Advanced Glycation End Products and Diabetic Complications
Open accessAbstract
During long standing hyperglycaemic state in diabetes mellitus, glucose forms covalent adducts with the plasma proteins through a non-enzymatic process known as glycation. Protein glycation and formation of advanced glycation end products (AGEs) play an important role in the pathogenesis of diabetic complications like retinopathy, nephropathy, neuropathy, cardiomyopathy along with some other diseases such as rheumatoid arthritis, osteoporosis and aging. Glycation of proteins interferes with their normal functions by disrupting molecular conformation, altering enzymatic activity, and interfering with receptor functioning. AGEs form intra- and extracellular cross linking not only with proteins, but with some other endogenous key molecules including lipids and nucleic acids to contribute in the development of diabetic complications. Recent studies suggest that AGEs interact with plasma membrane localized receptors for AGEs (RAGE) to alter intracellular signaling, gene expression, release of pro-inflammatory molecules and free radicals. The present review discusses the glycation of plasma proteins such as albumin, fibrinogen, globulins and collagen to form different types of AGEs. Furthermore, the role of AGEs in the pathogenesis of diabetic complications including retinopathy, cataract, neuropathy, nephropathy and cardiomyopathy is also discussed.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
AGEs are long-lived irreversibly formed molecules found in the circulatory system and tissues, particularly those with long-lasting proteins.
“AGEs are long-lived irreversibly formed molecules found in the circulatory system and tissues, particularly those with long-lasting proteins such as lens crystallins, cartilage, glomerular basement membrane, and extracellular matrix29,30.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [29]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Ma, H., Li, S., Xu, P., Babcock, S. A., Dolence, E. K., Brownlee, M., Li, J., & Ren, J. T. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00547.x · Cited by 155 · see citing works
RetractedBiochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107 · see citing works
Lang, G. E., Vaiser, A., Snyder, W. B., & Lynn, J. R. (1974) · doi:10.1159/isbn.978-3-318-01439-6 · Cited by 5,583 · see citing works
Role of Oxidative Stress in Development of Complications in Diabetes
Baynes, J. (1991) · Diabetes · doi:10.2337/diab.40.4.405 · Cited by 3,791 · see citing works
Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications
Flier, J. S., Underhill, L. H., Brownlee, M., Cerami, A., & Vlassara, H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805193182007 · Cited by 2,512 · see citing works
Role of oxidative stress in diabetic complications: a new perspective on an old paradigm.
Baynes, J. W., & Thorpe, S. R. (1999) · Diabetes · doi:10.2337/diabetes.48.1.1 · Cited by 2,441 · see citing works
RAGE Mediates a Novel Proinflammatory Axis
Hofmann, M. A., Drury, S., Fu, C., Qu, W., Taguchi, A., Lu, Y., Avila, C., Kambham, N., Bierhaus, A., Nawroth, P., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80801-6 · Cited by 1,864 · see citing works
Neeper, M. P., Schmidt, A. M., Brett, J., Yan, S. D., Wang, F., Pan, Y., Elliston, K. O., Stern, D., & SHAW, A. R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42138-2 · Cited by 1,542 · see citing works
Advanced glycation endproducts—role in pathology of diabetic complications
Ahmed, N. (2004) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2004.09.004 · Cited by 1,457 · see citing works
Advanced protein glycosylation in diabetes and aging
Brownlee, M. D. (1995) · Annual Review of Medicine · doi:10.1146/annurev.med.46.1.223 · Cited by 1,312 · see citing works
Yan, S. D., Schmidt, A. M., Anderson, G. M., Zhang, J., Brett, J., Zou, Y., Pinsky, D. J., & Stern, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36966-1 · Cited by 1,305 · see citing works
Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases
Taguchi, A., Blood, D. C., del Toro, G., Canet, A., Lee, D. C., Qu, W., Tanji, N., Lu, Y., Lalla, E., Fu, C., et al. (2000) · Nature · doi:10.1038/35012626 · Cited by 1,217 · see citing works
Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose
Thornalley, P. J., LANGBORG, A., & Minhas, H. S. (1999) · Biochemical Journal · doi:10.1042/bj3440109 · Cited by 1,209 · see citing works
Bucala, R., Tracey, K. J., & Cerami, A. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115014 · Cited by 1,162 · see citing works
Schmidt, A. M., Hori, O., Chen, J. X., Li, J. F., Crandall, J., Zhang, J., Cao, R., Yan, S. D., Brett, J., & Stern, D. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118175 · Cited by 896 · see citing works
Frank, R. N. (2003) · New England Journal of Medicine · doi:10.1056/nejmra021678 · Cited by 891 · see citing works
Kislinger, T., Fu, C., Huber, B., Qu, W., Taguchi, A., Yan, S. D., Hofmann, M. A., Yan, S. F., Pischetsrieder, M., Stern, D. M., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.44.31740 · Cited by 868 · see citing works
