Ten commercial antibodies for alpha-1-adrenergic receptor subtypes are nonspecific

Decreased blood pressure response in mice deficient of the α 1b -adrenergic receptor

Cavalli, A., Lattion, A.-L., Hümmler, E., Nenniger-Tosato, M., Pedrazzini, T., Aubert, J.-F., Michel, M. C., Yang, M., Lembo, G., Vecchione, C., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11589 · Cited by 289 · see citing works

The α1A/C- and α1B-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse

O’Connell, T. D., Ishizaka, S., Nakamura, A., Swigart, P. M., Rodrigo, M. C., Simpson, G. L., Cotecchia, S., Rokosh, G. D., Grossman, W., Foster, E., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16100 · Cited by 205 · see citing works

Knockout of the α1A/C-adrenergic receptor subtype: The α1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure

Rokosh, G. D., & Simpson, P. C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132552699 · Cited by 193 · see citing works

1-Adrenergic receptors prevent a maladaptive cardiac response to pressure overload

O’Connell, T. D. (2006) · Journal of Clinical Investigation · doi:10.1172/jci22811 · Cited by 141 · see citing works

The Alpha-1D Is the Predominant Alpha-1-Adrenergic Receptor Subtype in Human Epicardial Coronary Arteries

Jensen, B. C., Swigart, P. M., Laden, M.-E., DeMarco, T., Hoopes, C. W., & Simpson, P. C. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.05.056 · Cited by 73 · see citing works

Signal transduction and regulation: Are all α1-adrenergic receptor subtypes created equal?

Hein, P., & Michel, M. C. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.11.001 · Cited by 53 · see citing works

α1d Adrenoceptor signaling is required for stimulus induced locomotor activity

Kreibich, A. S., Coughlin, L., Fu, H., Wang, B., Valladares, O., Valentino, R. J., & Blendy, J. A. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001351 · Cited by 48 · see citing works

Influence of a Pressure Gradient Distal to Implanted Bare-Metal Stent on In-Stent Restenosis After Percutaneous Coronary Intervention

Jensen, L. O., Thayssen, P., Thuesen, L., Hansen, H. S., Lassen, J. F., Kelbæk, H., Junker, A., Hansen, K. N., Boetker, H. E., Krusell, L. R., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.704064 · Cited by 28 · see citing works

Clinical implications from studies of α1 adrenergic receptor knockout mice

Koshimizu, T., Tanoue, A., & Tsujimoto, G. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.11.002 · Cited by 13 · see citing works

The Adrenergic Receptors

Perez, D. M. (2006) · Humana Press eBooks · doi:10.1385/1592599311 · Cited by 13 · see citing works

The α1-Adrenergic Receptors

Simpson, P. C. (2006) · Humana Press eBooks · doi:10.1385/1-59259-931-1:207 · Cited by 7 · see citing works

Abstract 1405: The Alpha-1A is the Predominant Alpha-1-Adrenergic Receptor in the Human Heart at the mRNA but not the Protein Level

Jensen, B. C., Swigart, P. M., Myagmar, B., Shah, S. C., DeMarco, T., Hoopes, C. W., & Simpson, P. C. (2007) · Circulation · doi:10.1161/circ.116.suppl_16.ii_289 · Cited by 3 · see citing works

Antibody validation

Bordeaux, J., Welsh, A. W., Agarwal, S., Killiam, E. J., Baquero, M. T., Hanna, J. A., Anagnostou, V., & Rimm, D. L. (2010) · BioTechniques · doi:10.2144/000113382 · Cited by 597 · see citing works

Beyond natural antibodies: the power of in vitro display technologies

Bradbury, A. M., Sidhu, S. S., Dübel, S., & McCafferty, J. (2011) · Nature Biotechnology · doi:10.1038/nbt.1791 · Cited by 548 · see citing works

How reliable are G-protein-coupled receptor antibodies?

