Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: The LUNG SAFE study.

Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome

(2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421801 · Cited by 12,941 · see citing works

Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice

Chen, Y., Wang, L., Kang, Q., Zhang, X., Yu, G., Wan, X., Wang, J., & Zhu, K. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000477308 · Cited by 10,730 · see citing works

Acute Respiratory Distress Syndrome

Ards Definition Task Force (2012) · JAMA · doi:10.1001/jama.2012.5669 · Cited by 8,806 · see citing works

Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries.

Bellani, G., Laffey, J. G., Pham, T., Fan, E., Brochard, L., Esteban, A., Gattinoni, L., van Haren, F., Larsson, A., McAuley, D. F., et al. (2016) · JAMA · doi:10.1001/jama.2016.0291 · Cited by 5,766 · see citing works

Prone positioning in severe acute respiratory distress syndrome.

Guérin, C., Reignier, J., Richard, J.-C., Beuret, P., Gacouin, A., Boulain, T., Mercier, E., Badet, M., Mercat, A., Baudin, O., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1214103 · Cited by 4,040 · see citing works

Incidence and Outcomes of Acute Lung Injury

Rubenfeld, G. D., Caldwell, E., Peabody, E., Weaver, J., Martin, D. P., Neff, M., Stern, E. J., & Hudson, L. D. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050333 · Cited by 3,684 · see citing works

Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome.

Amato, M. B. P., Barbas, C. S. V., Medeiros, D. M., Magaldi, R. B., Schettino, G. P., Lorenzi-Filho, G., Kairalla, R. A., Deheinzelin, D., Munoz, C., Oliveira, R., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802053380602 · Cited by 3,654 · see citing works

Driving pressure and survival in the acute respiratory distress syndrome.

Amato, M. B. P., Meade, M. O., Slutsky, A. S., Brochard, L., Costa, E. L. V., Schoenfeld, D. A., Stewart, T. E., Briel, M., Talmor, D., Mercat, A., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmsa1410639 · Cited by 2,801 · see citing works

Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome

Papazian, L., Forel, J.-M., Gacouin, A., Penot-Ragon, C., Perrin, G., Loundou, A., Jaber, S., Arnal, J.-M., Perez, D., Seghboyan, J.-M., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1005372 · Cited by 2,432 · see citing works

Higher vs Lower Positive End-Expiratory Pressure in Patients With Acute Lung Injury and Acute Respiratory Distress Syndrome: Systematic Review and Meta-analysis

Briel, M., Meade, M., Mercat, A., Brower, R. G., Talmor, D., Walter, S. D., Slutsky, A. S., Pullenayegum, E., Zhou, Q., Cook, D., et al. (2010) · JAMA · doi:10.1001/jama.2010.218 · Cited by 1,467 · see citing works

Epidemiology and outcome of acute lung injury in European intensive care units

for the ALIVE Study Group, Brun‐Buisson, C., Minelli, C., Bertolini, G., Brazzi, L., Pimentel, J., Lewandowski, K., Bion, J., Romand, J.-A., Villar, J., et al. (2004) · Intensive Care Medicine · doi:10.1007/s00134-003-2022-6 · Cited by 685 · see citing works

Tidal Volume Reduction in Patients with Acute Lung Injury When Plateau Pressures Are Not High

Hager, D. N., Krishnan, J. A., Hayden, D. L., & Brower, R. G. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200501-048cp · Cited by 509 · see citing works

Epidemiology and Outcomes of Acute Lung Injury

Rubenfeld, G. D., & Herridge, M. S. (2007) · CHEST Journal · doi:10.1378/chest.06-1976 · Cited by 483 · see citing works

Mechanical Power and Development of Ventilator-induced Lung Injury

Cressoni, M., Gotti, M., Chiurazzi, C., Massari, D., Algieri, I., Amini, M., Cammaroto, A., Brioni, M., Montaruli, C., Nikolla, K., et al. (2016) · Anesthesiology · doi:10.1097/aln.0000000000001056 · Cited by 480 · see citing works

Clinical predictors of and mortality in acute respiratory distress syndrome: Potential role of red cell transfusion*

Gong, M. N., Thompson, B., Williams, P. L., Pothier, L., Boyce, P. D., & Christiani, D. C. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000165566.82925.14 · Cited by 436 · see citing works

Clinical Predictors of and Mortality in Acute Respiratory Distress Syndrome: Potential Role of Red Cell Transfusion

Barker, J. A. (2006) · Yearbook of Pulmonary Disease · doi:10.1016/s8756-3452(08)70227-5 · Cited by 361 · see citing works

Outcome of intensive care patients in a group of British intensive care units

Goldhill, D. R., & Sumner, A. (1998) · Critical Care Medicine · doi:10.1097/00003246-199808000-00017 · Cited by 325 · see citing works

Hypercapnic acidosis and mortality in acute lung injury*

Kregenow, D. A., Rubenfeld, G. D., Hudson, L. D., & Swenson, E. R. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000194533.75481.03 · Cited by 265 · see citing works

Rationing of intensive care unit services. An everyday occurrence

Strauss, M. J. (1986) · JAMA · doi:10.1001/jama.255.9.1143 · Cited by 213 · see citing works

Guidelines for the withdrawal of life-sustaining measures

Downar, J., Delaney, J. W., Hawryluck, L., & Kenny, L. (2016) · Intensive Care Medicine · doi:10.1007/s00134-016-4330-7 · Cited by 197 · see citing works

Feasibility and safety of low-flow extracorporeal carbon dioxide removal to facilitate ultra-protective ventilation in patients with moderate acute respiratory distress syndrome

