The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
The motivational valence of nicotine in the rat ventral tegmental area is switched from rewarding to aversive following blockade of the α7-subunit-containing nicotinic acetylcholine receptor
Abstract
Rationale Within the mammalian ventral tegmental area (VTA), nicotine produces both aversive and rewarding motivational effects. However, the specific neuronal nicotinic acetylcholine receptor (nAChR) subtypes responsible for these effects are not clearly understood. Objectives In the present study, we challenged the motivational effects of nicotine directly in the VTA with nAChR subunit specific antagonists. Methods Using an unbiased place-conditioning procedure as a behavioural assay, we performed bilateral microinfusions of nicotine over a wide range of concentrations (0.008, 8, 24 and 48 nmol/0.5 microl) and challenged the aversive and reinforcing behavioural effects of these nicotine doses with co-administration of di-hydro-beta-erythroidine (DHbetaE) (5 or 50 nmol/0.5 microl), a nAChR antagonist with higher relative affinity for the alpha4beta2 nAChR subunit, methyllycaconitine citrate (MLA) (0.4 or 4 nmol/0.5 microl), a nAChR antagonist that displays greater relative affinity for the alpha7 nAChR, and the NMDA receptor antagonist, d-2-amino-7-phosphoheptanoic acid (AP-7; 18 nmol/0.5 microl). Results The alpha4beta2 antagonist DHbetaE blocked both the rewarding and aversive properties of intra-VTA nicotine. However, the alpha7 antagonist MLA blocked nicotine reward and switched the motivational valence of higher doses of nicotine (8-48 nmol/0.5 microl) from rewarding to aversive. The NMDA antagonist AP-7 blocked both the aversive and rewarding effects of intra-VTA nicot…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“An accumulation of data suggests that both the β2* and α7 nAChR subtypes contribute to nicotine-associated increases in DA release and associated nicotine-dependent behaviors (Corrigall et al., 1994; Epping-Jordan et al., 1999; Laviolette and van der Kooy, 2003; Mansvelder et al., 2002; Picciotto et al., 1998; Pidoplichko et al., 2004; Shoaib and Stolerman, 1994).”
From It is not “either/or”: Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood (2008) · cites this paper as Laviolette and van der Kooy, 2003
Citations
Cites
Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229
The rat brain in stereotaxic coordinates (2nd edn)
Herman, J. P., & Watson, S. J. (1987) · Trends in Neurosciences · doi:10.1016/0166-2236(87)90017-8 · Cited by 1,751
Picciotto, M. R., Zoli, M., Rimondini, R., Léna, C., Marubio, L. M., Pich, E. M., Fuxe, K., & Changeux, J.-P. (1998) · Nature · doi:10.1038/34413 · Cited by 1,320
Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors
McGehee, D. S., Heath, M. J. S., Gelber, S., Devay, P., & Role, L. W. (1995) · Science · doi:10.1126/science.7569895 · Cited by 1,070
The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine
Corrigall, W. A., Franklin, K. B. J., Coen, K. M., & Clarke, P. B. S. (1992) · Psychopharmacology · doi:10.1007/bf02245149 · Cited by 829
Corrigall, W. A., Coen, K. M., & Adamson, K. L. (1994) · Brain Research · doi:10.1016/0006-8993(94)90401-4 · Cited by 740
Klink, R., d'Exaerde, A. D. K., Zoli, M., & Changeux, J.-P. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01452.2001 · Cited by 674
Nicotinic receptors in the brain: correlating physiology with function
Jones, S., Sudweeks, S. N., & Yakel, J. L. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01471-x · Cited by 450
Chavez-Noriega, L. E., Crona, J. H., Washburn, M. S., Urrutia, A., Elliott, K. J., & Johnson, E. C. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36376-1 · Cited by 405
Chavez-Noriega, L. E., Crona, J. H., Washburn, M. S., Urrutia, A., Elliott, K. J., & Johnson, E. C. (1997) · PubMed · Cited by 392
Nicotine self-administration in animals and humans: similarities and differences
Rose, J. E., & Corrigall, W. A. (1997) · Psychopharmacology · doi:10.1007/s002130050209 · Cited by 262
Schilström, B., Nomikos, G. G., Nisell, M., Hertel, P., & Svensson, T. H. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00243-1 · Cited by 207
Laviolette, S. R., & van der Kooy, D. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001197 · Cited by 180
Self-citationMarkou, A., & Paterson, N. E. (2001) · Nicotine & Tobacco Research · doi:10.1080/14622200110073380 · Cited by 154
Corrigall, W., Coen, K. M., Adamson, K. L., Chow, B. L., & Zhang, J. (2000) · Psychopharmacology · doi:10.1007/s002139900355 · Cited by 152
