DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans
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The NCTR has produced drug-induced toxicity benchmark datasets by manually reading and analyzing drug labeling documents, such as DILI, DICT, and DIRIL.
“during the past two decades, the research team at the NCTR has produced several drug-induced toxicity benchmark datasets by manually reading and analyzing drug labeling documents, such as those for drug-induced liver injury (DILI) [9–11], drug-induced cardiotoxicity (DICT) [12], drug-induced renal injury list (DIRIL) [13], and others”
From Leveraging FDA Labeling Documents and Large Language Model to Enhance Annotation, Profiling, and Classification of Drug Adverse Events with AskFDALabel (2025) · cites this paper as [10]
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“Eightyone of the 110 drugs have been assigned to either High, Low or No DILI concern classes by other investigators, who considered the clinical severity of DILI reported in the clinic and labeling approved by US FDA (Chen et al. 2011, 2016).”
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- Authors
- Chen, M., Suzuki, A., Thakkar, S., Yu, K., Hu, C., & Tong, W.
- Affiliations
- National Center for Toxicological Research (US)
- University of Arkansas for Medical Sciences (US)
- Corresponding author
- Tong, Weida
- Venue
- Drug Discovery Today
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 21
- Issue
- 4
- Pages
- 648-653
- ISSN
- 1359-6446 (ISSN-L)
- OpenAlex
- W2289901683
- Cited by
- 398
- References
- 48
- Citations by year
- 2026: 46 · 2025: 56 · 2024: 61 · 2023: 54 · 2022: 32 · 2021: 56 · 2020: 34 · 2019: 21 · 2018: 22 · 2017: 12 · 2016: 4
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug Discovery Today (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Physical Sciences › Computer Science › Computational Theory and Mathematics › Computational Drug Discovery Methods
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Keywords
- drug-induced liver injury, FDA-approved drugs, drug labeling, prediction model, hepatotoxicity
- MeSH terms
- Drug Labeling, Pharmaceutical Preparations, Humans, Risk, Databases, Factual, Chemical and Drug Induced Liver Injury
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