis, G. (2014) · Journal of Diabetes Research · doi:10.1155/2014/394206 · Cited by 76 · see citing works
Kang, K. S., Yamabe, N., Kim, H., Park, J. H., & Yokozawa, T. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.06.077 · Cited by 74 · see citing works
Barati, M. T., Merchant, M. L., Kain, A. B., Jevans, A. W., McLeish, K. R., & Klein, J. B. (2007) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00411.2006 · Cited by 74 · see citing works
Zhang, H., Saha, J., Byun, J., Schin, M., Lorenz, M. A., Kennedy, R. T., Kretzler, M., Feldman, E. L., Pennathur, S., & Brosius, F. C. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90208.2008 · Cited by 74 · see citing works
Mansouri, E., Panahi, M., Ghaffari, M. A., & Ghorbani, A. (2011) · Europe PMC (PubMed Central) · Cited by 73 · see citing works
A Review on Cellular and Molecular Mechanisms Linked to the Development of Diabetes Complications
Babel, R. A., & Dandekar, M. P. (2020) · Current Diabetes Reviews · doi:10.2174/1573399816666201103143818 · Cited by 76 · see citing works
Anjaneyulu, M., & Chopra, K. (2004) · American Journal of Nephrology · doi:10.1159/000080722 · Cited by 70 · see citing works
Potential role of active vitamin D in retarding the progression of chronic kidney disease
Tian, J., Liu, Y., Williams, L. A., & de Zeeuw, D. (2006) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfl595 · Cited by 70 · see citing works
Cytokines in diabetic nephropathy
Wu, C., Sytwu, H., & Lin, Y. (2012) · Advances in clinical chemistry · doi:10.1016/b978-0-12-394317-0.00014-5 · Cited by 67 · see citing works
Zhang, M., Feng, L., Gu, J., Ma, L., Qin, D., Wu, C., & Jia, X. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/463815 · Cited by 67 · see citing works
Angiotensin II and growth factors in the pathogenesis of diabetic nephropathy
Rincon-Choles, H., Kasinath, B. S., Gorin, Y. C., & Abboud, H. E. (2002) · Kidney International · doi:10.1046/j.1523-1755.62.s82.3.x · Cited by 67 · see citing works
Apelin/APJ system: A novel potential therapy target for kidney disease
Huang, Z., Wu, L., & Chen, L. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26144 · Cited by 66 · see citing works
Elabela, a newly discovered APJ ligand: Similarities and differences with Apelin
Zhang, Y., Wang, Y., Lou, Y., Luo, M., Lu, Y., Li, Z., Wang, Y., & Miao, L. (2018) · Peptides · doi:10.1016/j.peptides.2018.09.006 · Cited by 66 · see citing works
Davis, B. J., Forbes, J. M., Thomas, M. C., Jerums, G., Burns, W. C., Kawachi, H., Allen, T. J., & Cooper, M. E. (2004) · Diabetologia · doi:10.1007/s00125-003-1256-8 · Cited by 65 · see citing works
Self-citationGlucose and Blood Pressure-Dependent Pathways–The Progression of Diabetic Kidney Disease
Patel, D. M., Bose, M., & Cooper, M. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062218 · Cited by 65 · see citing works
Self-citationMatsui, T., Yamagishi, S., Takeuchi, M., Ueda, S., Fukami, K., & Okuda, S. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.07.004 · Cited by 64 · see citing works
VEGF gene polymorphism association with diabetic neuropathy
Tavakkoly‐Bazzaz, J., Amoli, M. M., Pravica, V., Chandrasecaran, R., Boulton, A. J. M., Larijani, B. A., & Hutchinson, I. V. (2010) · Molecular Biology Reports · doi:10.1007/s11033-010-0013-6 · Cited by 64 · see citing works
Anjaneyulu, M., & Chopra, K. (2004) · Pharmacology · doi:10.1159/000078631 · Cited by 64 · see citing works
Menne, J., Shushakova, N., Bartels, J., Kiyan, Y., Laudeley, R., Haller, H. G., Park, J.-K., & Meier, M. (2013) · Diabetes · doi:10.2337/db12-0534 · Cited by 63 · see citing works
Heat shock protein expression in diabetic nephropathy
Barutta, F., Pinach, S., Giunti, S., Vittone, F., Forbes, J. M., Chiarle, R., Arnstein, M., Perin, P. C., Camussi, G., Cooper, M. E., et al. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90234.2008 · Cited by 63 · see citing works
Self-citation
- Authors
- Cooper, M. E.
- Affiliations
- The University of Melbourne (AU)
- Corresponding author
- Cooper, M. E.
- ORCID
- Cooper, M. E.
- Venue
- Diabetologia
- Published
- 2001-11-01
- Volume
- 44
- Issue
- 11
- Pages
- 1957-1972
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W1991427290
- Cited by
- 375
- References
- 14
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 10 · 2023: 14 · 2022: 5 · 2021: 19 · 2020: 16 · 2019: 9 · 2018: 8 · 2017: 15 · 2016: 13 · 2015: 10 · 2014: 23 · 2013: 20 · 2012: 14
- FWCI
- 4.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kidney Health Australia
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Keywords
- diabetic nephropathy, metabolic factors, oxidative stress, advanced glycation end products, intraglomerular pressure, renin-angiotensin system, endothelin, protein kinase C, mitogen-activated protein kinase, NF-κB, TGF-beta, vascular endothelial growth factor, albumin permeability, extracellular matrix accumulation, glomerulosclerosis, tubulointerstitial fibrosis, proteinuria, aldose reductase inhibitors, renin-angiotensin system inhibitors, antihypertensive therapy, glycemic control, pathogenesis
- MeSH terms
- Animals, Diabetic Nephropathies, Diabetic Retinopathy, Disease Models, Animal, Hemodynamics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review