Oxidative stress in Alzheimer’s disease

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) · Nature · doi:10.1038/375754a0 · Cited by 4,051 · see citing works

Role of Oxidative Stress in Development of Complications in Diabetes

Baynes, J. (1991) · Diabetes · doi:10.2337/diab.40.4.405 · Cited by 3,791 · see citing works

Hydrogen peroxide mediates amyloid β protein toxicity

Behl, C. (1994) · Cell · doi:10.1016/0092-8674(94)90131-7 · Cited by 2,074 · see citing works

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

Yan, S. D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., et al. (1996) · Nature · doi:10.1038/382685a0 · Cited by 2,012 · see citing works

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

Yankner, B. A., Duffy, L. K., & Kirschner, D. A. (1990) · Science · doi:10.1126/science.2218531 · Cited by 1,975 · see citing works

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

Mattson, M. P., Cheng, B., Davis, D. G., Bryant, K., Lieberburg, I. M., & Rydel, R. E. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00376.1992 · Cited by 1,627 · see citing works

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

Smith, M. A., Harris, P. L. R., Sayre, L. M., & Perry, G. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9866 · Cited by 1,357 · see citing works

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

Smith, C. D., Carney, J. M., Starke-Reed, P. E., Oliver, C. N., Stadtman, E. R., Floyd, R. A., & Markesbery, W. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10540 · Cited by 1,296 · see citing works

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

Smith, M. A., Richey Harris, P. L., Sayre, L. M., Beckman, J. S., & Perry, G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02653.1997 · Cited by 1,239 · see citing works

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

Hensley, K., Carney, J. M., Mattson, M. P., Aksenova, M., Harris, M., Wu, J. F., Floyd, R. A., & Butterfield, D. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3270 · Cited by 1,086 · see citing works

4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease

Sayre, L., Zelasko, D. A., Harris, P. L. R., Perry, G., Salomon, R. G., & Smith, M. A. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68052092.x · Cited by 1,032 · see citing works

Oxidative damage in Alzheimer's

Smith, M. A., Perry, G. L., Richey, P. L., Sayrec, L. M., Anderson, V. E., Beal, M. F., & Kowall, N. W. (1996) · Nature · doi:10.1038/382120b0 · Cited by 897 · see citing works

Apolipoprotein E allele–specific antioxidant activity and effects on cytotoxicity by oxidative insults and β–amyloid peptides

Miyata, M., & Smith, J. D. (1996) · Nature Genetics · doi:10.1038/ng0996-55 · Cited by 889 · see citing works

Alzheimer's Disease--Genotypes, Phenotype, and Treatments

Selkoe, D. J. (1997) · Science · doi:10.1126/science.275.5300.630 · Cited by 875 · see citing works

Advanced glycation end products contribute to amyloidosis in Alzheimer disease

Vitek, M. P., Bhattacharya, K., Glendening, J. M., Stopa, E., Vlassara, H., Bucala, R., Manogue, K., & Cerami, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4766 · Cited by 806 · see citing works

RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease

Nunomura, A., Perry, G., Pappolla, M., Wade, R., Hirai, K., Chiba, S., & Smith, M. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-06-01959.1999 · Cited by 768 · see citing works

Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils

Khoury, J. E., Hickman, S. E., Thomas, C. A., Cao, L., Silverstein, S. C., & Loike, J. D. (1996) · Nature · doi:10.1038/382716a0 · Cited by 727 · see citing works

Advanced Maillard reaction end products are associated with Alzheimer disease pathology.

Smith, M. A., Taneda, S., Richey, P. L., Miyata, S., Yan, S. D., Stern, D., Sayre, L. M., Monnier, V. M., & Perry, G. L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5710 · Cited by 715 · see citing works

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

Koh, J., Yang, L. L., & Cotman, C. W. (1990) · Brain Research · doi:10.1016/0006-8993(90)91355-k · Cited by 617 · see citing works

Production of superoxide anions by a CNS macrophage, the microglia

Colton, C. A., & Gilbert, D. L. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80305-8 · Cited by 614 · see citing works

Evidence of neuronal oxidative damage in Alzheimer's disease.

Good, P. F., Werner, P., Hsu, A., Olanow, C. W., & Perl, D. P. (1996) · Europe PMC (PubMed Central) · Cited by 600 · see citing works

Cytochrome oxidase deficiency in Alzheimer’s disease

Parker, W. D., Filley, C. M., & Parks, J. K. (1990) · Neurology · doi:10.1212/wnl.40.8.1302 · Cited by 598 · see citing works

Vitamin E protects nerve cells from amyloid βprotein toxicity

Behl, C., Davis, J. B., Cole, G. M., & Schubert, D. A. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)90837-b · Cited by 582 · see citing works

Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress.

