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Cited by 116Bone health and osteoporosis researchLGBTQ Health, Identity, and PolicyHormonal and reproductive studies

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Preservation of volumetric bone density and geometry in trans women during cross-sex hormonal therapy: a prospective observational study

Van Caenegem, E., Wierckx, K., Taes, Y., Schreiner, T., Vandewalle, S., Toye, K., Kaufman, J.-M., T’Sjoen, G.·2015·Osteoporosis International
DOI 10.1007/s00198-014-2805-3
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Abstract

Unlabelled Although trans women before the start of hormonal therapy have a less bone and muscle mass compared with control men, their bone mass and geometry are preserved during the first 2 years of hormonal therapy, despite of substantial muscle loss, illustrating the major role of estrogen in the male skeleton.Purpose The aim of this study is to examine the evolution of areal and volumetric bone density, geometry, and turnover in trans women undergoing sex steroid changes, during the first 2 years of hormonal therapy.Methods In a prospective observational study, we examined 49 trans women (male-to-female) before and after 1 and 2 years of cross-sex hormonal therapy (CSH) in comparison with 49 age-matched control men measuring grip strength (hand dynamometer), areal bone mineral density (aBMD), and total body fat and lean mass using dual X-ray absorptiometry (DXA), bone geometry and volumetric bone mineral density, regional fat, and muscle area at the forearm and calf using peripheral quantitative computed tomography. Standardized treatment regimens were used with oral estradiol valerate, 4 mg daily (or transdermal 17-β estradiol 100 μg/24 h for patients >45 years old), both combined with oral cyproterone acetate 50 mg daily.Results Prior to CSH, trans women had lower aBMD at all measured sites (all p < 0.001), smaller cortical bone size (all p < 0.05), and lower muscle mass and strength and lean body mass (all p < 0.05) compared with control men. During CSH, muscle mass and strength decreased and all measures of fat mass increased (all p < 0.001). The aBMD increased at the femoral neck, radius, lumbar spine, and total body; cortical and trabecular bone remained stable and bone turnover markers decreased (all p < 0.05).Conclusions Although trans women, before CSH, have a lower aBMD and cortical bone size compared with control men, their skeletal status is well preserved during CSH treatment, despite of substantial muscle loss.

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Metadata

Authors
Van Caenegem, E., Wierckx, K., Taes, Y., Schreiner, T., Vandewalle, S., Toye, K., Kaufman, J.-M., & T’Sjoen, G.
Affiliations
  • Ghent University Hospital (BE)
  • Oslo University Hospital (NO)
ORCID
Venue
Osteoporosis International
Publisher
Springer Science and Business Media LLC
Published
2014-11-07
Volume
26
Issue
1
Pages
35-47
ISSN
  • 0937-941X (ISSN-L)
  • 1433-2965
DOI
10.1007/s00198-014-2805-3
OpenAlex
W2064274788
Cited by
116
References
49
Citations by year
2026: 5 · 2025: 16 · 2024: 18 · 2023: 13 · 2022: 12 · 2021: 6 · 2020: 12 · 2019: 16 · 2018: 7 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 1
FWCI
3.80
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Osteoporosis International (publishedVersion)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Social Sciences › Psychology › Social Psychology › LGBTQ Health, Identity, and Policy
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
transgender women, bone mineral density, volumetric bone density, bone geometry, bone turnover, muscle mass loss, muscle strength, estradiol valerate, cyproterone acetate, skeletal health, fat mass
MeSH terms
Adult, Body Composition, Estradiol, Female, Humans, Insulin-Like Growth Factor I, Male, Middle Aged, Motor Activity, Prospective Studies, Transsexualism, Vitamin D, Absorptiometry, Photon, Bone Density, Case-Control Studies, Bone Remodeling, Muscle, Skeletal, Leptin, Muscle Strength, Gender-Affirming Procedures

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