Michel, M. C., Wieland, T., & Tsujimoto, G. (2009) · Naunyn-Schmiedeberg's Archives of Pharmacology · doi:10.1007/s00210-009-0395-y · Cited by 306 · see citing works

Cardiac Alpha1-Adrenergic Receptors: Novel Aspects of Expression, Signaling Mechanisms, Physiologic Function, and Clinical Importance

O’Connell, T. D., Jensen, B. C., Baker, A. J., & Simpson, P. C. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.007203 · Cited by 205 · see citing works

Rapid Identification of Monospecific Monoclonal Antibodies Using a Human Proteome Microarray

Jeong, J. S., Jiang, L., Albino, E., Marrero, J., Rho, H., Hu, J., Hu, S., Vera, C., Poueymiroy, D. B., Rivera-Pacheco, Z. A., et al. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.o111.016253 · Cited by 171 · see citing works

Therapeutic antibodies directed at G protein-coupled receptors

Hutchings, C. J., Koglin, M., & Marshall, F. H. (2010) · mAbs · doi:10.4161/mabs.2.6.13420 · Cited by 171 · see citing works

Molecular and cellular analysis of human histamine receptor subtypes

Seifert, R., Straßer, A., Schneider, E. H., Neumann, D., Dove, S., & Buschauer, A. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.11.001 · Cited by 168 · see citing works

Lack of Specificity of Commercial Antibodies Leads to Misidentification of Angiotensin Type 1 Receptor Protein

Herrera, M., Sparks, M. A., Alfonso-Pecchio, A. R., Harrison‐Bernard, L. M., & Coffman, T. M. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.203679 · Cited by 168 · see citing works

The Glucagon-Like Peptide-1 Receptor—or Not?

Pyke, C., & Knudsen, L. B. (2013) · Endocrinology · doi:10.1210/en.2012-2124 · Cited by 154 · see citing works

An update on extra-oral bitter taste receptors

Tuzim, K., & Korolczuk, A. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03067-y · Cited by 144 · see citing works

α1-Adrenergic Receptors in Neurotransmission, Synaptic Plasticity, and Cognition

Perez, D. M. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.581098 · Cited by 131 · see citing works

Adrenergic Receptors in Individual Ventricular Myocytes

Myagmar, B., Flynn, J. M., Cowley, P. M., Swigart, P. M., Montgomery, M. D., Thai, K., Nair, D., Gupta, R., Deng, D. X.-F., Hosoda, C., et al. (2017) · Circulation Research · doi:10.1161/circresaha.117.310520 · Cited by 127 · see citing works

α1-Adrenergic Receptors Positively Regulate Toll-Like Receptor Cytokine Production from Human Monocytes and Macrophages

Grisanti, L. A., Woster, A. P., Dahlman, J., Sauter, E. R., Combs, C. K., & Porter, J. E. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.178012 · Cited by 126 · see citing works

Extrasensory perception: Odorant and taste receptors beyond the nose and mouth

Foster, S. R., Roura, E., & Thomas, W. G. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.11.004 · Cited by 112 · see citing works

Six Commercially Available Angiotensin II AT1 Receptor Antibodies are Non-specific

Benický, J., Hafko, R., Sánchez-Lemus, E., Aguilera, G., & Saavedra, J. M. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-012-9862-y · Cited by 112 · see citing works

Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and ‘cannabinoid‐like’ receptors in small arteries

Daly, C. S. M., Ross, R., Whyte, J., Henstridge, C. M., Irving, A. J., & McGrath, J. C. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00608.x · Cited by 91 · see citing works

Alpha-1–Adrenergic Receptors in Heart Failure

Jensen, B. C., O’Connell, T. D., & Simpson, P. C. (2013) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000032 · Cited by 88 · see citing works

α1-Adrenergic Receptor Subtypes in Nonfailing and Failing Human Myocardium

Jensen, B. C., Swigart, P. M., Marco, T. D., Hoopes, C. W., & Simpson, P. C. (2009) · Circulation Heart Failure · doi:10.1161/circheartfailure.108.846212 · Cited by 85 · see citing works