Yan, S. D., Chen, X., Schmidt, A. M., Brett, J., Godman, G., Zou, Y. S., Scott, C. W., Caputo, C., Frappier, T., & Smith, M. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7787 · Cited by 565 · see citing works

In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease

Sayre, L. M., Perry, G. L., Harris, P. L. R., Liu, Y. A., Schubert, K. A., & Smith, M. A. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0740270.x · Cited by 538 · see citing works

Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer's disease: A laser microprobe (LAMMA) study

Good, P. F., Perl, D. P., Bierer, L. M., & Schmeidler, J. (1992) · Annals of Neurology · doi:10.1002/ana.410310310 · Cited by 476 · see citing works

The toxicity in vitro of β-amyloid protein

Iversen, L. L., Mortishire‐Smith, R. J., Pollack, S. J., & Shearman, M. S. (1995) · Biochemical Journal · doi:10.1042/bj3110001 · Cited by 425 · see citing works

Participation of Presenilin 2 in Apoptosis: Enhanced Basal Activity Conferred by an Alzheimer Mutation

Wolozin, B. L., Iwasaki, K., Vito, P., Ganjei, J. K., Lacaná, E., Sunderland, T., Zhao, B., Kusiak, J. W., Wasco, W., & D'adamio, L. (1996) · Science · doi:10.1126/science.274.5293.1710 · Cited by 422 · see citing works

Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid β-peptide

Yan, S. D., Yan, S. F., Chen, X., Fu, J., Chen, M., Kuppusamy, P., Smith, M. A., Perry, G., Godman, G. C., Nawroth, P., et al. (1995) · Nature Medicine · doi:10.1038/nm0795-693 · Cited by 406 · see citing works

β-Amyloid Peptide Free Radical Fragments Initiate Synaptosomal Lipoperoxidation in a Sequence-Specific Fashion: Implications to Alzheimer′s Disease

Butterfield, D. A., Hensley, K., Harris‐White, M. E., Mattson, M. P., & Carney, J. M. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1508 · Cited by 404 · see citing works

Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain

Sorbi, S., Bird, E. D., & Blass, J. P. (1983) · Annals of Neurology · doi:10.1002/ana.410130116 · Cited by 395 · see citing works

Analysis of microtubule-associated protein tau glycation in paired helical filaments.

Ledesma, M. D., Bonay, P., Colaço, C., & Avila, J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31849-5 · Cited by 333 · see citing works

Marked changes in mitochondrial DNA deletion levels in Alzheimer brains

Corral-Debrinski, M., Horton, T., Lott, M. T., Shoffner, J. M., McKee, A. C., Beal, M. F., Graham, B. H., & Wallace, D. C. (1994) · Genomics · doi:10.1006/geno.1994.1525 · Cited by 309 · see citing works

Alzheimer's disease – synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts

Münch, G. W., Schinzel, R., Loske, C., Wong, A. O., Durany, N., Li, J. J., Vlassara, H., Smith, M. A., Perry, G. L., & Riederer, P. F. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050069 · Cited by 302 · see citing works

Transcriptional control and the role of silencers in transcriptional regulation in eukaryotes

Ogbourne, S. M., & Antalis, T. (1998) · Biochemical Journal · doi:10.1042/bj3310001 · Cited by 297 · see citing works

Carbonyl‐Related Posttranslational Modification of Neurofilament Protein in the Neurofibrillary Pathology of Alzheimer's Disease

Smith, M. A., Rudnicka-Nawrot, M., Richey, P., Praprotnik, D., Mulvihill, P., Miller, C., Sayre, L., & Perry, G. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64062660.x · Cited by 240 · see citing works

Mitochondrial function in brain tissue in primary degenerative dementia

Sims, N. R., Finegan, J. M., Blass, J. P., Bowen, D. M., & Neary, D. (1987) · Brain Research · doi:10.1016/0006-8993(87)91553-8 · Cited by 182 · see citing works

An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain

Sheu, K. R., Kim, Y., Blass, J. P., & Weksler, M. E. (1985) · Annals of Neurology · doi:10.1002/ana.410170505 · Cited by 180 · see citing works

Free radical damage to proteins: The influence of the relative localization of radical generation, antioxidants, and target proteins

Dean, R. T., Hunt, J. V., Grant, A. J., Yamamoto, Y., & Niki, E. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90167-2 · Cited by 179 · see citing works

A Mechanism for the Stimulatory Effect of Aluminum on Iron-Induced Lipid Peroxidation

Oteiza, P. I. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1053 · Cited by 178 · see citing works

Neuronal and microglial involvement in beta-amyloid protein deposition in Alzheimer's disease.

