Cited by 2,105COVID-19 Clinical Research StudiesSepsis Diagnosis and TreatmentRespiratory Support and Mechanisms

The DOI matches its Crossref record; 230 of the 230 references it cites were found in a registry or an index.

Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19)

Open access

Alhazzani, Waleed, Møller, Morten Hylander, Arabi, Yaseen M., Loeb, Mark, Gong, Michelle Ng, Fan, Eddy, Oczkowski, Simon, Levy, Mitchell M., Derde, Lennie, Dzierba, Amy, Du, Bin, Aboodi, Michael, Wunsch, Hannah, Cecconi, Maurizio, Koh, Younsuck, Chertow, Daniel S., Maitland, Kathryn, Alshamsi, Fayez, Belley-Cote, Emilie, Greco, Massimiliano, Laundy, Matthew, Morgan, Jill S., Kesecioglu, Jozef, McGeer, Allison, Mermel, Leonard, Mammen, Manoj J., Alexander, Paul E., Arrington, Amy, Centofanti, John E., Citerio, Giuseppe, Baw, Bandar, Memish, Ziad A., Hammond, Naomi, Hayden, Frederick G., Evans, Laura, Rhodes, Andrew·2020·Intensive Care Medicine

DOI 10.1007/s00134-020-06022-5PMC PMC7101866

Open this paper in CoChat — free account Open PDF

Abstract

Background The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting thousands of people around the world. Urgent guidance for clinicians caring for the sickest of these patients is needed.Methods We formed a panel of 36 experts from 12 countries. All panel members completed the World Health Organization conflict of interest disclosure form. The panel proposed 53 questions that are relevant to the management of COVID-19 in the ICU. We searched the literature for direct and indirect evidence on the management of COVID-19 in critically ill patients in the ICU. We identified relevant and recent systematic reviews on most questions relating to supportive care. We assessed the certainty in the evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach, then generated recommendations based on the balance between benefit and harm, resource and cost implications, equity, and feasibility. Recommendations were either strong or weak, or in the form of best practice recommendations.Results The Surviving Sepsis Campaign COVID-19 panel issued 54 statements, of which 4 are best practice statements, 9 are strong recommendations, and 35 are weak recommendations. No recommendation was provided for 6 questions. The topics were: (1) infection control, (2) laboratory diagnosis and specimens, (3) hemodynamic support, (4) ventilatory support, and (5) COVID-19 therapy.Conclusion The Surviving Sepsis Campaign COVID-19 panel issued several recommendations to help support healthcare workers caring for critically ill ICU patients with COVID-19. When available, we will provide new recommendations in further releases of these guidelines.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s00134-020-06022-5

Cites

230 of 230 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884
Clinical characteristics of coronavirus disease 2019 in China
Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Liu, L., Shan, H., Lei, C.-L., Hui, D. S. C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2002032 · Cited by 30,246
Self-citation
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30566-3 · Cited by 27,263
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Guyatt, G. H., Oxman, A. D., Vist, G. E., Kunz, R., Falck-Ytter, Y., Alonso-Coello, P., & Schünemann, H. J. (2008) · BMJ · doi:10.1136/bmj.39489.470347.ad · Cited by 23,305 · cited 1×
“We used the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach to assess the quality of evidence [7] , i.e. our confidence in the estimate of the effect to support a recommendation [8] .”
Epidemiological and clinical characteristics of 99 cases of 2019 novel Coronavirus pneumonia in Wuhan, China: a descriptive study.
Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30211-7 · Cited by 21,415
Clinical characteristics of 138 hospitalized patients with 2019 Novel Coronavirus-Infected pneumonia in Wuhan, China
Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Xiang, H., Cheng, Z., Xiong, Y., et al. (2020) · JAMA · doi:10.1001/jama.2020.1585 · Cited by 20,148
La certeza de lo impredecible: Cultura Educación y Sociedad en tiempos de COVID19
Martínez González, M. (2020) · DSPACE System - Metalibrary (University of the Coast) · Cited by 18,463
La certeza de lo impredecible
Martínez–González, M. B. (2020) · DSPACE System - Metalibrary (University of the Coast) · Cited by 18,292
Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention
Wu, Z., & McGoogan, J. M. (2020) · JAMA · doi:10.1001/jama.2020.2648 · Cited by 17,016
Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome
(2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421801 · Cited by 12,941

