Trace analysis of per- and polyfluorinated alkyl substances in various matrices-How do current methods perform?
Abstract
Per- and polyfluorinated alkyl substances (PFAS) are a group of industrial chemicals, some of which have been produced for over 50 years. Scarcely one decade ago, their ubiquity in wildlife, humans and the global environment was discovered. This urged the need for robust and reliable, yet very sensitive analytical methods allowing for their determination in various matrices. This article reviews the state-of-the-art in trace analysis of ionic and neutral PFAS in humans as well as environmental samples such as wildlife, water, solid matrices and air. Analytical protocols for PFAS determination in food and consumer products are also included. The methods are critically discussed in terms of their advantages, shortcomings, possibilities, limitations, and potential for further development.
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Since biological samples consist of complex matrices, development of efficient extraction and clean-up methods has attracted more attention than for other sample types.
“Since biological samples consist of complex matrices, development of efficient extraction and clean-up methods has attracted more attention than for other sample types [6,7,9].”
From Worldwide trends in tracing poly- and perfluoroalkyl substances (PFAS) in the environment (2019) · cites this paper as [7]
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- Authors
- Jahnke, A., & Berger, U.
- Affiliations
- Stockholm University (SE)
- Corresponding author
- Berger, Urs
- Venue
- Journal of Chromatography A
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 1216
- Issue
- 3
- Pages
- 410-421
- ISSN
- 0021-9673 (ISSN-L)
- OpenAlex
- W1989952456
- Cited by
- 188
- References
- 105
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 13 · 2023: 12 · 2022: 14 · 2021: 10 · 2020: 18 · 2019: 9 · 2018: 11 · 2017: 7 · 2016: 12 · 2015: 6 · 2014: 4 · 2013: 17 · 2012: 11
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Chromatography A (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Fluorine in Organic Chemistry
- Keywords
- per- and polyfluoroalkyl substances, PFAS, trace analysis, analytical method performance, human exposure, wildlife, water, solid matrices, air, environmental contamination
- MeSH terms
- Air, Animals, Chromatography, Gas, Chromatography, High Pressure Liquid, Fluorocarbons, Food Analysis, Humans, Magnetic Resonance Spectroscopy, Sensitivity and Specificity, Mass Spectrometry, Water
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