Cras, P. P., Kawai, M., Siedlak, S. L., Mulvihill, P., Gambetti, P. L., Lowery, D. E., Gonzalez‐DeWhitt, P. A., Greenberg, B., & Perry, G. L. (1990) · Europe PMC (PubMed Central) · Cited by 174 · see citing works

Induction of Alzheimer Antigens by an Uncoupler of Oxidative Phosphorylation

Blass, J. P., Baker, A. C., Ko, L., & Black, R. S. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530080046009 · Cited by 137 · see citing works

E-4-hydroxy-2-nonenal is cytotoxic and cross-links cytoskeletal proteins in P19 neuroglial cultures.

Montine, T. J., Amarnath, K., Martin, M. E., Strittmatter, W. J., & Graham, D. G. (1996) · Europe PMC (PubMed Central) · Cited by 136 · see citing works

Mechanisms of Neurotoxicity Associated with Amyloid β Deposition and the Role of Free Radicals in the Pathogenesis of Alzheimer's Disease: A Critical Appraisal

Sayre, L. M., Zagorski, M. G., Surewicz, W. K., Krafft, G. A., & Perry, G. L. (1997) · Chemical Research in Toxicology · doi:10.1021/tx970009n · Cited by 118 · see citing works

Early Glycoxidation Damage in Brains from Down's Syndrome

Odetti, P. R., Angelini, G., Dapino, D., Zaccheo, D., Garibaldi, S., Dagna-Bricarelli, F., Piombo, G., Perry, G. L., Smith, M. A., Traverso, N., et al. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8186 · Cited by 116 · see citing works

Inhibitors of free radical formation fail to attenuate direct β‐amyloid25–35 peptide‐mediated neurotoxicity in rat hippocampal cultures

Lockhart, B. P., Bénicourt, C., Junien, J., & Privat, A. (1994) · Journal of Neuroscience Research · doi:10.1002/jnr.490390416 · Cited by 92 · see citing works

Crosslinking of Apolipoprotein E by Products of Lipid Peroxidation

Montine, T. J., Huang, D. Y., Valentine, W. M., Amaranath, V., Saunders, A. M., Weisgraber, K. H., Graham, D. G., & Strittmatter, W. J. (1996) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199602000-00009 · Cited by 90 · see citing works

The cognition-enhancing drug tenilsetam is an inhibitor of protein crosslinking by advanced glycosylation

Münch, G. W., Taneli, Y., Schraven, E., Schindler, U., Schinzel, R., Palm, D., & Riederer, P. F. (1994) · Journal of Neural Transmission - Parkinsons Disease and Dementia Section · doi:10.1007/bf02260940 · Cited by 69 · see citing works

Amyloid β‐Mediated Oxidative and Metabolic Stress in Rat Cortical Neurons: No Direct Evidence for a Role for H2O2 Generation

Zhang, Z., Rydel, R. E., Drzewiecki, G. J., Fuson, K. S., Wright, S., Wogulis, M. D., Audia, J. E., May, P. C., & Hyslop, P. A. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67041595.x · Cited by 66 · see citing works

Electrophysiological effects of 25–35 amyloid-β-protein on guinea-pig lateral septal neurons

Carette, B., Poulain, P., & Delacourte, A. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90059-t · Cited by 30 · see citing works

Genetic evidence for oxidative stress in Alzheimerʼs disease

Raina, A. K., Takeda, A., Nunomura, A., et al. (1999) · Neuroreport · doi:10.1097/00001756-199904260-00036 · Cited by 17 · see citing works

Oxidative DNA damage: mechanisms, mutation, and disease

Cooke, M. S., Evans, M. D., Dizdaroglu, M., & Lunec, J. (2003) · The FASEB Journal · doi:10.1096/fj.02-0752rev · Cited by 3,245 · see citing works

Copper toxicity, oxidative stress, and antioxidant nutrients

Gaetke, L. M. (2003) · Toxicology · doi:10.1016/s0300-483x(03)00159-8 · Cited by 2,166 · see citing works

Long-Term Potentiation and Memory

Lynch, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00014.2003 · Cited by 2,001 · see citing works

Oxidative Damage Is the Earliest Event in Alzheimer Disease

Nunomura, A., Perry, G., Aliev, G., Hirai, K., Takeda, A., Balraj, E. K., Jones, P. K., Ghanbari, H., Wataya, T., Shimohama, S., et al. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.8.759 · Cited by 1,885 · see citing works

Review on in vivo and in vitro methods evaluation of antioxidant activity

Alam, M. N., Bristi, N. J., & Rafiquzzaman, M. (2012) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2012.05.002 · Cited by 1,769 · see citing works

