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Cited by 143Muscle Physiology and DisordersIntensive Care Unit Cognitive DisordersClinical Nutrition and Gastroenterology

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Dynamics of myosin degradation in intensive care unit-acquired weakness during severe critical illness

Wollersheim, Tobias, Woehlecke, Janine, Krebs, Martin, Hamati, Jida, Lodka, Doerte, Luther-Schroeder, Anja, Langhans, Claudia, Haas, Kurt, Radtke, Theresa, Kleber, Christian, Spies, Claudia, Labeit, Siegfried, Schuelke, Markus, Spuler, Simone, Spranger, Joachim, Weber-Carstens, Steffen, Fielitz, Jens·2014·Intensive Care Medicine
DOI 10.1007/s00134-014-3224-9
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Abstract

Importance Intensive care unit (ICU)-acquired muscle wasting is a devastating complication leading to persistent weakness and functional disability. The mechanisms of this myopathy are unclear, but a disturbed balance of myosin heavy chain (MyHC) is implicated. Objective To investigate pathways of myosin turnover in severe critically ill patients at high risk of ICU-acquired weakness. Design Prospective, mechanistic, observational study. Setting Interdisciplinary ICUs of a university hospital. Participants Twenty-nine patients with Sequential Organ Failure Assessment (SOFA) scores of at least 8 on three consecutive days within the first 5 days in ICU underwent two consecutive open skeletal muscle biopsies from the vastus lateralis at median days 5 and 15. Control biopsy specimens were from healthy subjects undergoing hip-replacement surgery. Interventions None. Main outcome(s) and measure(s) Time-dependent changes in myofiber architecture, MyHC synthesis, and degradation were determined and correlated with clinical data. Results ICU-acquired muscle wasting was characterized by early, disrupted myofiber ultrastructure followed by atrophy of slow- and fast-twitch myofibers at later time points. A rapid decrease in MyHC mRNA and protein expression occurred by day 5 and persisted at day 15 (P Conclusions and relevance Decreased synthesis and increased degradation of MyHCs contribute to ICU-acquired muscle wasting. The rates and time frames suggest that pathogenesis of muscle fail…

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Crossref · 10.1007/s00134-014-3224-9

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  • Both MuRF1 and Atrogin-1 are increased early and persistently during critical illness and possibly mediate muscle atrophy in ICUAW patients.

    “Both MuRF1 and Atrogin‐1 are increased early and persistently during critical illness and possibly mediate muscle atrophy in ICUAW patients.”

    From Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting (2022) · cites this paper as [4]

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Research works printed but not linked: 34