Flier, J. S., Mueckler, M., Usher, P., & Lodish, H. F. (1987) · Science · doi:10.1126/science.3103217 · Cited by 778 · see citing works
Brett, J., Schmidt, A. M., Yan, S. D., Zou, Y. S., Weidman, E., Pinsky, D. J., Nowygrod, R., Neeper, M. P., Przysiecki, C. T., & SHAW, A. R. (1993) · PubMed Central · Cited by 776 · see citing works
Age-related changes in the collagen network and toughness of bone
Wang, X., Shen, X., Li, X., & Agrawal, C. M. (2002) · Bone · doi:10.1016/s8756-3282(01)00697-4 · Cited by 769 · see citing works
Improved Arterial Compliance by a Novel Advanced Glycation End-Product Crosslink Breaker
Kass, D. A., Shapiro, E. P., Kawaguchi, M., Capriotti, A. R., Scuteri, A., deGroof, R. C., & Lakatta, E. G. (2001) · Circulation · doi:10.1161/hc3801.097806 · Cited by 727 · see citing works
Peer Bork, B., Holm, L., & Sander, C. (1994) · Journal of Molecular Biology · doi:10.1006/jmbi.1994.1582 · Cited by 676 · see citing works
The Pattern Recognition Receptor (RAGE) Is a Counterreceptor for Leukocyte Integrins
Chavakis, T., Bierhaus, A., Al‐Fakhri, N., Schneider, D., Witte, S., Linn, T., Nagashima, M., Morser, J., Arnold, B., Preissner, K. T., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030800 · Cited by 583 · see citing works
Antonetti, D. A., Barber, A. J., Khin, S., Lieth, E., Tarbell, J. M., & Gardner, T. W. (1998) · Diabetes · doi:10.2337/diabetes.47.12.1953 · Cited by 579 · see citing works
RAGE Blockade Stabilizes Established Atherosclerosis in Diabetic Apolipoprotein E–Null Mice
Bucciarelli, L. G., Wendt, T., Qu, W., Lu, Y., Lalla, E., Rong, L., Goova, M. T., Moser, B., Kislinger, T., Lee, D. C., et al. (2002) · Circulation · doi:10.1161/01.cir.0000039325.03698.36 · Cited by 562 · see citing works
Tanji, N., Markowitz, G. S., Fu, C., Kislinger, T., Taguchi, A., Pischetsrieder, M., Stern, D. M., Schmidt, A. M., & D’Agati, V. D. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1191656 · Cited by 485 · see citing works
Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice
Yamamoto, Y., Kato, I., Doi, T., Yonekura, H., Ohashi, S., Takeuchi, M., Watanabe, T., Yamagishi, S.-I., Sakurai, S., Takasawa, S., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11771 · Cited by 475 · see citing works
Oldfield, M. D., Bach, L. A., Forbes, J. M., Nikolic‐Paterson, D. J., McRobert, E. A., Thallas, V., Atkins, R. C., Osicka, T. M., Jerums, G., & Cooper, M. E. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11951 · Cited by 469 · see citing works
The wanderings of a free radical
Halliwell, B. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.11.008 · Cited by 467 · see citing works
Spector, K. S. (1998) · Clinical Cardiology · doi:10.1002/clc.4960211205 · Cited by 442 · see citing works
Saito, M., Fujii, K., Mori, Y., & Marumo, K. (2006) · Osteoporosis International · doi:10.1007/s00198-006-0155-5 · Cited by 437 · see citing works
The glycation of albumin: Structural and functional impacts
Rondeau, P., & Bourdon, E. (2011) · Biochimie · doi:10.1016/j.biochi.2010.12.003 · Cited by 433 · see citing works
Tanaka, N., Yonekura, H., Yamagishi, S., Fujimori, H., Yamamoto, Y., & Yamamoto, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001235200 · Cited by 425 · see citing works
Hyperglycemia and Glycation in Diabetic Complications
Nègre‐Salvayre, A., Salvayre, R., Augè, N., Pamplona, R., & Portero‐Otín, M. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2484 · Cited by 424 · see citing works
Diabetic Cataract—Pathogenesis, Epidemiology and Treatment
Pollreisz, A., & Schmidt-Erfurth, U. M. (2010) · Journal of Ophthalmology · doi:10.1155/2010/608751 · Cited by 422 · see citing works
Vlassara, H., Li, Y. M., Imani, F., Wojciechowicz, D., Yang, Z., Liu, F.-T., & Cerami, A. (1995) · Molecular Medicine · doi:10.1007/bf03401604 · Cited by 421 · see citing works
Zhang, Q., Ames, J. M., Smith, R. D., Baynes, J. W., & Metz, T. O. (2009) · Journal of Proteome Research · doi:10.1021/pr800858h · Cited by 421 · see citing works
Review article: albumin as a drug—biological effects of albumin unrelated to oncotic pressure
Evans, T. W. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.16.s5.2.x · Cited by 409 · see citing works
Zhou, J., Chan, L., & Zhou, S. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712801323171 · Cited by 395 · see citing works
Energy metabolism of the heart: From basic concepts to clinical applications applications
Taegtmeyer, H. (1994) · Current Problems in Cardiology · doi:10.1016/0146-2806(94)90008-6 · Cited by 391 · see citing works
Thornalley, P. J. (1998) · PubMed · Cited by 387 · see citing works
Advanced glycation end products and the kidney
Bohlender, J. M., Franke, S., Stein, G., & Wolf, G. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00398.2004 · Cited by 386 · see citing works
Riser, B. L., DeNichilo, M. O., Cortés, P., Baker, C. J., Grondin, J. M., Yee, J., & Narins, R. G. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v11125 · Cited by 386 · see citing works
Nonenzymatic glycosylation of albumin in vivo. Identification of multiple glycosylated sites.
