The role of impaired early insulin secretion in the pathogenesis of Type II diabetes mellitus

Glucose clamp technique: a method for quantifying insulin secretion and resistance.

DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425

The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus

Weyer, C., Bogardus, C., Mott, D. M., & Pratley, R. E. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7231 · Cited by 1,940

Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of pima indians

Lillioja, S., Mott, D. M., Spraul, M., Ferraro, R., Foley, J. E., Ravussin, E., Knowler, W. C., Bennett, P. H., & Bogardus, C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292703 · Cited by 1,508

Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study

Martin, B. C., Warram, J. H., Krolewski, A. S., Soeldner, J. S., Kahn, C. R., Martin, B. C., & Bergman, R. N. (1992) · The Lancet · doi:10.1016/0140-6736(92)92814-v · Cited by 1,158

Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents

Warram, J. H., Martin, B. C., Krolewski, A. S., Soeldner, J. S., & Kahn, C. R. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-12-909 · Cited by 1,038

Early Metabolic Defects in Persons at Increased Risk for Non-Insulin-Dependent Diabetes Mellitus

Eriksson, J., Franssila-Kallunki, A., Ekstrand, A., Saloranta, C., Widén, E., Schalin, C., & Groop, L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198908103210601 · Cited by 807

Diabetes mellitus in the Pima Indians: Incidence, risk factors and pathogenesis

Knowler, W. C., Pettitt, D. J., Saad, M. F., & Bennett, P. H. (1990) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610060101 · Cited by 578

Relationships Between Fasting Plasma Glucose Levels and Insulin Secretion During Intravenous Glucose Tolerance Tests

BRUNZELL, J. D., ROBERTSON, R. P., LERNER, R. L., HAZZARD, W. R., ENSINCK, J. W., BIERMAN, E. L., & PORTE, D. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-42-2-222 · Cited by 505

THE PLASMA INSULIN RESPONSE TO GLUCOSE INFUSION IN HEALTHY SUBJECTS AND IN DIABETES MELLITUS

Cerasi, E., & Luft, R. (1967) · Acta Endocrinologica · doi:10.1530/acta.0.0550278 · Cited by 371

Risk factors for worsening to diabetes in subjects with impaired glucose tolerance

Kadowaki, T., Miyake, Y., Hagura, R., Akanuma, Y., Kajinuma, H., Kuzuya, N., Takaku, F., & Kosaka, K. (1984) · Diabetologia · doi:10.1007/bf00252262 · Cited by 316

Decreased Insulin Secretion and Increased Insulin Resistance Are Independently Related to the 7-Year Risk of NIDDM in Mexican-Americans

Haffner, S. M., Miettinen, H., Gaskill, S. P., & Stern, M. P. (1995) · Diabetes · doi:10.2337/diab.44.12.1386 · Cited by 303

Metabolic characteristics of individuals with impaired fasting glucose and/or impaired glucose tolerance.

Weyer, C., Bogardus, C., & Pratley, R. E. (1999) · Diabetes · doi:10.2337/diabetes.48.11.2197 · Cited by 292

Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs.

Rebrin, K., Steil, G. M., Mittelman, S. D., & Bergman, R. N. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118846 · Cited by 289

Decreased Sensitivity of the Pancreatic Beta Cells to Glucose in Prediabetic and Diabetic Subjects: A Glucose Dose-Response Study

Cerasi, E., Luft, R., & Efendic, S. (1972) · Diabetes · doi:10.2337/diab.21.4.224 · Cited by 250

Plasma Insulin Response Among Nauruans: Prediction of Deterioration in Glucose Tolerance Over 6 Yr

Sicree, R. A., Zimmet, P. Z., King, H. O. M., & Coventry, J. S. (1987) · Diabetes · doi:10.2337/diab.36.2.179 · Cited by 232

BETA-CELL DYSFUNCTION, RATHER THAN INSULIN INSENSITIVITY, IS THE PRIMARY DEFECT IN FAMILIAL TYPE 2 DIABETES

O'Rahilly, S. P., Rudenski, A. S., Burnett, M. A., Nugent, Z., Hosker, J. P., Darling, P., & Turner, R. C. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90052-8 · Cited by 230

Risk factors for developing non-insulin dependent diabetes: a 10 year follow up of men in Uppsala.

Skarfors, E. T., Selinus, K. I., & Lithell, H. O. (1991) · BMJ · doi:10.1136/bmj.303.6805.755 · Cited by 215

Glucose Tolerance, Insulin Secretion, and Insulin Sensitivity in Nonobese and Obese Japanese Subjects

Matsumoto, K., Miyake, S., Yano, M., Ueki, Y., Yamaguchi, Y., Akazawa, S., & Tominaga, Y. (1997) · Diabetes Care · doi:10.2337/diacare.20.10.1562 · Cited by 212

Identification of the docked granule pool responsible for the first phase of glucose-stimulated insulin secretion.

Daniel, S., Noda, M., Straub, S. G., & Sharp, G. W. (1999) · Diabetes · doi:10.2337/diabetes.48.9.1686 · Cited by 210

Effect of loss of first-phase insulin secretion on hepatic glucose production and tissue glucose disposal in humans

Luzi, L., & DeFronzo, R. A. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.257.2.e241 · Cited by 186

Pancreatic Beta-Cell Dysfunction as the Primary Genetic Lesion in NIDDM: Evidence From Studies in Normal Glucose-Tolerant Individuals With a First-Degree NIDDM Relative

Pimenta, W. (1995) · JAMA · doi:10.1001/jama.1995.03520470063033 · Cited by 174

Study of the Relationship Between Glucose and Insulin Responses to an Oral Glucose Load in Man

Reaven, G., & Miller, R. (1968) · Diabetes · doi:10.2337/diab.17.9.560 · Cited by 171

Interstitial insulin concentrations determine glucose uptake rates but not insulin resistance in lean and obese men.

Castillo, C., Bogardus, C., Bergman, R. N., Thuillez, P., & Lillioja, S. (1994) · Journal of Clinical Investigation · doi:10.1172/jci116932 · Cited by 156

Loss of Early Phase of Insulin Release in Humans Impairs Glucose Tolerance and Blunts Thermic Effect of Glucose

Calles-Escandon, J., & Robbins, D. C. (1987) · Diabetes · doi:10.2337/diab.36.10.1167 · Cited by 154

Aspects of the Pathogenesis of Type 2 Diabetes*

Efendić, S., Luft, R., & Wajngot, A. (1984) · Endocrine Reviews · doi:10.1210/edrv-5-3-395 · Cited by 153

Rapid and short-acting mealtime insulin secretion with nateglinide controls both prandial and mean glycemia.

Hanefeld, M., Bouter, K. P., Dickinson, S., et al. (2000) · Diabetes Care · doi:10.2337/diacare.23.2.202 · Cited by 137

Normalization of Insulin Responses to Glucose by Overnight Infusion of Glucagon-Like Peptide 1 (7–36) Amide in Patients With NIDDM

Rachman, J., Gribble, F. M., Barrow, B. A., Lévy, J., Buchanan, K. D., & Turner, R. C. (1996) · Diabetes · doi:10.2337/diab.45.11.1524 · Cited by 119

Different Effects of Glyburide and Glipizide on Insulin Secretion and Hepatic Glucose Production in Normal and NIDDM Subjects

Groop, L., Luzi, L., Melander, A., Groop, P., Ratheiser, K., Simonson, D. C., & DeFronzo, R. A. (1987) · Diabetes · doi:10.2337/diab.36.11.1320 · Cited by 109

Impaired postprandial glucose utilization in non-insulin-dependent diabetes mellitus

Kelley, D., Mokan, M., & Veneman, T. (1994) · Metabolism · doi:10.1016/0026-0495(94)90015-9 · Cited by 107

Fasting Serum Insulin Concentration and Early Insulin Response as Risk Determinants for Developing Diabetes

Lundgren, H., Bengtsson, C., Blohmé, G., Lapidus, L., & Waldenström, J. (1990) · Diabetic Medicine · doi:10.1111/j.1464-5491.1990.tb01415.x · Cited by 103

New concepts in extracellular signaling for insulin action: the single gateway hypothesis.

Bergman, R. N. (1997) · PubMed · Cited by 101

Aerobic Exercise Training‐Induced Reductions in Abdominal Fat and Glucose‐Stimulated Insulin Responses in Middle‐Aged and Older Men

Pratley, R. E., Hagberg, J. M., Dengel, D. R., Rogus, E. M., Muller, D. C., & Goldberg, A. P. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb04780.x · Cited by 92

Relationship between heterogeneity of insulin responses and insulin resistance in normal subjects and patients with chemical diabetes

Reaven, G. M., & Olefsky, J. M. (1977) · Diabetologia · doi:10.1007/bf01219700 · Cited by 83

Analysis of Early-Phase Insulin Responses in Nonobese Subjects With Mild Glucose Intolerance

Yoneda, H., Ikegami, H., Yamamoto, Y., Yamato, E., Cha, T., Kawaguchi, Y., Tahara, Y., & Ogihara, T. (1992) · Diabetes Care · doi:10.2337/diacare.15.11.1517 · Cited by 66

Increased prandial insulin secretion after administration of a single preprandial oral dose of repaglinide in patients with type 2 diabetes.