Fanelli, V., Ranieri, V. M., Mancebo, J., Moerer, O., Quintel, M., Morley, S. W., Morán, I., Parrilla, F., Costamagna, A., Gaudiosi, M., et al. (2016) · Critical Care · doi:10.1186/s13054-016-1211-y · Cited by 175 · see citing works

Rationing of Intensive Care Unit Services

Strauss, M. J. (1986) · JAMA · doi:10.1001/jama.1986.03370090065021 · Cited by 166 · see citing works

Withholding and withdrawal of life-sustaining treatments in low-middle-income versus high-income Asian countries and regions

Phua, J., Joynt, G. M., Nishimura, M., Deng, Y., Myatra, S. N., Chan, Y. H., Bình, N. G., Tan, C. C., Faruq, M. O., Arabi, Y. M., et al. (2016) · Intensive Care Medicine · doi:10.1007/s00134-016-4347-y · Cited by 90 · see citing works

Why do patients die on general wards after discharge from intensive care units?

Wallis, C., Davies, H. T. O., & Shearer, A. J. (1997) · Anaesthesia · doi:10.1111/j.1365-2044.1997.003-az002.x · Cited by 87 · see citing works

Effects of respiratory rate on ventilator-induced lung injury at a constant Paco2 in a mouse model of normal lung

Vaporidi, K., Voloudakis, G., Prinianakis, G., Kondili, Ε., Koutsopoulos, A. V., Tsatsanis, C., & Georgopoulos, D. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e318169f30e · Cited by 77 · see citing works

Respective impact of no escalation of treatment, withholding and withdrawal of life-sustaining treatment on ICU patients’ prognosis: a multicenter study of the Outcomerea Research Group

Outcomerea Study Group, Lautrette, A., Garrouste-Orgeas, M., Bertrand, P.-M., Goldgran-Tolédano, D., Jamali, S., Laurent, V., Argaud, L., Schwebel, C., Mourvillier, B., et al. (2015) · Intensive Care Medicine · doi:10.1007/s00134-015-3944-5 · Cited by 73 · see citing works

Is the Mortality Higher in the Pulmonary vs the Extrapulmonary ARDS?

Agarwal, R., Rajagopala, S., Nath, A., & Jindal, S. K. (2007) · CHEST Journal · doi:10.1378/chest.07-2182 · Cited by 68 · see citing works

Low Respiratory Rate Plus Minimally Invasive Extracorporeal Co2 Removal Decreases Systemic and Pulmonary Inflammatory Mediators in Experimental Acute Respiratory Distress Syndrome*

Grasso, S., Stripoli, T., Mazzone, P., Pezzuto, M., Lacitignola, L., Centonze, P., Guarracino, A., Esposito, C., Herrmann, P., Quintel, M., et al. (2014) · Critical Care Medicine · doi:10.1097/ccm.0000000000000312 · Cited by 63 · see citing works

Rationing of intensive care unit services. An everyday occurrence.

Strauss, M. J., LoGerfo, J. P., YELTATZIE, J. A., Temkin, N. R., & Hudson, L. D. (1986) · PubMed · Cited by 56 · see citing works

Recovery from lung injury in survivors of acute respiratory distress syndrome: difference between pulmonary and extrapulmonary subtypes

Kim, S. J., Oh, B. J., Lee, J., Lim, C., Shim, T. S., Lee, S., Kim, W. S., Kim, D. S., Kim, W. D., & Koh, Y. (2004) · Intensive Care Medicine · doi:10.1007/s00134-004-2374-6 · Cited by 36 · see citing works

Spontaneous Breathing, Extrapulmonary CO2 Removal, and Ventilator-Induced Lung Injury Risk

Marini, J. J. (2014) · Critical Care Medicine · doi:10.1097/ccm.0000000000000206 · Cited by 3 · see citing works

Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021

Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Intensive Care Medicine · doi:10.1007/s00134-021-06506-y · Cited by 5,082 · see citing works

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005337 · Cited by 2,935 · see citing works

Global burden of liver disease: 2023 update

Devarbhavi, H., Asrani, S. K., Arab, J. P., Nartey, Y. A., Pose, E., & Kamath, P. S. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.03.017 · Cited by 2,267 · see citing works

Formal guidelines: Management of acute respiratory distress syndrome.

Papazian, L., Aubron, C., Brochard, L., Chiche, J.-D., Combes, A., Dreyfuss, D., Forel, J.-M., Guérin, C., Jaber, S., Mekontso-Dessap, A., et al. (2019) · Annals of Intensive Care · doi:10.1186/s13613-019-0540-9 · Cited by 761 · see citing works

Mechanical Ventilation: State of the Art

Pham, T. O., Brochard, L. J., & Slutsky, A. S. (2017) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2017.05.004 · Cited by 380 · see citing works

Mechanical ventilation in patients with acute brain injury: recommendations of the European Society of Intensive Care Medicine consensus

Robba, C., Poole, D., McNett, M., Asehnoune, K., Bösel, J., Bruder, N. J., Chieregato, A., Cinotti, R., Duranteau, J., Einav, S., et al. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06283-0 · Cited by 347 · see citing works

Acute lung injury

Mowery, N. T., Terzian, W. T. H., & Nelson, A. C. (2020) · Current Problems in Surgery · doi:10.1016/j.cpsurg.2020.100777 · Cited by 323 · see citing works

F ifty Y ears of R esearch in ARDS. The Epidemiology of Acute Respiratory Distress Syndrome. A 50th Birthday Review

Pham, T. O., & Rubenfeld, G. D. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201609-1773cp · Cited by 264 · see citing works

