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Cited by 162Abdominal vascular conditions and treatmentsSepsis Diagnosis and TreatmentAppendicitis Diagnosis and Management

Outcome of acute mesenteric ischemia in the intensive care unit: a retrospective, multicenter study of 780 cases

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Leone, Marc, Bechis, Carole, Baumstarck, Karine, Ouattara, Alexandre, Collange, Olivier, Augustin, Pascal, Annane, Djillali, Arbelot, Charlotte +32 more·2015·Intensive Care Medicine
DOI 10.1007/s00134-015-3690-8
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Abstract

Background In the intensive care unit (ICU), the outcomes of patients with acute mesenteric ischemia (AMI) are poorly documented. This study aimed to determine the risk factors for death in ICU patients with AMI. Methods A retrospective, observational, non-interventional, multicenter study was conducted in 43 ICUs of 38 public institutions in France. From January 2008 to December 2013, all adult patients with a diagnosis of AMI during their hospitalization in ICU were included in a database. The diagnosis was confirmed by at least one of three procedures (computed tomography scan, gastrointestinal endoscopy, or upon surgery). To determine factors associated with ICU death, we established a logistic regression model. Recursive partitioning analysis was applied to construct a decision tree regarding risk factors and their interactions most critical to determining outcomes. Results The death rate of the 780 included patients was 58 %. Being older, having a higher sequential organ failure assessment (SOFA) severity score at diagnosis, and a plasma lactate concentration over 2.7 mmol/l at diagnosis were independent risk factors of ICU mortality. In contrast, having a prior history of peripheral vascular disease or an initial surgical treatment were independent protective factors against ICU mortality. Using age and SOFA severity score, we established an ICU mortality score at diagnosis based on the cutoffs provided by recursive partitioning analysis. Probability of survival was statistically different (p < 0.001) between patients with a score from 0 to 2 and those with a score of 3 and 4. Conclusion Acute mesenteric ischemia in ICU patients was associated with a 58 % ICU death rate. Age and SOFA severity score at diagnosis were risk factors for mortality. Plasma lactate concentration over 2.7 mmol/l was also an independent risk factor, but values in the normal range did not exclude the diagnosis of AMI.

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  • Mesenteric ischemia carries a mortality exceeding 75%.

    “mesenteric ischemia carries a mortality exceeding 75%.141”

    From Malnutrition and Cachexia in Inpatients With Acute Cardiac Conditions: A Scientific Statement From the American Heart Association (2026) · cites this paper as [141]

    The Abstract reports a 58% death rate among 780 ICU patients with acute mesenteric ischemia, not a rate exceeding 75%. The Discussion also gives a previously reported operative mortality range of 26–72%; its near-100% figure applies specifically to missed cases that did not undergo surgery. (LLM, conf=0.88)

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Authors
Leone, M., Bechis, C., Baumstarck, K., Ouattara, A., Collange, O., Augustin, P., Annane, D., Arbelot, C., Asehnoune, K., Baldési, O., Bourcier, S., Delapierre, L., Demory, D., Hengy, B., Ichai, C., Kipnis, E., Brasdefer, E., Lasocki, S., Legrand, M., Mimoz, O., Rimmelé, T., Aliane, J., Bertrand, P.-M., Bruder, N., Klasen, F., Friou, E., Lévy, B., Martinez, O., Peytel, E., Piton, A., Richter, E., Toufik, K., Vogler, M.-C., Wallet, F., Boufi, M., Allaouchiche, B., Constantin, J.-M., Martin, C., Jaber, S., & Lefrant, J.-Y.
Affiliations
  • Aix-Marseille Université (FR)
  • Université de Bordeaux (FR)
  • Hôpitaux Universitaires de Strasbourg (FR)
  • Hôpital Bichat-Claude-Bernard (FR)
  • Université de Versailles Saint-Quentin-en-Yvelines (FR)
  • Assistance Publique – Hôpitaux de Paris (FR)
  • Centre Hospitalier Intercommunal Aix-Pertuis (FR)
  • Hôpital Cochin (FR)
  • Centre Hospitalier Intercommunal Toulon-La Seyne-sur-Mer (FR)
  • Hospices Civils de Lyon (FR)
  • Université de Lille (FR)
  • Centre Hospitalier Universitaire d'Angers (FR)
  • Inserm (FR)
  • Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
  • Centre Hospitalier de Cannes (FR)
  • Centre Hospitalier Régional et Universitaire de Nancy (FR)
  • Centre Hospitalier Universitaire de Montpellier (FR)
  • Hôpital Laveran (FR)
  • Université Toulouse III - Paul Sabatier (FR)
  • Centre Hospitalier Universitaire de Saint-Étienne (FR)
  • Centre Hospitalier Universitaire de Nîmes (FR)
ORCID
Venue
Intensive Care Medicine
Publisher
Springer Science and Business Media LLC
Published
2015-03-03
Volume
41
Issue
4
Pages
667-676
ISSN
  • 0342-4642 (ISSN-L)
  • 1432-1238
DOI
10.1007/s00134-015-3690-8
OpenAlex
W2010406259
Cited by
162
References
5
Citations by year
2026: 5 · 2025: 10 · 2024: 9 · 2023: 13 · 2022: 20 · 2021: 23 · 2020: 19 · 2019: 12 · 2018: 18 · 2017: 16 · 2016: 13 · 2015: 3
FWCI
16.80
Type
journal article
Language
en
Update notices
correction (2015-03-12)
Open access
Licence
Locations
  • Intensive Care Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Emergency Medicine › Appendicitis Diagnosis and Management
Keywords
acute mesenteric ischemia, ICU mortality, risk factors, SOFA score, plasma lactate, age, peripheral vascular disease, surgical treatment, prognosis
MeSH terms
Age Factors, Aged, Aged, 80 and over, Female, France, Humans, Intensive Care Units, Male, Middle Aged, Multiple Organ Failure, Retrospective Studies, Risk Factors, Severity of Illness Index, Logistic Models, Hospital Mortality, Mesenteric Ischemia

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