Clearance systems in the brain—implications for Alzheimer disease

Tarasoff-Conway, J. M., Carare, R. O., Osorio, R. S., Glodzik, L., Butler, T., Fieremans, E., Axel, L., Rusinek, H., Nicholson, C., Zlokovic, B. V., et al. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.119 · Cited by 1,678 · see citing works

Oxidative DNA damage and disease: induction, repair and significance

Evans, M. D., Dizdaroglu, M., & Cooke, M. S. (2004) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.11.001 · Cited by 1,372 · see citing works

Trace elements in human physiology and pathology: zinc and metallothioneins

Tapiero, H., & Tew, K. D. (2003) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(03)00081-7 · Cited by 1,296 · see citing works

Curcumin has potent anti‐amyloidogenic effects for Alzheimer's β‐amyloid fibrils in vitro

Ono, K., Hasegawa, K., Naiki, H., & Yamada, M. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20025 · Cited by 1,254 · see citing works

Antioxidants and Prevention of Chronic Disease

Willcox, J. K., Ash, S. L., & Catignani, G. L. (2004) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690490468489 · Cited by 1,183 · see citing works

Oxidative stress and Alzheimer disease

Christen, Y. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.2.621s · Cited by 1,158 · see citing works

Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease

Ngo, V., & Duennwald, M. L. (2022) · Antioxidants · doi:10.3390/antiox11122345 · Cited by 1,130 · see citing works

A review of the antioxidant potential of medicinal plant species

Krishnaiah, D., Sarbatly, R., & Nithyanandam, R. (2010) · Food and Bioproducts Processing · doi:10.1016/j.fbp.2010.04.008 · Cited by 1,104 · see citing works

Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer’s disease

Bartzokis, G. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.03.001 · Cited by 968 · see citing works

Plant phenolic antioxidant and prooxidant activities: phenolics-induced oxidative damage mediated by metals in plants

Sakihama, Y. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00196-8 · Cited by 895 · see citing works

Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment

Scheff, S. W., Price, D. A., Schmitt, F. A., DeKosky, S. T., & Mufson, E. J. (2007) · Neurology · doi:10.1212/01.wnl.0000260698.46517.8f · Cited by 824 · see citing works

Copper: toxicological relevance and mechanisms

Gaetke, L. M., Chow-Johnson, H. S., & Chow, C. K. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1355-y · Cited by 745 · see citing works

Involvement of oxidative stress in Alzheimer disease

Nunomura, A., Castellani, R. J., Zhu, X., Moreira, P. I., Perry, G., & Smith, M. A. (2006) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/01.jnen.0000228136.58062.bf · Cited by 611 · see citing works

Oxidative stress hypothesis in Alzheimer’s disease: a reappraisal

Praticò, D. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.09.001 · Cited by 606 · see citing works

Oxidative stress, cell cycle, and neurodegeneration

Klein, J. A., & Ackerman, S. L. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18182 · Cited by 584 · see citing works

Neuropathology and Pathogenesis of Encephalitis following Amyloid β Immunization in Alzheimer's Disease

Ferrer, I., Boada, M., Guerra, M. L. S., Rey, M. J., & Costa‐Jussà, F. R. (2004) · Brain Pathology · doi:10.1111/j.1750-3639.2004.tb00493.x · Cited by 567 · see citing works

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554 · see citing works

Intracellular Coenzymes as Natural Biomarkers for Metabolic Activities and Mitochondrial Anomalies

Heikal, A. A. (2010) · Biomarkers in Medicine · doi:10.2217/bmm.10.1 · Cited by 460 · see citing works

Indian medicinal herbs as sources of antioxidants

Ali, S. S., Kasoju, N., Luthra, A., Singh, A., Hallihosur, S., Sahu, A., & Bora, U. (2007) · Food Research International · doi:10.1016/j.foodres.2007.10.001 · Cited by 460 · see citing works

Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease

Wang, J., Xiong, S., Xie, C., Markesbery, W. R., & Lovell, M. A. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03053.x · Cited by 452 · see citing works

REVIEW: Curcumin and Alzheimer’s disease

Hamaguchi, T., Ono, K., & Yamada, M. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00147.x · Cited by 450 · see citing works

Proteins as biomarkers of oxidative/nitrosative stress in diseases: The contribution of redox proteomics

Dalle‐Donne, I., Scaloni, A., Giustarini, D., Cavarra, E., Tell, G., Lungarella, G., Colombo, R., Rossi, R., & Milzani, A. (2004) · Mass Spectrometry Reviews · doi:10.1002/mas.20006 · Cited by 448 · see citing works

Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches

Behl, C. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00055-0 · Cited by 444 · see citing works

Mice with Mitochondrial Complex I Deficiency Develop a Fatal Encephalomyopathy

Kruse, S. E., Watt, W. C., Marcinek, D. J., Kapur, R. P., Schenkman, K. A., & Palmiter, R. D. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.02.004 · Cited by 420 · see citing works

Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins

Butterfield, D. A., & Kański, J. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00249-4 · Cited by 418 · see citing works

Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia

Calabrese, V., Lodi, R., Tonon, C., D’Agata, V., Sapienza, M. A., Scapagnini, G., Mangiameli, A., Pennisi, G., Stella, A. M. G., & Butterfield, D. A. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.03.012 · Cited by 407 · see citing works

In vitro models for antioxidant activity evaluation and some medicinal plants possessing antioxidant properties: An overview

Ch, S., & Dave, R. A. (2009) · African Journal of Microbiology Research · doi:10.5897/ajmr.9000401 · Cited by 406 · see citing works

Food-Derived Bioactive Peptides on Inflammation and Oxidative Stress

Chakrabarti, S., Jahandideh, F., & Wu, J. (2014) · BioMed Research International · doi:10.1155/2014/608979 · Cited by 404 · see citing works

Melatonin, human aging, and age-related diseases

Karasek, M. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.04.012 · Cited by 380 · see citing works

The role of oxidative stress in the toxicity induced by amyloid β-peptide in Alzheimer’s disease

Miranda, S., Opazo, C., Larrondo, L. F., Muñoz, F. J., Ruiz, F., Leighton, F., & Inestrosa, N. C. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00015-0 · Cited by 369 · see citing works

Role of mitochondrial dysfunction in Alzheimer's disease

Castellani, R. J., Hirai, K., Aliev, G. M., Drew, K. L., Nunomura, A., Takeda, A., Cash, A., Obrenovich, M. E., Perry, G. L., & Smith, M. A. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10389 · Cited by 366 · see citing works

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361 · see citing works

Metals and amyloid‐β in Alzheimer's disease

Maynard, C. J., Bush, A. I., Masters, C. L., Cappai, R., & Li, Q. (2005) · International Journal of Experimental Pathology · doi:10.1111/j.0959-9673.2005.00434.x · Cited by 353 · see citing works

Overexpression of Alzheimer's Disease Amyloid-β Opposes the Age-dependent Elevations of Brain Copper and Iron

Maynard, C. J., Cappai, R., Volitakis, I., Cherny, R. A., White, A. R., Beyreuther, K. T., Masters, C. L., Bush, A. I., & Li, Q. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204379200 · Cited by 352 · see citing works

Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease

Zhao, W., & Townsend, M. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.10.014 · Cited by 353 · see citing works

Vitamin E and Cognitive Decline in Older Persons

Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C. C., & Wilson, R. S. (2002) · Archives of Neurology · doi:10.1001/archneur.59.7.1125 · Cited by 346 · see citing works

Oxidative stress in Alzheimer's disease

Chauhan, V. P. S., & Chauhan, A. (2006) · Pathophysiology · doi:10.1016/j.pathophys.2006.05.004 · Cited by 341 · see citing works

Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease

de la Monte, S. M., & Wands, J. R. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9209 · Cited by 318 · see citing works

Iron (III) induces aggregation of hyperphosphorylated τ and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease

Yamamoto, A., Shin, R., Hasegawa, K., Naiki, H., Sato, H., Yoshimasu, F., & Kitamoto, T. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.t01-1-01061.x · Cited by 313 · see citing works

Mitochondrial dysfunction, apoptotic cell death, and Alzheimer’s disease

Eckert, A., Keil, U., Marques, C. A., Bonert, A., Frey, C., Schüssel, K., & Müller, W. E. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00534-3 · Cited by 309 · see citing works

Antioxidant Capacity Determination in Plants and Plant‐Derived Products: A Review

Pisoschi, A. M., Pop, A., Cimpeanu, C. L., & Predoi, G. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/9130976 · Cited by 305 · see citing works

Early Vitamin E supplementation in young but not aged mice reduces Aβ levels and amyloid deposition in a transgenic model of Alzheimer's disease

Sung, S., Yao, Y., Uryu, K., Yang, H., Lee, V. M. ‐., Trojanowski, J. Q., & Praticò, D. (2003) · The FASEB Journal · doi:10.1096/fj.03-0961fje · Cited by 298 · see citing works

Alzheimer disease, the two-hit hypothesis: An update

Zhu, X., Lee, H., Perry, G. L., & Smith, M. A. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.10.014 · Cited by 292 · see citing works

Amyloid β-induced Changes in Nitric Oxide Production and Mitochondrial Activity Lead to Apoptosis

Keil, U., Bonert, A., Marques, C. A., Scherping, I., Weyermann, J., Strosznajder, J. B., Müller-Spahn, F., Haass, C., Czech, C., Pradier, L., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405600200 · Cited by 287 · see citing works

Dietary protein oxidation: A silent threat to human health?