Definition and epidemiology of acute respiratory distress syndrome

Rezoagli, E., Fumagalli, R., & Bellani, G. (2017) · Annals of Translational Medicine · doi:10.21037/atm.2017.06.62 · Cited by 226 · see citing works

Respiratory physiology of COVID-19-induced respiratory failure compared to ARDS of other etiologies

Grieco, D. L., Bongiovanni, F., Chen, L., Menga, L. S., Cutuli, S. L., Pintaudi, G., Carelli, S., Michi, T., Torrini, F., Lombardi, G., et al. (2020) · Critical Care · doi:10.1186/s13054-020-03253-2 · Cited by 211 · see citing works

Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries

for the LUNG-SAFE Investigators and the ESICM Trials Group, Abe, T., Madotto, F., Pham, T. O., Nagata, I., Uchida, M., Tamiya, N., Kurahashi, K., Bellani, G., & Laffey, J. G. (2018) · Critical Care · doi:10.1186/s13054-018-2126-6 · Cited by 186 · see citing works

Effect of mechanical power on intensive care mortality in ARDS patients

Coppola, S., Caccioppola, A., Froio, S., Formenti, P., Giorgis, V. D., Galanti, V., Consonni, D., & Chiumello, D. (2020) · Critical Care · doi:10.1186/s13054-020-02963-x · Cited by 181 · see citing works

Mechanical power normalized to predicted body weight as a predictor of mortality in patients with acute respiratory distress syndrome

Zhang, Z., Zheng, B., Liu, N., Ge, H., & Hong, Y. (2019) · Intensive Care Medicine · doi:10.1007/s00134-019-05627-9 · Cited by 173 · see citing works

Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Cardiovascular, Endocrine, Hematologic, Pulmonary, and Renal Considerations

Nanchal, R. S., Subramanian, R., Karvellas, C. J., Hollenberg, S. M., Peppard, W., Singbartl, K., Truwit, J. D., Al-Khafaji, A. H., Killian, A. J., Alquraini, M., et al. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004192 · Cited by 156 · see citing works

AASLD Practice Guidance on Acute-on-chronic liver failure and the management of critically ill patients with cirrhosis

Karvellas, C. J., Bajaj, J. S., Kamath, P. S., Napolitano, L. M., O’Leary, J. G., Solà, E., Subramanian, R., Wong, F. S.-H., & Asrani, S. K. (2023) · Hepatology · doi:10.1097/hep.0000000000000671 · Cited by 164 · see citing works

Association of Driving Pressure With Mortality Among Ventilated Patients With Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis*

Aoyama, H., Pettenuzzo, T., Aoyama, K., Pinto, R. L., Englesakis, M. F., & Fan, E. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002838 · Cited by 145 · see citing works

Six-Month Outcome of Immunocompromised Patients with Severe Acute Respiratory Distress Syndrome Rescued by Extracorporeal Membrane Oxygenation. An International Multicenter Retrospective Study

Schmidt, M., Schellongowski, P., Patroniti, N. A., Taccone, F. S., Miranda, D. R., Reuter, J., Prodanovic, H., Pierrot, M., Dorget, A., Park, S., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201708-1761oc · Cited by 140 · see citing works

Compliance Phenotypes in Early Acute Respiratory Distress Syndrome before the COVID-19 Pandemic

Panwar, R., Madotto, F., Laffey, J. G., & van Haren, F. M. P. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202005-2046oc · Cited by 137 · see citing works

Outcomes of Patients With Coronavirus Disease 2019 Receiving Organ Support Therapies: The International Viral Infection and Respiratory Illness Universal Study Registry

Domecq, J. P., Lal, A., Sheldrick, R. C., Kumar, V. K., Boman, K., Bolesta, S., Bansal, V., Harhay, M. O., Garcia, M. A., Kaufman, M., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000004879 · Cited by 136 · see citing works

Transpulmonary pressure: importance and limits

Grieco, D. L., Chen, L., & Brochard, L. J. (2017) · Annals of Translational Medicine · doi:10.21037/atm.2017.07.22 · Cited by 136 · see citing works

Driving Pressure Is Associated with Outcome during Assisted Ventilation in Acute Respiratory Distress Syndrome

Bellani, G., Grassi, A., Sosio, S., Gatti, S., Kavanagh, B. P., Pesenti, A. M., & Foti, G. (2019) · Anesthesiology · doi:10.1097/aln.0000000000002846 · Cited by 133 · see citing works

Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database

LUNG SAFE Investigators and the ESICM Trials Group, Cortegiani, A., Madotto, F., Gregoretti, C., Bellani, G., Laffey, J. G., Pham, T. O., van Haren, F. M. P., Giarratano, A., Antonelli, M. M., et al. (2018) · Critical Care · doi:10.1186/s13054-018-2079-9 · Cited by 130 · see citing works

Beginning at the ends: telomeres and human disease

Savage, S. A. (2018) · F1000Research · doi:10.12688/f1000research.14068.1 · Cited by 124 · see citing works

Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study

Laffey, J. G., Madotto, F., Bellani, G., Pham, T. O., Fan, E., Brochard, L. J., Amin, P. R., Arabi, Y. M., Bajwa, E. K., Bruhn, A. R., et al. (2017) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(17)30213-8 · Cited by 125 · see citing works

S3-Leitlinie Sepsis – Prävention, Diagnose, Therapie und Nachsorge

Deutsche Sepsis Gesellschaft e., V., Brunkhorst, F. M., Weigand, M. A., Pletz, M. W., Gastmeier, P., Lemmen, S., Meier‐Hellmann, A., Ragaller, M., Weyland, A., Marx, G., et al. (2020) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-020-00685-0 · Cited by 119 · see citing works

Driving pressure: a marker of severity, a safety limit, or a goal for mechanical ventilation?

