Cited by 162Pharmaceutical industry and healthcareGlobal Public Health Policies and EpidemiologyPolitical Influence and Corporate Strategies

The DOI matches its Crossref record; 57 of the 58 references it cites were found in a registry or an index.

Industry sponsorship and research outcome: systematic review with meta-analysis

Lundh, Andreas, Lexchin, Joel, Mintzes, Barbara, Schroll, Jeppe B., Bero, Lisa·2018·Intensive Care Medicine

DOI 10.1007/s00134-018-5293-7

Open this paper in CoChat — free account

Abstract

Purpose Clinical research is widely sponsored by drug and device companies. We investigated whether industry sponsored drug and device studies have more favorable outcomes and differ in risk of bias, compared with studies having other sources of sponsorship. This review is an update of a previous Cochrane review.Methods In this update we searched MEDLINE and Embase (2010 to February 2015), Cochrane Methodology Register (2015, Issue 2) and Web of Science (June 2015). We included empirical studies that quantitatively compared primary research studies of drugs or medical devices sponsored by industry with studies with other sources of sponsorship. Two assessors included papers, extracted data and assessed risk of bias. Outcomes included favorable results, favorable conclusions, effect size, risk of bias and whether conclusions agreed with results.Results We included 27 additional papers in this update (review now includes 75 papers). Industry sponsored studies more often had favorable efficacy results, RR: 1.27 (95% CI 1.17-1.37), no difference in harms results RR: 1.37 (95% CI 0.64-2.93) and more often favorable conclusions RR: 1.34 (95% CI 1.19-1.51) compared with non-industry sponsored studies. Nineteen papers reported on sponsorship and efficacy effect size, but could not be pooled due to differences in reporting of data and heterogeneity of results. Comparing industry and non-industry sponsored studies, we did not find a difference in risk of bias from sequence generation, allocation concealment, follow-up and selective outcome reporting. However, industry sponsored studies more often had low risk of bias from blinding, RR: 1.25 (95% CI 1.05-1.50), compared with non-industry sponsored studies.Conclusions Drug and device studies sponsored by manufacturing companies have more favorable efficacy results and conclusions than studies sponsored by other sources.

Integrity signals

Registry

Crossref · 10.1007/s00134-018-5293-7

Cites

57 of 57 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Guyatt, G. H., Oxman, A. D., Vist, G. E., Kunz, R., Falck-Ytter, Y., Alonso-Coello, P., & Schünemann, H. J. (2008) · BMJ · doi:10.1136/bmj.39489.470347.ad · Cited by 23,305
Development of AMSTAR: A measurement tool to assess the methodological quality of systematic reviews
Shea, B. J., Grimshaw, J. M., Wells, G. A., Boers, M., Andersson, N., Hamel, C., Porter, A. C., Tugwell, P., Moher, D., & Bouter, L. M. (2007) · BMC Medical Research Methodology · doi:10.1186/1471-2288-7-10 · Cited by 4,374
Pharmaceutical industry sponsorship and research outcome and quality: systematic review
Lexchin, J., Bero, L. A., Djulbegovic, B., & Clark, O. (2003) · BMJ · doi:10.1136/bmj.326.7400.1167 · Cited by 2,147
Self-citation
Empirical Evidence for Selective Reporting of Outcomes in Randomized Trials: Comparison of Protocols to Published Articles
Chan, A.-W., Hróbjartsson, A., Haahr, M. T., Gøtzsche, P. C., & Altman, D. G. (2004) · JAMA · doi:10.1001/jama.291.20.2457 · Cited by 1,845
Scope and Impact of Financial Conflicts of Interest in Biomedical Research: A Systematic Review
Bekelman, J. E., Li, Y., & Gross, C. P. (2003) · JAMA · doi:10.1001/jama.289.4.454 · Cited by 1,816
Industry sponsorship and research outcome
Lundh, A., Lexchin, J., Mintzes, B., Schroll, J. B., & Bero, L. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.mr000033.pub3 · Cited by 1,697
Self-citation
Systematic Review of the Empirical Evidence of Study Publication Bias and Outcome Reporting Bias
Dwan, K., Altman, D. G., Arnaiz, J. A., Bloom, J., Chan, A.-W., Cronin, E., Decullier, E., Easterbrook, P. J., Von Elm, E., Gamble, C., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003081 · Cited by 1,546
Reporting and interpretation of randomized controlled trials with statistically nonsignificant results for primary outcomes
Boutron, I. (2010) · JAMA · doi:10.1001/jama.2010.651 · Cited by 842

Show all 58 references

Research works printed but not linked: 3

Lundh A, Lexchin J, Sismondo S, Busuioc OA, Bero L (2011) Industry sponsorship and research outcome. Cochrane Database Syst Rev 9:MR000033
Lundh A, Sismondo S, Lexchin J, Busuioc OA, Bero L (2012) Industry sponsorship and research outcome. Cochrane Database Syst Rev 12:MR000033
The Cochrane Collaboration (2014) Review Manager (RevMan), version 5.3.5.: The Nordic Cochrane Centre, Copenhagen