Show all 227 references

Sorted by citations

Items 201–300 of 1,000

Diabetes and COVID-19: Global and regional perspectives
Jeong, I., Yoon, K., & Lee, M. K. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108303 · Cited by 80
Prone positioning as an emerging tool in the care provided to patients infected with COVID-19: a scoping review
de Araújo, M. S., dos Santos, M. M. P., Silva, C. J. D. A., de Menezes, R. M. P., Feijão, A. R., & de Medeiros, S. M. (2021) · Revista Latino-Americana de Enfermagem · doi:10.1590/1518-8345.4732.3397 · Cited by 83
β-glucan-coupled superparamagnetic iron oxide nanoparticles induce trained immunity to protect mice against sepsis
Pan, Y., Li, J., Xia, X., Wang, J., Jiang, Q., Yang, J., Dou, H., Liang, H., Li, K., & Hou, Y. (2021) · Theranostics · doi:10.7150/thno.64874 · Cited by 78
The Impact of COVID-19 Pandemic on Spine Surgeons Worldwide
Louie, P. K., Harada, G. K., McCarthy, M. H., Germscheid, N., Cheung, J. P. Y., Neva, M. H., El-Sharkawi, M. M., Valacco, M., Sciubba, D. M., Chutkan, N. B., et al. (2020) · Global Spine Journal · doi:10.1177/2192568220925783 · Cited by 76
High-flow nasal oxygen: a safe, efficient treatment for COVID-19 patients not in an ICU
Guy, T., Créac'hcadec, A., Ricordel, C., Salé, A., Arnouat, B., Bizec, J., Langelot, M., Lineau, C., Marquette, D., Martin, F., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.01154-2020 · Cited by 76
Feline infectious peritonitis (FIP) and coronavirus disease 19 (COVID‐19): Are they similar?
Paltrinieri, S., Giordano, A., Stranieri, A., & Lauzi, S. (2020) · Transboundary and Emerging Diseases · doi:10.1111/tbed.13856 · Cited by 75
Sarilumab use in severe SARS-CoV-2 pneumonia
Gremese, E., Cingolani, A., Bosello, S. L., Alivernini, S., Tolusso, B., Perniola, S., Landi, F., Pompili, M., Murri, R., Santoliquido, A., et al. (2020) · EClinicalMedicine · doi:10.1016/j.eclinm.2020.100553 · Cited by 75
VDA-RWLRLS: An anti-SARS-CoV-2 drug prioritizing framework combining an unbalanced bi-random walk and Laplacian regularized least squares
Shen, L., Liu, F., Huang, L., Liu, G., Zhou, L., & Peng, L. (2021) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2021.105119 · Cited by 75
Management of respiratory failure due to covid-19
Wilcox, S. R. (2020) · BMJ · doi:10.1136/bmj.m1786 · Cited by 76
Multidisciplinary Safety Recommendations After Tracheostomy During COVID‐19 Pandemic: State of the Art Review
Meister, K. D., Pandian, V., Hillel, A. T., Walsh, B. K., Brodsky, M. B., Balakrishnan, K., Best, S. R., Chinn, S. B., Cramer, J. D., Graboyes, E. M., et al. (2020) · Otolaryngology · doi:10.1177/0194599820961990 · Cited by 74
Noninvasive ventilation for acute hypoxemic respiratory failure in patients with COVID-19
Avdeev, S. N., Yaroshetskiy, A. I., Tsareva, N. A., Мержоева, З. М., Трушенко, Н. В., Nekludova, G. V., & Chikina, S. Y. (2020) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2020.09.075 · Cited by 74
S2k-Leitlinie – Empfehlungen zur stationären Therapie von Patienten mit COVID-19
Kluge, S., Janssens, U., Welte, T., Weber‐Carstens, S., Schälte, G., Spinner, C. D., Malin, J. J., Gastmeier, P., Länger, F. P., Wepler, M., et al. (2021) · Pneumologie · doi:10.1055/a-1334-1925 · Cited by 75
Initial emergency department mechanical ventilation strategies for COVID-19 hypoxemic respiratory failure and ARDS
Lentz, S. A., Roginski, M. A., Montrief, T., Ramzy, M. M., Gottlieb, M. A., & Long, B. (2020) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2020.06.082 · Cited by 78
Inadequate use of antibiotics in the covid-19 era: effectiveness of antibiotic therapy
Estrada, A. D. B., Calderón‐Parra, J., Carracedo, E. F., Míguez, A. M., Ramos, A., Múñez, E., Rubio‐Rivas, M., de Blas, P. A., Arnalich, F., Pérez, V. E., et al. (2021) · BMC Infectious Diseases · doi:10.1186/s12879-021-06821-1 · Cited by 73
The Arab region’s contribution to global COVID-19 research: Bibliometric and visualization analysis
Zyoud, S. H. (2021) · Globalization and Health · doi:10.1186/s12992-021-00690-8 · Cited by 74
Cardiopulmonary Resuscitation During the COVID-19 Pandemic
DeFilippis, E. M., Ranard, L. S., & Berg, D. D. (2020) · Circulation · doi:10.1161/circulationaha.120.047260 · Cited by 71
Swallowing and Voice Outcomes in Patients Hospitalized With COVID-19: An Observational Cohort Study
Archer, S. K., Iezzi, C., & Gilpin, L. (2021) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2021.01.063 · Cited by 70
Acute Myocardial Injury at Hospital Admission Is Associated With All-Cause Mortality in COVID-19
Ni, W., Yang, X., Liu, J., Bao, J., Li, R., Xu, Y. S., Guo, W., Hu, Y., & Gao, Z. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.05.007 · Cited by 69
Delirium Incidence, Duration, and Severity in Critically Ill Patients With Coronavirus Disease 2019
Khan, S., Lindroth, H. L., Perkins, A. J., Jamil, Y., Wang, S., Roberts, S., Farber, M. O., Rahman, O., Gao, S., Marcantonio, E. R., et al. (2020) · Critical Care Explorations · doi:10.1097/cce.0000000000000290 · Cited by 72
