Family history and pelvic organ prolapse: a systematic review and meta-analysis
Open accessAbstract
Numerous analytic observational studies assess family history as a risk factor for POP and report a wide range of associations. This review aims to systematically evaluate the role of family history of POP in relation to POP risk and its recurrence. A review was performed of the PubMed/MEDLINE database with search criteria specifying family history, risk factors, POP, and their synonyms as title/abstract keywords, as well as MESH terms, up to March 2020. We aggregated evidence across studies with fixed effects (FE) and random effects (RE) meta-analysis. Forty-three articles underwent full-text review. Eighteen independent studies evaluating the relationship between family history of POP and POP risk in 3639 POP cases and 10,912 controls were eligible for meta-analysis. Four studies evaluating family history and POP recurrence in 224 recurrent cases and 400 non-recurrent cases were eligible for inclusion into another meta-analyses. A positive family history of POP is on average associated with 2.3- to 2.7-fold increased risk for POP (RE OR = 2.64; 95% CI = 2.07, 3.35) as well as a 1.4-fold increased risk for POP recurrence (FE OR = 1.44; 95% CI = 1.00, 2.08). Meta-analysis estimates of POP risk varied by study design, definition of family history, and model adjustment status. We found evidence that publication bias and recall bias are a possibility. Family history of POP is a risk factor for both POP presence and recurrence. However, reported magnitudes may be overestimates due to confounding, recall bias, and publication bias.
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In contrast to this review, two recent meta-analyses also included case-control studies, data of univariable analyses, and studies about pelvic organ prolapse recurrence after mesh surgery.
“In contrast to our review, these meta-analyses also included caseecontrol studies, data of univariable analyses, and studies about POP recurrence after mesh surgery.”
From Risk factors for primary pelvic organ prolapse and prolapse recurrence: an updated systematic review and meta-analysis (2022) · cites this paper as [58]
The Materials and Methods section says the meta-analysis considered case-control studies and could use unadjusted odds ratios, supporting those two parts of the claim. It also included studies of POP recurrence after corrective surgery, but the passages do not establish that those surgeries used mesh; a search for mesh found no passage identifying mesh surgery. (LLM, conf=0.85)
Experimental — accuracy not yet measuredTwo recent meta-analyses reported family history as a risk factor for primary pelvic organ prolapse and pelvic organ prolapse recurrence.
“Two recent meta-analyses reported family history as a risk factor for primary POP and POP recurrence.6,58”
From Risk factors for primary pelvic organ prolapse and prolapse recurrence: an updated systematic review and meta-analysis (2022) · cites this paper as [58]
Other studies identified family history as a risk factor for POP recurrence.
“whereas other studies identified family history as a risk factor.6,7”
From Risk factors for pelvic organ prolapse recurrence after sacrospinous hysteropexy or vaginal hysterectomy with uterosacral ligament suspension (2022) · cites this paper as [7]
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- [36]Jelovsek JE, Chagin K, Gyhagen M, Hagen S, Wilson D, Kattan MW, Predicting risk of pelvic floor disorders 12 and 20 years after delivery. Am J Obstet Gynecol 2018; 218: 222.e1– 222.e19. 10.1016/j.ajog.2017.10.014. 29056536 · DOI
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Schulten, S. F. M., Claas-Quax, M. J., Weemhoff, M., van Eijndhoven, H. W., van Leijsen, S. A., Vergeldt, T. F., IntHout, J., & Kluivers, K. B. (2022) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2022.04.046 · Cited by 245 · see citing works
“Two recent meta-analyses reported family history as a risk factor for primary POP and POP recurrence.(6,58) In contrast to our review, these meta-analyses also included caseecontrol studies, data of univariable analyses, and studies about POP recurrence after mesh surgery.”
ResultSchulten, S. F., Detollenaere, R. J., IntHout, J., Kluivers, K. B., & Van Eijndhoven, H. W. (2022) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2022.04.017 · Cited by 39 · see citing works
“factor.(6,7) Most of these studies focused on objective recurrence,(8) combined data of mesh and nonmesh surgeries, and lacked long-term follow-up.”
BackgroundJiang, W., Cheung, R. Y. K., Chung, C. Y., Chan, S. S. C., & Choy, K. W. (2024) · Genes · doi:10.3390/genes16010005 · Cited by 9 · see citing works
- Authors
- Samimi, P., Jones, S. H., & Giri, A.
- Affiliations
- Vanderbilt University Medical Center (US)
- Corresponding author
- Giri, Ayush
- Venue
- International Urogynecology Journal
- Published
- 2020-10-21
- Volume
- 32
- Issue
- 4
- Pages
- 759-774
- ISSN
- 0937-3462 (ISSN-L)
- 1433-3023
- PMC
- PMC8086380
- OpenAlex
- W3093593118
- Semantic Scholar
- 51c7662eb6fda70ab28c4e60d46beba46bd0694a
- Cited by
- 42
- References
- 44
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 12 · 2023: 8 · 2022: 9 · 2021: 4
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- International Urogynecology Journal (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Building Interdisciplinary Research Careers in Women’s Health (2K12HD043483)
- NIDDK (1K01DK120631-01A1)
- Topics
- Health Sciences › Medicine › Rheumatology › Pelvic floor disorders treatments
- Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Keywords
- pelvic organ prolapse, family history (medicine), risk factors, prolapse recurrence, genetic risk, publication bias, recall bias, confounding
- MeSH terms
- Humans, Medical History Taking, Recurrence, Risk Factors, Pelvic Organ Prolapse
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