Sorted by citations

Strengthening the Reporting of Observational Studies in Epidemiology using Mendelian Randomisation (STROBE-MR): explanation and elaboration.
Skrivankova, V. W., Richmond, R. C., Woolf, B. A. R., Davies, N. M., Swanson, S. A., VanderWeele, T. J., Timpson, N. J., Higgins, J. P. T., Dimou, N., Langenberg, C., et al. (2021) · BMJ · doi:10.1136/bmj.n2233 · Cited by 1,648
Long-term (10-year) dental implant survival: A systematic review and sensitivity meta-analysis
Howe, M.-S., Keys, W., & Richards, D. (2019) · Journal of Dentistry · doi:10.1016/j.jdent.2019.03.008 · Cited by 602
Student Evaluations of Teaching Encourages Poor Teaching and Contributes to Grade Inflation: A Theoretical and Empirical Analysis
Stroebe, W. (2020) · Basic and Applied Social Psychology · doi:10.1080/01973533.2020.1756817 · Cited by 223
Efficacy of preprocedural mouthrinses in the reduction of microorganisms in aerosol
Marui, V. C., Souto, M. L. S., Rovai, E. S., Romito, G. A., Chambrone, L., & Pannuti, C. M. (2019) · The Journal of the American Dental Association · doi:10.1016/j.adaj.2019.06.024 · Cited by 200
Clinical Effectiveness of Liposomal Bupivacaine Administered by Infiltration or Peripheral Nerve Block to Treat Postoperative Pain
Ilfeld, B. M., Eisenach, J. C., & Gabriel, R. A. (2020) · Anesthesiology · doi:10.1097/aln.0000000000003630 · Cited by 206
Monoclonal antibodies in type 2 asthma: a systematic review and network meta-analysis
Edris, A., Feyter, S. D., Maes, T., Joos, G., & Lahousse, L. (2019) · Respiratory Research · doi:10.1186/s12931-019-1138-3 · Cited by 132
European clinical guidelines for Tourette syndrome and other tic disorders: summary statement
Müller‐Vahl, K., Szejko, N., Verdellen, C. W. J., Roessner, V., Hoekstra, P. J., Hartmann, A., & Cath, D. C. (2021) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-021-01832-4 · Cited by 117
Pharmacological interventions for people with borderline personality disorder
Stoffers‐Winterling, J., Storebø, O. J., Ribeiro, J. P., Kongerslev, M., Vӧllm, B., Mattivi, J. T., Faltinsen, E. G., Todorovac, A., Jørgensen, M. S., Edemann-Callesen, H., et al. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012956.pub2 · Cited by 128
Berberine and health outcomes: An umbrella review
Li, Z., Yang, W., Xu, Q., Ma, J., Li, X., Yan, J., Tian, Y., Wen, Y., & Chen, T. (2023) · Phytotherapy Research · doi:10.1002/ptr.7806 · Cited by 109
Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)
Storebø, O. J., Storm, M. R. O., Ribeiro, J. P., Skoog, M., Groth, C., Edemann-Callesen, H., Schaug, J. P., Rasmussen, P. D., Huus, C.-M. L., Zwi, M., et al. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009885.pub3 · Cited by 118
COVID-19 Digital Health Innovation Policy: A Portal to Alternative Futures in the Making
Bayram, M., Springer, S., Garvey, C. K., & Özdemir, V. (2020) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2020.0089 · Cited by 91
Carvedilol versus traditional, non-selective beta-blockers for adults with cirrhosis and gastroesophageal varices
Zacharias, A. P., Jeyaraj, R., Hobolth, L., Bendtsen, F., Gluud, L. L., & Morgan, M. Y. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011510.pub2 · Cited by 78
Adverse childhood experiences: A scoping review of measures and methods
Karatekin, C., Mason, S. M., Riegelman, A., Bakker, C., Hunt, S., Gresham, B. L., Corcoran, F., & Barnes, A. J. (2022) · Children and Youth Services Review · doi:10.1016/j.childyouth.2022.106425 · Cited by 85
Breastfeeding and the origins of health: Interdisciplinary perspectives and priorities
Azad, M. B., Nickel, N. C., Bode, L., Brockway, M. L., Brown, A., Chambers, C., Goldhammer, C., Hinde, K., McGuire, M., Munblit, D., et al. (2020) · Maternal and Child Nutrition · doi:10.1111/mcn.13109 · Cited by 77
Interventions for treatment of COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING Project)
Juul, S., Nielsen, N., Bentzer, P., Veroniki, A. A., Thabane, L., Linder, A., Klingenberg, S. L., Gluud, C. N., & Jakobsen, J. C. (2020) · Systematic Reviews · doi:10.1186/s13643-020-01371-0 · Cited by 71
A science-based agenda for health-protective chemical assessments and decisions: overview and consensus statement
Woodruff, T. J., Rayasam, S. D. G., Axelrad, D. A., Koman, P. D., Chartres, N., Bennett, D. H., Birnbaum, L. S., Brown, P., Carignan, C. C., Cooper, C., et al. (2023) · Environmental Health · doi:10.1186/s12940-022-00930-3 · Cited by 59
The Net Benefit of Personalized Medicine: A Systematic Literature Review and Regression Analysis
Vellekoop, H., Versteegh, M., Huygens, S. A., Ramos, I. C., Szilberhorn, L., Zelei, T., Nagy, B., Tsiachristas, A., Koleva‐Kolarova, R., Wordsworth, S., et al. (2022) · Value in Health · doi:10.1016/j.jval.2022.01.006 · Cited by 49
Saffron (Crocus sativus L.) and health outcomes: a meta-research review of meta-analyses and an evidence mapping study
Lu, C., Ke, L., Li, J., Zhao, H., Lu, T., Mentis, A. A., Wang, Y., Wang, Z., Polissiou, M. G., Tang, L., et al. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153699 · Cited by 51
Comparative Effectiveness and Safety of Monoclonal Antibodies (Bevacizumab, Cetuximab, and Panitumumab) in Combination with Chemotherapy for Metastatic Colorectal Cancer: A Systematic Review and Meta-Analysis
da Silva, W. C., de Araújo, V. E., Lima, E. M. A., dos Santos, J. B. R., da Silva, M. R. R., Almeida, P. H. R. F., Acúrcio, F. D. A., Godman, B., Kurdi, A. B., Cherchiglia, M. L., et al. (2018) · BioDrugs · doi:10.1007/s40259-018-0322-1 · Cited by 50
Vaccines to prevent COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING VACCINE Project)
Korang, S. K., Juul, S., Nielsen, E. E., Feinberg, J. B., Siddiqui, F., Ong, G., Klingenberg, S. L., Veroniki, A. A., Bu, F.-L., Thabane, L., et al. (2020) · Systematic Reviews · doi:10.1186/s13643-020-01516-1 · Cited by 44
Physical functioning following spinal cord stimulation: a systematic review and meta-analysis
ElSaban, M., Kleppel, D. J., Kubrova, E., Alvarez, G. A. M., Hussain, N., & D'Souza, R. S. (2023) · Regional Anesthesia & Pain Medicine · doi:10.1136/rapm-2022-104295 · Cited by 36
Consumption of ultra-processed foods and multiple health outcomes: An umbrella study of meta-analyses
Wang, Z., Lu, C., Cui, L., Fenfen, E., Shang, W., Wang, Z., Qiao, M., Song, G., Yang, K., & Li, X. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2023.137460 · Cited by 40
Methodological quality of systematic reviews on treatments for osteoporosis: A cross-sectional study
Tsoi, A. K., Ho, L. T. F., Wu, I. X. Y., Wong, C. H. L., Ho, R. S. T., Lim, J. Y. Y., Mao, C., Lee, E. K. P., & Chung, V. C. (2020) · Bone · doi:10.1016/j.bone.2020.115541 · Cited by 32
Integrating Smartphone Applications and Wearable Devices for Postoperative Rehabilitation in Total Knee Arthroplasty: A Critical Review
Hameed, D., Sodhi, N., Dubin, J. A., Schneider, A. M., Barrack, R. L., & Mont, M. A. (2024) · The Journal of Arthroplasty · doi:10.1016/j.arth.2024.02.003 · Cited by 30
Ginseng and health outcomes: an umbrella review
Li, Z., Wang, Y., Xu, Q., Ma, J., Li, X., Tian, Y., Wen, Y., & Chen, T. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1069268 · Cited by 34
Chinese Medicine as an Adjunctive Treatment for Gastric Cancer: Methodological Investigation of meta-Analyses and Evidence Map
Lu, C., Ke, L., Li, J., Wu, S., Feng, L., Wang, Y., Mentis, A. A., Xu, P., Zhao, X., & Yang, K. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.797753 · Cited by 28
The commercialization of the biomedical sciences: (mis)understanding bias
de Melo‐Martín, I. (2019) · History & Philosophy of the Life Sciences · doi:10.1007/s40656-019-0274-x · Cited by 28
Role of sacubitril-valsartan in the prevention of atrial fibrillation occurrence in patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Liu, X., Liu, H., Wang, L., Zhang, L., & Xu, Q. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263131 · Cited by 26
Dopamine partial agonists and prodopaminergic drugs for schizophrenia: Systematic review and meta-analysis of randomized controlled trials
Osugo, M., Whitehurst, T., Shatalina, E., Townsend, L., O’Brien, O., Mak, T. L. A., McCutcheon, R. A., & Howes, O. D. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104568 · Cited by 24
Bioavailable gluconate chelated stannous fluoride toothpaste meta-analyses: Effects on dentine hypersensitivity and enamel erosion
West, N. X., He, T., Zou, Y., DiGennaro, J., Biesbrock, A. R., & Davies, M. (2020) · Journal of Dentistry · doi:10.1016/j.jdent.2020.103566 · Cited by 25
Review of disease-modifying drug trials in amyotrophic lateral sclerosis
Tornese, P., Lalli, S., Cocco, A., & Albanese, A. (2022) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2021-328470 · Cited by 23
Emotional and psychosocial function after dorsal column spinal cord stimulator implantation: a systematic review and meta-analysis
Klasová, J., Hussain, N., Umer, I., Al-Hindawi, A., ElSaban, M., Lahori, S., & D'Souza, R. S. (2024) · Regional Anesthesia & Pain Medicine · doi:10.1136/rapm-2024-105523 · Cited by 23
Kanglaite (Coix Seed Extract) as Adjunctive Therapy in Cancer: Evidence Mapping Overview Based on Systematic Reviews With Meta-Analyses
Lu, C., Wu, S., Ke, L., Liu, F., Shang, W., Deng, X., Huang, Y., Zhang, Q., Cui, X., Mentis, A. A., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.901875 · Cited by 22
Tricyclic antidepressants versus ‘active placebo’, placebo or no intervention for adults with major depressive disorder: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis
Kamp, C. B., Juul, S., Siddiqui, F., Barbateskovic, M., Munkholm, K., Hengartner, M. P., Kirsch, I., Gluud, C. N., & Jakobsen, J. C. (2021) · Systematic Reviews · doi:10.1186/s13643-021-01789-0 · Cited by 18
Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment.
(2021) · PubMed Central · Cited by 19
To Be Scientific Is To Be Communist
Bright, L. K., & Heesen, R. (2023) · Social Epistemology · doi:10.1080/02691728.2022.2156308 · Cited by 22
Decolonizing Knowledge Upstream: New Ways to Deconstruct and Fight Disinformation in an Era of COVID-19, Extreme Digital Transformation, and Climate Emergency
Özdemir, V., & Springer, S. (2022) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2022.0041 · Cited by 22
Beneficial and harmful effects of antidepressants versus placebo, ‘active placebo’, or no intervention for adults with major depressive disorder: a protocol for a systematic review of published and unpublished data with meta-analyses and trial sequential analyses
Juul, S., Siddiqui, F., Barbateskovic, M., Kamp, C. B., Hengartner, M. P., Kirsch, I., Gluud, C. N., & Jakobsen, J. C. (2021) · Systematic Reviews · doi:10.1186/s13643-021-01705-6 · Cited by 18
The effect of minimally invasive sacroiliac joint fusion compared to sham operation: a double-blind randomized placebo-controlled trial
Randers, E. M., Gerdhem, P., Stuge, B., Diarbakerli, E., Nordsletten, L., Röhrl, S. M., & Kibsgård, T. J. (2024) · EClinicalMedicine · doi:10.1016/j.eclinm.2024.102438 · Cited by 18
Agomelatine for the Treatment of Generalized Anxiety Disorder: A Meta-Analysis
Wang, S., Woo, Y. S., Kim, N.-Y., Na, H.-R., Lim, H. K., & Bahk, W. (2020) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2020.18.3.423 · Cited by 17
Real‐World Analysis: Long‐Term Effect of Spinal Cord Stimulation With Different Waveforms for Patients With Failed Back Surgery Syndrome
Thoai, T., Smet, I., Jerjir, A., Vandamme, K., Devos, M., & Buyten, J. V. (2020) · Pain Practice · doi:10.1111/papr.12952 · Cited by 16
Is meta-analysis of RCTs assessing the efficacy of interventions a reliable source of evidence for therapeutic decisions?
Maziarz, M. (2021) · Studies in History and Philosophy of Science Part A · doi:10.1016/j.shpsa.2021.11.007 · Cited by 17
Metabolic Strategies in Healthcare: A New Era
Phillips, M. C. L. (2022) · Aging and Disease · doi:10.14336/ad.2021.1018 · Cited by 16
Methodological quality of systematic reviews on treatments for Alzheimer’s disease: a cross-sectional study
Zhong, C. C., Zhao, J., Wong, C. H. L., Wu, I. X. Y., Mao, C., Yeung, W., & Chung, V. C. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01100-w · Cited by 16
Conflicts of Interest in Studies Related to Mesh Use in Ventral Hernia Repair and Abdominal Wall Reconstruction
Sekigami, Y., Tian, T. M., Char, S., Radparvar, J., Aalberg, J. J., Chen, L., & Chatterjee, A. (2021) · Annals of Surgery · doi:10.1097/sla.0000000000004565 · Cited by 15
Methodological quality of systematic reviews on Chinese herbal medicine: a methodological survey
Cheung, A. K. L., Wong, C. H. L., Ho, L. T. F., Wu, X., Ke, F. Y. T., & Chung, V. C. (2022) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-022-03529-w · Cited by 15
Involvement of the food industry in nutrition conferences in Latin America and the Caribbean
Mialon, M., Jaramillo, Á., Caro, P., Flores, M., González, L., Gutiérrez‐Gómez, Y. Y., Mendivil, L. L., López‐Arana, S., López-Bautista, F., Mata, C. L., et al. (2020) · Public Health Nutrition · doi:10.1017/s1368980020003870 · Cited by 16
The Genetic Data Market: Institutional Governance of Academic/Industry Research Partnerships for the Public Good
Spector‐Bagdady, K. (2025) · The American Journal of Bioethics · doi:10.1080/15265161.2025.2554770 · Cited by 13
Design and outcome measures for the AB InBev Global Smart Drinking Goals evaluation
Miller, T. R., Ringwalt, C. L., Grube, J. W., Paschall, M. J., Fisher, D. A., & Gordon, M. V. (2019) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2019.100458 · Cited by 13
Conducting evaluations of evidence that are transparent, timely and can lead to health-protective actions
