Cited by 484Antibiotic Resistance in BacteriaDrug Transport and Resistance MechanismsBacterial Genetics and Biotechnology

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Tetracyclines: antibiotic action, uptake, and resistance mechanisms

Schnappinger, Dirk, Hillen, W.·1996·Archives of Microbiology

DOI 10.1007/s002030050339

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Abstract

Tetracyclines probably penetrate bacterial cells by passive diffusion and inhibit bacterial growth by interfering with protein synthesis or by destroying the membrane. A growing number of various bacterial species acquire resistance to the bacteriostatic activity of tetracycline. The two widespread mechanisms of bacterial resistance do not destroy tetracycline: one is mediated by efflux pumps, the other involves an EF-G-like protein that confers ribosome protection. Oxidative destruction of tetracycline has been found in a few species. Several efflux transporters, including multidrug-resistance pumps and tetracycline-specific exporters, confer bacterial resistance against tetracycline. Single amino acids of these carrier proteins important for tetracycline transport and substrate specificity have been identified, allowing the mechanism of tetracycline transport to begin to emerge.

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Authors: Schnappinger, D., & Hillen, W.
Affiliations: Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
ORCID: Schnappinger, Dirk
Venue: Archives of Microbiology
Publisher: Springer Science and Business Media LLC
Published: 1996-06-24
Volume: 165
Issue: 6
Pages: 359-369
ISSN: 0003-9276 (ISSN-L)
0302-8933
1432-072X
DOI: 10.1007/s002030050339
OpenAlex: W2033647833
Cited by: 484
References: 105
Citations by year: 2026: 18 · 2025: 22 · 2024: 25 · 2023: 22 · 2022: 13 · 2021: 29 · 2020: 23 · 2019: 25 · 2018: 21 · 2017: 23 · 2016: 22 · 2015: 25 · 2014: 17 · 2013: 22 · 2012: 16
FWCI: 2.82
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Archives of Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: Bundesministerium für Bildung und Forschung
Topics: Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: tetracycline, antibiotic resistance, efflux pumps, multidrug resistance, ribosome protection, oxidative degradation, passive diffusion, bacterial membranes, protein synthesis inhibition, substrate specificity
MeSH terms: Escherichia coli, Ribosomes, Tetracycline Resistance, Tetracyclines

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Tetracyclines: antibiotic action, uptake, and resistance mechanisms

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