Bugedo, G. J., Retamal, J., & Bruhn, A. R. (2017) · Critical Care · doi:10.1186/s13054-017-1779-x · Cited by 118 · see citing works

Demographics, management and outcome of females and males with acute respiratory distress syndrome in the LUNG SAFE prospective cohort study

McNicholas, B., Madotto, F., Pham, T. O., Rezoagli, E., Masterson, C. H., Horie, S., Bellani, G., Brochard, L. J., & Laffey, J. G. (2019) · European Respiratory Journal · doi:10.1183/13993003.00609-2019 · Cited by 104 · see citing works

Feasibility and safety of low-flow extracorporeal CO2 removal managed with a renal replacement platform to enhance lung-protective ventilation of patients with mild-to-moderate ARDS

Schmidt, M., Jaber, S., Zogheib, E. H., Godet, T., Capellier, G., & Combes, A. (2018) · Critical Care · doi:10.1186/s13054-018-2038-5 · Cited by 103 · see citing works

The Epidemiology of Acute Respiratory Distress Syndrome Before and After Coronavirus Disease 2019

Hendrickson, K. W., Peltan, I. D., & Brown, S. M. (2021) · Critical Care Clinics · doi:10.1016/j.ccc.2021.05.001 · Cited by 104 · see citing works

ARDS Clinical Practice Guideline 2021

Tasaka, S., Ohshimo, S., Takeuchi, M., Yasuda, H., Ichikado, K., Tsushima, K., Egi, M., Hashimoto, S., Shime, N., Saitô, O., et al. (2022) · Journal of Intensive Care · doi:10.1186/s40560-022-00615-6 · Cited by 89 · see citing works

Challenges in ARDS Definition, Management, and Identification of Effective Personalized Therapies

Battaglini, D., Fazzini, B., Silva, P. L., Cruz, F. F., Ball, L., Robba, C., Rocco, P. R. M., & Pelosi, P. P. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12041381 · Cited by 92 · see citing works

Electrical impedance tomography-guided positive end-expiratory pressure titration in ARDS: a systematic review and meta-analysis

Songsangvorn, N., Xu, Y., Lü, C., Rotstein, O. D., Brochard, L. J., Slutsky, A. S., Burns, K. E. A., & Zhang, H. (2024) · Intensive Care Medicine · doi:10.1007/s00134-024-07362-2 · Cited by 93 · see citing works

Management and outcomes of acute respiratory distress syndrome patients with and without comorbid conditions

Azoulay, É., Lemiale, V., Mourvillier, B., Garrouste-Orgeas, M., Schwebel, C., Ruckly, S., Argaud, L., Cohen, Y., Souweine, B., Papazian, L., et al. (2018) · Intensive Care Medicine · doi:10.1007/s00134-018-5209-6 · Cited by 86 · see citing works

The acute respiratory distress syndrome: pathophysiology, current clinical practice, and emerging therapies

Derwall, M., Märtin, L., & Rossaint, R. (2018) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2018.1548280 · Cited by 85 · see citing works

Spontaneous breathing: a double-edged sword to handle with care

Mauri, T., Cambiaghi, B., Spinelli, E., Länger, T., & Grasselli, G. (2017) · Annals of Translational Medicine · doi:10.21037/atm.2017.06.55 · Cited by 86 · see citing works

The basics of respiratory mechanics: ventilator-derived parameters

Silva, P. L., & Rocco, P. R. M. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.06.06 · Cited by 88 · see citing works

Lessons to learn from epidemiologic studies in ARDS

McNicholas, B., Rooney, G. M., & Laffey, J. G. (2017) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000473 · Cited by 80 · see citing works

Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study

Madotto, F., Pham, T. O., Bellani, G., Bos, L. D. J., Simonis, F. D., Fan, E., Artigas, A., Brochard, L. J., Schultz, M. J., Laffey, J. G., et al. (2018) · Intensive Care Medicine · doi:10.1007/s00134-018-5152-6 · Cited by 83 · see citing works

Vagus nerve stimulation enhances the cholinergic anti-inflammatory pathway to reduce lung injury in acute respiratory distress syndrome via STAT3

Li, S., Qi, D., Li, J.-N., Deng, X., & Wang, D. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00431-1 · Cited by 76 · see citing works

Plasma sRAGE Acts as a Genetically Regulated Causal Intermediate in Sepsis-associated Acute Respiratory Distress Syndrome

Jones, T. K., Feng, R., Kerchberger, V. E., Reilly, J. P., Anderson, B. J., Shashaty, M. G. S., Wang, F., Dunn, T. G., Riley, T. R., Abbott, J. A., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201810-2033oc · Cited by 74 · see citing works

ECCO2R therapy in the ICU: consensus of a European round table meeting

Combes, A., Auzinger, G. M., Capellier, G., du Cheyron, D., Clement, I. D., Consales, G., Dąbrowski, W., Bels, D. D., de Molina, F. J. G., Gottschalk, A., et al. (2020) · Critical Care · doi:10.1186/s13054-020-03210-z · Cited by 71 · see citing works

The Injurious Effects of Elevated or Nonelevated Respiratory Rate during Mechanical Ventilation

Akoumianaki, E., Vaporidi, K., & Georgopoulos, D. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201804-0726ci · Cited by 73 · see citing works

Determinants of the effect of extracorporeal carbon dioxide removal in the SUPERNOVA trial: implications for trial design

Goligher, E. C., Combes, A., Brodie, D., Ferguson, N. D., Pesenti, A. M., Ranieri, V. M., Slutsky, A. S., for the SUPERNOVA investigators (European Society of Intensive Care Medicine trials group) and for the International ECMO Network (ECMONet), Beale, R., Brochard, L. J., et al. (2019) · Intensive Care Medicine · doi:10.1007/s00134-019-05708-9 · Cited by 68 · see citing works

