The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Copper: toxicological relevance and mechanisms
Open accessAbstract
Copper (Cu) is a vital mineral essential for many biological processes. The vast majority of all Cu in healthy humans is associated with enzyme prosthetic groups or bound to proteins. Cu homeostasis is tightly regulated through a complex system of Cu transporters and chaperone proteins. Excess or toxicity of Cu, which is associated with the pathogenesis of hepatic disorder, neurodegenerative changes and other disease conditions, can occur when Cu homeostasis is disrupted. The capacity to initiate oxidative damage is most commonly attributed to Cu-induced cellular toxicity. Recently, altered cellular events, including lipid metabolism, gene expression, alpha-synuclein aggregation, activation of acidic sphingomyelinase and release of ceramide, and temporal and spatial distribution of Cu in hepatocytes, as well as Cu-protein interaction in the nerve system, have been suggested to play a role in Cu toxicity. However, whether these changes are independent of, or secondary to, an altered cellular redox state of Cu remain to be elucidated.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis
D'Autréaux, B., & Toledano, M. B. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2256 · Cited by 3,642
The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate
Buettner, G. R. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1074 · Cited by 2,417 · cited 2×
“2010; Powell 2000; Burkitt 2001), and inducing DNA strand breaks and oxidation of bases (Kawanishi et al. 1989; Hayashi et al. 2000; Buettner 1993; Liang and Dedon 2001).”
Essentiality of copper in humans
Uauy, R., Olivares, M., & Gonzalez, M. (1998) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/67.5.952s · Cited by 1,052
Oxidative stress in Alzheimer’s disease
Smith, M. A., Rottkamp, C. A., Nunomura, A., Raina, A. K., & Perry, G. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(00)00040-5 · Cited by 895
Copper Delivery by Metallochaperone Proteins
Rosenzweig, A. C. (2001) · Accounts of Chemical Research · doi:10.1021/ar000012p · Cited by 279
Cited by
Copper bioavailability, uptake, toxicity and tolerance in plants: A comprehensive review
Kumar, V., Pandita, S., Singh Sidhu, G. P., Sharma, A., Khanna, K., Kaur, P., Bali, A. S., & Setia, R. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2020.127810 · Cited by 594
Toxicity of heavy metals in plants and animals and their uptake by magnetic iron oxide nanoparticles
Rehman, A. U., Nazir, S., Irshad, R., Tahir, K., ur Rehman, K., Islam, R. U., & Wahab, Z. (2021) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2020.114455 · Cited by 322
Ceruloplasmin and other copper binding components of blood plasma and their functions: an update
Linder, M. C. (2016) · Metallomics · doi:10.1039/c6mt00103c · Cited by 308
Luminescent rare-earth-based MOFs as optical sensors
Mahata, P., Mondal, S. K., Singha, D. K., & Majee, P. (2017) · Dalton Transactions · doi:10.1039/c6dt03419e · Cited by 292
Lu, Y., Pan, Q., Gao, W., Pu, Y., Luo, K., He, B., & Gu, Z. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2021.121335 · Cited by 149
Metadata
- Authors
- Gaetke, L. M., Chow-Johnson, H. S., & Chow, C. K.
- Venue
- Archives of Toxicology
- Published
- 2014-09-09
- Volume
- 88
- Issue
- 11
- Pages
- 1929-1938
- ISSN
- 0340-5761 (ISSN-L)
- 1432-0738
- OpenAlex
- W1985092163
- Cited by
- 743
- References
- 5
- FWCI
- 16.52
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Copper: toxicological relevance and mechanisms. https://app.cochat.ai/papers/10.1007/s00204-014-1355-y
- The paper
- Gaetke, L. M., Chow-Johnson, H. S., & Chow, C. K. (2014). Copper: toxicological relevance and mechanisms. Archives of Toxicology. https://doi.org/10.1007/s00204-014-1355-y
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