Implementation of new ECMO centers during the COVID-19 pandemic: experience and results from the Middle East and India
Rabie, A. A., Azzam, M. H., Al-Fares, A. A., Abdelbary, A., Mufti, H. N., Hassan, I. F., Chakraborty, A., Oza, P. L., Elhazmi, A., Alfoudri, H., et al. (2021) · Intensive Care Medicine · doi:10.1007/s00134-021-06451-w · Cited by 69
Self-citation
World Sepsis Day: a global agenda to target a leading cause of morbidity and mortality
Schlapbach, L. J., Kissoon, N. “., Alhawsawi, A. M., Aljuaid, M. H., Daniels, R., Gorordo-Delsol, L. A., Machado, F. R., Malik, I., Nsutebu, E. F., Finfer, S. R., et al. (2020) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00369.2020 · Cited by 74
Staphylococcus aureus ventilator-associated pneumonia in patients with COVID-19: clinical features and potential inference with lung dysbiosis
PASCALE, G. D., Maio, F. D., Carelli, S., Angelis, G. D., Cacaci, M., Montini, L. M., Bello, G., Cutuli, S. L., Pintaudi, G., Tanzarella, E. S., et al. (2021) · Critical Care · doi:10.1186/s13054-021-03623-4 · Cited by 70
Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome Associated with COVID-19: An Emulated Target Trial Analysis
Hajage, D., Combes, A., Guervilly, C., Lebreton, G., Mercat, A., Pavot, A., Nseir, S., Dessap, A. M., Mongardon, N., Mira, J. P., et al. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202111-2495oc · Cited by 68
Inhaled nitric oxide in mechanically ventilated patients with COVID-19
Ferrari, M., Santini, A., Protti, A., Andreis, D. T., Iapichino, G., Castellani, G., Rendiniello, V., Costantini, E., & Cecconi, M. (2020) · Journal of Critical Care · doi:10.1016/j.jcrc.2020.08.007 · Cited by 67
Self-citation
Surging bloodstream infections and antimicrobial resistance during the first wave of COVID–19: a study in a large multihospital institution in the Paris region
Amarsy, R., Trystram, D., Cambau, E., Monteil, C., Fournier, S., Oliary, J., Junot, H., Sabatier, P., Porcher, R., Robert, J., et al. (2021) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2021.10.034 · Cited by 67
High- Versus Low-Dose Dexamethasone for the Treatment of COVID-19-Related Acute Respiratory Distress Syndrome: A Multicenter, Randomized Open-Label Clinical Trial
Maskin, L. P., Bonelli, I., Olarte, G. L., Pálizas, F., Velo, A. E., Lurbet, M. F., Lovazzano, P., Kotsias, S., Attie, S., Saubidet, I. L., et al. (2021) · Journal of Intensive Care Medicine · doi:10.1177/08850666211066799 · Cited by 67
Clinical phenotypes of critically ill COVID-19 patients
Azoulay, É., Zafrani, L., Mirouse, A., Lengliné, É., Darmon, M., & Chevret, S. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06120-4 · Cited by 66
COVID-19 Pandemic: the greatest challenge in the history of critical care
Ferrer, R. (2020) · Medicina Intensiva (English Edition) · doi:10.1016/j.medine.2020.04.005 · Cited by 66
The Use of the SpO2 to FiO2 Ratio to Individualize the Hypoxic Dose in Sport Science, Exercise, and Health Settings
Soo, J., Girard, O., Ihsan, M., & Fairchild, T. J. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.570472 · Cited by 66
Recomendaciones de «hacer» y «no hacer» en el tratamiento de los pacientes críticos ante la pandemia por coronavirus causante de COVID-19 de los Grupos de Trabajo de la Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias (SEMICYUC)
Ballesteros, M. Á., Hernández-Tejedor, A., Estella, Á., Rivera, J. J. J., de Molina, F. J. G., Camps, A. S., Vidal, P., de Haro, C., Aguilar-Alonso, E., Laguna, L. B., et al. (2020) · Medicina Intensiva · doi:10.1016/j.medin.2020.04.001 · Cited by 70
Brazilian Nursing Process Research Network contributions for assistance in the COVID-19 pandemic
de Barros, A. L. B. L., da Silva, V. M., Santana, R. F., Cavalcante, Á. M. R. Z., Vítor, A. F., Lucena, A. D. F., Napoleão, A. A., Lopes, C. T., Primo, C. Ç., Carmona, E. V., et al. (2020) · Revista Brasileira de Enfermagem · doi:10.1590/0034-7167-2020-0798 · Cited by 65
Use of Helmet CPAP in COVID-19 – A practical review
Amirfarzan, H., Cereda, M. F., Gaulton, T. G., Leissner, K. B., Cortegiani, A., Schumann, R., & Gregoretti, C. (2021) · Pulmonology · doi:10.1016/j.pulmoe.2021.01.008 · Cited by 65
High sedation needs of critically ill COVID-19 ARDS patients—A monocentric observational study
Flinspach, A. N., Booke, H., Zacharowski, K. D., Balaban, Ü., Herrmann, E. M., & Adam, E. (2021) · PLoS ONE · doi:10.1371/journal.pone.0253778 · Cited by 65
A label-free impedance biosensing assay based on CRISPR/Cas12a collateral activity for bacterial DNA detection
Bonini, A., Poma, N. V., Vivaldi, F. M., Biagini, D., Bottai, D., Tavanti, A., & Francesco, F. D. (2021) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2021.114268 · Cited by 64
Helmet continuous positive airway pressure and prone positioning: A proposal for an early management of COVID-19 patients