Monitoring Lung Injury Severity and Ventilation Intensity during Mechanical Ventilation

Rezoagli, E., Laffey, J. G., & Bellani, G. (2022) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0042-1748917 · Cited by 67 · see citing works

Assessing predictive accuracy for outcomes of ventilator-associated events in an international cohort: the EUVAE study

Ramirez‐Estrada, S., Lagunes, L., Peña-López, Y., Vahedian‐Azimi, A., Nseir, S., Arvaniti, K., Baştuğ, A., Totorika, I., Öztoprak, N., Bouadma, L., et al. (2018) · Intensive Care Medicine · doi:10.1007/s00134-018-5269-7 · Cited by 65 · see citing works

Precision medicine in acute respiratory distress syndrome: workshop report and recommendations for future research

Bos, L. D. J., Artigas, A., Constantin, J., Hagens, L. A., Heijnen, N. F. L., Laffey, J. G., Meyer, N. J., Papazian, L., Pisani, L., Schultz, M. J., et al. (2021) · European Respiratory Review · doi:10.1183/16000617.0317-2020 · Cited by 64 · see citing works

Feasibility and safety of ultra-low tidal volume ventilation without extracorporeal circulation in moderately severe and severe ARDS patients

Richard, J., Marqué, S., Gros, A., Müller, M., Prat, G., Beduneau, G., Quenot, J., Dellamonica, J., Tapponnier, R., Soum, E., et al. (2019) · Intensive Care Medicine · doi:10.1007/s00134-019-05776-x · Cited by 60 · see citing works

F ifty Y ears of R esearch in ARDS. V t Selection in Acute Respiratory Distress Syndrome

Sahetya, S. K., Mancebo, J., & Brower, R. G. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201708-1629ci · Cited by 56 · see citing works

Clinical Guideline for Treating Acute Respiratory Insufficiency with Invasive Ventilation and Extracorporeal Membrane Oxygenation: Evidence-Based Recommendations for Choosing Modes and Setting Parameters of Mechanical Ventilation

Fichtner, F., Moerer, O., Weber‐Carstens, S., Nothacker, M., Kaisers, U. X., Laudi, S., & on behalf of the Guideline group (2019) · Respiration · doi:10.1159/000502157 · Cited by 53 · see citing works

Prone positioning during venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a pooled individual patient data analysis

Giani, M., Rezoagli, E., Guervilly, C., Rilinger, J., Duburcq, T., Petit, M., Textoris, L., Garcia, B., Wengenmayer, T., Grasselli, G., et al. (2022) · Critical Care · doi:10.1186/s13054-021-03879-w · Cited by 53 · see citing works

Acute Respiratory Distress Syndrome

Pan, C. S., Liu, L., Xie, J., & Qiu, H. (2018) · Chinese Medical Journal · doi:10.4103/0366-6999.228765 · Cited by 54 · see citing works

Managing portal hypertension in patients with liver cirrhosis

Sauerbruch, T., Schierwagen, R., & Trebicka, J. (2018) · F1000Research · doi:10.12688/f1000research.13943.1 · Cited by 51 · see citing works

Disassociating Lung Mechanics and Oxygenation in Pediatric Acute Respiratory Distress Syndrome*

Yehya, N., & Thomas, N. J. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002406 · Cited by 50 · see citing works

Patterns and Impact of Arterial CO2 Management in Patients With Acute Respiratory Distress Syndrome

Madotto, F., Rezoagli, E., McNicholas, B., Pham, T. O., Slutsky, A. S., Bellani, G., & Laffey, J. G. (2020) · CHEST Journal · doi:10.1016/j.chest.2020.05.605 · Cited by 50 · see citing works

The intensive care medicine research agenda for airways, invasive and noninvasive mechanical ventilation

Jaber, S., Bellani, G., Blanch, L. L., Demoule, A., Esteban, A., Gattinoni, L., Guérin, C., Hill, N. S., Laffey, J. G., Maggiore, S. M., et al. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4896-8 · Cited by 49 · see citing works

A Physiologically Informed Strategy to Effectively Open, Stabilize, and Protect the Acutely Injured Lung

Nieman, G. F., Al-Khalisy, H., Kollisch-Singule, M. C., Satalin, J. M., Blair, S., Trikha, G., Andrews, P., Madden, M., Gatto, L. A., & Habashi, N. M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00227 · Cited by 49 · see citing works

How I set up positive end-expiratory pressure: evidence- and physiology-based!

Rezoagli, E., & Bellani, G. (2019) · Critical Care · doi:10.1186/s13054-019-2695-z · Cited by 49 · see citing works

Ten golden rules for individualized mechanical ventilation in acute respiratory distress syndrome

Battaglini, D., Sottano, M., Ball, L., Robba, C., Rocco, P. R. M., & Pelosi, P. P. (2021) · Journal of Intensive Medicine · doi:10.1016/j.jointm.2021.01.003 · Cited by 47 · see citing works

Evidence-Based Mechanical Ventilatory Strategies in ARDS

Liaqat, A., Mason, M., Foster, B. J., Kulkarni, S., Barlas, A., Farooq, A. M., Patak, P., Liaqat, H., Basso, R., Zaman, M. S., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11020319 · Cited by 48 · see citing works

Respiratory mechanics to understand ARDS and guide mechanical ventilation

Mauri, T., Lazzeri, M., Bellani, G., Zanella, A., & Grasselli, G. (2017) · Physiological Measurement · doi:10.1088/1361-6579/aa9052 · Cited by 45 · see citing works

Driving Pressure Is Associated With Outcome in Pediatric Acute Respiratory Failure

van Schelven, P., Koopman, A. A., Burgerhof, J. G. M., Markhorst, D. G., Blokpoel, R. G. T., & Kneyber, M. C. J. (2021) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000002848 · Cited by 45 · see citing works

Mechanical Ventilation in Patients with Traumatic Brain Injury: Is it so Different?

