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Cited by 59Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Cardiac and neuroprotection regulated by α1-adrenergic receptor subtypes

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Perez, Dianne M., Doze, Van A.·2011·Journal of Receptors and Signal Transduction
DOI 10.3109/10799893.2010.550008PMC PMC3623295
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Abstract

Sympathetic nervous system regulation by the α(1)-adrenergic receptor (AR) subtypes (α(1A), α(1B), α(1D)) is complex, whereby chronic activity can be either detrimental or protective for both heart and brain function. This review will summarize the evidence that this dual regulation can be mediated through the different α(1)-AR subtypes in the context of cardiac hypertrophy, heart failure, apoptosis, ischemic preconditioning, neurogenesis, locomotion, neurodegeneration, cognition, neuroplasticity, depression, anxiety, epilepsy, and mental illness.

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  • Terazosin has a proconvulsant effect via antagonizing α1-adrenergic receptor.

    “Considering the proconvulsant effect of terazosin via antagonizing α1-adrenergic receptor (Chen et al., 2007; Perez and Doze, 2011)”

    From APOE4 reduces hippocampal expression of phosphoglycerate kinase 1 and sodium potassium pump to enhance seizure susceptibility in mice (2026) · cites this paper as Perez and Doze, 2011

    The Neurophysiology section (‘α1A-ARs in epilepsy’; page unavailable) says α1-receptor activity can mediate anticonvulsant effects and that α1A-receptor knockout mice often have spontaneous seizures. It does not report that terazosin is proconvulsant or establish that terazosin causes seizures by antagonizing α1 receptors; a search for terazosin found no relevant passage. (LLM, conf=0.83)

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Cited by

Sorted by citations

Authors
Perez, D. M., & Doze, V. A.
Affiliations
  • Cleveland Clinic (US)
  • University of North Dakota (US)
Corresponding author
Perez, Dianne M.
ORCID
Venue
Journal of Receptors and Signal Transduction
Publisher
Informa UK Limited
Published
2011-02-21
Volume
31
Issue
2
Pages
98-110
ISSN
  • 1079-9893 (ISSN-L)
  • 1532-4281
DOI
10.3109/10799893.2010.550008
PMC
PMC3623295
OpenAlex
W2016991385
Cited by
59
References
3
Citations by year
2026: 1 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 3 · 2021: 8 · 2020: 8 · 2019: 1 · 2018: 5 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 4
FWCI
0.35
Type
journal article
Language
en
Open access
Locations
  • Journal of Receptors and Signal Transduction (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Heart, Lung, and Blood Institute (R01HL098279)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
alpha1-adrenoceptors, cardiac hypertrophy, heart failure, apoptosis, ischemic preconditioning, neurogenesis, neurodegeneration, neuroplasticity, depression, anxiety, epilepsy, mental illness, sympathetic nervous system, neuroprotection
MeSH terms
Animals, Humans, Myocardium, Neurons, Receptors, Adrenergic, alpha-1, Cytoprotection, Protective Agents

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