The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Platelet‐rich plasma intra‐articular injections for cartilage degeneration and osteoarthritis: single‐ versus double‐spinning approach
Abstract
Purpose: To compare the safety and efficacy of two different approaches of platelet‐rich plasma (PRP) production methods as intra‐articular injection treatment for knee cartilage degenerative lesions and osteoarthritis (OA). Methods: The study involved 144 symptomatic patients affected by cartilage degenerative lesions and OA. Seventy‐two patients were treated with 3 injections of platelet concentrate prepared with a single‐spinning procedure (PRGF), the other 72 with 3 injections of PRP obtained with a double‐spinning approach. The patients were evaluated prospectively at the enrollment and at 2, 6, and 12 months’ follow‐up with IKDC, EQ‐VAS and Tegner scores; adverse events and patient satisfaction were also recorded. Results: Both treatment groups presented a statistically significant improvement in all the scores evaluated at all the follow‐up times. Better results were achieved in both groups in younger patients with a lower degree of cartilage degeneration. The comparative analysis showed similar improvements with the two procedures: in particular, IKDC subjective evaluation increased from 45.0 ± 10.1 to 59.0 ± 16.2, 61.3 ± 16.3, and 61.6 ± 16.2 at 2, 6, and 12 months in the PRGF group, and from 42.1 ± 13.5 to 60.8 ± 16.6, 62.5 ± 19.9, and 59.9 ± 20.0 at 2, 6, and 12 months in the PRP group, respectively. Concerning adverse events, more swelling (P = 0.03) and pain reaction (P = 0.0005), were found after PRP injections. Conclusions: Although PRP injections produced more pain and swelling reaction with respect to that produced by PRGF, similar results were found at the follow‐up times, with a significant clinical improvement with respect to the basal level. Better results were achieved in younger patients with a low degree of cartilage degeneration. Level of evidence: II.
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Cites
Cartilage injuries: A review of 31,516 knee arthroscopies
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Guidelines for the medical management of osteoarthritis
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Guidelines for the medical management of osteoarthritis
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Self-citationKon, E., Buda, R., Filardo, G., Di Martino, A., Timoncini, A., Cenacchi, A., Fornasari, P. M., Giannini, S., & Marcacci, M. (2010) · Knee Surgery, Sports Traumatology, Arthroscopy · doi:10.1007/s00167-009-0940-8 · Cited by 570
Self-citationIs platelet-rich plasma the perfect enhancement factor? A current review.
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Filardo, G., Kon, E., Buda, R., Timoncini, A., Di Martino, A., Cenacchi, A., Fornasari, P. M., Giannini, S., & Marcacci, M. (2011) · Knee Surgery, Sports Traumatology, Arthroscopy · doi:10.1007/s00167-010-1238-6 · Cited by 475
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Cited by
Chahla, J., Cinque, M. E., Piuzzi, N. S., Mannava, S., Geeslin, A. G., Murray, I. R., Dornan, G. J., Muschler, G. F., & LaPrade, R. F. (2017) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.16.01374 · Cited by 504
Platelet-rich plasma for managing pain and inflammation in osteoarthritis
Andia, I., & Maffulli, N. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.141 · Cited by 465
Ayhan, E. (2014) · World Journal of Orthopedics · doi:10.5312/wjo.v5.i3.351 · Cited by 441
Belk, J. W., Kraeutler, M. J., Houck, D. A., Goodrich, J. A., Dragoo, J. L., & McCarty, E. C. (2021) · The American Journal of Sports Medicine · doi:10.1177/0363546520909397 · Cited by 432
Sánchez, M., Fiz, N., Azofra, J., Usabiaga, J., Aduriz Recalde, E., Garcia Gutierrez, A., Albillos, J., Gárate, R., Aguirre, J. J., Padilla, S., et al. (2012) · Arthroscopy: The Journal of Arthroscopic & Related Surgery · doi:10.1016/j.arthro.2012.05.011 · Cited by 403
Metadata
- Authors
- Filardo, G., Kon, E., Pereira Ruiz, M. T., Vaccaro, F., Guitaldi, R., Di Martino, A., Cenacchi, A., Fornasari, P. M., & Marcacci, M.
- Venue
- Knee Surgery, Sports Traumatology, Arthroscopy
- Publisher
- Wiley
- Published
- 2011-12-28
- Volume
- 20
- Issue
- 10
- Pages
- 2082-2091
- ISSN
- 0942-2056 (ISSN-L)
- 1433-7347
- OpenAlex
- W2086838304
- Cited by
- 405
- References
- 33
- FWCI
- 24.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Filardo, G., Kon, E., Pereira Ruiz, M. T., Vaccaro, F., Guitaldi, R., Di Martino, A., Cenacchi, A., Fornasari, P. M., & Marcacci, M. (2012). Platelet‐rich plasma intra‐articular injections for cartilage degeneration and osteoarthritis: single‐ versus double‐spinning approach. Knee Surgery, Sports Traumatology, Arthroscopy. https://doi.org/10.1007/s00167-011-1837-x
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