  1. De Jonghe B, Sharshar T, Lefaucheur JP, Authier FJ, Durand-Zaleski I, Boussarsar M, Cerf C, Renaud E, Mesrati F, Carlet J, Raphael JC, Outin H, Bastuji-Garin S (2002) Paresis acquired in the intensive care unit: a prospective multicenter study. JAMA 288:2859–2867 · DOI
  2. Jaber S, Jung B, Matecki S, Petrof BJ (2011) Clinical review: ventilator-induced diaphragmatic dysfunction—human studies confirm animal model findings! Crit Care 15:206 · DOI
  3. Tobin MJ, Laghi F, Jubran A (2010) Narrative review: ventilator-induced respiratory muscle weakness. Ann Intern Med 153:240–245 · DOI
  4. Cheung AM, Tansey CM, Tomlinson G, Diaz-Granados N, Matte A, Barr A, Mehta S, Mazer CD, Guest CB, Stewart TE, Al-Saidi F, Cooper AB, Cook D, Slutsky AS, Herridge MS (2006) Two-year outcomes, health care use, and costs of survivors of acute respiratory distress syndrome. Am J Respir Crit Care Med 174:538–544 · DOI
  5. Helliwell TR, Wilkinson A, Griffiths RD, McClelland P, Palmer TE, Bone JM (1998) Muscle fibre atrophy in critically ill patients is associated with the loss of myosin filaments and the presence of lysosomal enzymes and ubiquitin. Neuropathol Appl Neurobiol 24:507–517 · DOI
  6. Gruther W, Benesch T, Zorn C, Paternostro-Sluga T, Quittan M, Fialka-Moser V, Spiss C, Kainberger F, Crevenna R (2008) Muscle wasting in intensive care patients: ultrasound observation of the M. quadriceps femoris muscle layer. J Rehabil Med 40:185–189 · DOI · Paper page
  7. Poulsen JB, Rose MH, Jensen BR, Moller K, Perner A (2013) Biomechanical and nonfunctional assessment of physical capacity in male ICU survivors. Crit Care Med 41:93–101 · DOI
  8. Callahan LA, Supinski GS (2009) Hyperglycemia and acquired weakness in critically ill patients: potential mechanisms. Crit Care 13:125 · DOI
  9. Winkelman C (2010) The role of inflammation in ICU-acquired weakness. Crit Care 14:186 · DOI · Paper page
  10. Klaude M, Mori M, Tjader I, Gustafsson T, Wernerman J, Rooyackers O (2012) Protein metabolism and gene expression in skeletal muscle of critically ill patients with sepsis. Clin Sci (Lond) 122:133–142 · DOI
  11. Lecker SH (2003) Ubiquitin-protein ligases in muscle wasting: multiple parallel pathways? Curr Opin Clin Nutr Metab Care 6:271–275
  12. Lecker SH, Solomon V, Mitch WE, Goldberg AL (1999) Muscle protein breakdown and the critical role of the ubiquitin–proteasome pathway in normal and disease states. J Nutr 129:227S–237S · DOI
  13. Levine S, Biswas C, Dierov J, Barsotti R, Shrager JB, Nguyen T, Sonnad S, Kucharchzuk JC, Kaiser LR, Singhal S, Budak MT (2011) Increased proteolysis, myosin depletion, and atrophic AKT–FOXO signaling in human diaphragm disuse. Am J Respir Crit Care Med 183:483–490 · DOI
  14. Levine S, Nguyen T, Taylor N, Friscia ME, Budak MT, Rothenberg P, Zhu J, Sachdeva R, Sonnad S, Kaiser LR, Rubinstein NA, Powers SK, Shrager JB (2008) Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans. N Engl J Med 358:1327–1335 · DOI
  15. Puthucheary ZA, Rawal J, McPhail M, Connolly B, Ratnayake G, Chan P, Hopkinson NS, Padhke R, Dew T, Sidhu PS, Velloso C, Seymour J, Agley CC, Selby A, Limb M, Edwards LM, Smith K, Rowlerson A, Rennie MJ, Moxham J, Harridge SD, Hart N, Montgomery HE (2013) Acute skeletal muscle wasting in critical illness. JAMA 310:1591–1600 · DOI · Paper page
  16. Fielitz J, Kim MS, Shelton JM, Latif S, Spencer JA, Glass DJ, Richardson JA, Bassel-Duby R, Olson EN (2007) Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3. J Clin Invest 117:2486–2495 · DOI
  17. Derde S, Hermans G, Derese I, Guiza F, Hedstrom Y, Wouters PJ, Bruyninckx F, D’Hoore A, Larsson L, Van den Berghe G, Vanhorebeek I (2012) Muscle atrophy and preferential loss of myosin in prolonged critically ill patients. Crit Care Med 40:79–89 · DOI
  18. Wollersheim T, Woehlecke J, Krebs M, Hamati J, Lodka D, Langhans C, Luther-Schroeder A, Haas K, Rathke T, Kleber C, Spies C, Labeit S, Schuelke M, Spuler S, Spranger J, Weber-Carstens S, Fielitz J (2013) Rapid myosin loss in intensive care unit acquired weakness. Intensive Care Med 39:228
  19. Wollersheim T, Weber-Carstens S, Egbers C, Luther A, Krebs M, Hamati J, Lodka D, Kleber C, Spies C, Spuler S, Fielitz J (2012) Dynamics of skeletal muscle atrophy and atrophy gene expression in critically ill patients during ICU stay. Intensive Care Med 38:130
  20. Weber-Carstens S, Koch S, Spuler S, Spies CD, Bubser F, Wernecke KD, Deja M (2009) Nonexcitable muscle membrane predicts intensive care unit-acquired paresis in mechanically ventilated, sedated patients. Crit Care Med 37:2632–2637 · DOI
  21. Kim MS, Fielitz J, McAnally J, Shelton JM, Lemon DD, McKinsey TA, Richardson JA, Bassel-Duby R, Olson EN (2008) Protein kinase D1 stimulates MEF2 activity in skeletal muscle and enhances muscle performance. Mol Cell Biol 28:3600–3609 · DOI
  22. Eikermann M, Latronico N (2013) What is new in prevention of muscle weakness in critically ill patients? Intensive Care Med 39:2200–2203 · DOI
  23. Du J, Wang X, Miereles C, Bailey JL, Debigare R, Zheng B, Price SR, Mitch WE (2004) Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions. J Clin Invest 113:115–123 · DOI
  24. Tidball JG, Spencer MJ (2002) Expression of a calpastatin transgene slows muscle wasting and obviates changes in myosin isoform expression during murine muscle disuse. J Physiol 545:819–828 · DOI
  25. Smith IJ, Alamdari N, O’Neal P, Gonnella P, Aversa Z, Hasselgren PO (2010) Sepsis increases the expression and activity of the transcription factor Forkhead Box O 1 (FOXO1) in skeletal muscle by a glucocorticoid-dependent mechanism. Int J Biochem Cell Biol 42:701–711 · DOI
  26. Ciechanover A (2006) The ubiquitin proteolytic system: from a vague idea, through basic mechanisms, and onto human diseases and drug targeting. Neurology 66:S7–S19 · DOI
  27. Weber-Carstens S, Schneider J, Wollersheim T, Assmann A, Bierbrauer J, Marg A, Al Hasani H, Chadt A, Wenzel K, Koch S, Fielitz J, Kleber C, Faust K, Mai K, Spies CD, Luft FC, Boschmann M, Spranger J, Spuler S (2012) Critical illness myopathy and GLUT4—significance of insulin and muscle contraction. Am J Respir Crit Care Med 187:387–396 · DOI
  28. Moriscot AS, Baptista IL, Bogomolovas J, Witt C, Hirner S, Granzier H, Labeit S (2010) MuRF1 is a muscle fiber-type II associated factor and together with MuRF2 regulates type-II fiber trophicity and maintenance. J Struct Biol 170:344–353 · DOI
  29. Crossland H, Constantin-Teodosiu D, Gardiner SM, Constantin D, Greenhaff PL (2008) A potential role for Akt/FOXO signalling in both protein loss and the impairment of muscle carbohydrate oxidation during sepsis in rodent skeletal muscle. J Physiol 586:5589–5600 · DOI
  30. Dardevet D, Sornet C, Taillandier D, Savary I, Attaix D, Grizard J (1995) Sensitivity and protein turnover response to glucocorticoids are different in skeletal muscle from adult and old rats. Lack of regulation of the ubiquitin-proteasome proteolytic pathway in aging. J Clin Invest 96:2113–2119 · DOI
  31. Minneci PC, Deans KJ, Banks SM, Eichacker PQ, Natanson C (2004) Meta-analysis: the effect of steroids on survival and shock during sepsis depends on the dose. Ann Intern Med 141:47–56 · DOI
  32. Griffiths RD, Hall JB (2010) Intensive care unit-acquired weakness. Crit Care Med 38:779–787 · DOI
  33. Ali NA, O’Brien JM Jr, Hoffmann SP, Phillips G, Garland A, Finley JC, Almoosa K, Hejal R, Wolf KM, Lemeshow S, Connors AF Jr, Marsh CB (2008) Acquired weakness, handgrip strength, and mortality in critically ill patients. Am J Respir Crit Care Med 178:261–268 · DOI
  34. Kress JP, Herridge MS (2012) Medical and economic implications of physical disability of survivorship. Semin Respir Crit Care Med 33:339–347 · DOI

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Metadata

Authors
Wollersheim, T., Woehlecke, J., Krebs, M., Hamati, J., Lodka, D., Luther-Schroeder, A., Langhans, C., Haas, K., Radtke, T., Kleber, C., Spies, C., Labeit, S., Schuelke, M., Spuler, S., Spranger, J., Weber-Carstens, S., & Fielitz, J.
Affiliations
  • Charité – Universitätsmedizin Berlin (DE)
  • Max Delbrück Center (DE)
  • University Medical Centre Mannheim (DE)
Corresponding author
Fielitz, Jens
ORCID
Venue
Intensive Care Medicine
Publisher
Springer Science and Business Media LLC
Published
2014-02-15
Volume
40
Issue
4
Pages
528-538
ISSN
  • 0342-4642 (ISSN-L)
  • 1432-1238
DOI
10.1007/s00134-014-3224-9
OpenAlex
W1978492957
Cited by
143
References
9
Citations by year
2026: 8 · 2025: 12 · 2024: 5 · 2023: 10 · 2022: 18 · 2021: 12 · 2020: 11 · 2019: 17 · 2018: 5 · 2017: 11 · 2016: 8 · 2015: 19 · 2014: 6
FWCI
6.01
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Intensive Care Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Keywords
ICU-acquired weakness, myosin heavy chain, myosin degradation, myosin synthesis, MuRF1, atrogin-1, muscle atrophy, muscle biopsy, critical illness, muscle protein turnover, vastus lateralis
MeSH terms
Adult, Aged, Critical Care, Female, Humans, Male, Middle Aged, Myosins, Prospective Studies, Critical Illness, Muscle Weakness

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