Grottick, A. J., Trube, G., Corrigall, W. A., Huwyler, J., Malherbe, P., Wyler, R., & Higgins, G. A. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39179-7 · Cited by 144
Grottick, A. J., Trube, G., Corrigall, W., Huwyler, J., Malherbe, P., Wyler, R., & Higgins, G. A. (2000) · PubMed · Cited by 142
Laviolette, S. R., & van der Kooy, D. (2001) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2001.01458.x · Cited by 140
Self-citationNader, K., & van der Kooy, D. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-01-00383.1997 · Cited by 134
Marks, M. J., Whiteaker, P., Calcaterra, J., Stitzel, J. A., Bullock, A. E., Grady, S. R., Picciotto, M. R., Changeux, J., & Collins, A. C. (1999) · PubMed · Cited by 126
Shoaib, M., Gommans, J., Morley, A., Stolerman, I. P., Grailhe, R., & Changeux, J.-P. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(01)00194-0 · Cited by 110
Aversion instead of preference learning indicated by nicotine place conditioning in rats
Jorenby, D. E., Steinpreis, R. E., Sherman, J. E., & Baker, T. B. (1990) · Psychopharmacology · doi:10.1007/bf02244233 · Cited by 99
Yin, R., & French, E. D. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00237-9 · Cited by 87
Barazangi, N., & Role, L. W. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.1.463 · Cited by 81
Marks, M. J., Whiteaker, P., Calcaterra, J., Stitzel, J. A., Bullock, A. E., Grady, S. R., Picciotto, M. R., Changeux, J.-P., & Collins, A. C. (1999) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38240-0 · Cited by 79
Methyl lycaconitine: A novel nicotinic antagonist
Drasdo, A. L., Caulfield, M. P., Bertrand, D., Bertrand, S., & Wonnacott, S. (1992) · Molecular and Cellular Neuroscience · doi:10.1016/1044-7431(92)90043-2 · Cited by 78
Antagonism of the discriminative and aversive stimulus properties of nicotine in C57BL/6J mice
Gommans, J., Stolerman, I. P., & Shoaib, M. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00130-1 · Cited by 61
Fisher, J. L., Pidoplichko, V. I., & Dani, J. A. (1998) · Journal of Physiology-Paris · doi:10.1016/s0928-4257(98)80012-0 · Cited by 55
Mecamylamine Blockade of Both Positive and Negative Effects of IV Nicotine in Human Volunteers
Lundahl, L. H., Henningfield, J. E., & Lukas, S. E. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00252-5 · Cited by 31
Cited by
Sorted by citations
Tzschentke, T. M. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00070.x · Cited by 1,336
Guidelines on nicotine dose selection for in vivo research
Matta, S. G., Balfour, D. J., Benowitz, N. L., Boyd, R. T., Buccafusco, J. J., Caggiula, A. R., Craig, C. R., Collins, A. C., Damaj, M. I., Donny, E. C., et al. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0441-0 · Cited by 824
Nicotine Activation of α4* Receptors: Sufficient for Reward, Tolerance, and Sensitization
Tapper, A. R., McKinney, S. L., Nashmi, R., Schwarz, J., Deshpande, P., Labarca, C., Whiteaker, P., Marks, M. J., Collins, A. C., & Lester, H. A. (2004) · Science · doi:10.1126/science.1099420 · Cited by 686
The neurobiology of positive emotions
Burgdorf, J., & Panksepp, J. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.06.001 · Cited by 677
The neurobiology of nicotine addiction: bridging the gap from molecules to behaviour
Laviolette, S. R., & van der Kooy, D. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1298 · Cited by 469
Self-citation
Metadata
- Authors
- Laviolette, S. R., & van der Kooy, D.
- Affiliations
- University of Toronto (CA)
- Venue
- Psychopharmacology
- Published
- 2003-02-05
- Volume
- 166
- Issue
- 3
- Pages
- 306-313
- ISSN
- 0033-3158 (ISSN-L)
- OpenAlex
- W1540199296
- Cited by
- 113
- References
- 30
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 6 · 2021: 3 · 2020: 2 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 8 · 2013: 8 · 2012: 5
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Keywords
- nicotine, ventral tegmental area, nicotinic acetylcholine receptors, alpha7 nAChR, alpha4beta2 nAChR, nicotine reward, nicotine aversion, dihydro-beta-erythroidine, methyllycaconitine, NMDA receptor, glutamatergic mechanisms, place conditioning, microinfusion
- MeSH terms
- Aconitine, Animals, Conditioning, Operant, Dihydro-beta-Erythroidine, Dose-Response Relationship, Drug, Male, Microinjections, Motivation, Nicotine, Receptors, Nicotinic, Reinforcement, Psychology, Reward, 2-Amino-5-phosphonovalerate, Receptors, N-Methyl-D-Aspartate, Rats, Wistar, Ventral Tegmental Area, Excitatory Amino Acid Antagonists, Nicotinic Agonists, Nicotinic Antagonists, Rats, alpha7 Nicotinic Acetylcholine Receptor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
