Commentary: Cumulative Risk Assessment of Perfluoroalkyl Carboxylic Acids and Perfluoralkyl Sulfonic Acids: What Is the Scientific Support for Deriving Tolerable Exposures by Assembling 27 PFAS into 1 Common Assessment Group?

Colnot, Thomas; Dekant, Wolfgang

doi:10.1007/s00204-022-03336-9

Cited by 9Per- and polyfluoroalkyl substances researchAgricultural safety and regulationsToxic Organic Pollutants Impact

Commentary: Cumulative Risk Assessment of Perfluoroalkyl Carboxylic Acids and Perfluoralkyl Sulfonic Acids: What Is the Scientific Support for Deriving Tolerable Exposures by Assembling 27 PFAS into 1 Common Assessment Group?

Colnot, Thomas, Dekant, Wolfgang·2022·Archives of Toxicology

DOI 10.1007/s00204-022-03336-9

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Abstract

This commentary proposes an approach to risk assessment of mixtures of per- and polyfluorinated alkyl substances (PFAS) as EFSA was tasked to derive a tolerable intake for a group of 27 PFAS. The 27 PFAS to be considered contain different functional groups and have widely variable physicochemical (PC) properties and toxicokinetics and thus should not treated as one group based on regulatory guidance for risk assessment of mixtures. The proposed approach to grouping is to split the 27 PFAS into two groups, perfluoroalkyl carboxylates and perfluoroalkyl sulfonates, and apply a relative potency factor approach (as proposed by RIVM) to obtain two separate group TDIs based on liver toxicity in rodents since liver toxicity is a sensitive response of rodents to PFAS. Short chain PFAS and other PFAS structures should not be included in the groups due to their low potency and rapid elimination. This approach is in better agreement with scientific and regulatory guidance for mixture risk assessment.

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Colnot and Dekant (2022) proposed a classification strategy for PFAS that divides them into two distinct groups: PFCA and PFSA; they concluded that PFAS with short chains or non-linear structures should not be included in either group because of their low toxicological potency and rapid elimination.
“To overcome the problems associated with estimating TEFs, Colnot and Dekant (2022) proposed a classification strategy for PFAS that divides them into two distinct groups: PFCA and PFSA. The authors concluded that PFAS with short chains or non-linear structures should not be included in either group because of their low toxicological potency and rapid elimination [51].”
From The EU’s Per- and Polyfluoroalkyl Substances (PFAS) Ban: A Case of Policy over Science (2023) · cites this paper as [51]

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Authors: Colnot, T., & Dekant, W.
Affiliations: University of Würzburg (DE)
Corresponding author: Dekant, Wolfgang
ORCID: Dekant, Wolfgang
Venue: Archives of Toxicology
Publisher: Springer Science and Business Media LLC
Published: 2022-08-17
Volume: 96
Issue: 11
Pages: 3127-3139
ISSN: 0340-5761 (ISSN-L)
1432-0738
DOI: 10.1007/s00204-022-03336-9
OpenAlex: W4292291335
Cited by: 9
References: 40
Citations by year: 2026: 2 · 2024: 4 · 2023: 3
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Archives of Toxicology (publishedVersion)
PubMed (publishedVersion)
Funders: 3M
Topics: Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural safety and regulations
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Keywords: per- and polyfluoroalkyl substances, PFAS mixtures, cumulative risk assessment, tolerable daily intake, chemical grouping, perfluorinated carboxylic acids, perfluoroalkyl sulfonic acids, relative potency factors, hepatotoxicity, toxicokinetics, EFSA
MeSH terms: Carboxylic Acids, Fluorocarbons, Sulfonic Acids, Alkanesulfonic Acids, Risk Assessment

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Commentary: Cumulative Risk Assessment of Perfluoroalkyl Carboxylic Acids and Perfluoralkyl Sulfonic Acids: What Is the Scientific Support for Deriving Tolerable Exposures by Assembling 27 PFAS into 1 Common Assessment Group?

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