Commercially Available Angiotensin II At2 Receptor Antibodies Are Nonspecific

Hafko, R., Villapol, S., Nostramo, R., Symes, A. J., Sabban, E. L., Inagami, T., & Saavedra, J. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069234 · Cited by 83 · see citing works

Modulation of Immune Cell Function by α1-Adrenergic Receptor Activation

Grisanti, L. A., Perez, D. M., & Porter, J. E. (2011) · Current topics in membranes · doi:10.1016/b978-0-12-384921-2.00006-9 · Cited by 78 · see citing works

Prostatic α1‐adrenoceptors: New concepts of function, regulation, and intracellular signaling

Hennenberg, M., Stief, C. G., & Gratzke, C. (2013) · Neurourology and Urodynamics · doi:10.1002/nau.22467 · Cited by 74 · see citing works

The Alpha-1D Is the Predominant Alpha-1-Adrenergic Receptor Subtype in Human Epicardial Coronary Arteries

Jensen, B. C., Swigart, P. M., Laden, M.-E., DeMarco, T., Hoopes, C. W., & Simpson, P. C. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.05.056 · Cited by 73 · see citing works

Open Science 2.0: Towards a truly collaborative research ecosystem

Thibault, R. T., Amaral, O. B., Argolo, F., Bandrowski, A. E., Davidson, A. R., & Drude, N. I. (2023) · PLOS Biology · doi:10.1371/journal.pbio.3002362 · Cited by 72 · see citing works

Commercially available antibodies against human and murine histamine H4-receptor lack specificity

Beermann, S., Seifert, R., & Neumann, D. (2011) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-011-0700-4 · Cited by 72 · see citing works

Antibodies for immunolabeling by light and electron microscopy: not for the faint hearted

Griffiths, G. W., & Lucocq, J. M. (2014) · Histochemistry and Cell Biology · doi:10.1007/s00418-014-1263-5 · Cited by 72 · see citing works

Nuclear localization drives α1-adrenergic receptor oligomerization and signaling in cardiac myocytes

Wright, C. D., Wu, S. C., Dahl, E. F., Sazama, A. J., & O’Connell, T. D. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.11.014 · Cited by 70 · see citing works

Cardiac α1A-adrenergic receptors: emerging protective roles in cardiovascular diseases

Zhang, J., Simpson, P. C., & Jensen, B. C. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00621.2020 · Cited by 69 · see citing works

Evaluation of the specificity of antibodies raised against cannabinoid receptor type 2 in the mouse retina

Cécyre, B., Thomas, S., Ptito, M., Casanova, C., & Bouchard, J. (2013) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-013-0930-8 · Cited by 68 · see citing works

Editorial: Antibody Can Get It Right: Confronting Problems of Antibody Specificity and Irreproducibility

Schönbrunn, A. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1230 · Cited by 66 · see citing works

The alpha1-adrenergic receptors in cardiac hypertrophy: Signaling mechanisms and functional implications

Cotecchia, S., del Vescovo, C. D., Colella, M., Caso, S., & Diviani, D. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.06.009 · Cited by 65 · see citing works

Expression of α1-adrenoceptors on peripheral nociceptive neurons

Dawson, L. F., Phillips, J. K., Finch, P. M., Inglis, J. J., & Drummond, P. D. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.11.064 · Cited by 65 · see citing works

Increased inducible nitric oxide synthase and arginase II expression in heart failure: no net nitrite/nitrate production and protein S-nitrosylation

Heusch, P., Aker, S., Boengler, K., Deindl, E., van de Sand, A., Klein, K., Rassaf, T., Konietzka, I., Sewell, A., Menazza, S., et al. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01034.2009 · Cited by 62 · see citing works

Validation of dopamine receptor DRD1 and DRD2 antibodies using receptor deficient mice

Stojanovic, T., Orlova, M., Sialana, F. J., Höger, H., Stuchlı́k, S., Milenković, I., Lubec, J., & Lübec, G. (2017) · Amino Acids · doi:10.1007/s00726-017-2408-3 · Cited by 61 · see citing works

Cardiac and neuroprotection regulated by α₁-adrenergic receptor subtypes

Perez, D. M., & Doze, V. A. (2011) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2010.550008 · Cited by 59 · see citing works

