The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Sarcopenia: etiology, clinical consequences, intervention, and assessment
Open accessAbstract
The aging process is associated with loss of muscle mass and strength and decline in physical functioning. The term sarcopenia is primarily defined as low level of muscle mass resulting from age-related muscle loss, but its definition is often broadened to include the underlying cellular processes involved in skeletal muscle loss as well as their clinical manifestations. The underlying cellular changes involve weakening of factors promoting muscle anabolism and increased expression of inflammatory factors and other agents which contribute to skeletal muscle catabolism. At the cellular level, these molecular processes are manifested in a loss of muscle fiber cross-sectional area, loss of innervation, and adaptive changes in the proportions of slow and fast motor units in muscle tissue. Ultimately, these alterations translate to bulk changes in muscle mass, strength, and function which lead to reduced physical performance, disability, increased risk of fall-related injury, and, often, frailty. In this review, we summarize current understanding of the mechanisms underlying sarcopenia and age-related changes in muscle tissue morphology and function. We also discuss the resulting long-term outcomes in terms of loss of function, which causes increased risk of musculoskeletal injuries and other morbidities, leading to frailty and loss of independence.
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BackgroundNotch-Mediated Restoration of Regenerative Potential to Aged Muscle
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Self-citationMyostatin negatively regulates satellite cell activation and self-renewal
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M USCLE T RIGLYCERIDE AND I NSULIN R ESISTANCE
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Cited by
An overview of sarcopenia: facts and numbers on prevalence and clinical impact
von Haehling, S., Morley, J. E., & Anker, S. D. (2010) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1007/s13539-010-0014-2 · Cited by 888
Inflammation and sarcopenia: A systematic review and meta-analysis
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Lean Tissue Imaging: A New Era for Nutritional Assessment and Intervention
Prado, C. M. M., & Heymsfield, S. B. (2014) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607114550189 · Cited by 550
Metadata
- Authors
- Lang, T., Streeper, T., Cawthon, P., Baldwin, K., Taaffe, D. R., & Harris, T. B.
- Venue
- Osteoporosis International
- Published
- 2009-09-25
- Volume
- 21
- Issue
- 4
- Pages
- 543-559
- ISSN
- 0937-941X (ISSN-L)
- 1433-2965
- OpenAlex
- W2143149622
- Cited by
- 777
- References
- 19
- FWCI
- 22.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lang, T., Streeper, T., Cawthon, P., Baldwin, K., Taaffe, D. R., & Harris, T. B. (2010). Sarcopenia: etiology, clinical consequences, intervention, and assessment. Osteoporosis International. https://doi.org/10.1007/s00198-009-1059-y
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