Chartres, N., Sass, J. B., Gee, D., Bălan, S. A., Birnbaum, L. S., Cogliano, V. J., Cooper, C., Fedinick, K. P., Harrison, R. M., Kolossa‐Gehring, M., et al. (2022) · Environmental Health · doi:10.1186/s12940-022-00926-z · Cited by 12
PEER simplified decision aid: osteoarthritis treatment options in primary care.
Lindblad, A. J., McCormack, J. P., Korownyk, C. S., Kolber, M. R., Ton, J., Perry, D., Thomas, B., Moe, S., Garrison, S., Dugré, N., et al. (2020) · PubMed Central · Cited by 11
Spin is Prevalent in the Abstracts of Systematic Reviews and Meta‐Analyses of Ulnar Collateral Ligament Reconstruction
Thompson, A. A., Mayfield, C. K., Bashrum, B. S., Abu-Zahra, M., Petrigliano, F. A., & Liu, J. N. (2023) · Arthroscopy Sports Medicine and Rehabilitation · doi:10.1016/j.asmr.2023.100808 · Cited by 12
Analysis of Conflicts of Interest in Studies Related to Robotics in Gastrointestinal and Abdominal Wall Surgery
Jafar, U., Usama, M., Hase, N. E., Yaseen, H., Nayyar, A., Rabinowitz, J. B., & Aziz, H. (2023) · Journal of the American College of Surgeons · doi:10.1097/xcs.0000000000000871 · Cited by 11
Drug company payments to General Practices in England: Cross-sectional and social network analysis
Sághy, E., Mulinari, S., & Ozierański, P. (2021) · PLoS ONE · doi:10.1371/journal.pone.0261077 · Cited by 10
The Utility of Virtual Reality in Ophthalmology: A Review
Ahuja, A. S., Paredes, A. A., Eisel, M. L. S., Ahuja, S., Wagner, I. V., Vasu, P., Dorairaj, S. K., Miller, D. D., & Abubaker, Y. (2025) · Clinical ophthalmology · doi:10.2147/opth.s517974 · Cited by 10
The undisclosed disclosures: Conflicts of interest in studies related to robotics in hepatobiliary and pancreatic surgery
Hase, N. E., Passarelli, J. P., Robichaud, S., Segalini, N., Ganguli, S., Song, C., Rabinowitz, J. B., & Aziz, H. (2022) · Surgery · doi:10.1016/j.surg.2022.08.013 · Cited by 9
Smoke and mirrors? Conflict of interest declarations in tobacco and e-cigarette-related academic publications
McDonald, A., McCausland, K., Thomas, L. T., Daube, M., & Jancey, J. M. (2023) · Australian and New Zealand Journal of Public Health · doi:10.1016/j.anzjph.2023.100055 · Cited by 9
Modified dietary fat intake for treatment of gallstone disease
Madden, A. M., Trivedi, D. P., Smeeton, N., & Culkin, A. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012608 · Cited by 9
Health Care Industry Payments to Editorial Board Members of Imaging-related Journals
Kwee, R. M., & Kwee, T. C. (2022) · Radiology · doi:10.1148/radiol.212527 · Cited by 9
Data sharing and transparency indicators in published RCTs in Oral Health between 2017 and 2023
Mikelis, F., Karamalaki, D., Mikeli, A., Tzanetakis, G. N., & Koletsi, D. (2024) · Journal of Dentistry · doi:10.1016/j.jdent.2024.105263 · Cited by 8
The Cost-Effectiveness of Intermediate-Acting, Long-Acting, Ultralong-Acting, and Biosimilar Insulins for Type 1 Diabetes Mellitus: A Systematic Review
Saunders, H., Pham, B., Loong, D., Mishra, S., Ashoor, H. M., Antony, J., Darvesh, N., Bains, S. K., Jamieson, M., Plett, D., et al. (2022) · Value in Health · doi:10.1016/j.jval.2021.12.016 · Cited by 8
Funding has no effect on clinical outcomes of total joint arthroplasty emerging technologies: a systematic review of bibliometrics and conflicts of interest
Via, G. G., Brueggeman, D. A., Lyons, J. G., Ely, I., Froehle, A. W., & Krishnamurthy, A. (2022) · Arthroplasty · doi:10.1186/s42836-022-00146-3 · Cited by 8
When patient advocacy organizations meet industry: a novel approach to dealing with financial conflicts of interest
Ehrlich, O. G., Wingate, L., Heller, C. A., & de Melo‐Martín, I. (2019) · BMC Medical Ethics · doi:10.1186/s12910-019-0435-1 · Cited by 8
Risk of any hypoglycaemia with newer antihyperglycaemic agents in patients with type 2 diabetes: A systematic review and meta‐analysis
Kamalinia, S., Josse, R. G., Donio, P. J., Leduc, L., Shah, B. R., & Tobe, S. W. (2019) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.100 · Cited by 7
The landscape of biomedical research funding in Brazil: a current overview
Gomes, C. M., Marchini, G. S., de Bessa, J., Carvalhal, G. F., Caldeira, M. P. D. R., Saldiva, P. H. N., Krieger, J. E., Agena, F., Reis, S. T., Paschoal, C., et al. (2024) · International braz j urol · doi:10.1590/s1677-5538.ibju.2024.9905 · Cited by 7
Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)
Storebø, O. J., Storm, M. R. O., Ribeiro, J. P., Skoog, M., Groth, C., Edemann-Callesen, H., Schaug, J. P., Darling, P. J., Huus, C.-M. L., Zwi, M., et al. (2025) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009885.pub4 · Cited by 10
Psychosocial interventions indicate prolonged survival in cancer patients in a systematic review, meta-analysis, and multiverse meta-analysis of randomized controlled trials
Asakawa-Haas, K. D., Spiegel, D., Bossert, L., Garić, A., Schwartz, K., Voracek, M., & Tran, U. S. (2026) · Communications Psychology · doi:10.1038/s44271-026-00414-x · Cited by 9
Funding has no effect on studies evaluating viscosupplementation for knee osteoarthritis: A systematic review of bibliometrics and conflicts of interest
Via, G. G., Brueggeman, D. A., Lyons, J. G., Frommeyer, T. C., Froehle, A. W., & Krishnamurthy, A. (2023) · Journal of Orthopaedics · doi:10.1016/j.jor.2023.03.015 · Cited by 7
Patron or Poison?
Critical Platform Studies Group, Irani, L. C., Salehi, N., Pal, J., Monroy‐Hernández, A., Churchill, E. F., & Narayan, S. (2019) · ACM Conference on Computer Supported Cooperative Work (CSCW) · doi:10.1145/3311957.3358610 · Cited by 7
Evaluation of Selective Outcome Reporting Bias in Efficacy Endpoints in Print and Television Advertisements for Oncology Drugs
Wayant, C., Aran, G., Johnson, B. S., & Vassar, M. B. (2020) · Journal of General Internal Medicine · doi:10.1007/s11606-020-06028-1 · Cited by 7
Emotional tones in scientific writing: comparison of commercially funded studies and non-commercially funded orthopedic studies
Steffens, A. N. V., Langerhuizen, D. W. G., Doornberg, J. N., Ring, D., & Janssen, S. J. (2020) · Acta Orthopaedica · doi:10.1080/17453674.2020.1853341 · Cited by 7
Comparative analysis of systemic oncological treatments and best supportive care for advanced gastresophageal cancer: A comprehensive scoping review and evidence map
Santero, M., Meade, A.-G., Selva, A., Roberto, A., Nicolas, M., Quintana, M. J., Bracchiglione, J., Requeijo, C., Josefina, S., Rodríguez-Grijalva, G., et al. (2023) · Journal of Evidence-Based Medicine · doi:10.1111/jebm.12539 · Cited by 6
Industry Sponsorship and Research Outcomes in A Sample of Landmark Ophthalmology Trials
Tao, B. K.-L., Dhivagaran, T., Butt, F. S., Popovic, M. M., Margolin, E., & Kohly, R. P. (2025) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2025.06.037 · Cited by 6
Citation of updated and co-published Cochrane Methodology Reviews
Zhu, L., Yang, Z., Deng, H., Zhang, Y., Liao, X., & Clarke, M. J. (2023) · Systematic Reviews · doi:10.1186/s13643-023-02270-w · Cited by 6
Developing a clinical trial governance framework for pharmaceutical industry-funded clinical trials
Nair, S. C., AlGhafli, S., & AlJaberi, A. (2018) · Accountability in Research · doi:10.1080/08989621.2018.1527222 · Cited by 6
Physicians’ attitudes towards disclosure of payments from pharmaceutical companies in a nationwide voluntary transparency database: a cross-sectional survey
Stoll, M., Hubenschmid, L., Koch, C., Lieb, K., & Egloff, B. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-055963 · Cited by 6
Canadian cannabis researcher perspectives on the conduct and sponsorship of scientific research by the for-profit cannabis industry
Buchman, D. Z., Magel, B., Shier, R., Davies, T. E., Sud, A., Mahajan, S., Timothy, R. K., Soklaridis, S., & Grundy, Q. (2024) · Social Science & Medicine · doi:10.1016/j.socscimed.2024.117556 · Cited by 5
Meta measurement of intelligence with crowd network
Yang, Z., & Ji, W. (2020) · International Journal of Crowd Science · doi:10.1108/ijcs-03-2020-0008 · Cited by 5
Results Reporting and Early Termination of Childhood Obesity Trials Registered on ClinicalTrials.gov
Wang, X., Long, Y., Liu, Y., Huang, J., & Du, L. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.860610 · Cited by 5
Bioethics and sociology: the place of social studies of science and technology
Lorenzo, C., & Neves, F. M. (2022) · Interface - Comunicação Saúde Educação · doi:10.1590/interface.220046 · Cited by 5
Acupuncture treatment of diabetic peripheral neuropathy: an overview of systematic reviews based on evidence mapping
Jiang, J.-J., Shen, H., Zhang, Y., Li, Y., Jing, Y., Chen, X., Wu, H., Xie, Y., & Liu, H. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1420510 · Cited by 5
Ten Years of Sports Health : Authorship Characteristics and Levels of Evidence
Judy, R. P., Talentino, S. E., Bedi, A., & Lesniak, B. P. (2020) · Sports Health A Multidisciplinary Approach · doi:10.1177/1941738120922163 · Cited by 5
Should clinical automated perimetry be considered for routine functional assessment of early/intermediate age‐related macular degeneration (AMD)? A systematic review of current literature