Estévez, M., & Luna, C. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1165182 · Cited by 288 · see citing works

Alzheimer’s disease-related alterations in synaptic density: neocortex and hippocampus.

Scheff, S. W., & Price, D. A. (2006) · Journal of Alzheimer's Disease · doi:10.3233/jad-2006-9s312 · Cited by 284 · see citing works

Hypoxia-inducible Factor Prolyl 4-Hydroxylase Inhibition

Siddiq, A., Ayoub, I. A., Chavez, J. C., Aminova, L. R., Shah, S., LaManna, J. C., Patton, S. M., Connor, J. R., Cherny, R. A., Volitakis, I., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504963200 · Cited by 280 · see citing works

Intracellular Aβ42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease

Ohyagi, Y., Asahara, H., Chui, D.-H., Tsuruta, Y., Sakae, N., Miyoshi, K., Yamada, T., Kikuchi, H., Taniwaki, T., Murai, H., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-2637fje · Cited by 281 · see citing works

Parallel findings in age-related macular degeneration and Alzheimer’s disease

Ohno-Matsui, K. (2011) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.02.004 · Cited by 280 · see citing works

High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex

ZHANG, X., Dong, F., Ren, J. T., Driscoll, M., & Culver, B. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.10.011 · Cited by 280 · see citing works

Ferulic acid ethyl ester protects neurons against amyloid β‐ peptide(1–42)‐induced oxidative stress and neurotoxicity: relationship to antioxidant activity

Rukhsana Sultana, A., Ravagna, A., Abdul, H. M., Calabrese, V., & Butterfield, D. A. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02899.x · Cited by 276 · see citing works

Oxidative stress in alzheimer’s disease: A review on emergent natural polyphenolic therapeutics

Cassidy, L., Fernandez, F., Johnson, J. B., Naiker, M., Owoola, A. G., & Broszczak, D. A. (2019) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2019.102294 · Cited by 283 · see citing works

Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment

Markesbery, W. R., Kryscio, R. J., Lovell, M. A., & Morrow, J. D. (2005) · Annals of Neurology · doi:10.1002/ana.20629 · Cited by 272 · see citing works

Bioactive metabolites from macrofungi: ethnopharmacology, biological activities and chemistry

Silva, D. D. D., Rapior, S., Sudarman, E., Stadler, M., Xu, J., Alias, S. A., & Hyde, K. D. (2013) · Fungal Diversity · doi:10.1007/s13225-013-0265-2 · Cited by 271 · see citing works

Homocysteine potentiates β‐amyloid neurotoxicity: role of oxidative stress

Ho, P. I., Collins, S. C., Dhitavat, S., Ortiz, D., Ashline, D. J., Rogers, E. J., & Shea, T. B. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00384.x · Cited by 271 · see citing works

Neurobiology of Alzheimer′s disease

Mohandas, E., Velayudhan, R., & Raghunath, B. (2009) · Indian Journal of Psychiatry · doi:10.4103/0019-5545.44908 · Cited by 270 · see citing works

Anti-amyloidogenic activity of tannic acid and its activity to destabilize Alzheimer's β-amyloid fibrils in vitro

Ono, K., Hasegawa, K., Naiki, H., & Yamada, M. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.06.008 · Cited by 264 · see citing works

Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients

Migliore, L., Fontana, I., Trippi, F., Colognato, R., Coppedè, F., Tognoni, G., Nucciarone, B., & Siciliano, G. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.07.016 · Cited by 263 · see citing works

Maculas Affected by Age-Related Macular Degeneration Contain Increased Chelatable Iron in the Retinal Pigment Epithelium and Bruch's Membrane

Hahn, P. (2003) · Archives of Ophthalmology · doi:10.1001/archopht.121.8.1099 · Cited by 258 · see citing works

Vascular dysfunction in the pathogenesis of Alzheimer's disease — A review of endothelium-mediated mechanisms and ensuing vicious circles

Marco, L. Y. D., Venneri, A., Farkas, E., Evans, P. C., Marzo, A., & Frangi, A. F. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.08.014 · Cited by 258 · see citing works

Prion Protein Accumulation and Neuroprotection in Hypoxic Brain Damage

McLennan, N. F., Brennan, P. M., McNeill, A., Davies, I., Fotheringham, A. P., Rennison, K. A., Ritchie, D. L., Brannan, F., Head, M. W., Ironside, J. W., et al. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63291-9 · Cited by 252 · see citing works

Carbonylation of Adipose Proteins in Obesity and Insulin Resistance

Grimsrud, P. A., Picklo, M. J., Griffin, T. J., & Bernlohr, D. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m600120-mcp200 · Cited by 249 · see citing works