Longhini, F., Bruni, A., Garofalo, E., Navalesi, P., Grasselli, G., Cosentini, R., Foti, G., Mattei, A., Ippolito, M., Accurso, G., et al. (2020) · Pulmonology · doi:10.1016/j.pulmoe.2020.04.014 · Cited by 64
COVID-19 and Diabetes Mellitus: The Link and Clinical Implications
Ugwueze, C. V., Ezeokpo, B. C., Nnolim, B. I., Agim, E. A., Anikpo, N. C., & Onyekachi, K. E. (2020) · Dubai Diabetes and Endocrinology Journal · doi:10.1159/000511354 · Cited by 63
The efficacy of IL-6 inhibitor Tocilizumab in reducing severe COVID-19 mortality: a systematic review
Kaye, A. G., & Siegel, R. (2020) · PeerJ · doi:10.7717/peerj.10322 · Cited by 62
Multicenter Evaluation of the FilmArray Blood Culture Identification 2 Panel for Pathogen Detection in Bloodstream Infections
Caméléna, F., de Ponfilly, G. P., Pailhories, H., Bonzon, L., Alanio, A., Poncin, T., Lafaurie, M., Dépret, F., Cambau, E., Godreuil, S., et al. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.02547-22 · Cited by 62
Iran's Approach to COVID-19: Evolving Treatment Protocols and Ongoing Clinical Trials
Rahmanzade, R., Rahmanzadeh, R., Hashemian, S. M. R., & Tabarsi, P. (2020) · Frontiers in Public Health · doi:10.3389/fpubh.2020.551889 · Cited by 61
Procalcitonin and secondary bacterial infections in COVID-19: association with disease severity and outcomes
Vazzana, N., Dipaola, F., & Ognibene, S. (2020) · Acta Clinica Belgica · doi:10.1080/17843286.2020.1824749 · Cited by 61
A Review of Treatment of Coronavirus Disease 2019 (COVID-19): Therapeutic Repurposing and Unmet Clinical Needs
Chen, P., Lee, N., Cia, C.-T., Ko, W., & Hsueh, P. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.584956 · Cited by 62
COVID-19 grave: entenda o papel da imunidade, do endotélio e da coagulação na prática clínica
Brandão, S. C. S., Godoi, E. T. A. M., Ramos, J. D. O. X., de Melo, L. M. M. P., & SARINHO, E. S. C. (2020) · Jornal Vascular Brasileiro · doi:10.1590/1677-5449.200131 · Cited by 67
Challenges and Solutions in translating sepsis guidelines into practice in resource-limited settings
Ranjit, S., & Kissoon, N. “. (2021) · Translational Pediatrics · doi:10.21037/tp-20-310 · Cited by 63
Lung Response to a Higher Positive End-Expiratory Pressure in Mechanically Ventilated Patients With COVID-19
Protti, A., Santini, A., Pennati, F., Chiurazzi, C., Cressoni, M., Ferrari, M., Iapichino, G., Carenzo, L., Lanza, E., Picardo, G., et al. (2021) · CHEST Journal · doi:10.1016/j.chest.2021.10.012 · Cited by 61
Self-citation
Co-infection and ICU-acquired infection in COVID-19 ICU patients: a secondary analysis of the UNITE-COVID data set
Morris, A. C., Kohler, K., Corte, T. D., Ercole, A., de Grooth, H., Elbers, P., Póvoa, P. M. S. R., Morais, R., Koulenti, D., Jog, S., et al. (2022) · Critical Care · doi:10.1186/s13054-022-04108-8 · Cited by 61
Self-citation
Pharmaceutical nanotechnology: which products are been designed against COVID-19?
Cavalcanti, I. D. L., & Nogueira, M. C. D. B. L. (2020) · Journal of Nanoparticle Research · doi:10.1007/s11051-020-05010-6 · Cited by 60
Continuous Positive Airway Pressure (CPAP) face-mask ventilation is an easy and cheap option to manage a massive influx of patients presenting acute respiratory failure during the SARS-CoV-2 outbreak: A retrospective cohort study
Alviset, S., Riller, Q., Aboab, J., Dilworth, K., Billy, P.-A., Lombardi, Y., Azzi, M., Vargas, L. F., Lainé, L., Lermuzeaux, M., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0240645 · Cited by 60
Dexamethasone may improve severe COVID-19 via ameliorating endothelial injury and inflammation: A preliminary pilot study
Kim, W., Kweon, O. J., Cha, M. J., Baek, M. S., & Choi, S. (2021) · PLoS ONE · doi:10.1371/journal.pone.0254167 · Cited by 63
Adverse Events of Prone Positioning in Mechanically Ventilated Adults With ARDS
González-Seguel, F., Pinto-Concha, J. J., Aranis, N., & Leppe, J. (2021) · Respiratory Care · doi:10.4187/respcare.09194 · Cited by 60
The severe COVID-19: A sepsis induced by viral infection? And its immunomodulatory therapy
Lin, H. (2020) · Chinese Journal of Traumatology · doi:10.1016/j.cjtee.2020.06.002 · Cited by 60
How the Covid-19 epidemic is challenging our practice in clinical nutrition—feedback from the field
Thibault, R., Coëffier, M., Joly, F., Bohé, J., Schneider, S. M., & Déchelotte, P. (2020) · European Journal of Clinical Nutrition · doi:10.1038/s41430-020-00757-6 · Cited by 61
Novel coronavirus pandemic: A global health threat
Abu-Zidan, F., Khan, G., Sheek‐Hussein, M., Alsuwaidi, A. R., & Idris, K. M. (2020) · Turkish Journal of Emergency Medicine · doi:10.4103/2452-2473.285016 · Cited by 59
High Failure Rate of Noninvasive Oxygenation Strategies in Critically Ill Subjects With Acute Hypoxemic Respiratory Failure Due to COVID-19
Menga, L. S., Cese, L. D., Bongiovanni, F., Lombardi, G., Michi, T., Luciani, F., Cicetti, M., Timpano, J., Ferrante, M. C., Cesarano, M., et al. (2021) · Respiratory Care · doi:10.4187/respcare.08622 · Cited by 60