Current Developments on the Role of α1-Adrenergic Receptors in Cognition, Cardioprotection, and Metabolism

Perez, D. M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.652152 · Cited by 57 · see citing works

Age-related changes in the innervation of the prostate gland

White, C. W., Xie, J. H., & Ventura, S. (2013) · Organogenesis · doi:10.4161/org.24843 · Cited by 55 · see citing works

Using a Reporter Mouse to Map Known and Novel Sites of GLP-1 Receptor Expression in Peripheral Tissues of Male Mice

Andersen, D. B., Grunddal, K. V., Pedersen, J., Kuhre, R. E., Lund, M. L., Holst, J. J., & Ørskov, C. (2021) · Endocrinology · doi:10.1210/endocr/bqaa246 · Cited by 54 · see citing works

Altered adrenergic receptor signaling following traumatic brain injury contributes to working memory dysfunction

Kobori, N., Hu, B., & Dash, P. K. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2010.10.048 · Cited by 53 · see citing works

Antibody validation: a view from the mountains

Taussig, M., Fonseca, C., & Trimmer, J. S. (2018) · New Biotechnology · doi:10.1016/j.nbt.2018.08.002 · Cited by 54 · see citing works

Identification and Profiling of Novel α1A-Adrenoceptor-CXC Chemokine Receptor 2 Heteromer

Mustafa, S., See, H. B., Seeber, R. M., Armstrong, S. P., White, C. W., Ventura, S., Ayoub, M. A., & Pfleger, K. D. G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.322834 · Cited by 51 · see citing works

Von Economo Neurons and Fork Cells: A Neurochemical Signature Linked to Monoaminergic Function

Dijkstra, A. A., Lin, L., Nana, A. L., Gaus, S. E., & Seeley, W. W. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw358 · Cited by 49 · see citing works

α1-Adrenergic Receptors: Insights into Potential Therapeutic Opportunities for COVID-19, Heart Failure, and Alzheimer’s Disease

Perez, D. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044188 · Cited by 45 · see citing works

Increased Noradrenergic Neurotransmission to a Pain Facilitatory Area of the Brain Is Implicated in Facilitation of Chronic Pain

Martins, I., Carvalho, P., de Vries, M. G., Teixeira-Pinto, A. M., Wilson, S. P., Westerink, B. H. C., & Tavares, I. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000749 · Cited by 44 · see citing works

Cannabinoid modulation of alpha2adrenergic receptor function in rodent medial prefrontal cortex

Cathel, A. M., Reyes, B. A. S., Wang, Q., Palma, J. D., Mackie, K., Bockstaele, E. J. V., & Kirby, L. G. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12690 · Cited by 43 · see citing works

α1A/B‐Knockout mice explain the native α1D‐adrenoceptor's role in vasoconstriction and show that its location is independent of the other α1‐subtypes

Methven, L., Simpson, P. C., & McGrath, J. C. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00462.x · Cited by 43 · see citing works

Evaluation of commercially available glucagon receptor antibodies and glucagon receptor expression

Billeschou, A., Johansen, C. D., Christensen, J. B., Kjeldsen, S. A. S., Galsgaard, K. D., Winther‐Sørensen, M., Serizawa, R., Hornum, M., Porrini, E., Pedersen, J., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-04242-7 · Cited by 42 · see citing works

The Role of α1-Adrenoceptor Antagonists in the Treatment of Prostate and Other Cancers

Batty, M., Pugh, R., Rathinam, I., Simmonds, J. B., Walker, E., Forbes, A., Anoopkumar‐Dukie, S., McDermott, C., Spencer, B. H., Christie, D., et al. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081339 · Cited by 41 · see citing works

Nuclear Localization of α1A‐Adrenergic Receptors Is Required for Signaling in Cardiac Myocytes: An “Inside‐Out” α1‐AR Signaling Pathway

Wu, S. C., Dahl, E. F., Wright, C. D., Cypher, A. L., Healy, C. L., & O’Connell, T. D. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.113.000145 · Cited by 41 · see citing works