Iberg, N., & Flückiger, R. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67052-8 · Cited by 380 · see citing works
Alikhani, M., Alikhani, Z., Boyd, C. M., MacLellan, C. M., Raptis, M., Liu, R., Pischon, N., Trackman, P. C., Gerstenfeld, L. C., & Graves, D. T. (2006) · Bone · doi:10.1016/j.bone.2006.09.011 · Cited by 376 · see citing works
Interaction of metabolic and haemodynamic factors in mediating experimental diabetic nephropathy
Cooper, M. E. (2001) · Diabetologia · doi:10.1007/s001250100000 · Cited by 375 · see citing works
Diabetes Treatment — Bridging the Divide
Rother, K. I. (2007) · New England Journal of Medicine · doi:10.1056/nejmp078030 · Cited by 371 · see citing works
Giardino, I., Edelstein, D., & Brownlee, M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117296 · Cited by 364 · see citing works
Wolf, G. (2004) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2004.01429.x · Cited by 352 · see citing works
Role of Advanced Glycation End Products in Diabetic Nephropathy
Forbes, J. M., Cooper, M. E., Oldfield, M. D., & Thomas, M. C. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000077413.41276.17 · Cited by 351 · see citing works
Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis
Yan, S. D., Zhu, H., Zhu, A., Golabek, A., Du, H., Roher, A., Yu, J., Soto, C., Schmidt, A. M., Stern, D., et al. (2000) · Nature Medicine · doi:10.1038/76216 · Cited by 343 · see citing works
Li, Y. M., Mitsuhashi, T., Wojciechowicz, D. C., Shimizu, N., Li, J., Stitt, A. W., He, C., Banerjee, D., & Vlassara, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.20.11047 · Cited by 340 · see citing works
Schmidt, A. M., Hasu, M., Popov, D., Zhang, J. H., Chen, J., Yan, S. D., Brett, J., Cao, R. Y., Kuwabara, K., & Costache, G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8807 · Cited by 327 · see citing works
Advanced Glycation End Product Interventions Reduce Diabetes-Accelerated Atherosclerosis
Forbes, J. M., Yee, L. T. L., Thallas, V., Lassila, M., Candido, R., Jandeleit-Dahm, K. A. M., Thomas, M. C., Burns, W. C., Deemer, E. K., Thorpe, S. R., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.7.1813 · Cited by 314 · see citing works
Caldwell, R. B., Bartoli, M., Behzadian, M. A., El‐Remessy, A. E. B., Al‐Shabrawey, M., Platt, D. H., & Caldwell, R. W. (2003) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.415 · Cited by 293 · see citing works
Heilig, C. W., Concepcion, L. A., Riser, B. L., Freytag, S. O., Zhu, M., & Cortés, P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118226 · Cited by 270 · see citing works
The renin-angiotensin-aldosterone system, glucose metabolism and diabetes
Giacchetti, G., Sechi, L. A., Rilli, S., & Carey, R. M. (2005) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2005.02.003 · Cited by 267 · see citing works
Receptor for advanced glycation endproducts (RAGE) and the complications of diabetes
Stern, D., Yan, S. D., Yan, S. D., & SCHMIDT, A. (2002) · Ageing Research Reviews · doi:10.1016/s0047-6374(01)00366-9 · Cited by 267 · see citing works
Role of Advanced Glycation End Products and Their Receptors in Development of Diabetic Neuropathy
Wada, R., & Yagihashi, S. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1338.067 · Cited by 264 · see citing works
Mechanisms of diabetic vasculopathy: an overview
Cooper, M. E. (2001) · American Journal of Hypertension · doi:10.1016/s0895-7061(00)01323-6 · Cited by 264 · see citing works
Trost, S. U., Belke, D. D., Bluhm, W. F., Meyer, M., Swanson, E., & DILLMANN, W. H. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1166 · Cited by 262 · see citing works
AGEs, RAGE, and Diabetic Retinopathy
Zong, H., Ward, M. S., & Stitt, A. W. (2011) · Current Diabetes Reports · doi:10.1007/s11892-011-0198-7 · Cited by 257 · see citing works
Structural Basis for Pattern Recognition by the Receptor for Advanced Glycation End Products (RAGE)
Xie, J., Reverdatto, S., Frolov, A., Hoffmann, R., Burz, D. S., & Shekhtman, A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801622200 · Cited by 252 · see citing works
Experimental diabetic neuropathy: an update
Sima, A. A. F., & Sugimoto, K. (1999) · Diabetologia · doi:10.1007/s001250051227 · Cited by 251 · see citing works
Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose
Thornalley, P. J., LANGBORG, A., & Minhas, H. S. (1999) · Biochemical Journal · doi:10.1042/0264-6021:3440109 · Cited by 243 · see citing works
The effects of the Maillard reaction on the physical properties and cell interactions of collagen
Avery, N. C., & Bailey, A. J. (2006) · Pathologie Biologie · doi:10.1016/j.patbio.2006.07.005 · Cited by 240 · see citing works
Importance of measuring products of non-enzymatic glycation of proteins
Lapolla, A., Traldi, P., & Fedele, D. (2005) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2004.09.007 · Cited by 236 · see citing works
Bidasee, K. R., Zhang, Y., Shao, C. H., Wang, M., Patel, K. P., Dinçer, Ü. D., & Besch, H. R. (2004) · Diabetes · doi:10.2337/diabetes.53.2.463 · Cited by 229 · see citing works
Ookawara, T., Kawamura, N., Kitagawa, Y., & Taniguchi, N. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36991-1 · Cited by 227 · see citing works
Chilelli, N. C., Burlina, S., & Lapolla, A. (2013) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2013.04.004 · Cited by 226 · see citing works
The role of advanced glycation in the pathogenesis of diabetic retinopathy
Stitt, A. W. (2003) · Experimental and Molecular Pathology · doi:10.1016/s0014-4800(03)00035-2 · Cited by 226 · see citing works
Huang, J., Guh, J., Chen, H., Hung, W., Lai, Y., & Chuang, L. (2001) · Journal of Cellular Biochemistry · doi:10.1002/1097-4644(20010401)81:1 · Cited by 225 · see citing works
Therapeutic potential of breakers of advanced glycation end product–protein crosslinks
Vasan, S., Foiles, P. G., & Founds, H. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.08.016 · Cited by 221 · see citing works
Podestà, F., Romeo, G. R., Liu, W., Krajewski, S., Reed, J. C., Gerhardinger, C., & Lorenzi, M. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64970-x · Cited by 216 · see citing works
Yamagishi, S., Amano, S., Inagaki, Y., Okamoto, T., Koga, K., Sasaki, N., Yamamoto, H., Takeuchi, M., & Makita, Z. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6312 · Cited by 210 · see citing works
Joussen, A. M., Poulaki, V., Mitsiades, N., Cai, W., Suzuma, I., Pak, J. E., Ju, S., Rook, S. L., Esser, P., Mitsiades, C., et al. (2002) · The FASEB Journal · doi:10.1096/fj.02-0157fje · Cited by 209 · see citing works
Advanced glycation end products: role in pathology of diabetic cardiomyopathy
Bodiga, V. L., Eda, S. R., & Bodiga, S. (2013) · Heart Failure Reviews · doi:10.1007/s10741-013-9374-y · Cited by 207 · see citing works
Prevention of diabetic nephropathy in mice by a diet low in glycoxidation products
Zheng, F., He, C., Cai, W., Hattori, M., Steffes, M. W., & Vlassara, H. (2002) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.283 · Cited by 207 · see citing works
Differential accumulation of advanced glycation end products in the course of diabetic retinopathy
Hammes, H. P., Alt, A., Niwa, T., Clausen, J. T., Bretzel, R. G., Brownlee, M., & Schleicher, E. D. (1999) · Diabetologia · doi:10.1007/s001250051221 · Cited by 205 · see citing works
Nonenzymatic glycosylation of peripheral nerve protein in diabetes mellitus.
