Nutrition in the acute phase of critical illness

Casaer, Michael P.; Van den Berghe, Greet

doi:10.1056/nejmra1304623

Cited by 335Clinical Nutrition and GastroenterologyHyperglycemia and glycemic control in critically ill and hospitalized patientsSepsis Diagnosis and Treatment

Nutrition in the acute phase of critical illness

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Casaer, Michael P., Van den Berghe, Greet·2014·New England Journal of Medicine

DOI 10.1056/nejmra1304623

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Abstract

† No diagram showing how patients were selected was included in the study by Montejo et al. 10 ‡ No information on the way in which investigators concealed study-group assignments was included in the study by Acosta-Escribano et al. 13 § No sample-size calculation and only partial outcome data in the intention-to-treat population were included in the study by Pontes-Arruda et al., 22 and no diagram showing how patients were selected was included in the study by Umpierrez et al. 23¶ The study by Rice et al. 24 was stopped prematurely for futility at the first interim analysis.

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These findings may explain differences in results of nutritional trials depending on clinical setting, with several nutritional studies in ICU settings or in patients with advanced cancer not showing significant benefits from nutrition in regard to clinical outcomes.
“These findings may also explain differences in results of nutritional trials, depending on the clinical setting with several nutritional studies in the ICU setting or in patients with advanced cancer not showing significant benefits form nutrition in regard to clinical outcomes [165,168].”
From ESPEN guideline on nutritional support for polymorbid medical inpatients (2023) · cites this paper as [168]
Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
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Data from studies conducted in the past 10 years challenge the appropriateness of standard calorie and protein targets during the acute phase of critical illness.
“Data from studies conducted in the past 10 years challenge the appropriateness of these standard calorie and protein targets during the acute phase of critical illness.8,9”
From Low versus standard calorie and protein feeding in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group trial (NUTRIREA-3). (2023) · cites this paper as [8]

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“These ﬁ ndings may also explain differences in results of nutritional trials, depending on the clinical setting with several nutritional studies in the ICU setting or in patients with advanced cancer not showing signi ﬁ cant bene ﬁ ts form nutrition in regard to clinical outcomes [165,168].”
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Enteral nutrition improves clinical outcome and reduces costs of acute mesenteric ischaemia after recanalisation in the intensive care unit.
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Authors: Casaer, M. P., & Van den Berghe, G.
Affiliations: KU Leuven (BE)
ORCID: Casaer, Michael P.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2014-03-27
Volume: 370
Issue: 13
Pages: 1227-1236
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmra1304623
OpenAlex: W2167108605
Semantic Scholar: 0cb329f79bd3d2161f4d43c16bc04bf14fe369d7
Cited by: 335
References: 58
Citations by year: 2026: 17 · 2025: 18 · 2024: 18 · 2023: 17 · 2022: 24 · 2021: 29 · 2020: 23 · 2019: 23 · 2018: 30 · 2017: 34 · 2016: 27 · 2015: 56 · 2014: 18
FWCI: 5.12
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Lirias (KU Leuven) (submittedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
Keywords: nutrition, critical illness, acute phase, critically ill patients, nutritional support, methodological quality, reporting quality, sample size determination, blinding, early trial termination
MeSH terms: Amino Acids, Animals, Anorexia, Enteral Nutrition, Food, Humans, Lipids, Nutritional Requirements, Parenteral Nutrition, Time Factors, Randomized Controlled Trials as Topic, Critical Illness, Micronutrients

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Nutrition in the acute phase of critical illness

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