The Rationale for Potential Pharmacotherapy of COVID-19
Saber-Ayad, M. M., Saleh, M. A., & Abu‐Gharbieh, E. (2020) · Pharmaceuticals · doi:10.3390/ph13050096 · Cited by 59
Positionspapier zur praktischen Umsetzung der apparativen Differenzialtherapie der akuten respiratorischen Insuffizienz bei COVID-19
Pfeifer, M., Ewig, S., Voshaar, T., Randerath, W., Bauer, T., Geiseler, J., Dellweg, D., Westhoff, M., Windisch, W., Schönhofer, B., et al. (2020) · Pneumologie · doi:10.1055/a-1157-9976 · Cited by 64
Conscious Proning: An Introduction of a Proning Protocol for Nonintubated, Awake, Hypoxic Emergency Department COVID‐19 Patients
Jiang, L. G., LeBaron, J., Bodnar, D., Caputo, N. D., Chang, B., Chiricolo, G. C., Flores, S., Kenny, J. F., Melville, L. D., Sayan, O. R., et al. (2020) · Academic Emergency Medicine · doi:10.1111/acem.14035 · Cited by 58
Effectiveness of remdesivir in patients with COVID-19 under mechanical ventilation in an Italian ICU
Pasquini, Z. A. I., Montalti, R., Temperoni, C., Canovari, B., Mancini, M., Tempesta, M., Pimpini, D., Zallocco, N., & Barchiesi, F. (2020) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkaa321 · Cited by 58
Clinical Significance of Timing of Intubation in Critically Ill Patients with COVID-19: A Multi-Center Retrospective Study
Lee, Y. H., Choi, K.-J., Choi, S. H., Lee, S. Y., Kim, K. C., Kim, E. J., & Lee, J. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092847 · Cited by 58
SARS-CoV-2 and Health Care Worker Protection in Low-Risk Settings: a Review of Modes of Transmission and a Novel Airborne Model Involving Inhalable Particles
Zhang, X. S., & Duchaine, C. (2020) · Clinical Microbiology Reviews · doi:10.1128/cmr.00184-20 · Cited by 59
Prone positioning for patients with hypoxic respiratory failure related to COVID-19
Venus, K., Munshi, L., & Fralick, M. (2020) · Canadian Medical Association Journal · doi:10.1503/cmaj.201201 · Cited by 57
Endothelialitis plays a central role in the pathophysiology of severe COVID-19 and its cardiovascular complications
Vrints, C. J., Krychtiuk, K. A., Craenenbroeck, E. M. V., Segers, V. F. M., Price, S., & Heidbüchel, H. (2020) · Acta cardiologica. Supplementum · doi:10.1080/00015385.2020.1846921 · Cited by 58
Multi-Drug Resistance Bacterial Infections in Critically Ill Patients Admitted with COVID-19
Pasero, D., Cossu, A. P., & Terragni, P. (2021) · Microorganisms · doi:10.3390/microorganisms9081773 · Cited by 60
ROX index as predictor of high flow nasal cannula therapy success in acute respiratory failure due to SARS-CoV-2
Ferrer, S., Sancho, J., Bocigas, I., Burés, E., Mora, H., Monclou, E., Mulet, A., Quezada, A., Royo, P., & Signes‐Costa, J. (2021) · Respiratory Medicine · doi:10.1016/j.rmed.2021.106638 · Cited by 58
COVID-19: Potential of Microalgae Derived Natural Astaxanthin As Adjunctive Supplement in Alleviating Cytokine StormPreprint
Talukdar, J., Dasgupta, S., Nagle, V. L., & Bhadra, B. (2020) · SSRN Electronic Journal · doi:10.2139/ssrn.3579738 · Cited by 58
COVID-19 Preparedness Within the Surgical, Obstetric, and Anesthetic Ecosystem in Sub-Saharan Africa
Ademuyiwa, A. O., Bekele, A., Berhea, A. B., Borgstein, E. S., Capo‐Chichi, N., Derbew, M., Evans, F. M., Feyssa, M. D., Galukande, M., Gawande, A. A., et al. (2020) · Annals of Surgery · doi:10.1097/sla.0000000000003964 · Cited by 57
PEEP levels in COVID-19 pneumonia
Tsolaki, V., Siempos, I. Ι., Magira, E. E., Kokkoris, S., Zakynthinos, G. Ε., & Zakynthinos, S. G. (2020) · Critical Care · doi:10.1186/s13054-020-03049-4 · Cited by 56
Non-invasive ventilation for SARS-CoV-2 acute respiratory failure: a subanalysis from the HOPE COVID-19 registry
Bertaina, M., Nuñez-Gil, I. J., Franchin, L., Rozas, I. F., Arroyo‐Espliguero, R., Viana-Llamas, M. C., Romero, R., Maroun‐Eid, C., Uribarri, A., Becerra‐Muñoz, V. M., et al. (2021) · Emergency Medicine Journal · doi:10.1136/emermed-2020-210411 · Cited by 56
Multidisciplinary Guidance Regarding the Use of Immunomodulatory Therapies for Acute Coronavirus Disease 2019 in Pediatric Patients
Dulek, D. E., Fuhlbrigge, R. C., Tribble, A. C., Connelly, J. A., Loi, M. M., Chebib, H. E., Chandrakasan, S., Otto, W. R., Diorio, C. J., Keim, G. P., et al. (2020) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/piaa098 · Cited by 56
Impulse Dispersion of Aerosols during Singing and Speaking: A Potential COVID-19 Transmission Pathway
Echternach, M., Gantner, S., Peters, G., Westphalen, C., Benthaus, T., Jakubaß, B., Kuranova, L., Döllinger, M., & Kniesburges, S. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202009-3438le · Cited by 59
Effectiveness of mid-regional pro-adrenomedullin (MR-proADM) as prognostic marker in COVID-19 critically ill patients: An observational prospective study
Montrucchio, G. G., Sales, G., Rumbolo, F., Palmesino, F., Fanelli, V., Urbino, R., Filippini, C., Mengozzi, G., & Brazzi, L. (2021) · PLoS ONE · doi:10.1371/journal.pone.0246771 · Cited by 55
