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Cited by 258Bone health and osteoporosis researchNutrition and Health in AgingHIV-related health complications and treatments

The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.

Factors associated with the lumbar spine and proximal femur bone mineral density in older men

Cauley, Jane A., Fullman, Robin L., Stone, Katie L., Zmuda, Joseph M., Bauer, Douglas C., Barrett-Connor, Elizabeth, Ensrud, Kristine, Lau, Edith M. C., Orwoll, Eric S., For the Mr. OS Research Group·2005·Osteoporosis International
DOI 10.1007/s00198-005-1866-8
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Abstract

Bone mass is a major determinant of fracture, but there have been few comprehensive studies of the correlates of bone mineral density (BMD) in older men. The objective of the current cross-sectional analysis was to determine the factors associated with BMD of the lumbar spine and proximal femur in a large population-based sample of older men enrolled in The Osteoporotic Fractures in Men Study, "Mr.OS." We enrolled 5,995 men 65 years of age or older, 89% Caucasian, in Mr.OS at six US clinical centers. Demographic, medical and family history and lifestyle information was obtained by interview and physical function and anthropometric data by examination. Spine and hip BMD was measured using dual-energy X-ray absorptimetry. The multivariable linear regression models predicted 19 and 10% of the overall variance in BMD of the femoral neck and spine, respectively. African-American men had 6 to 11% higher BMD than Caucasian men independent of multiple factors. Hip BMD declined with advancing age, while spine BMD increased. Body weight (per 10 kg) and self report of diabetes were each associated with 2 to 4% higher BMD, while history of a non-trauma fracture and current use of selective serotonin reuptake inhibitors, but not other antidepressants, were associated with at least 4% lower BMD. Both maternal and paternal histories of fracture were associated with 1.4-1.7% lower BMD. Osteoarthritis, physical activity, grip strength, alcohol intake, and dietary calcium were positively related to BMD, while a history of chronic lung disease, prostate cancer, and kidney stones was associated with lower BMD. Smoking, caffeine intake, and thiazide diuretics were not related to BMD in older men. A number of lifestyle and behavioral characteristics and medical conditions were associated with BMD in older men. Identification of these correlates could improve methods to identify men at risk for fracture and improve our understanding of fracture etiology.

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Metadata

Authors
Cauley, J. A., Fullman, R. L., Stone, K. L., Zmuda, J. M., Bauer, D. C., Barrett-Connor, E., Ensrud, K., Lau, E. M. C., Orwoll, E. S., & For the Mr. OS Research Group
Affiliations
  • University of Pittsburgh (US)
  • California Pacific Medical Center (US)
  • University of California, San Francisco (US)
  • University of California San Diego (US)
  • University of Minnesota (US)
  • Chinese University of Hong Kong (HK)
  • Oregon Health & Science University (US)
Corresponding author
Cauley, Jane A.
ORCID
Venue
Osteoporosis International
Publisher
Springer Science and Business Media LLC
Published
2005-05-11
Volume
16
Issue
12
Pages
1525-1537
ISSN
  • 0937-941X (ISSN-L)
  • 1433-2965
DOI
10.1007/s00198-005-1866-8
OpenAlex
W2049096000
Cited by
258
References
60
Citations by year
2026: 3 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 2 · 2021: 6 · 2020: 12 · 2019: 9 · 2018: 10 · 2017: 11 · 2016: 8 · 2015: 10 · 2014: 15 · 2013: 16 · 2012: 15
FWCI
21.21
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Osteoporosis International (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (UO1 AG18197-02, U01AG018197)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (UO1-AR-45647, UO1 AR45654, U01AR045583, UO1AR45580-02, U01AR045580, UO1-AR-45632, U01AR045632, U01AR045654, U01AR045614, U01AR045647, UO1-AR-45614, UO1-AR-45583)
  • National Center for Research Resources (M01RR000334)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
  • Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
Keywords
bone mineral density, older men, lumbar spine, proximal femur, osteoporosis, fracture risk, selective serotonin reuptake inhibitors, family history of fracture, diabetes mellitus, body weight, African American men, physical activity, osteoarthritis, dietary calcium, chronic lung disease, prostate cancer, kidney stones, smoking, thiazide diuretics, alcohol consumption, caffeine consumption, grip strength
MeSH terms
Aged, Analysis of Variance, Cross-Sectional Studies, Diet, Exercise Test, Family Health, Femur, Femur Neck, Humans, Life Style, Lumbar Vertebrae, Male, Osteoporosis, Bone Density, Fractures, Bone, Drug-Related Side Effects and Adverse Reactions

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