Low lumbar bone mineral density in patients with major depression
Abstract
Major depression is associated with hypercorticoidism, a risk factor for osteoporosis. However, it is unknown whether depressive disorders are associated with alterations in bone mineral density. The authors measured the density of trabecular bone from the first to the third lumbar vertebra by quantitative computerized tomography in 80 depressed inpatients older than 40 years and in 57 healthy comparison subjects. An analysis of covariance model with age as a covariate showed a significant effect of diagnosis on the dependent variable spinal bone mineral density: depressed patients had lower values. Other factors could not explain the finding. The authors conclude that major depression is a significant risk factor for osteoporosis.
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Although the association between depression and loss of bone mineral density has been reported inconsistently, most studies have found low bone mineral density in patients with depressive symptoms or major depressive disorder.
“Although the association between depression and loss of BMD has been reported inconsistently, most studies have found low BMD in patients with depressive symptoms or major depressive disorder (477-483).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [479]
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Self-citation
- Authors
- Schweiger, U., Deuschle, M., Körner, A., Lammers, C. H., Schmider, J., Gotthardt, U., Holsboer, F., & Heuser, I.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- Max Planck Society (DE)
- Venue
- American Journal of Psychiatry
- Published
- 1994-11-01
- Volume
- 151
- Issue
- 11
- Pages
- 1691-1693
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W30545629
- Cited by
- 165
- References
- 5
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 3 · 2018: 1 · 2017: 1 · 2016: 8 · 2015: 6 · 2014: 4 · 2013: 7 · 2012: 6
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- major depressive disorder, bone mineral density, lumbar spine, osteoporosis, trabecular bone, older adults, depressive disorders
- MeSH terms
- Age Factors, Depressive Disorder, Female, Humans, Lumbar Vertebrae, Male, Menopause, Middle Aged, Osteoporosis, Risk Factors, Sex Factors, Tomography, X-Ray Computed, Bone Density, Comorbidity, Body Mass Index
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