Cited by 484Antibiotic Resistance in BacteriaDrug Transport and Resistance MechanismsBacterial Genetics and Biotechnology

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Tetracyclines: antibiotic action, uptake, and resistance mechanisms

Schnappinger, Dirk, Hillen, W.·1996·Archives of Microbiology

DOI 10.1007/s002030050339

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Abstract

Tetracyclines probably penetrate bacterial cells by passive diffusion and inhibit bacterial growth by interfering with protein synthesis or by destroying the membrane. A growing number of various bacterial species acquire resistance to the bacteriostatic activity of tetracycline. The two widespread mechanisms of bacterial resistance do not destroy tetracycline: one is mediated by efflux pumps, the other involves an EF-G-like protein that confers ribosome protection. Oxidative destruction of tetracycline has been found in a few species. Several efflux transporters, including multidrug-resistance pumps and tetracycline-specific exporters, confer bacterial resistance against tetracycline. Single amino acids of these carrier proteins important for tetracycline transport and substrate specificity have been identified, allowing the mechanism of tetracycline transport to begin to emerge.

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The unstable tetracycline resistance gene of Streptomyces lividans 1326 encodes a putative protein with similarities to translational elongation factors and Tet(M) and Tet(O) proteins
Dittrich, W., & Schrempf, H. (1992) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.36.5.1119 · Cited by 22
Tetracycline uptake by susceptible Escherichia coli cells
Argast, M., & Beck, C. F. (1985) · Archives of Microbiology · doi:10.1007/bf00408069 · Cited by 22
Tet(O), a protein that mediates ribosomal protection to tetracycline, binds, and hydrolyses GTP
Taylor, D. E., Jerome, L. J., Grewal, J., & Chang, N. (1995) · Canadian Journal of Microbiology · doi:10.1139/m95-134 · Cited by 17
Serine residues responsible for tetracycline transport are on a vertical stripe including Asp‐84 on one side of transmembrane helix 3 in transposon Tn10‐encoded tetracycline/H+ antiporter of Escherichia coli
Yamaguchi, A., Ono, N., Akasaka, T., & Sawai, T. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80773-a · Cited by 17
Effect of mutational alteration of Asn-128 in the putative GTP-binding domain of tetracycline resistance determinant Tet(O) from Campylobacter jejuni
Grewal, J., Manavathu, E. K., & Taylor, D. E. (1993) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.37.12.2645 · Cited by 16
Hot Spots for Sulfhydryl Inactivation of Cys Mutants in the Widely Conserved Sequence Motifs of the Metal-Tetracycline/H+ Antiporter of Escherichia coli1
Yamaguchi, A., Kimura, T., & Sawai, T. (1994) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a124445 · Cited by 13

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Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance
Chopra, I., & Roberts, M. (2001) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.65.2.232-260.2001 · Cited by 4,517
Mechanisms of antibiotic resistance in enterococci
Miller, W. R., Munita, J. M., & Arias, C. A. (2014) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2014.956092 · Cited by 772
Molecular Ecology of Tetracycline Resistance: Development and Validation of Primers for Detection of Tetracycline Resistance Genes Encoding Ribosomal Protection Proteins
Aminov, R. I., Garrigues-Jeanjean, N., & Mackie, R. I. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.1.22-32.2001 · Cited by 667
Molecular Detection of Antimicrobial Resistance
Fluit, A. C., Visser, M. R., & Schmitz, F. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.4.836-871.2001 · Cited by 537
Structural basis of gene regulation by the tetracycline inducible Tet repressor-operator system.
Saenger, W., Hinrichs, W., Orth, P., Schnappinger, D., & Hillen, W. (2000) · Nature Structural Biology · doi:10.1038/73324 · Cited by 462
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Authors: Schnappinger, D., & Hillen, W.
Affiliations: Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
ORCID: Schnappinger, Dirk
Venue: Archives of Microbiology
Publisher: Springer Science and Business Media LLC
Published: 1996-06-24
Volume: 165
Issue: 6
Pages: 359-369
ISSN: 0003-9276 (ISSN-L)
0302-8933
1432-072X
DOI: 10.1007/s002030050339
OpenAlex: W2033647833
Cited by: 484
References: 105
Citations by year: 2026: 18 · 2025: 22 · 2024: 25 · 2023: 22 · 2022: 13 · 2021: 29 · 2020: 23 · 2019: 25 · 2018: 21 · 2017: 23 · 2016: 22 · 2015: 25 · 2014: 17 · 2013: 22 · 2012: 16
FWCI: 2.82
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Archives of Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: Bundesministerium für Bildung und Forschung
Topics: Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: tetracycline, antibiotic resistance, efflux pumps, multidrug resistance, ribosome protection, oxidative degradation, passive diffusion, bacterial membranes, protein synthesis inhibition, substrate specificity
MeSH terms: Escherichia coli, Ribosomes, Tetracycline Resistance, Tetracyclines

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Tetracyclines: antibiotic action, uptake, and resistance mechanisms

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