α1-Adrenergic Receptors Regulate Neurogenesis and Gliogenesis

Gupta, M. K., Papay, R. S., Jurgens, C., Gaivin, R. J., Shi, T., Doze, V. A., & Perez, D. M. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.057307 · Cited by 40 · see citing works

Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells

Jensen, B. C., Swigart, P. M., Montgomery, M. D., & Simpson, P. C. (2010) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-010-0558-x · Cited by 38 · see citing works

Distribution of the Noradrenaline Innervation and Adrenoceptors in the Macaque Monkey Thalamus

Pérez-Santos, I., Palomero‐Gallagher, N., Zilles, K., & Cavada, C. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab073 · Cited by 35 · see citing works

Recombinant renewable polyclonal antibodies

Ferrara, F., D’Angelo, S., Gaiotto, T., Naranjo, L. A., Tian, H., Gräslund, S., Dobrovetsky, E., Hraber, P., Lund‐Johansen, F., Saragozza, S., et al. (2014) · mAbs · doi:10.4161/19420862.2015.989047 · Cited by 37 · see citing works

Cannabinoids: Potential Targets for Bladder Dysfunction

Ruggieri, M. R. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-16499-6_20 · Cited by 36 · see citing works

Discovery of the First Environment-Sensitive Near-Infrared (NIR) Fluorogenic Ligand for α1-Adrenergic Receptors Imaging in Vivo

Ma, Z., Lin, Y., Cheng, Y., Wu, W., Cai, R., Chen, S., Shi, B., Han, B., Shi, X., Zhou, Y., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01843 · Cited by 35 · see citing works

Gq neuromodulation of BLA parvalbumin interneurons induces burst firing and mediates fear-associated network and behavioral state transition in mice

Fu, X., Teboul, E., Weiss, G. L., Antonoudiou, P., Borkar, C. D., Fadok, J. P., Maguire, J. L., & Tasker, J. G. (2022) · Nature Communications · doi:10.1038/s41467-022-28928-y · Cited by 34 · see citing works

Noradrenergic modulation of hypoglossal motoneuron excitability: developmental and putative state-dependent mechanisms.

Funk, G. D., Zwicker, J. D., Selvaratnam, R., & Robinson, D. M. (2011) · PubMed · doi:10.4449/aib.v149i4.1271 · Cited by 35 · see citing works

Intraoperative Floppy Iris Syndrome

Panagis, L. (2010) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2010.243 · Cited by 35 · see citing works

Investigating Internalization and Intracellular Trafficking of GPCRs: New Techniques and Real-Time Experimental Approaches

Foster, S. R., & Bräuner‐Osborne, H. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2017_57 · Cited by 35 · see citing works

Nuclear Compartmentalization of α1-Adrenergic Receptor Signaling in Adult Cardiac Myocytes

Wu, S. C., & O’Connell, T. D. (2014) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000165 · Cited by 33 · see citing works

Comparative Expression Study of the Endo–G Protein Coupled Receptor (GPCR) Repertoire in Human Glioblastoma Cancer Stem-like Cells, U87-MG Cells and Non Malignant Cells of Neural Origin Unveils New Potential Therapeutic Targets

Fève, M., Saliou, J., Zeniou, M., Lennon, S., Carapito, C., Dong, J., DORSSELAER, A. V., Junier, M., Chneiweiss, H., Cianférani, S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091519 · Cited by 32 · see citing works

Expression of Adrenoceptor Subtypes in Preterm Piglet Heart Is Different to Term Heart

Kim, M. Y., Finch, A. M., Lumbers, E. R., Boyce, A. C., Gibson, K. J., Eiby, Y. A., & Lingwood, B. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092167 · Cited by 31 · see citing works

Molecular chaperones and G protein-coupled receptor maturation and pharmacology

Tao, Y. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110862 · Cited by 31 · see citing works

Prenatal Androgen Treatment Alters Body Composition and Glucose Homeostasis in Male Rats

