The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The landscape of hepatobiliary adverse reactions across 53 herbal and dietary supplements reveals immune-mediated injury as a common cause of hepatitis
Abstract
Recent evidence suggests herbal-induced liver injury (HILI) to account for 20% of cases among the U.S. Drug-Induced-Liver-Injury-Network. To define injury patterns of HILI, we reviewed the clinical data of 413 patients exposed to 53 HDS products by considering the evidence for HILI and its grades of severity. Outstandingly, females developed HILI more rapidly (p = 0.018) and the time to recovery was significantly increased (p = 0.0153). > 90% of reported cases were severe and half of HDS products caused acute liver failure (ALF) requiring liver transplantation or resulted in fatal outcomes. Liver biopsies of 243 patients defined 13 histological features; two-thirds of products elicited immune-mediated hepatitis and included 154 Hy's law positive cases. The histological injury patterns were confirmed among unrelated patients, while accidental re-challenges evidenced culprits as causative. Furthermore, one-fifth of patients presented elevated autoantibody titres indicative of autoimmune-like HILI, and one-third of the products were linked to chronic hepatitis and cholestatic injuries not resolving within 6 months. Lastly, INR and TBL are critical laboratory parameters to predict progression of severe HILI to ALF. Our study highlights the need for a regulatory framework to minimize the risk for HILI. Better education of the public and a physician-supervised self-medication plan will be important measures to abate risk of HILI.
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“used the method of the Drug-Induced Liver Injury Network (DILIN)67 for causality assessment, which comes along without any specific element scoring and provides only arbitrary causality gradings as percentage ranges;68”
From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [67]
In the citing paper
“additionally, other CAMs were used,67 known for being not specific for liver injury cases and not based on typical, individually scored liver-related key elements, as amply discussed previously15 and reiterated recently.68”
From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [67]
In the citing paper
“Critical is also the data source of used cases, which were partially retrieved from the USA’s National Institutes of Health LiverTox database,67 known for inclusion of liver injury cases lacking robust CAMs and being therefore disputed.69–71”
From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [67]
In the citing paper
“In contrast, cases presented by the second group of the USA FDA67 were partially assessed using the updated RUCAM15 or a unique, not validated evidence-based method.”
From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [67]
In the citing paper
“Generally problematic are reports presented as network data when case presentations and causality assessments are poor.67,96,100”
From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [67]
In the citing paper
“Cases were also derived from the LiverTox database,67 with its published problems in assessing a correct causality in liver injury cases.69–71”
From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [67]
In the citing paper
“From outside of Asia, reports were published by authors of the USA on a few cases of HILI by TCMs.3,67”
From Herb-induced Liver Injury in Asia and Current Role of RUCAM for Causality Assessment in 11,160 Published Cases (2020) · cites this paper as [67]
Citations
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Self-citation
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Cited by
Sorted by citations
Teschke, R., Zhu, Y., & Jing, J. (2020) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2020.00009 · Cited by 41
Metadata
- Authors
- Zhu, J., Chen, M., Borlak, J., & Tong, W.
- ORCID
- Borlak, Jürgen
- Venue
- Archives of Toxicology
- Published
- 2019-11-13
- Volume
- 94
- Issue
- 1
- Pages
- 273-293
- ISSN
- 0340-5761
- 1432-0738
- Cited by
- 18
- References
- 3
- Language
- en
- Funders
- FDA Office of Women’s Health
- ORISE Research Participation Program at the National Center for Toxicological Research, U.S. FDA
- US Food and Drug Administration's National Center for Toxicological Research
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- Zhu, J., Chen, M., Borlak, J., & Tong, W. (2020). The landscape of hepatobiliary adverse reactions across 53 herbal and dietary supplements reveals immune-mediated injury as a common cause of hepatitis. Archives of Toxicology. https://doi.org/10.1007/s00204-019-02621-4
