Cited by 2,105COVID-19 Clinical Research StudiesSepsis Diagnosis and TreatmentRespiratory Support and Mechanisms

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Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19)

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Alhazzani, Waleed, Møller, Morten Hylander, Arabi, Yaseen M., Loeb, Mark, Gong, Michelle Ng, Fan, Eddy, Oczkowski, Simon, Levy, Mitchell M., Derde, Lennie, Dzierba, Amy, Du, Bin, Aboodi, Michael, Wunsch, Hannah, Cecconi, Maurizio, Koh, Younsuck, Chertow, Daniel S., Maitland, Kathryn, Alshamsi, Fayez, Belley-Cote, Emilie, Greco, Massimiliano, Laundy, Matthew, Morgan, Jill S., Kesecioglu, Jozef, McGeer, Allison, Mermel, Leonard, Mammen, Manoj J., Alexander, Paul E., Arrington, Amy, Centofanti, John E., Citerio, Giuseppe, Baw, Bandar, Memish, Ziad A., Hammond, Naomi, Hayden, Frederick G., Evans, Laura, Rhodes, Andrew·2020·Intensive Care Medicine

DOI 10.1007/s00134-020-06022-5PMC PMC7101866

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Abstract

Background The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting thousands of people around the world. Urgent guidance for clinicians caring for the sickest of these patients is needed.Methods We formed a panel of 36 experts from 12 countries. All panel members completed the World Health Organization conflict of interest disclosure form. The panel proposed 53 questions that are relevant to the management of COVID-19 in the ICU. We searched the literature for direct and indirect evidence on the management of COVID-19 in critically ill patients in the ICU. We identified relevant and recent systematic reviews on most questions relating to supportive care. We assessed the certainty in the evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach, then generated recommendations based on the balance between benefit and harm, resource and cost implications, equity, and feasibility. Recommendations were either strong or weak, or in the form of best practice recommendations.Results The Surviving Sepsis Campaign COVID-19 panel issued 54 statements, of which 4 are best practice statements, 9 are strong recommendations, and 35 are weak recommendations. No recommendation was provided for 6 questions. The topics were: (1) infection control, (2) laboratory diagnosis and specimens, (3) hemodynamic support, (4) ventilatory support, and (5) COVID-19 therapy.Conclusion The Surviving Sepsis Campaign COVID-19 panel issued several recommendations to help support healthcare workers caring for critically ill ICU patients with COVID-19. When available, we will provide new recommendations in further releases of these guidelines.

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Authors: Alhazzani, W., Møller, M. H., Arabi, Y. M., Loeb, M., Gong, M. N., Fan, E., Oczkowski, S., Levy, M. M., Derde, L., Dzierba, A., Du, B., Aboodi, M., Wunsch, H., Cecconi, M., Koh, Y., Chertow, D. S., Maitland, K., Alshamsi, F., Belley-Cote, E., Greco, M., Laundy, M., Morgan, J. S., Kesecioglu, J., McGeer, A., Mermel, L., Mammen, M. J., Alexander, P. E., Arrington, A., Centofanti, J. E., Citerio, G., Baw, B., Memish, Z. A., Hammond, N., Hayden, F. G., Evans, L., & Rhodes, A.
Affiliations: McMaster University (CA)
Copenhagen University Hospital (DK)
King Saud bin Abdulaziz University for Health Sciences (SA)
Albert Einstein College of Medicine (US)
University of Toronto (CA)
Brown University (US)
Utrecht University (NL)
NewYork–Presbyterian Hospital (US)
Peking Union Medical College Hospital (CN)
Sunnybrook Health Science Centre (CA)
Humanitas University (IT)
Asan Medical Center (KR)
National Institute of Allergy and Infectious Diseases (US)
Imperial College London (GB)
United Arab Emirates University (AE)
St George's, University of London (GB)
Emory University Hospital (US)
University at Buffalo, State University of New York (US)
Baylor College of Medicine (US)
Azienda Ospedaliera San Gerardo (IT)
King Abdulaziz Medical City (SA)
King Saud Medical City (SA)
The George Institute for Global Health (GB)
University of Virginia (US)
University of Washington (US)
Corresponding author: Rhodes, Andrew
ORCID: Alhazzani, Waleed
Møller, Morten Hylander
Arabi, Yaseen M.
Loeb, Mark
Gong, Michelle Ng
Fan, Eddy
Oczkowski, Simon
Levy, Mitchell M.
Derde, Lennie
Dzierba, Amy
Du, Bin
Wunsch, Hannah
Cecconi, Maurizio
Koh, Younsuck
Chertow, Daniel S.
Maitland, Kathryn
Alshamsi, Fayez
Greco, Massimiliano
Laundy, Matthew
Morgan, Jill S.
McGeer, Allison
Mermel, Leonard
Mammen, Manoj J.
Alexander, Paul E.
Centofanti, John E.
Citerio, Giuseppe
Memish, Ziad A.
Hammond, Naomi
Hayden, Frederick G.
Evans, Laura
Rhodes, Andrew
Venue: Intensive Care Medicine
Publisher: Springer Science and Business Media LLC
Published: 2020-03-28
Volume: 46
Issue: 5
Pages: 854-887
ISSN: 0342-4642 (ISSN-L)
1432-1238
DOI: 10.1007/s00134-020-06022-5
PMC: PMC7101866
OpenAlex: W3013671288
Cited by: 2,105
References: 227
Citations by year: 2026: 32 · 2025: 49 · 2024: 92 · 2023: 157 · 2022: 340 · 2021: 607 · 2020: 821
FWCI: 62.79
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Intensive Care Medicine (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
St George's Online Research Archive (St George's University of London) (acceptedVersion)
BOA (University of Milano-Bicocca) (submittedVersion)
Spiral (Imperial College London) (submittedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Keywords: COVID-19 pandemic, SARS-CoV-2, critically ill adults, intensive care unit management, infection control, laboratory diagnosis, hemodynamic support, ventilatory support, COVID-19 treatment, Surviving Sepsis Campaign
MeSH terms: COVID-19, Critical Care, Humans, Intensive Care Units, Pneumonia, Viral, Survivors, Coronavirus Infections, Sepsis, Pandemics

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Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19)

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