Trinh, M., Kalloniatis, M., & Nivison‐Smith, L. (2021) · Ophthalmic and Physiological Optics · doi:10.1111/opo.12919 · Cited by 5
The risks of adverse events with venlafaxine and mirtazapine versus ‘active placebo’, placebo, or no intervention for adults with major depressive disorder: a protocol for two separate systematic reviews with meta-analysis and Trial Sequential Analysis
Kamp, C. B., Juul, S., Siddiqui, F., Horowitz, M. A., Moncrieff, J., Munkholm, K., Hengartner, M. P., Kirsch, I., Gluud, C. N., & Jakobsen, J. C. (2023) · Systematic Reviews · doi:10.1186/s13643-023-02221-5 · Cited by 5
Values as heuristics: a contextual empiricist account of assessing values scientifically
ChoGlueck, C., & Lloyd, E. A. (2023) · Synthese · doi:10.1007/s11229-023-04198-z · Cited by 5
Photoselective vaporization of the prostate: study outcomes as a function of risk of bias, conflicts of interest, and industrial sponsorship
Wettstein, M., Pazhepurackel, C., Neumann, A., Woon, D., Herrera-Caceres, J., Kozomara, M., Poyet, C., Sulser, T., Kulkarni, G., & Hermanns, T. (2019) · World journal of urology · doi:10.1007/s00345-019-02799-3 · Cited by 5
Analysis of Funding Source and Spin in the Reporting of Studies of Intravitreal Corticosteroid Therapy for Diabetic Macular Edema: A Systematic Review
Nithianandan, H., Kuriyan, A. E., Venincasa, M. J., & Sridhar, J. S. (2020) · Clinical ophthalmology · doi:10.2147/opth.s262085 · Cited by 4
Systematic reviews and metaanalyses of air pollution epidemiological studies
Lam, J., Vesterinen, H. M., & Woodruff, T. J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818122-5.00008-9 · Cited by 6
Centralised Full Access to Clinical Study Data Can Support Unbiased Guideline Development, Continuing Medical Education, and Patient Information
McGauran, N., & Wieseler, B. (2021) · Journal of European CME · doi:10.1080/21614083.2021.1989172 · Cited by 4
Conflicts of Interest in Psychopharmacology Textbooks
Cosgrove, L., Herrawi, F., & Shaughnessy, A. F. (2021) · Community Mental Health Journal · doi:10.1007/s10597-021-00906-6 · Cited by 4
Modified dietary fat intake for treatment of gallstone disease
Madden, A. M., Trivedi, D. P., Smeeton, N., & Culkin, A. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012608.pub2 · Cited by 5
Stop tobacco industry sponsorship of continuing medical education
Malone, R. E. (2024) · BMJ · doi:10.1136/bmj.q950 · Cited by 4
Reporting guideline for overviews of reviews of healthcare interventions: The Preferred Reporting Items for Overviews of Reviews (PRIOR) Explanation & Elaboration
Gates, M., Gates, A., Pieper, D., Fernandes, R., Tricco, A., Moher, D., Brennan, S. E., Li, T., Pollock, M., Lunny, C., et al. (2022) · doi:10.31222/osf.io/23b6j · Cited by 3
Systematic review with cross sectional comparative analysis identifies adverse event reporting discrepancies between ClinicalTrials.gov and published glaucoma randomized controlled trials
Elghzali, A., Chaudhry, M., Khan, S. M., Khan, A., & Vassar, M. B. (2025) · Scientific Reports · doi:10.1038/s41598-025-24290-3 · Cited by 2
The value for money of artificial intelligence-empowered precision medicine: a systematic review and regression analysis
Zhang, Y., Lin, Z., Teerawattananon, Y., Akksilp, K., Morton, A., Wang, Y., Prapinvanich, T., Dulsamphan, T., & Chen, W. (2025) · npj Digital Medicine · doi:10.1038/s41746-025-02259-w · Cited by 5
International Collaboration and Commercial Involvement in Randomized Controlled Trials From 10 Leading Countries, 1997 Through 2019
Fukuhara, S., Kataoka, Y., Aoki, T., Green, J., Shimizu, S., & Toyoda, N. (2024) · Cureus · doi:10.7759/cureus.61205 · Cited by 3
Unsolicited Patient Complaints and Industry Payments for US Physicians
Park, Y. H., Domenico, H. J., Su, Z. T., Trock, B. J., Jing, Y., Hickson, G. B., Cooper, W. O., & Han, M. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.26643 · Cited by 3
The Statistical Fragility of Lumbar Disc Arthroplasty vs Lumbar Fusion: A Systematic Review of Randomized Controlled Trials
Tiao, J., Song, J., Hoang, R., Mejia, M. R., Rajjoub, R., Bhadouria, N., Koehne, N. H., Locke, A. R., Yendluri, A., Huang, J. J., et al. (2025) · Global Spine Journal · doi:10.1177/21925682251368313 · Cited by 3
Exogenous Melatonin and Sleep Quality: A Scoping Review of Systematic Reviews
Iyer, S., Monk, V., Slater, R., & Baxter, L. (2025) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.70115 · Cited by 3
The Island of Research (Do Not Block the Path of Enquiry)
Renzo, G. C. D., Tosto, V., & Tsibizova, V. I. (2021) · Springer eBooks · doi:10.1007/978-3-030-84954-2_1 · Cited by 3

Authors: Lundh, A., Lexchin, J., Mintzes, B., Schroll, J. B., & Bero, L.
Affiliations: University of Southern Denmark (DK)
York University (CA)
The University of Sydney (AU)
Hvidovre Hospital (DK)
Corresponding author: Lundh, Andreas
ORCID: Lundh, Andreas
Lexchin, Joel
Mintzes, Barbara
Schroll, Jeppe B.
Bero, Lisa
Venue: Intensive Care Medicine
Publisher: Springer Science and Business Media LLC
Published: 2018-08-21
Volume: 44
Issue: 10
Pages: 1603-1612
ISSN: 0342-4642 (ISSN-L)
1432-1238
DOI: 10.1007/s00134-018-5293-7
OpenAlex: W2888260605
Semantic Scholar: c39013a69577395e9c63ac2e2d7e4e8ac4c36583
Cited by: 162
References: 58
Citations by year: 2026: 12 · 2025: 21 · 2024: 18 · 2023: 21 · 2022: 27 · 2021: 23 · 2020: 23 · 2019: 13 · 2018: 3
FWCI: 3.01
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Intensive Care Medicine (publishedVersion)
PubMed (publishedVersion)
University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
Funders: Macquarie University
Topics: Health Sciences › Nursing › Issues, ethics and legal aspects › Pharmaceutical industry and healthcare
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Global Public Health Policies and Epidemiology
Social Sciences › Business, Management and Accounting › Strategy and Management › Political Influence and Corporate Strategies
Keywords: industry funding, pharmaceutical industry, medical device industry, research funding sources, research bias, risk of bias, blinding, selective outcome reporting, conflicts of interest, clinical trials
MeSH terms: Drug Industry, Equipment and Supplies, Research Support as Topic, Treatment Outcome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Industry sponsorship and research outcome: systematic review with meta-analysis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks