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Cited by 777

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Sarcopenia: etiology, clinical consequences, intervention, and assessment

Open access
Lang, T., Streeper, T., Cawthon, P., Baldwin, K., Taaffe, D. R., Harris, T. B.·2010·Osteoporosis International
DOI 10.1007/s00198-009-1059-y
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Abstract

The aging process is associated with loss of muscle mass and strength and decline in physical functioning. The term sarcopenia is primarily defined as low level of muscle mass resulting from age-related muscle loss, but its definition is often broadened to include the underlying cellular processes involved in skeletal muscle loss as well as their clinical manifestations. The underlying cellular changes involve weakening of factors promoting muscle anabolism and increased expression of inflammatory factors and other agents which contribute to skeletal muscle catabolism. At the cellular level, these molecular processes are manifested in a loss of muscle fiber cross-sectional area, loss of innervation, and adaptive changes in the proportions of slow and fast motor units in muscle tissue. Ultimately, these alterations translate to bulk changes in muscle mass, strength, and function which lead to reduced physical performance, disability, increased risk of fall-related injury, and, often, frailty. In this review, we summarize current understanding of the mechanisms underlying sarcopenia and age-related changes in muscle tissue morphology and function. We also discuss the resulting long-term outcomes in terms of loss of function, which causes increased risk of musculoskeletal injuries and other morbidities, leading to frailty and loss of independence.

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Metadata

Authors
Lang, T., Streeper, T., Cawthon, P., Baldwin, K., Taaffe, D. R., & Harris, T. B.
Venue
Osteoporosis International
Publisher
Springer Science and Business Media LLC
Published
2009-09-25
Volume
21
Issue
4
Pages
543-559
ISSN
  • 0937-941X (ISSN-L)
  • 1433-2965
DOI
10.1007/s00198-009-1059-y
OpenAlex
W2143149622
Cited by
777
References
19
FWCI
22.44
Type
journal article
Language
en
Open access
hybrid

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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