Taran, S., Cho, S., & Stevens, R. D. (2022) · Neurocritical Care · doi:10.1007/s12028-022-01593-1 · Cited by 44 · see citing works

Outcomes of Patients Presenting with Mild Acute Respiratory Distress Syndrome

Pham, T. O., Neto, A. S., Pelosi, P. P., Laffey, J. G., de Haro, C., Lorente, J. Á., Bellani, G., Fan, E., Brochard, L. J., Pesenti, A., et al. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002508 · Cited by 43 · see citing works

Mechanical Ventilation, Past, Present, and Future

Rubulotta, F. M., Blanch, L. L., Naidoo, K. D., Soliman-Aboumarie, H., Mathivha, L. R., Asiri, A. Y., Sarlabous, L., & Soussi, S. (2024) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000006701 · Cited by 46 · see citing works

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: insights from the LUNG SAFE study

for the LUNG SAFE Investigators and the ESICM Trials Group, Madotto, F., Rezoagli, E., Pham, T. O., Schmidt, M. F. S., McNicholas, B., Protti, A., Panwar, R., Bellani, G., Fan, E., et al. (2020) · Critical Care · doi:10.1186/s13054-020-2826-6 · Cited by 42 · see citing works

Characteristics, management and survival of ICU patients with coronavirus disease‐19 in Norway, March‐June 2020. A prospective observational study

Laake, J. H., Buanes, E. A., Småstuen, M. C., Kvåle, R., Olsen, B. F., Rustøen, T., Strand, K., Sørensen, V., & Hofsø, K. (2021) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.13785 · Cited by 42 · see citing works

Effect of mechanical power on mortality in invasively ventilated ICU patients without the acute respiratory distress syndrome

van Meenen, D. M. P., Algera, A. G., Schuijt, M. T. U., Simonis, F. D., van der Hoeven, S. M., Neto, A. S., de Abreu, M. G., Pelosi, P. P., Paulus, F., & Schultz, M. J. (2022) · European Journal of Anaesthesiology · doi:10.1097/eja.0000000000001778 · Cited by 41 · see citing works

Airway and transpulmonary driving pressures and mechanical powers selected by INTELLiVENT-ASV in passive, mechanically ventilated ICU patients

Arnal, J.-M., Saoli, M., & Garnero, A. (2019) · Heart & Lung · doi:10.1016/j.hrtlng.2019.11.001 · Cited by 41 · see citing works

Early identification and diagnosis, pathophysiology, and treatment of sepsis-related acute lung injury: a narrative review

Zhang, J., Yan, W., Dong, Y., Luo, X., Miao, H., Maimaijuma, T., Xu, X., Jiang, H., Huang, Z., Qi, L., et al. (2024) · Journal of Thoracic Disease · doi:10.21037/jtd-24-1191 · Cited by 43 · see citing works

Intraoperative Anesthetic Management of Lung Transplantation: Center-Specific Practices and Geographic and Centers Size Differences

Tomasi, R., Betz, D., Schlager, S., Kammerer, T., Hoechter, D. J., Weig, T. G., Slinger, P., Klotz, L. V., Zwißler, B., Marczin, N., et al. (2017) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2017.05.025 · Cited by 39 · see citing works

Driving pressure during proportional assist ventilation: an observational study

Vaporidi, K., Psarologakis, C., Proklou, Α., Pediaditis, E., Akoumianaki, E., Koutsiana, E., Chytas, A., Chouvarda, I., Kondili, Ε., & Georgopoulos, D. (2019) · Annals of Intensive Care · doi:10.1186/s13613-018-0477-4 · Cited by 39 · see citing works

Utility of Driving Pressure and Mechanical Power to Guide Protective Ventilator Settings in Two Cohorts of Adult and Pediatric Patients With Acute Respiratory Distress Syndrome: A Computational Investigation

Saffaran, S., Das, A., Laffey, J. G., Hardman, J. G., Yehya, N., & Bates, D. G. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004372 · Cited by 38 · see citing works

Ultra-low tidal volume ventilation for COVID-19-related ARDS in France (VT4COVID): a multicentre, open-label, parallel-group, randomised trial

Richard, J., Terzi, N., Yonis, H., Abbas‐Chorfa, F., Wallet, F., Dupuis, C., Argaud, L., Delannoy, B., Thiéry, G., Pommier, C., et al. (2023) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(23)00221-7 · Cited by 37 · see citing works

External validation of a biomarker and clinical prediction model for hospital mortality in acute respiratory distress syndrome

Zhao, Z., Wickersham, N. E., Kangelaris, K. N., May, A. K., Bernard, G. R., Matthay, M. A., Calfee, C. S., Koyama, T., & Ware, L. B. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4854-5 · Cited by 37 · see citing works

Potentially modifiable respiratory variables contributing to outcome in ICU patients without ARDS: a secondary analysis of PRoVENT

Simonis, F. D., Barbas, C. S. V., Artigas, A., Canet, J., Determann, R. M., Anstey, J. R., Hedenstierna, G., Hemmes, S. N. T., Hermans, G., Hiesmayr, M., et al. (2018) · Annals of Intensive Care · doi:10.1186/s13613-018-0385-7 · Cited by 38 · see citing works

PEEP Titration to Minimize Driving Pressure in Subjects With ARDS: A Prospective Physiological Study

Sahetya, S. K., Hager, D. N., Stephens, R. S., Needham, D. M., & Brower, R. G. (2019) · Respiratory Care · doi:10.4187/respcare.07102 · Cited by 38 · see citing works

Emerging therapies for hemophilia: controversies and unanswered questions

Arruda, V. R., Doshi, B. S., & Samelson‐Jones, B. J. (2018) · F1000Research · doi:10.12688/f1000research.12491.1 · Cited by 36 · see citing works

Survival predictors in elderly patients with acute respiratory distress syndrome: a prospective observational cohort study

Kao, K., Hsieh, M., Lin, S., Chuang, L., Chang, C.-H., Hu, H., Wang, C.-H., Li, L., Huang, C.-C., & Wu, H.-P. (2018) · Scientific Reports · doi:10.1038/s41598-018-31811-w · Cited by 36 · see citing works

Septic shock in adults: guidelines of the All-Russian public organization “Federation of Anesthesiologists and Reanimatologists”

Кirov, М. Y., Владимирович, К. В., Николаевич, П. Д., Щеголев, А. В., Babaev, M. A., Belotserkovskiy, B. Z., Bykov, A. O., Gritsan, A. I., Кулабухов, В. В., Kulikov, A. V., et al. (2023) · Annals of critical care · doi:10.21320/1818-474x-2023-4-7-42 · Cited by 36 · see citing works

Mortality of Adult Respiratory Distress Syndrome in Trauma Patients: A Systematic Review over a Period of Four Decades

Birkner, D. R., Halvachizadeh, S., Pape, H., & Pfeifer, R. (2020) · World Journal of Surgery · doi:10.1007/s00268-020-05483-5 · Cited by 35 · see citing works

Influence of Clinical Factors and Exclusion Criteria on Mortality in ARDS Observational Studies and Randomized Controlled Trials

Pais, F. M., Sinha, P., Liu, K. D., & Matthay, M. A. (2018) · Respiratory Care · doi:10.4187/respcare.06034 · Cited by 33 · see citing works

A 2-year multicenter, observational, prospective, cohort study on extracorporeal CO2 removal in a large metropolis area

Augy, J.-L., Aïssaoui, N., Richard, C., Maury, É., Fartoukh, M. S., Dessap, A. M., Paulet, R., Anguel, N., Blayau, C., Cohen, Y., et al. (2019) · Journal of Intensive Care · doi:10.1186/s40560-019-0399-8 · Cited by 33 · see citing works

Association of ventilation volumes, pressures and rates with the mechanical power of ventilation in patients without acute respiratory distress syndrome: exploring the impact of rate reduction

Buiteman‐Kruizinga, L. A., van Meenen, D. M. P., Neto, A. S., Mazzinari, G., Bos, L. D. J., van der Heiden, P. L. J., Paulus, F., Schultz, M. J., NEBULAE, F. T., PReVENT, et al. (2025) · Anaesthesia · doi:10.1111/anae.16537 · Cited by 32 · see citing works

Ventilatory frequency during intraoperative mechanical ventilation and postoperative pulmonary complications: a hospital registry study

Santer, P., Zheng, S., Hammer, M., Nabel, S. Y., Pannu, A., Li, Y., Ramachandran, S. K., Melo, M. F. V., & Eikermann, M. (2020) · British Journal of Anaesthesia · doi:10.1016/j.bja.2020.02.018 · Cited by 33 · see citing works

Ventilation parameters and early graft function in double lung transplantation

Schwarz, S., Benazzo, A., Dunkler, D., Muckenhuber, M., Sorbo, L. D., Nardo, M. D., Sinn, K., Moser, B., Matilla, J. R., Láng, G., et al. (2020) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2020.10.003 · Cited by 32 · see citing works

Presence of comorbidities alters management and worsens outcome of patients with acute respiratory distress syndrome: insights from the LUNG SAFE study

Rezoagli, E., McNicholas, B., Madotto, F., Pham, T. O., Bellani, G., & Laffey, J. G. (2022) · Annals of Intensive Care · doi:10.1186/s13613-022-01015-7 · Cited by 35 · see citing works

Prospective Assessment of the Feasibility of a Trial of Low–Tidal Volume Ventilation for Patients with Acute Respiratory Failure

Lanspa, M. J., Gong, M. N., Schoenfeld, D., Lee, K. T., Grissom, C. K., Hou, P. C., Neto, A. S., Brown, S. M., Iwashyna, T. J., Yealy, D. M., et al. (2018) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201807-459oc · Cited by 33 · see citing works

Clinical value of electrical impedance tomography (EIT) in the management of patients with acute respiratory failure: a single centre experience

Bronco, A., Grassi, A., Meroni, V., Giovannoni, C., Rabboni, F., Rezoagli, E., Droghi, M. T., Foti, G., & Bellani, G. (2021) · Physiological Measurement · doi:10.1088/1361-6579/ac0e85 · Cited by 32 · see citing works

S3-Leitlinie Sepsis – Prävention, Diagnose, Therapie und Nachsorge

Deutsche Sepsis Gesellschaft e., V., Brunkhorst, F. M., Weigand, M. A., Pletz, M. W., Gastmeier, P., Lemmen, S., Meier‐Hellmann, A., Ragaller, M., Weyland, A., Marx, G., et al. (2020) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-020-00671-6 · Cited by 30 · see citing works

Driving pressure-guided ventilation decreases the mechanical power compared to predicted body weight-guided ventilation in the Acute Respiratory Distress Syndrome

Haudebourg, A.-F., Tuffet, S., Perier, F., Razazi, K., de Prost, N., Dessap, A. M., & Carteaux, G. (2022) · Critical Care · doi:10.1186/s13054-022-04054-5 · Cited by 29 · see citing works

S3-Leitlinie Sepsis – Prävention, Diagnose, Therapie und Nachsorge – Update 2025

Brunkhorst, F. M., Adamzik, M., Axer, H., Bauer, M. W., Bode, C., Bone, H.-G., Brenner, T., Bucher, M., David, S., Dietrich, M., et al. (2025) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-025-01317-1 · Cited by 32 · see citing works

First tidal volume greater than 8 mL/kg is associated with increased mortality in complicated influenza infection with acute respiratory distress syndrome

Chan, M.-C., Chao, W., Liang, S., Tseng, C., Wang, H., Chien, Y., Yang, K., Chen, W., Perng, W., Kao, K., et al. (2018) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2018.06.010 · Cited by 27 · see citing works

Nutritional support for successful weaning in patients undergoing prolonged mechanical ventilation

Lo, S., Sheng‐Kai, K., Li, Y.-R., Li, Z., Lin, C., Lin, H.-C., & Yang, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-15917-w · Cited by 28 · see citing works

Practice of mechanical ventilation in cardiac arrest patients and effects of targeted temperature management: A substudy of the targeted temperature management trial

Harmon, M. B. A., van Meenen, D. M. P., van der Veen, A., Binnekade, J. M., Dankiewicz, J., Ebner, F. H., Nielsen, N., Pelosi, P. P., Schultz, M. J., Horn, J., et al. (2018) · Resuscitation · doi:10.1016/j.resuscitation.2018.04.040 · Cited by 28 · see citing works

Diverse pro-inflammatory endotoxin recognition systems of mammalian innate immunity

Weiss, J. P., & Barker, J. H. (2018) · F1000Research · doi:10.12688/f1000research.13977.1 · Cited by 27 · see citing works

Unshrinking the baby lung to calm the VILI vortex

Nieman, G. F., Kollisch-Singule, M. C., Ramcharran, H., Satalin, J. M., Blair, S., Gatto, L. A., Andrews, P., Ghosh, A., Kaczka, D. W., Gaver, D. P., et al. (2022) · Critical Care · doi:10.1186/s13054-022-04105-x · Cited by 27 · see citing works

Time-Controlled Adaptive Ventilation (TCAV): a personalized strategy for lung protection

Al-Khalisy, H., Nieman, G. F., Kollisch-Singule, M. C., Andrews, P., Camporota, L., Shiber, J., Manougian, T., Satalin, J. M., Blair, S., Ghosh, A., et al. (2024) · Respiratory Research · doi:10.1186/s12931-023-02615-y · Cited by 27 · see citing works

Defining Organ Failures in Patients With Cirrhosis: Consensus Statements

Bajaj, J. S., Shawcross, D. L., Choudhury, A. K., Karvellas, C. J., O’Leary, J. G., Trebicka, J., Kulkarni, A. V., Marciano, S., Asrani, S. K., Premkumar, M., et al. (2025) · Gastroenterology · doi:10.1053/j.gastro.2025.05.026 · Cited by 26 · see citing works

ABO blood types and major outcomes in patients with acute hypoxaemic respiratory failure: A multicenter retrospective cohort study

Rezoagli, E., Gatti, S., Villa, S., Villa, G., Muttini, S., Rossi, F., Faraldi, L., Fumagalli, R., Grasselli, G., Foti, G., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0206403 · Cited by 26 · see citing works

Demographics, Treatments, and Outcomes of Acute Respiratory Distress Syndrome: the Focused Outcomes Research in Emergency Care in Acute Respiratory Distress Syndrome, Sepsis, and Trauma (FORECAST) Study

Fujishima, S., Gando, S., Saitoh, D., Kushimoto, S., Ogura, H., Abe, T., Shiraishi, A., Mayumi, T., Sasaki, J., Kotani, J., et al. (2019) · Shock · doi:10.1097/shk.0000000000001416 · Cited by 26 · see citing works

Modifiable risk factors and the role of driving pressure in acute respiratory distress syndrome

Keeley, J. A., & Kim, D. Y. (2017) · Journal of Thoracic Disease · doi:10.21037/jtd.2017.03.140

Potentially modifiable ventilatory factors contributing to outcome in patients with pulmonary and extrapulmonary ARDS — An individual patient data analysis

Dorland, G. A., Blok, S. G., Swart, P., van der Ven, F. L. I. M., Hollmann, M. W., Azevedo, L. C. P., Bellani, G., Botta, M., Estenssoro, E., Fan, E., et al. (2026) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2025.112120 · Cited by 1 · see citing works

Potentially modifiable respiratory variables contributing to outcome in ICU patients without ARDS: a secondary analysis of PRoVENT

Simonis, F. D., Barbas, C. S. V., Artigas, A., Canet, J., Determann, R. M., Anstey, J. R., Hedenstierna, G., Hemmes, S. N. T., Hermans, G., Hiesmayr, M., et al. (2018) · Annals of Intensive Care · doi:10.1186/s13613-018-0385-7 · Cited by 38 · see citing works

ARDS: Risikofaktoren für die Sterblichkeit sind teilweise modifizierbar

(2017) · Journal Club AINS · doi:10.1055/s-0042-122697

Reduced mortality in association with the acute respiratory distress syndrome (ARDS)

Abel, S. J. C., Finney, S. J., Brett, S. J., Keogh, B. F., Morgan, C., & Evans, T. W. (1998) · Thorax · doi:10.1136/thx.53.4.292 · Cited by 231 · see citing works