Iron (III) induces aggregation of hyperphosphorylated τ and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease

Yamamoto, A., Shin, R., Hasegawa, K., Naiki, H., Sato, H., YOSHIMASU, F., & Kitamoto, T. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01061.x · Cited by 246 · see citing works

Caspase-9 Activation and Caspase Cleavage of tau in the Alzheimer's Disease Brain

Rohn, T. T., Rissman, R. A., Davis, M. C., Kim, Y., Cotman, C. W., & Head, E. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0549 · Cited by 242 · see citing works

Emerging Roles of Anacardic Acid and Its Derivatives: A Pharmacological Overview

Hemshekhar, M., Sebastin Santhosh, M., Kemparaju, K., & Girish, K. S. (2012) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2011.00833.x · Cited by 239 · see citing works

Elevation of serum copper levels in Alzheimer’s disease

Squitti, R., Lupoi, D., Pasqualetti, P., Forno, G. D., Vernieri, F., Chiovenda, P., Rossi, L. C., Cortesi, M., Cassetta, E., & Rossini, P. M. (2002) · Neurology · doi:10.1212/wnl.59.8.1153 · Cited by 236 · see citing works

Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons

Pugazhenthi, S., Wang, M., Pham, S. T., Sze, C., & Eckman, C. B. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-60 · Cited by 240 · see citing works

Qualitative and Quantitative Determination of Phytochemical Contents of Indigenous Nigerian Softwoods

Ezeonu, C. S., & Ejikeme, C. M. (2016) · New Journal of Science · doi:10.1155/2016/5601327 · Cited by 228 · see citing works

Functional foods, herbs and nutraceuticals: towards biochemical mechanisms of healthy aging

Ferrari, C. K. B. (2004) · Biogerontology · doi:10.1007/s10522-004-2566-z · Cited by 227 · see citing works

Does measurement of oxidative damage to DNA have clinical significance?

Cooke, M. S., Oliński, R., & Evans, M. D. (2005) · Clinica Chimica Acta · doi:10.1016/j.cca.2005.09.009 · Cited by 223 · see citing works

Melatonin in Alzheimer's disease and other neurodegenerative disorders

Srinivasan, V. J., Pandi-Perumal, S. R., Cardinali, D. P., Pöeggeler, B., & Hardeland, R. (2006) · Behavioral and Brain Functions · doi:10.1186/1744-9081-2-15 · Cited by 226 · see citing works

Peroxynitrite Mediates Neurotoxicity of Amyloid β-Peptide _1–42 - and Lipopolysaccharide-Activated Microglia

Xie, Z., Wei, M., Morgan, T. E., Fabrizio, P., Han, D., Finch, C. E., & Longo, V. D. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03484.2002 · Cited by 272 · see citing works

Nitration of Tau Protein Is Linked to Neurodegeneration in Tauopathies

Horiguchi, T., Uryu, K., Giasson, B. I., Ischiropoulos, H., Lightfoot, R. T., Bellmann, C., Richter‐Landsberg, C., Lee, V. M. ‐., & Trojanowski, J. Q. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63462-1 · Cited by 220 · see citing works

Amyloid‐fibril formation

Žerovnik, E. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.03024.x · Cited by 218 · see citing works

Vitamin D cell signalling in health and disease

Berridge, M. J. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.01.008 · Cited by 214 · see citing works

Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO

Narayanaswami, V., Dahl, K., Bernard‐Gauthier, V., Josephson, L., Cumming, P. D., & Vasdev, N. (2018) · Molecular Imaging · doi:10.1177/1536012118792317 · Cited by 215 · see citing works

Biochemical pharmacology of functional foods and prevention of chronic diseases of aging

Ferrari, C. K. B., & Torres, E. A. F. S. (2003) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(03)00032-5 · Cited by 211 · see citing works

Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus

Valente, T., Gella, A., Fernàndez‐Busquets, X., Unzeta, M., & Durany, N. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.09.008 · Cited by 210 · see citing works

Berberine and neurodegeneration: A review of literature

Ahmed, T., Gilani, A. H., Abdollahi, M. R., Daglia, M., Nabavi, S. F., & Nabavi, S. M. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2015.03.002 · Cited by 210 · see citing works

Estrogen, neuroinflammation and neuroprotection in Parkinson’s disease: Glia dictates resistance versus vulnerability to neurodegeneration

Morale, M. C., Serra, P. A., L’Episcopo, F., Tirolo, C., Caniglia, S., Testa, N., Gennuso, F., Giaquinta, G., Rocchitta, G., Desole, M. S., et al. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.060 · Cited by 207 · see citing works

Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies

Chaudhary, M. R., Chaudhary, S., Sharma, Y., Singh, T. A., Mishra, A. K., Sharma, S. G., & Mehdi, M. M. (2023) · Biogerontology · doi:10.1007/s10522-023-10050-1 · Cited by 210 · see citing works

Oxidized cholesterol as the driving force behind the development of Alzheimer’s disease

Gamba, P., Testa, G., Gargiulo, S., Staurenghi, E., Poli, G., & Leonarduzzi, G. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00119 · Cited by 202 · see citing works

Antioxidative enzymes and increased oxidative stress in depressive women

Kodydková, J., Vávrová, L., Zeman, M., Jirák, R., Macášek, J., Staňková, B., Tvrzická, E., & Žák, A. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2009.06.006 · Cited by 197 · see citing works

Antioxidant strategies for Alzheimer's disease

Grundman, M., & Delaney, P. (2002) · Proceedings of The Nutrition Society · doi:10.1079/pns2002146 · Cited by 193 · see citing works

Design and synthesis of tacrine–ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates

Fang, L., Kraus, B., Lehmann, J., Heilmann, J., Zhang, Y., & Decker, M. W. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.03.073 · Cited by 192 · see citing works

The Canine (Dog) Model of Human Aging and Disease: Dietary, Environmental and Immunotherapy Approaches

Cotman, C. W., & Head, E. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15413 · Cited by 188 · see citing works

Alzheimer’s disease and oxygen radicals: new insights

Praticò, D. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00919-4 · Cited by 186 · see citing works

Brain Ferritin Iron as a Risk Factor for Age at Onset in Neurodegenerative Diseases

Bartzokis, G., Tishler, T. A., Shin, I., Lu, P. H., & Cummings, J. L. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1306.019 · Cited by 184 · see citing works

Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice

Lee, J. H., Won, S. M., Suh, J., Son, S. J., Moon, G. J., Park, U. J., & Gwag, B. J. (2010) · Experimental & Molecular Medicine · doi:10.3858/emm.2010.42.5.040 · Cited by 184 · see citing works

Natural Antioxidants Protect Neurons in Alzheimer’s Disease and Parkinson’s Disease

Zhao, B. (2009) · Neurochemical Research · doi:10.1007/s11064-008-9900-9 · Cited by 180 · see citing works

Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery

Buccellato, F. R., D’Anca, M., Fenoglio, C., Scarpini, E., & Galimberti, D. (2021) · Antioxidants · doi:10.3390/antiox10091353 · Cited by 179 · see citing works

Cognitive disturbances in old dogs suffering from the canine counterpart of Alzheimer's disease

Rofina, J., van Ederen, A. M., Toussaint, M. J. M., Secrève, M., van der Spek, A., van der Meer, I., Eerdenburg, F. J. C. M. V., & Gruys, E. (2006) · Brain Research · doi:10.1016/j.brainres.2005.11.021 · Cited by 178 · see citing works

Amyloid-β: an antioxidant that becomes a pro-oxidant and critically contributes to Alzheimer’s disease

Kontush, A. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00688-8 · Cited by 176 · see citing works

Rasagiline: A novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity

Weinreb, O., Amit, T., Bar‐Am, O., & Youdim, M. B. H. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.06.008 · Cited by 170 · see citing works

The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease

Ng, L. F., Gruber, J., Cheah, I. K.-M., Goo, C. K., Cheong, W. F., Shui, G., Sit, K. P., Wenk, M. R., & Halliwell, B. B. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.03.003 · Cited by 170 · see citing works

[The role of apolipoprotein E in the pathogenesis of Alzheimer disease].

Okuizumi, K. (1999) · PubMed · Cited by 1 · see citing works

Diagnostic criteria for primary progressive mutiple sclerosis: a position paper.

(2000) · Pure Amsterdam UMC · doi:10.1002/1531-8249(200006)47:6 · Cited by 2 · see citing works

Distribution of apolipoprotein E in senile plaques in brains with Alzheimer's disease: investigation with the confocal laser scan microscope

Nishiyama, E., Iwamoto, N., Ohwada, J., & Arai, H. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01329-7 · Cited by 18 · see citing works

Apolipoprotein E Interaction with the Neurofibrillary Tangles and Senile Plaques in Alzheimer Disease: Implications for Disease Pathogenesis

Richey, P. L., Siedlak, S. L., Smith, M. A., & Perry, G. L. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1389 · Cited by 72 · see citing works

Presenilin and Amyloidogenesis: A Structure-Function Relationship Study on Presenilin 2

Iwatsubo, T., Tomita, T., Watabiki, T., Takikawa, R., Morohashi, Y., & Takasugi, N. (2002) · Advances in behavioral biology · doi:10.1007/978-0-306-47593-1_11