Lazić, M., Aird, F., Levine, J., & Dunaif, A. E. (2010) · Journal of Endocrinology · doi:10.1677/joe-10-0263 · Cited by 31 · see citing works

The Protein Acyl Transferase ZDHHC21 Modulates α1 Adrenergic Receptor Function and Regulates Hemodynamics

Marin, E. P., József, L., Lorenzo, A. D., Held, K. F., Luciano, A. K., Melendez, J., Milstone, L. M., Velázquez, H., & Sessa, W. C. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.306942 · Cited by 30 · see citing works

Characterization of monoclonal antibody's binding kinetics using oblique-incidence reflectivity difference approach

Liu, S., Zhang, H., Dai, J., Hu, S., Pino, I., Eichinger, D. J., Lyu, H., & Zhu, H. (2014) · mAbs · doi:10.4161/19420862.2014.985919 · Cited by 29 · see citing works

Strategies for Site‐Specific Labeling of Receptor Proteins on the Surfaces of Living Cells by Using Genetically Encoded Peptide Tags

Wolf, P., Gavins, G. C., Beck‐Sickinger, A. G., & Seitz, O. (2021) · ChemBioChem · doi:10.1002/cbic.202000797 · Cited by 27 · see citing works

α1-Adrenoceptors in the Urinary Tract

Yamada, S., & Ito, Y. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-16499-6_14 · Cited by 28 · see citing works

Specificity concerns with antibodies for receptor mapping

Kirkpatrick, P. N. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2854 · Cited by 28 · see citing works

Three commercial antibodies against α1-adrenergic receptor subtypes lack specificity in paraffin-embedded sections of murine tissues

Böhmer, T., Pfeiffer, N., & Gericke, A. (2014) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-014-0992-2 · Cited by 26 · see citing works

Therapeutic Modulation of Urinary Bladder Function: Multiple Targets at Multiple Levels

Michel, M. C. (2014) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010814-124536 · Cited by 26 · see citing works

Endogenous N-terminal Domain Cleavage Modulates α1D-Adrenergic Receptor Pharmacodynamics

Kountz, T. S., Lee, K.-S., Aggarwal-Howarth, S., Curran, E. C., Park, J.-M., Harris, D.-A., Stewart, A., Hendrickson, J., Camp, N. D., Wolf‐Yadlin, A., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.729517 · Cited by 26 · see citing works

Generation and Characterization of Specific Antibodies to the Murine and Human Ectonucleotidase NTPDase8

Pelletier, J., Salem, M., Lecka, J., Fausther, M., Bigonnesse, F., & Sévigny, J. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00115 · Cited by 24 · see citing works

Recent advances in microscale western blotting

Sanders, B. J., Kim, D. C., & Dunn, R. C. (2016) · Analytical Methods · doi:10.1039/c6ay01947a · Cited by 24 · see citing works

The Role of Adrenoceptors in the Retina

Ruan, Y., Böhmer, T., Jiang, S., & Gericke, A. (2020) · Cells · doi:10.3390/cells9122594 · Cited by 23 · see citing works

The α 1B ‐adrenoceptor subtype mediates adrenergic vasoconstriction in mouse retinal arterioles with damaged endothelium

Böhmer, T., Manicam, C., Steege, A., Michel, M. C., Pfeiffer, N., & Gericke, A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12743 · Cited by 23 · see citing works

Subcellular compartmentalization of proximal Gαq-receptor signaling produces unique hypertrophic phenotypes in adult cardiac myocytes

Dahl, E. F., Wu, S. C., Healy, C. L., Harsch, B. A., Shearer, G. C., & O’Connell, T. D. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002283 · Cited by 23 · see citing works

Validation of commercial Mas receptor antibodies for utilization in Western Blotting, immunofluorescence and immunohistochemistry studies

Burghi, V., Fernández, N. C., Gándola, Y. B., Piazza, V. G., Quiroga, D. T., Mário, É. G., Braga, J. F., Bäder, M., Santos, R. A. S., Dominici, F. P., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183278 · Cited by 23 · see citing works

Nociceptin/Orphanin FQ (N/OFQ) conjugated to ATTO 594: a novel fluorescent probe for the N/OFQ (NOP) receptor

Bird, M. F., Guerrini, R., Willets, J. M., Thompson, J. P., Calò, G., & Lambert, D. G. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14504 · Cited by 22 · see citing works

Retinoid acid induced 16 deficiency aggravates colitis and colitis-associated tumorigenesis in mice

Xu, Y., Ding, C., Qian, C.-L., Qi, Z., & Wang, W. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2186-9 · Cited by 21 · see citing works

Alpha adrenergic receptor signaling in the hypothalamic paraventricular nucleus is diminished by the chronic intermittent hypoxia model of sleep apnea

Domingos-Souza, G., Martínez, D., Sinkler, S., Heesch, C. M., & Kline, D. D. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113517 · Cited by 21 · see citing works

Localization of the delta opioid receptor and corticotropin-releasing factor in the amygdalar complex: role in anxiety

Reyes, B. A. S., Kravets, J. L., Connelly, K. L., Unterwald, E. M., & Bockstaele, E. J. V. (2016) · Brain Structure and Function · doi:10.1007/s00429-016-1261-6 · Cited by 21 · see citing works

Strategies for immunohistochemical protein localization using antibodies: What did we learn from neurotransmitter transporters in glial cells and neurons

Danbolt, N. C., Zhou, Y., Furness, D. N., & Holmseth, S. (2016) · Glia · doi:10.1002/glia.23027 · Cited by 19 · see citing works

The effects of hitchhiker antigens co-eluting with affinity-purified research antibodies

Mechetner, L., Sood, R., Nguyen, V., Gagnon, P., & Parseghian, M. H. (2011) · Journal of Chromatography B · doi:10.1016/j.jchromb.2011.07.016 · Cited by 18 · see citing works

Development of an antigen microarray for high throughput monoclonal antibody selection

Staudt, N. D., Müller, N., & Wright, G. J. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.12.033 · Cited by 18 · see citing works

Poor antibody validation is a challenge in biomedical research: a case study for detection of c-FLIP

Bucur, O., Pennarun, B., Stancu, A. L., Nadler, M. J. S., Muraru, M. S., Bertomeu, T., & Khosravi‐Far, R. (2013) · APOPTOSIS · doi:10.1007/s10495-013-0880-0 · Cited by 17 · see citing works

Robust Comparison of Protein Levels Across Tissues and Throughout Development Using Standardized Quantitative Western Blotting

Huang, Y.-T., van der Hoorn, D., Ledahawsky, L. M., Motyl, A. A. L., Jordan, C. Y., Gillingwater, T. H., & Groen, E. J. N. (2019) · Journal of Visualized Experiments · doi:10.3791/59438 · Cited by 17 · see citing works

Phenotype pharmacology of lower urinary tract α1‐adrenoceptors

Nishimune, A., Yoshiki, H., Uwada, J., Anisuzzaman, A. S. M., Umada, H., & Muramatsu, I. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01591.x · Cited by 16 · see citing works

Functional protein microarray as molecular decathlete: A versatile player in clinical proteomics

Zhu, H., Cox, E. D., & Qian, J. X. (2012) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201200041 · Cited by 16 · see citing works

Inhibitory designer receptors aggravate memory loss in a mouse model of down syndrome

Hamlett, E. D., Ledreux, A., Gilmore, A., Vazey, E. M., Aston‐Jones, G., Boger, H. A., Paredes, D., & Granholm, A. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104616 · Cited by 15 · see citing works

Should we ignore western blots when selecting antibodies for other applications?

Lund‐Johansen, F., & Browning, M. D. (2017) · Nature Methods · doi:10.1038/nmeth.4192 · Cited by 16 · see citing works

Generation of VHH antibodies against the Arabidopsis thaliana seed storage proteins

Meyer, T. D., Eeckhout, D., Rycke, R. M. D., Buck, S. D., Muyldermans, S., & Depicker, A. (2013) · Plant Molecular Biology · doi:10.1007/s11103-013-0118-0 · Cited by 15 · see citing works

Evaluation of primary opioid receptor antibodies for use in western blotting

Niwa, H., Rowbotham, D. J., & Lambert, D. G. (2012) · British Journal of Anaesthesia · doi:10.1093/bja/aes015 · Cited by 15 · see citing works

High Throughput Identification of Monoclonal Antibodies to Membrane Bound and Secreted Proteins Using Yeast and Phage Display

Lequn, Z., Qu, L., Zhou, J., Sun, Z., Zou, H., Chen, Y., Marks, J. D., & Zhou, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111339 · Cited by 15 · see citing works

Selection of recombinant anti‐ SH 3 domain antibodies by high‐throughput phage display

Huang, H., Economopoulos, N. O., Liu, B. A., Uetrecht, A. C., Gu, J., Jarvik, N., Nadeem, V., Pawson, T. J., Moffat, J., Miersch, S., et al. (2015) · Protein Science · doi:10.1002/pro.2799 · Cited by 14 · see citing works

Stimulation of α1a Adrenergic Receptors Induces Cellular Proliferation or Antiproliferative Hypertrophy Dependent Solely on Agonist Concentration

Lei, B., Schwinn, D. A., & Morris, D. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072430 · Cited by 14 · see citing works

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors

Linares, A., Couling, L. E., Carrera, E. J., & Speth, R. C. (2016) · Journal of Visualized Experiments · doi:10.3791/53866 · Cited by 14 · see citing works

Cardiac and Vascular α1-Adrenoceptors in Congestive Heart Failure: A Systematic Review

Kayki‐Mutlu, G., Papazisi, O., Palmen, M., Danser, A. H. J., Michel, M. C., & Arioglu‐Inan, E. (2020) · Cells · doi:10.3390/cells9112412 · Cited by 14 · see citing works

α1-adrenergic drugs modulate differentiation and cell death of human erythroleukemia cells through non adrenergic mechanism

Fuchs, R., Schraml, E., Leitinger, G., Stelzer, I., Allard, N., Haas, H. S., Schauenstein, K., & Sadjak, A. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.07.005 · Cited by 14 · see citing works

Role of 1-Adrenoceptor Subtypes in Pupil Dilation Studied With Gene-Targeted Mice

Kordasz, M., Manicam, C., Steege, A., Goloborodko, E., Amato, C., Laspas, P., Brochhausen, C., Pfeiffer, N., & Gericke, A. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-15706 · Cited by 14 · see citing works

Cardiomyocyte Alpha-1A Adrenergic Receptors Mitigate Postinfarct Remodeling and Mortality by Constraining Necroptosis

Zhang, J., Sandroni, P. B., Huang, W. C., Gao, X., Oswalt, L. E., Schroder, M. A., Lee, S., Shih, Y. I., Huang, H. S., Swigart, P. M., et al. (2023) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2023.08.013 · Cited by 13 · see citing works

Ten commercial antibodies for alpha-1-adrenergic receptor subtypes

Jensen, B. C., Swigart, P. M., & Simpson, P. C. (2015)

Lack of Specificity of Commercial Antibodies Leads to Misidentification of Angiotensin Type 1 Receptor Protein

Herrera, M., Sparks, M. A., Alfonso-Pecchio, A. R., Harrison‐Bernard, L. M., & Coffman, T. M. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.203679 · Cited by 168 · see citing works

Six Commercially Available Angiotensin II AT1 Receptor Antibodies are Non-specific

Benický, J., Hafko, R., Sánchez-Lemus, E., Aguilera, G., & Saavedra, J. M. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-012-9862-y · Cited by 112 · see citing works

Lack of specificity for AT1 angiotensin receptor antibodies in Western blot analysis

Herrera, M., Sparks, M. A., & Coffman, T. M. (2012) · The FASEB Journal · doi:10.1096/fasebj.26.1_supplement.1105.7

Localization of alpha-2 adrenergic receptor subtypes using subtype-specific antibodies.

Huang, Y. (1995) · UA Campus Repository (The University of Arizona)