Association Between Early Invasive Mechanical Ventilation and Day-60 Mortality in Acute Hypoxemic Respiratory Failure Related to Coronavirus Disease-2019 Pneumonia
Dupuis, C., Bouadma, L., de Montmollin, É., Goldgran-Tolédano, D., Schwebel, C., Reignier, J., Neuville, M., Ursino, M., Siami, S., Ruckly, S., et al. (2021) · Critical Care Explorations · doi:10.1097/cce.0000000000000329 · Cited by 55
An open-label randomized controlled trial evaluating the efficacy of chloroquine/hydroxychloroquine in severe COVID-19 patients
Réa-Neto, Á., Bernardelli, R. S., Câmara, B. M. D., Reese, F. B., Queiroga, M. V. O., & de Oliveira, M. C. (2021) · Scientific Reports · doi:10.1038/s41598-021-88509-9 · Cited by 58
Issues for the management of people with diabetes and COVID-19 in ICU
Ceriello, A., Standl, E., Catrinoiu, D., Itzhak, B., Lalic, N. M., Rahelić, D., Schnell, O., Škrha, J., & Valensi, P. E. (2020) · Cardiovascular Diabetology · doi:10.1186/s12933-020-01089-2 · Cited by 54
A Review on SARS-CoV-2-Induced Neuroinflammation, Neurodevelopmental Complications, and Recent Updates on the Vaccine Development
Karnik, M., Beeraka, N. M., Uthaiah, C. A., Nataraj, S. M., Bettadapura, A. D. S., Aliev, G., & Madhunapantula, S. V. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02399-6 · Cited by 56
German S3 Guideline: Oxygen Therapy in the Acute Care of Adult Patients
Gottlieb, J., Capetian, P., Hamsen, U., Janssens, U., Karagiannidis, C., Kluge, S., Nothacker, M., Roiter, S., Volk, T. J., Worth, H., et al. (2021) · Respiration · doi:10.1159/000520294 · Cited by 56
Cardiovascular Complications of COVID-19: Pharmacotherapy Perspective
Talasaz, A. H., Kakavand, H., Tassell, B. W. V., Aghakouchakzadeh, M., Sadeghipour, P., Dunn, S. P., & Geraiely, B. (2020) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-07037-2 · Cited by 54
Clinical Management of Diabetes Mellitus in the Era of COVID-19: Practical Issues, Peculiarities and Concerns
Koliaki, C. C., Tentolouris, A., Eleftheriadou, I., Melidonis, A. J., Dimitriadis, G., & Tentolouris, N. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072288 · Cited by 56
Individualized resuscitation strategy for septic shock formalized by finite mixture modeling and dynamic treatment regimen
Ma, P., Liu, J., Shen, F., Liao, X., Xiu, M., Zhao, H., Zhao, M., Xie, J., Wang, P., Huang, M., et al. (2021) · Critical Care · doi:10.1186/s13054-021-03682-7 · Cited by 54
Using GRADE in situations of emergencies and urgencies: certainty in evidence and recommendations matters during the COVID-19 pandemic, now more than ever and no matter what
Schünemann, H. J., Santesso, N. A., Vist, G. E., Cuello‐García, C. A., Lotfi, T., Flottorp, S. A., Davoli, M., Mustafa, R. A., Meerpohl, J. J., Alonso‐Coello, P., et al. (2020) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2020.05.030 · Cited by 53
Use of glucocorticoids in patients with adrenal insufficiency and COVID-19 infection
Isidori, A. M., Pofi, R., Hasenmajer, V., Lenzi, A., & Pivonello, R. (2020) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(20)30149-2 · Cited by 53
Treatment of patients with nonsevere and severe coronavirus disease 2019: an evidence-based guideline
Ye, Z., Rochwerg, B. N., Wang, Y., Adhikari, N. K. J., Murthy, S., Lamontagne, F., Fowler, R., Qiu, H., Li, W., Sang, L., et al. (2020) · Canadian Medical Association Journal · doi:10.1503/cmaj.200648 · Cited by 52
Self-citation
Tracheostomy, ventilatory wean, and decannulation in COVID-19 patients
Tornari, C., Šurda, P., Takhar, A., Amin, N., Dinham, A., Harding, R., Ranford, D., Archer, S. K., Wyncoll, D. L. A., Tricklebank, S., et al. (2020) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-020-06187-1 · Cited by 52
Characteristics and outcomes of acute respiratory distress syndrome related to COVID-19 in Belgian and French intensive care units according to antiviral strategies: the COVADIS multicentre observational study
Grimaldi, D., Aïssaoui, N., Blonz, G., Carbutti, G., Courcelle, R., Gaudry, S., Gaultier, A., D’hondt, A., Higny, J., Horlait, G., et al. (2020) · Annals of Intensive Care · doi:10.1186/s13613-020-00751-y · Cited by 52
Cynaroside prevents macrophage polarization into pro-inflammatory phenotype and alleviates cecal ligation and puncture-induced liver injury by targeting PKM2/HIF-1α axis
Pei, L., Le, Y., Chen, H., Feng, J., Liu, Z., Zhu, J., Wang, C., Chen, L., Dou, X., & Lu, D. (2021) · Fitoterapia · doi:10.1016/j.fitote.2021.104922 · Cited by 52
Evidence-based Physiotherapy and Functionality in Adult and Pediatric patients with COVID-19
Silva, C. M. D. S. E., Andrade, A. D. N., Júnior, B. R. V. N., Xavier, D. S., Lima, E., Gonzalez, I., Santos, J. C., Esquivel, M. S., Novais, M. C. M., Magalhães, P., et al. (2020) · Journal of Human Growth and Development · doi:10.7322/jhgd.v30.10086 · Cited by 55