Vlassara, H., Brownlee, M., & Cerami, A. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.8.5190 · Cited by 201 · see citing works
Zong, H., Ward, M. S., Madden, A. F., Yong, P. H., Limb, G. A., Curtis, T. M., & Stitt, A. W. (2010) · Diabetologia · doi:10.1007/s00125-010-1900-z · Cited by 201 · see citing works
Bell, D. S. H. (2003) · Diabetes Care · doi:10.2337/diacare.26.10.2949 · Cited by 200 · see citing works
Non-enzymatic Glycation of Bone Collagen Modifies Osteoclastic Activity and Differentiation
Valcourt, U., Merle, B., Gineyts, É., Viguet‐Carrin, S., Delmas, P. D., & Garnero, P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m610536200 · Cited by 195 · see citing works
Neumann, A., Schinzel, R., Palm, D., Riederer, P. F., & Münch, G. W. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00731-0 · Cited by 195 · see citing works
Dunn, E. J., Philippou, H., Ariëns, R. A. S., & Grant, P. J. (2006) · Diabetologia · doi:10.1007/s00125-006-0197-4 · Cited by 177 · see citing works
Throckmorton, D. C., Brogden, A. P., Min, B., Rasmussen, H., & Kashgarian, M. J. (1995) · Kidney International · doi:10.1038/ki.1995.274 · Cited by 174 · see citing works
The Role of Advanced Glycation End Products in Retinal Microvascular Leukostasis
Moore, T., Moore, J. E., Kaji, Y., Frizzell, N., Usui, T., Poulaki, V., Campbell, I. L., Stitt, A. W., Gardiner, T. A., ARCHER, D. B., et al. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-1063 · Cited by 172 · see citing works
Nonenzymatic glycation of type IV collagen and matrix metalloproteinase susceptibility
Mott, J. D., Khalifah, R. G., Nagase, H., Shield, C. F., Hudson, J. K., & Hudson, B. G. (1997) · Kidney International · doi:10.1038/ki.1997.455 · Cited by 170 · see citing works
Glycation—a sweet tempter for neuronal death
Kikuchi, S. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00273-4 · Cited by 169 · see citing works
Hudson, B. I., Bucciarelli, L. G., Wendt, T., Sakaguchi, T., Lalla, E., Qu, W., Lu, Y., Lee, L., Stern, D. M., Naka, Y., et al. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.08.030 · Cited by 166 · see citing works
Advanced Glycation End Products and Insulin Resistance
Unoki‐Kubota, H., & Yamagishi, S. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208784139747 · Cited by 162 · see citing works
Twigg, S. M., Chen, M. M., Joly, A. H., Chakrapani, S. D., Tsubaki, J., Kim, H.-S., Oh, Y., & Rosenfeld, R. G. (2001) · Endocrinology · doi:10.1210/endo.142.5.8141 · Cited by 161 · see citing works
Altered Ca2+ handling in ventricular myocytes isolated from diabetic rats
Lagadic‐Gossmann, D., Buckler, K. J., Prigent, K. L., & Feuvray, D. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.270.5.h1529 · Cited by 159 · see citing works
Ojima, A., Ishibashi, Y., Matsui, T., Maeda, S., Nishino, Y., Takeuchi, M., Fukami, K., & Yamagishi, S.-I. (2013) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.09.016 · Cited by 156 · see citing works
Unoki‐Kubota, H., Bujo, H., Yamagishi, S., Takeuchi, M., Imaizumi, T., & Saitō, Y. (2006) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2006.09.016 · Cited by 155 · see citing works
Diabetes, glaucoma, sex, and cataract: analysis of combined data from two case control studies.
Harding, J. J., Egerton, M., van Heyningen, R., et al. (1993) · British Journal of Ophthalmology · doi:10.1136/bjo.77.1.2 · Cited by 154 · see citing works
Berner, A., Brouwers, O., Pringle, R., Klaassen, I., Colhoun, L. M., McVicar, C. M., Brockbank, S., Curry, J., Miyata, T., Brownlee, M., et al. (2011) · Diabetologia · doi:10.1007/s00125-011-2393-0 · Cited by 153 · see citing works
Nicholl, I. D., Stitt, A. W., Moore, J. E., Ritchie, A. J., ARCHER, D. B., & Bucala, R. (1998) · Molecular Medicine · doi:10.1007/bf03401759 · Cited by 152 · see citing works
The pathogenic role of Maillard reaction in the aging eye
Nagaraj, R. H., Linetsky, M. D., & Stitt, A. W. (2010) · Amino Acids · doi:10.1007/s00726-010-0778-x · Cited by 151 · see citing works
The Maillard Hypothesis on Aging: Time to Focus on DNA
Baynes, J. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02107.x · Cited by 150 · see citing works
Roles of the Receptor for Advanced Glycation Endproducts in Diabetes-Induced Vascular Injury
Yonekura, H., Yamamoto, Y., Sakurai, S., Watanabe, T., & Yamamoto, H. (2005) · Journal of Pharmacological Sciences · doi:10.1254/jphs.cpj04005x · Cited by 147 · see citing works
Comparison of modification sites formed on human serum albumin at various stages of glycation
Barnaby, O. S., Cerny, R. L., Clarke, W. A., & Hage, D. S. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.10.018 · Cited by 144 · see citing works
Twigg, S. M., Cao, Z., McLennan, S., Burns, W. C., Brammar, G. C., Forbes, J. M., & Cooper, M. E. (2002) · Endocrinology · doi:10.1210/en.2002-220619 · Cited by 143 · see citing works
Sugimoto, K., Nishizawa, Y., Horiuchi, S., & Yagihashi, S. (1997) · Diabetologia · doi:10.1007/s001250050839 · Cited by 142 · see citing works
Nonenzymatic glycation alters protein structure and stability. A study of two eye lens crystallins.
Luthra, M., & Balasubramanian, D. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)46819-0 · Cited by 141 · see citing works
Pentosidine Effects on Human Osteoblasts in Vitro
Sanguineti, R., Storace, D., Monacelli, F., Federici, A., & Odetti, P. R. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1433.044 · Cited by 140 · see citing works
CD36, serves as a receptor for advanced glycation endproducts (AGE)
Ohgami, N., Nagai, R., Ikemoto, M., Arai, H., Miyazaki, A., Hakamata, H., Horiuchi, S., & Nakayama, H. (2002) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(01)00208-2 · Cited by 140 · see citing works
Role of advanced glycation endproducts and glyoxalase I in diabetic peripheral sensory neuropathy
Jack, M. M., & Wright, D. E. (2012) · Translational research · doi:10.1016/j.trsl.2011.12.004 · Cited by 135 · see citing works
Chibber, R., Molinatti, P. A., Rosatto, N., Lambourne, B., & KOHNER, E. M. (1997) · Diabetologia · doi:10.1007/s001250050657 · Cited by 133 · see citing works
Hesperidin Prevents Retinal and Plasma Abnormalities in Streptozotocin-Induced Diabetic Rats
Shi, X., Liao, S., Mi, H., Guo, C.-R., Qi, D., Li, F., Zhang, C.-F., & Yang, Z. (2012) · Molecules · doi:10.3390/molecules171112868 · Cited by 133 · see citing works
Kelly, D. J., Gilbert, R. E., Cox, A. J., et al. (2001) · Journal of the American Society of Nephrology · doi:10.1681/asn.v12102098 · Cited by 132 · see citing works
Jung, H. A., Jung, Y. J., Yoon, N. Y., Jeong, D. M., Bae, H. J., Kim, D., Na, D. H., & Choi, J. S. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.10.004 · Cited by 131 · see citing works
Smit, A. J., & Lutgers, H. L. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043364342 · Cited by 130 · see citing works
Structural and functional consequences of increased tubulin glycosylation in diabetes mellitus.
Williams, S. K., Howarth, N. L., Devenny, J. J., et al. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.21.6546 · Cited by 127 · see citing works
Yamagishi, S., Hsu, C., Taniguchi, M., Harada, S. I., Yamamoto, Y., Ohsawa, K. S., Kobayashi, K. I., & Yamamoto, H. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2185 · Cited by 126 · see citing works
The Maillard Reaction in Eye Diseases
Stitt, A. W. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1338.066 · Cited by 126 · see citing works
Advanced Glycation Endproduct-Induced Calcium Handling Impairment in Mouse Cardiac Myocytes
Petrova, R. G., Yamamoto, Y., Muraki, K., Yonekura, H., Sakurai, S., Watanabe, T., Li, H., Takeuchi, M., Makita, Z., Kato, I., et al. (2002) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2002.2084 · Cited by 124 · see citing works
Non-enzymic glycation of individual plasma proteins in normoglycemic and hyperglycemic patients.
Austin, G. E., Mullins, R. H., & Morin, L. G. (1987) · Clinical Chemistry · doi:10.1093/clinchem/33.12.2220 · Cited by 122 · see citing works
Curtis, T. M., Hamilton, R. W., Yong, P. H., McVicar, C. M., Berner, A., Pringle, R., Uchida, K., Nagai, R., Brockbank, S., & Stitt, A. W. (2010) · Diabetologia · doi:10.1007/s00125-010-1971-x · Cited by 121 · see citing works
Kumar, M., Reddy, P. Y., Pasupulati, A. K., Surolia, I., & Reddy, G. B. (2004) · Biochemical Journal · doi:10.1042/bj20031633 · Cited by 118 · see citing works
High extracellular glucose impairs cardiac E-C coupling in a glycosylation-dependent manner
Ren, J., Gintant, G. A., Miller, R. E., et al. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.6.h2876 · Cited by 116 · see citing works
Beswick, H. T., & Harding, J. J. (1987) · Biochemical Journal · doi:10.1042/bj2460761 · Cited by 115 · see citing works
Advanced Glycation End Products and Diabetic Retinopathy
Chen, M., Curtis, T. M., & Stitt, A. W. (2013) · Current Medicinal Chemistry · doi:10.2174/09298673113209990025 · Cited by 115 · see citing works
Glycation alters collagen fibril organization
Bai, P., Phua, K., Hardt, T. A., Cernadas, M., & Brodsky, B. (1992) · Connective Tissue Research · doi:10.3109/03008209209014224 · Cited by 114 · see citing works
Turk, Z., Ljubic, S., Turk, N., & Benko, B. (2001) · Clinica Chimica Acta · doi:10.1016/s0009-8981(00)00389-2 · Cited by 111 · see citing works
Genotoxicity of advanced glycation end products in mammalian cells
Stopper, H., Schinzel, R., Šebeková, K., & Heidland, A. (2003) · Cancer Letters · doi:10.1016/s0304-3835(02)00626-2 · Cited by 108 · see citing works
Sekido, H., Suzuki, T., Jomori, T., Takeuchi, M., Yabe‐Nishimura, C., & Yagihashi, S. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.05.159 · Cited by 103 · see citing works
Recent advances in diabetic nephropathy
Marshall, S. M. (2004) · Postgraduate Medical Journal · doi:10.1136/pgmj.2004.021287 · Cited by 98 · see citing works
Effects of OPB‐9195, anti‐glycation agent, on experimental diabetic neuropathy
Wada, R., Nishizawa, Y., Yagihashi, N., Takeuchi, M., Ishikawa, Y., YASUMURA, K., Nakano, M., & Yagihashi, S. (2001) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2001.00826.x · Cited by 94 · see citing works
Advanced glycation endproducts: A biomarker for age as an outcome predictor after cardiac surgery?
Simm, A., Wagner, J., Gursinsky, T., et al. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.03.006 · Cited by 92 · see citing works
Cui, X., Li, B., Gao, H., Wei, N., Wang, W., & Lü, M. (2008) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.54.321 · Cited by 90 · see citing works
Increased levels of advanced glycation end products in human cataractous lenses
Franke, S., Dawczynski, J., Strobel, J., et al. (2003) · Journal of Cataract & Refractive Surgery · doi:10.1016/s0886-3350(02)01841-2 · Cited by 89 · see citing works
Structural and Functional Changes of Laminin and Type IV Collagen After Nonenzymatic Glycation
CHARONIS, A. S., & Tsilibary, E. C. (1992) · Diabetes · doi:10.2337/diab.41.2.s49 · Cited by 86 · see citing works
Advanced glycation end products in diabetic and non-diabetic human subjects suffering from cataract
Hashim, Z., & Zarina, S. (2010) · AGE · doi:10.1007/s11357-010-9177-1 · Cited by 84 · see citing works
Amore, A., Cirina, P., Mitola, S. M. F., Peruzzi, L., Gianoglio, B., Rabbone, I., Sacchetti, C., Cerutti, F., Grillo, C., & Coppo, R. (1997) · Kidney International · doi:10.1038/ki.1997.4 · Cited by 82 · see citing works
Methylglyoxal-modified collagen promotes myofibroblast differentiation
Yuen, A., Laschinger, C. A., Talior‐Volodarsky, I., Lee, W., Chan, M. K. W., Birek, J., Young, E. W. K., Sivagurunathan, K. S., Won, E., Simmons, C. A., et al. (2010) · Matrix Biology · doi:10.1016/j.matbio.2010.04.004 · Cited by 81 · see citing works
Microorganisms and Maillard reaction products: a review of the literature and recent findings
Helou, C., Marier, D., Jacolot, P., Abdennebi‐Najar, L., Niquet‐Léridon, C., Tessier, F. J., & Gadonna‐Widehem, P. (2013) · Amino Acids · doi:10.1007/s00726-013-1496-y · Cited by 81 · see citing works
Ishibashi, Y., Yamagishi, S., Matsui, T., Ohta, K., Tanoue, R., Takeuchi, M., Ueda, S., Nakamura, K., & Okuda, S. (2012) · Metabolism · doi:10.1016/j.metabol.2012.01.006 · Cited by 80 · see citing works
Mamputu, J., & Renier, G. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603265 · Cited by 80 · see citing works
Ihm, S., Chang, K., Kim, H.-Y., Baek, S. H., Youn, H., Seung, K., & Kim, J. (2009) · Basic Research in Cardiology · doi:10.1007/s00395-009-0071-x · Cited by 75 · see citing works
Lapolla, A., Fedele, D., Garbeglio, M., Martano, L., Tonani, R., Seraglia, R., Favretto, D., Fedrigo, M. A., & Traldi, P. (2000) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(99)00134-8 · Cited by 74 · see citing works
Glycation of monoclonal antibodies impairs their ability to bind antigen
KENNEDY, D. M., SKILLBN, A. W., & SELF, C. H. (2008) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.1994.tb06133.x · Cited by 74 · see citing works
Structure of advanced Maillard reaction products and their pathological role
Monnier, V. M., Nagaraj, R. H., Portero‐Otín, M., Glomb, M. A., Elgawish, A.-H., Sell, D. R., & Friedlander, M. A. (1996) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/11.supp5.20 · Cited by 74 · see citing works
Kim, Y.-S., Kim, B. C., Song, C. Y., et al. (2001) · Journal of Laboratory and Clinical Medicine · doi:10.1067/mlc.2001.115494 · Cited by 73 · see citing works
Nakamura, N., Hasegawa, G., Obayashi, H., et al. (2003) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(03)00109-8 · Cited by 71 · see citing works
Choudhuri, S., Dutta, D., Sen, A., Chowdhury, I. H., Mitra, B., Mondal, L. K., Saha, A., Bhadhuri, G., & Bhattacharya, B. (2013) · Europe PMC (PubMed Central) · Cited by 70 · see citing works
O’Connor, A. S., & Schelling, J. R. (2005) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2005.05.032 · Cited by 68 · see citing works
Krishnamurti, U., Rondeau, E. P., Sraer, J., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.44.27966 · Cited by 64 · see citing works
Stitt, A. W., Hughes, S.-J., Canning, P., Lynch, O. T., Cox, Ó. T., Frizzell, N., Thorpe, S. R., Cotter, T. G., Curtis, T. M., & Gardiner, T. A. (2004) · Diabetologia · doi:10.1007/s00125-004-1523-3 · Cited by 62 · see citing works
Skin aging by glycation: lessons from the reconstructed skin model
Pageon, H., Zucchi, H., Rousset, F., Monnier, V. M., & Asselineau, D. (2013) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2013-0091 · Cited by 62 · see citing works
Administration of AGEs in vivo induces extracellular matrix gene expression
Striker, L. J., & Striker, G. E. (1996) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/11.supp5.62 · Cited by 62 · see citing works
Posch, K., Simecek, S., Wascher, T. C., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1331 · Cited by 59 · see citing works
Physicochemical studies on glycation‐induced structural changes in human IgG
Ahmad, S., Moinuddin, M., Khan, R. H., & Ali, A. (2012) · IUBMB Life · doi:10.1002/iub.582 · Cited by 56 · see citing works
Glycated albumin modulates platelet susceptibility to flow induced activation and aggregation
Rubenstein, D. A., & Yin, W. (2009) · Platelets · doi:10.1080/09537100902795492 · Cited by 54 · see citing works
Kawai, T., Takei, I., Tokui, M., Funae, O., Miyamoto, K., Tabata, M., Hirata, T., Saruta, T., Shimada, A., & Itoh, H. (2009) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2008.10.005 · Cited by 52 · see citing works
Kemeny, S. F., Figueroa, D. S., Andrews, A. M., Barbee, K. A., & Clyne, A. M. (2011) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2011.04.026 · Cited by 52 · see citing works
EL-Mesallamy, H. O., Hamdy, N. Μ., Ezzat, O., & Reda, A. M. (2011) · Journal of Investigative Medicine · doi:10.2310/jim.0b013e318231db64 · Cited by 51 · see citing works
Jono, T., Kimura, T., Takamatsu, J., Nagai, R., Miyazaki, K., Yuzuriha, T., Kitamura, T., & Horiuchi, S. (2002) · Pathology International · doi:10.1046/j.1320-5463.2002.01390.x · Cited by 47 · see citing works
Nyengaard, J. R., Chang, K. C., Berhorst, S., et al. (1997) · Diabetes · doi:10.2337/diab.46.1.94 · Cited by 46 · see citing works
Therapeutic Strategies for Diabetic Neuropathy
Habib, A. A., & Brannagan, T. H. (2010) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-010-0093-7 · Cited by 46 · see citing works
Rodrigues, B. B. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00045-x · Cited by 45 · see citing works
Receptor for Advanced Glycation End Products Is a Promising Target of Diabetic Nephropathy
Yamamoto, Y., Doi, T., Kato, I., Shinohara, H., Sakurai, S., Yonekura, H., Watanabe, T., MYINT, K. M., Harashima, A., Takeuchi, M., et al. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1333.064 · Cited by 45 · see citing works
Jörneskog, G., Hansson, L.-O., Wallén, N. H., et al. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1046/j.1538-7836.2003.00301.x · Cited by 43 · see citing works
Lund, T., Svindland, A., Pepaj, M., et al. (2011) · Diabetes and Vascular Disease Research · doi:10.1177/1479164111416831 · Cited by 38 · see citing works
Diabetic cardiomyopathy: how much does it depend on AGE?
Montagnani, M. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.121 · Cited by 35 · see citing works
Stefañska, B. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01959.x · Cited by 34 · see citing works
Walton, H., BYRNE, J., & Robinson, G. B. (1992) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(92)90035-l · Cited by 34 · see citing works
Hsieh, C.-L., Yang, M.-H., Chyau, C.-C., et al. (2006) · Biosystems · doi:10.1016/j.biosystems.2006.04.004 · Cited by 34 · see citing works
Korean red ginseng extract alleviates advanced glycation end product-mediated renal injury
Quan, H. Y., Kim, D. Y., & Chung, S. H. (2013) · Journal of Ginseng Research · doi:10.5142/jgr.2013.37.187 · Cited by 33 · see citing works
Han, D. G., Yamamoto, Y., Munesue, S., Motoyoshi, S., Saito, H., Win, M. T. T., Watanabe, T., Tsuneyama, K., & Yamamoto, H. (2013) · Genes to Cells · doi:10.1111/gtc.12036 · Cited by 32 · see citing works
Forbes, J. M., Soldatos, G., & Thomas, M. C. (2005) · Europe PMC (PubMed Central) · Cited by 30 · see citing works
Sohn, E., Kim, J., Kim, J., et al. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/769416 · Cited by 30 · see citing works
Telmisartan inhibits AGE-induced podocyte damage and detachment
Fukami, K., Yamagishi, S., Kaifu, K., Matsui, T., Kaida, Y., Ueda, S., Takeuchi, M., Asanuma, K., & Okuda, S. (2013) · Microvascular Research · doi:10.1016/j.mvr.2013.04.006 · Cited by 29 · see citing works
Diabetes-related adduct formation and retinopathy
Stitt, A. W., & Curtis, T. M. (2011) · Journal of ocular biology, diseases, and informatics · doi:10.1007/s12177-011-9070-x · Cited by 28 · see citing works
Effects of trace elements on albumin and lipoprotein glycation in diabetic retinopathy
Hasan, N. A. (2009) · Saudi Medical Journal · doi:10.15537/1658-3175.4845 · Cited by 26 · see citing works
Could Oxidative Stress Associate with Age Products in Cataractogenesis?
Gul, A., Rahman, M. A., Hasnain, S. N., Salim, A., & Sımjee, S. U. (2008) · Current Eye Research · doi:10.1080/02713680802250939 · Cited by 26 · see citing works
Regulator of Calcineurin 1 Isoform 4 (RCAN1.4) Is Overexpressed in the Glomeruli of Diabetic Mice
Jang, C., Lim, J. H., Park, C. W., et al. (2011) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2011.15.5.299 · Cited by 25 · see citing works
Ai, J., Liu, Y., & Sun, J. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2012.1152 · Cited by 24 · see citing works
Jeannesson, P. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1393 · Cited by 24 · see citing works
Ameliorative Potential of Spironolactone in Diabetes Induced Hyperalgesia in Mice
Nadeem, K. H. A. N., Bakshi, K. S., Jaggi, A. S., et al. (2009) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.129.593 · Cited by 24 · see citing works
Self-citationNA+/K+ATPase Impairment and Experimental Glycation: The Role of Glucose Autoxidation
Santini, S. A., Cotroneo, P., Marra, G., et al. (1996) · Free Radical Research · doi:10.3109/10715769609088036 · Cited by 22 · see citing works
Elseweidy, M. M., El-Swefy, S. E., Younis, N. N., & Zaghloul, M. S. (2013) · Experimental Biology and Medicine · doi:10.1177/1535370213494644 · Cited by 21 · see citing works
Miller, A. G., Zhu, T., & Wilkinson‐Berka, J. L. (2013) · Current Clinical Pharmacology · doi:10.2174/1574884711308040004 · Cited by 20 · see citing works
Sato, K., Tatsunami, R., Yama, K., & Tampo, Y. (2013) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b13-00046 · Cited by 19 · see citing works
Role of Glycation in Human Lens Protein Structure Change
Ramalho, J. S., Marques, C., Pereira, P., & Mota, M. C. (1996) · European Journal of Ophthalmology · doi:10.1177/112067219600600211 · Cited by 19 · see citing works
Singh, N. R. (2010) · The Open Obesity Journal · doi:10.2174/1876823701002010110 · Cited by 5 · see citing works
Self-citation[Glucose, glycotoxins, and protein glycation products: the role in pathogensis].
Vn, T., Nv, K., & Shiriaeva, I. K. (2013) · PubMed · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [73]Hofmann MA Drury S Fu C Qu W Taguchi A Lu Y Avila C Kambham N Bierhaus A Nawroth P Neurath MF Slattery T Beach D McClary J Nagashima M Morser J Stern D Schmidt AM RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides Cell 1999 97 889 901 10399917
Cited by
Sorted by citations
Reactive Oxygen Species in Metabolic and Inflammatory Signaling
Forrester, S. J., Kikuchi, D. S., Hernandes, M. S., Xu, Q., & Griendling, K. K. (2018) · Circulation Research · doi:10.1161/circresaha.117.311401 · Cited by 2,081 · see citing works
Feldman, E. L., Callaghan, B. C., Pop-Busui, R., Zochodne, D. W., Wright, D. E., Bennett, D. L., Bril, V., Russell, J. W., & Viswanathan, V. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0092-1 · Cited by 1,697 · see citing works
Chaudhuri, J., Bains, Y., Guha, S., Kahn, A., Hall, D., Bose, N., Gugliucci, A., & Kapahi, P. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.08.014 · Cited by 669 · see citing works
Reactive oxygen species (ROS) in macrophage activation and function in diabetes
Rendra, E., Riabov, V., Mossel, D. M., Sevastyanova, T., Harmsen, M. C., & Kzhyshkowska, J. (2019) · Immunobiology · doi:10.1016/j.imbio.2018.11.010 · Cited by 636 · see citing works
Rungratanawanich, W., Qu, Y., Wang, X., Essa, M. M., & Song, B.-J. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00561-7 · Cited by 411 · see citing works
The cardio-renal-metabolic connection: a review of the evidence
Marassi, M., & Fadini, G. P. (2023) · Cardiovascular Diabetology · doi:10.1186/s12933-023-01937-x · Cited by 386 · see citing works
Fishman, S. L., Sonmez, H., Basman, C., Singh, V., & Poretsky, L. (2018) · Molecular Medicine · doi:10.1186/s10020-018-0060-3 · Cited by 330 · see citing works
Self-citationThe Role of Advanced Glycation End Products in Diabetic Vascular Complications
Rhee, S. Y., & Kim, Y. S. (2018) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2017.0105 · Cited by 274 · see citing works
The Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction
Sergi, D., Boulestin, H., Campbell, F. M., & Williams, L. M. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900934 · Cited by 194 · see citing works
The AGE-RAGE Axis: Implications for Age-Associated Arterial Diseases
Senatus, L. M., & Schmidt, A. M. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00187 · Cited by 167 · see citing works
Yacoub, R., Nugent, M., Cai, W., Nadkarni, G. N., Chaves, L. D., Abyad, S., Honan, A. M., Thomas, S. A., Zheng, W., Valiyaparambil, S. A., et al. (2017) · PLOS ONE · doi:10.1371/journal.pone.0184789 · Cited by 139 · see citing works
Role of advanced glycation end products in carcinogenesis and their therapeutic implications
Schröter, D., & Höhn, A. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190130145549 · Cited by 126 · see citing works
Shabalala, S. C., Johnson, R., Basson, A. K., Ziqubu, K., Hlengwa, N., Mthembu, S. X. H., Mabhida, S. E., Mazibuko-Mbeje, S. E., Hanser, S., Cirilli, I., et al. (2022) · Antioxidants · doi:10.3390/antiox11102071 · Cited by 102 · see citing works
Bao, Y., Jiang, L., Chen, H., Zou, J., Liu, Z., & Shi, Y. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430199 · Cited by 60 · see citing works
Quantification of protein glycation using vibrational spectroscopy
McAvan, B. S., France, A. P., Bellina, B., Barran, P. E., Goodacre, R., & Doig, A. J. (2020) · The Analyst · doi:10.1039/c9an02318f · Cited by 35 · see citing works
Xu, Y., Zhang, Q., Luo, D., Wang, J., & Duan, D. (2017) · Journal of Applied Phycology · doi:10.1007/s10811-016-0942-0 · Cited by 29 · see citing works
Dhananjayan, K., Gunawardena, D., Hearn, N., Sonntag, T., Moran, C., Gyengesi, E., Srikanth, V., & Münch, G. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161152 · Cited by 24 · see citing works
Ansari, P., Khan, J. T., Choudhary, S., Reberio, A. D., Kumar, S., Seidel, V., Abdel-Wahab, Y. H. A., & Flatt, P. R. (2024) · doi:10.20944/preprints202408.1739.v1 · Cited by 89 · see citing works
- Authors
- Singh, V. P., Bali, A., Singh, N., & Jaggi, A. S.
- Affiliations
- Punjabi University (IN)
- Corresponding author
- Jaggi, Amteshwar Singh
- Venue
- The Korean Journal of Physiology & Pharmacology
- Published
- 2014
- Volume
- 18
- Issue
- 1
- Pages
- 1
- ISSN
- 1226-4512 (ISSN-L)
- 2093-3827
- PMC
- PMC3951818
- OpenAlex
- W2120293565
- Cited by
- 1,518
- References
- 187
- Citations by year
- 2026: 109 · 2025: 144 · 2024: 146 · 2023: 144 · 2022: 185 · 2021: 159 · 2020: 174 · 2019: 119 · 2018: 117 · 2017: 96 · 2016: 70 · 2015: 36 · 2014: 18
- FWCI
- 9.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Korean Journal of Physiology and Pharmacology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- advanced glycation end products, diabetes complications, glycation, protein glycation, receptor for advanced glycation end products, retinopathy, kidney disease, neuropathy, cardiomyopathy, cataract, albumin, fibrinogen, collagen, hyperglycemia, pro-inflammatory signaling, free radicals
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