Owens, D. R., Luzio, S. D., Ismail, I. S., & Bayer, A. J. (2000) · Diabetes Care · doi:10.2337/diacare.23.4.518 · Cited by 64

Subcutaneous glucagon-like peptide-1 improves postprandial glycaemic control over a 3-week period in patients with early Type 2 diabetes

Todd, J. F., Edwards, C. M. B., Ghatei, M. A., Mather, H. M., & Bloom, S. R. (1998) · Clinical Science · doi:10.1042/cs0950325 · Cited by 53

Relationship Between Glucose Tolerance and Glucose-Stimulated Insulin Response in 65-Year-Olds

Bourey, R. E., Kohrt, W. M., Kirwan, J. P., Staten, M. A., King, D. S., & Holloszy, J. O. (1993) · Journal of Gerontology · doi:10.1093/geronj/48.4.m122 · Cited by 52

Biphasic insulin secretion during intravenous glucose tolerance test promotes optimal interstitial insulin profile.

Getty‐Kaushik, L., Hamilton-Wessler, M., Ader, M., Dea, M. K., & Bergman, R. N. (1998) · Diabetes · doi:10.2337/diabetes.47.12.1941 · Cited by 46

Factors determining serum-insulin response in a population sample

Welborn, T. A., STENHOUSE, N. S., & Johnstone, C. (1969) · Diabetologia · doi:10.1007/bf01212096 · Cited by 43

Effects of the new oral hypoglycaemic agent nateglinide on insulin secretion in Type 2 diabetes mellitus

Whitelaw, D. C., Clark, P. M. S., Smith, J. M., & Nattrass, M. (2000) · Diabetic Medicine · doi:10.1046/j.1464-5491.2000.00256.x · Cited by 41

Influence of gliclazide on glucose-stimulated insulin release in man

van Haeften, T. W., Veneman, T. F., Gerich, J. E., & van der Veen, E. A. (1991) · Metabolism · doi:10.1016/0026-0495(91)90096-f · Cited by 32

Differential Effects of Tolbutamide on First and Second Phase Insulin Secretion in Noninsulin-Dependent Diabetes Mellitus*

PFEIFER, M. A., Halter, J. B., Beard, J. C., & Porte, D. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-6-1256 · Cited by 26

Alterations in Glucose Metabolism in the Elderly Patient with Diabetes

Meneilly, G. S., Dawson, K. G., & Tessier, D. (1993) · Diabetes Care · doi:10.2337/diacare.16.9.1241 · Cited by 25

Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary: The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD)

Authors/Task Force Members, Ryden, L., Standl, E., Bartnik, M., Van den Berghe, G., Betteridge, J., de Boer, M.-J., Cosentino, F., Jonsson, B., Laakso, M., et al. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl260 · Cited by 1,647

Preservation of Pancreatic β-Cell Function and Prevention of Type 2 Diabetes by Pharmacological Treatment of Insulin Resistance in High-Risk Hispanic Women

Buchanan, T. A., Xiang, A. H., Peters, R. K., Kjos, S. L., Marroquin, A., Goico, J., Ochoa, C., Tan, S., Berkowitz, K., Hodis, H. N., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2796 · Cited by 1,339

Monocyte chemoattractant protein 1 in obesity and insulin resistance

Sartipy, P., & Loskutoff, D. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1133870100 · Cited by 1,201

Contributions of β-Cell Dysfunction and Insulin Resistance to the Pathogenesis of Impaired Glucose Tolerance and Impaired Fasting Glucose

Abdul-Ghani, M. A., Tripathy, D., & DeFronzo, R. A. (2006) · Diabetes Care · doi:10.2337/dc05-2179 · Cited by 744

Prevention of type 2 diabetes by lifestyle intervention: a Japanese trial in IGT males

Kosaka, K., Noda, M., & Kuzuya, T. (2005) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2004.06.010 · Cited by 656