Performance of a multiplex polymerase chain reaction panel for identifying bacterial pathogens causing pneumonia in critically ill patients with COVID-19
Caméléna, F., Moy, A.-C., Dudoignon, E., Poncin, T., Deniau, B., Guillemet, L., LeGoff, J., Budoo, M., Benyamina, M., Chaussard, M., et al. (2020) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2020.115183 · Cited by 52
Cardiovascular Collapse in COVID-19 Infection: The Role of Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO)
Chow, J. Y., Alhussaini, A., Arguelles, O. C., Billia, F., & Luk, A. C. (2020) · CJC Open · doi:10.1016/j.cjco.2020.04.003 · Cited by 51
In Defense of Evidence-based Medicine for the Treatment of COVID-19 Acute Respiratory Distress Syndrome
Rice, T. W., & Janz, D. R. (2020) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202004-325ip · Cited by 51
Acute respiratory distress syndrome (ARDS) caused by the novel coronavirus disease (COVID-19): a practical comprehensive literature review
Montenegro, F., Unigarro, L., Paredes, G., Moya, T., Romero, A., Torres, L., López, J. C., González, F. E. J., Pozo, G., López‐Cortés, A., et al. (2020) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2020.1820329 · Cited by 53
Novel insights into the treatment of SARS-CoV-2 infection: An overview of current clinical trials
Oroojalian, F., Haghbin, A., Baradaran, B., Hemmat, N., Shahbazi, M., Baghi, H. B., Mokhtarzadeh, A., & Hamblin, M. R. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.09.204 · Cited by 51
Surgical mask on top of high-flow nasal cannula improves oxygenation in critically ill COVID-19 patients with hypoxemic respiratory failure
Montiel, V., Robert, A., Robert, A. R., Nabaoui, A., Marie, T., Mestre, N. M., Maerckx, G., Laterre, P., & Wittebole, X. (2020) · Annals of Intensive Care · doi:10.1186/s13613-020-00744-x · Cited by 51
Development of a Critical Care Response - Experiences from Italy During the Coronavirus Disease 2019 Pandemic
Rezoagli, E., Magliocca, A., Bellani, G., Pesenti, A., & Grasselli, G. (2021) · Anesthesiology Clinics · doi:10.1016/j.anclin.2021.02.003 · Cited by 51
Improving Prone Positioning for Severe Acute Respiratory Distress Syndrome during the COVID-19 Pandemic. An Implementation-Mapping Approach
Klaiman, T. A., Silvestri, J. A., Srinivasan, T. L., Szymanski, S., Tran, T., Oredeko, F., Sjoding, M. W., Fuchs, B. D., Maillie, S., Jablonski, J., et al. (2020) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202005-571oc · Cited by 53
Comparison of hydroxychloroquine, lopinavir/ritonavir, and standard of care in critically ill patients with SARS-CoV-2 pneumonia: an opportunistic retrospective analysis
Lecronier, M., Beurton, A., Burrel, S., Haudebourg, L., Déléris, R., Marec, J. L., Virolle, S., Nemlaghi, S., Bureau, C., Mora, P., et al. (2020) · Critical Care · doi:10.1186/s13054-020-03117-9 · Cited by 50
Low‐dose hydrocortisone in patients with COVID‐19 and severe hypoxia: The COVID STEROID randomised, placebo‐controlled trial
Munch, M. W., Meyhoff, T. S., Helleberg, M., Kjær, M. N., Granholm, A., Hjortsø, C. J. S., Jensen, T. S., Møller, M. H., Hjortrup, P. B., Wetterslev, M., et al. (2021) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.13941 · Cited by 50
Self-citation
Cyclosporine A plus low‐dose steroid treatment in COVID‐19 improves clinical outcomes in patients with moderate to severe disease: A pilot study
Gálvez-Romero, J. L., Palmeros-Rojas, O., Real‐Ramírez, F. A., Sánchez-Romero, S., Tome‐Maxil, R., Ramírez-Sandoval, M. D. L. P., Olivos‐Rodríguez, R., Flores‐Encarnación, S. E., Cabrera‐Estrada, A. A., Ávila‐Morales, J., et al. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13223 · Cited by 49
Evaluation of inhaled nitric oxide (iNO) treatment for moderate-to-severe ARDS in critically ill patients with COVID-19: a multicenter cohort study
Sulaiman, K. A. A., Korayem, G. B., Altebainawi, A. F., Harbi, S. A. A., Alissa, A. S., Alharthi, A. F., Kensara, R., Alfahed, A., Vishwakarma, R. K., Haji, H. A., et al. (2022) · Critical Care · doi:10.1186/s13054-022-04158-y · Cited by 49
SARS-CoV-2/COVID-19: Evolving Reality, Global Response, Knowledge Gaps, and Opportunities
Osuchowski, M. F., Aletti, F. M., Cavaillon, J., Flohé, S. B., Giamarellos‐Bourboulis, E. J., Huber-Lang, M. S., Relja, B., Skirecki, T., Szabó, A., & Maegele, M. (2020) · Shock · doi:10.1097/shk.0000000000001565 · Cited by 50
Structural Basis of SARS-CoV-2– and SARS-CoV–Receptor Binding and Small-Molecule Blockers as Potential Therapeutics
Sivaraman, H., Er, S. Y., Choong, Y. K., Gavor, E., & Sivaraman, J. (2020) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-061220-093932 · Cited by 49
Stroke Care during the COVID-19 Pandemic: International Expert Panel Review
Venketasubramanian, N., Anderson, C. S., Ay, H., Aybek, S., Brinjikji, W., de Freitas, G. R., Brutto, Ó. H. D., Fassbender, K. C., Fujimura, M., Goldstein, L. B., et al. (2021) · Cerebrovascular Diseases · doi:10.1159/000514155 · Cited by 49

Authors: Alhazzani, W., Møller, M. H., Arabi, Y. M., Loeb, M., Gong, M. N., Fan, E., Oczkowski, S., Levy, M. M., Derde, L., Dzierba, A., Du, B., Aboodi, M., Wunsch, H., Cecconi, M., Koh, Y., Chertow, D. S., Maitland, K., Alshamsi, F., Belley-Cote, E., Greco, M., Laundy, M., Morgan, J. S., Kesecioglu, J., McGeer, A., Mermel, L., Mammen, M. J., Alexander, P. E., Arrington, A., Centofanti, J. E., Citerio, G., Baw, B., Memish, Z. A., Hammond, N., Hayden, F. G., Evans, L., & Rhodes, A.
Affiliations: McMaster University (CA)
Copenhagen University Hospital (DK)
King Saud bin Abdulaziz University for Health Sciences (SA)
Albert Einstein College of Medicine (US)
University of Toronto (CA)
Brown University (US)
Utrecht University (NL)
NewYork–Presbyterian Hospital (US)
Peking Union Medical College Hospital (CN)
Sunnybrook Health Science Centre (CA)
Humanitas University (IT)
Asan Medical Center (KR)
National Institute of Allergy and Infectious Diseases (US)
Imperial College London (GB)
United Arab Emirates University (AE)
St George's, University of London (GB)
Emory University Hospital (US)
University at Buffalo, State University of New York (US)
Baylor College of Medicine (US)
Azienda Ospedaliera San Gerardo (IT)
King Abdulaziz Medical City (SA)
King Saud Medical City (SA)
The George Institute for Global Health (GB)
University of Virginia (US)
University of Washington (US)
Corresponding author: Rhodes, Andrew
ORCID: Alhazzani, Waleed
Møller, Morten Hylander
Arabi, Yaseen M.
Loeb, Mark
Gong, Michelle Ng
Fan, Eddy
Oczkowski, Simon
Levy, Mitchell M.
Derde, Lennie
Dzierba, Amy
Du, Bin
Wunsch, Hannah
Cecconi, Maurizio
Koh, Younsuck
Chertow, Daniel S.
Maitland, Kathryn
Alshamsi, Fayez
Greco, Massimiliano
Laundy, Matthew
Morgan, Jill S.
McGeer, Allison
Mermel, Leonard
Mammen, Manoj J.
Alexander, Paul E.
Centofanti, John E.
Citerio, Giuseppe
Memish, Ziad A.
Hammond, Naomi
Hayden, Frederick G.
Evans, Laura
Rhodes, Andrew
Venue: Intensive Care Medicine
Publisher: Springer Science and Business Media LLC
Published: 2020-03-28
Volume: 46
Issue: 5
Pages: 854-887
ISSN: 0342-4642 (ISSN-L)
1432-1238
DOI: 10.1007/s00134-020-06022-5
PMC: PMC7101866
OpenAlex: W3013671288
Cited by: 2,105
References: 227
Citations by year: 2026: 32 · 2025: 49 · 2024: 92 · 2023: 157 · 2022: 340 · 2021: 607 · 2020: 821
FWCI: 62.79
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Intensive Care Medicine (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
St George's Online Research Archive (St George's University of London) (acceptedVersion)
BOA (University of Milano-Bicocca) (submittedVersion)
Spiral (Imperial College London) (submittedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Keywords: COVID-19 pandemic, SARS-CoV-2, critically ill adults, intensive care unit management, infection control, laboratory diagnosis, hemodynamic support, ventilatory support, COVID-19 treatment, Surviving Sepsis Campaign
MeSH terms: COVID-19, Critical Care, Humans, Intensive Care Units, Pneumonia, Viral, Survivors, Coronavirus Infections, Sepsis, Pandemics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19)

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks